@book{UBHD-69118448, editor={Klimm, Hans-Dieter and Peters-Klimm, Frank}, title={Allgemeinmedizin}, subtitle={der Mentor f{\"u}r die Facharztpr{\"u}fung und f{\"u}r die allgemeinmedizinische ambulante Versorgung}, edition={7., {\"u}berarbeitete und erweiterte Auflage}, publisher={Thieme}, address={Stuttgart}, year={2023}, pages={1 Online-Ressource (853 Seiten)}, language={ger}, doi={10.1055/b000000120}, keywords={Allgemeinmedizin}, } @book{UBHD-69103644, editor={Klimm, Hans-Dieter and Peters-Klimm, Frank}, title={Allgemeinmedizin}, subtitle={der Mentor f{\"u}r die Facharztpr{\"u}fung und f{\"u}r die allgemeinmedizinische ambulante Versorgung}, edition={7., {\"u}berarbeitete und erweiterte Auflage}, publisher={Georg Thieme Verlag}, address={Stuttgart ; New York}, year={2023}, pages={853 Seiten}, language={ger}, isbn={978-3-13-243593-3 and 3-13-243593-7}, note={Auf dem Umschlag: + Online-Version in der eRef ; Literaturangaben}, keywords={Allgemeinmedizin}, library={UB [Signatur: UBN/XC 1601 K65(7)] ; UG [Signatur: UG/XC 1400 K65(7)] ; UW [Signatur: G 1 b]}, } @article{UBHD-68021258, author={Blank, Antje and Markert, Christoph and Hohmann, Nicolas and Carls, Alexandra and Mikus, Gerd and Urban, Stephan and Haefeli, Walter E.}, title={First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B}, year={2016}, pages={483-489}, language={eng}, issn={1600-0641}, volume={65}, number={3}, note={Gesehen am 24.08.2016}, journal={Journal of hepatology}, doi={10.1016/j.jhep.2016.04.013}, } @article{UBHD-68299233, author={Blank, Antje and Eidam, Annette and Hohmann, Nicolas and Burhenne, J{\"u}rgen and Meyer, Markus Robert and Meier, Katrin and Weiß, Johanna and Bruckner, Thomas and Urban, Stephan and Mikus, Gerd and Haefeli, Walter E.}, title={The NTCP-inhibitor Myrcludex B}, subtitle={effects on bile acid disposition and tenofovir pharmacokinetics}, year={2018}, pages={341-348}, language={eng}, issn={1532-6535}, volume={103}, number={2}, note={Gesehen am 27.08.2018 ; Advance online publication 21 June 2017}, journal={Clinical pharmacology & therapeutics}, doi={10.1002/cpt.744}, } @article{UBHD-68261264, author={Burhenne, J{\"u}rgen and Halama, Birte and Maurer, Monika and Riedel, Klaus-Dieter and Hohmann, Nicolas and Mikus, Gerd and Haefeli, Walter E.}, title={Quantification of femtomolar concentrations of the CYP3A substrate midazolam and its main metabolite 1′-hydroxymidazolam in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry}, year={2012}, pages={2439-2450}, language={eng}, issn={1618-2650}, volume={402}, number={7}, note={Die Zahl 3 ist im Titel tiefgestellt ; Gesehen am 14.06.2018}, journal={Analytical and bioanalytical chemistry}, doi={10.1007/s00216-011-5675-y}, } @article{UBHD-67398865, author={Burhenne, J{\"u}rgen and Halama, Birte and Maurer, Monika and Riedel, Klaus-Dieter and Hohmann, Nicolas and Mikus, Gerd and Haefeli, Walter E.}, title={Quantification of femtomolar concentrations of the CYP3A substrate midazolam and its main metabolite 1'-hydroxymidazolam in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry}, year={2012}, pages={2439-2450}, language={eng}, issn={1618-2642}, volume={402}, number={7}, note={Die Zahl 3 ist im Titel tiefgestellt}, journal={Analytical & bioanalytical chemistry}, } @article{UBHD-67879734, author={Carls, Alexandra and Jedamzik, Julia and Witt, Lukas and Hohmann, Nicolas and Burhenne, J{\"u}rgen and Mikus, Gerd}, title={Systemic exposure of topical erythromycin in comparison to oral administration and the effect on cytochrome P450 3A4 activity}, year={2014}, pages={1433-1440}, language={eng}, issn={1365-2125}, volume={78}, number={6}, note={Gesehen am 01.10.2015}, journal={British journal of clinical pharmacology}, doi={10.1111/bcp.12497}, } @article{UBHD-68415868, author={Geist, Marcus Julian Peter and Egerer, Gerlinde and Mikus, Gerd and Blank, Antje and Hohmann, Nicolas and Carls, Alexandra}, title={Impact of patient education on plasma concentrations and effectiveness of posaconazole oral suspension under clinical conditions}, year={2019}, pages={56-61}, language={eng}, issn={1742-7843}, volume={124}, number={1}, note={First published: 10 July 2018 ; Gesehen am 05.08.2019}, journal={Basic & clinical pharmacology & toxicology}, doi={10.1111/bcpt.13093}, } @article{UBHD-68861755, author={Hajda, Jacek and Leuchs, Barbara and Angelova, Assia L. and Frehtman, Veronika and Rommelaere, Jean and Mertens, Mieke and Pilz, Maximilian and Kieser, Meinhard and Krebs, Ottheinz and Dahm, Michael and Huber, Bernard and Engeland, Christine Elisabeth and Mavratzas, Athanasios and Hohmann, Nicolas and Schreiber, Jutta Sylvina and J{\"a}ger, Dirk and Halama, Niels and Sedlaczek, Oliver and Gaida, Matthias and Daniel, Volker and Springfeld, Christoph and Ungerechts, Guy}, title={Phase 2 trial of oncolytic H-1 parvovirus therapy shows safety and signs of immune system activation in patients with metastatic pancreatic ductal adenocarcinoma}, year={2021}, pages={5546-5556}, language={eng}, issn={1557-3265}, volume={27}, number={20}, note={Gesehen am 30.12.2021}, journal={Clinical cancer research}, doi={10.1158/1078-0432.CCR-21-1020}, } @article{UBHD-68702713, author={Halama, Birte and Hohmann, Nicolas and Burhenne, J{\"u}rgen and Weiß, Johanna and Mikus, Gerd and Haefeli, Walter E.}, title={A nanogram dose of the CYP3A probe substrate midazolam to evaluate drug interactions}, year={2013}, pages={564-571}, language={eng}, issn={1532-6535}, volume={93}, number={6}, note={Gesehen am 13.10.2021}, journal={Clinical pharmacology & therapeutics}, doi={10.1038/clpt.2013.27}, } @article{UBHD-68297425, author={Hohmann, Nicolas and Kreuter, Rebecca and Blank, Antje and Weiß, Johanna and Burhenne, J{\"u}rgen and Haefeli, Walter E. and Mikus, Gerd}, title={Autoinhibitory properties of the parent but not of the N-oxide metabolite contribute to infusion rate-dependent voriconazole pharmacokinetics}, year={2017}, pages={1954-1965}, language={eng}, issn={1365-2125}, volume={83}, number={9}, note={Gesehen am 21.08.2018}, journal={British journal of clinical pharmacology}, doi={10.1111/bcp.13297}, } @article{UBHD-68445736, author={Hohmann, Nicolas and Haefeli, Walter E. and Mikus, Gerd}, title={CYP3A activity}, subtitle={towards dose adaptation to the individual}, year={2016}, pages={479-497}, language={eng}, issn={1744-7607}, volume={12}, number={5}, note={Gesehen am 25.10.2019}, journal={Expert opinion on drug metabolism & toxicology}, doi={10.1517/17425255.2016.1163337}, } @article{UBHD-68069516, author={Hohmann, Nicolas and Kocheise, Franziska and Carls, Alexandra and Burhenne, J{\"u}rgen and Weiß, Johanna and Haefeli, Walter E. and Mikus, Gerd}, title={Dose-dependent bioavailability and CYP3A inhibition contribute to non-linear pharmacokinetics of voriconazole}, year={2016}, pages={1535-1545}, language={eng}, issn={1179-1926}, volume={55}, number={12}, note={Gesehen am 05.01.2017}, journal={Clinical pharmacokinetics}, doi={10.1007/s40262-016-0416-1}, } @article{UBHD-69320525, author={Hohmann, Nicolas and Friedrichs, Anna S. and Burhenne, J{\"u}rgen and Blank, Antje and Mikus, Gerd and Haefeli, Walter E.}, title={Dose-dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin}, year={2024}, pages={1-11}, language={eng}, issn={1752-8062}, volume={17}, note={Erste Ver{\"o}ffentlichung: 16. August 2024 ; Gesehen am 20.03.2025}, journal={Clinical and translational science}, doi={10.1111/cts.70007}, } @article{UBHD-67985166, author={Hohmann, Nicolas and Mikus, Gerd and Czock, David}, title={Effects and risks associated with novel psychoactive substances}, subtitle={mislabeling and sale as bath salts, spice, and research chemicals}, year={2014}, pages={139-147}, language={eng}, issn={1866-0452}, volume={111}, number={9}, note={Gesehen am 18.05.2016}, journal={Deutsches {\"A}rzteblatt international}, doi={10.3238/arztebl.2014.0139}, } @book{UBHD-68629180, author={Hohmann, Nicolas}, organization={Universit{\"a}t Heidelberg}, title={Entwicklung und Anwendung mikrodosierter Substrate der Cytochrom P450-Isoenzyme als Ph{\"a}notypisierungstest in Arzneimittelwechselwirkungsstudien und zur Dosisindividualisierung am Patientenbett}, address={Heidelberg}, year={2019}, pages={1 Band (verschiedene Seitenz{\"a}hlungen)}, language={ger}, note={Publikationsbasierte Habilitationsschrift bestehend aus einem Text und 7 Zeitschriftenaufs{\"a}tzen}, school={Habilitationsschrift, Ruprecht-Karls-Universit{\"a}t Heidelberg, 2020, Kumulative Habilitationsschrift}, library={UB [Signatur: 2020 U 604]}, } @article{UBHD-68579319, author={Hohmann, Nicolas and Xia, Ning and Steinkamp-Fenske, Katja and F{\"o}rstermann, Ulrich and Li, Huige}, title={Estrogen receptor signaling and the PI3K/akt pathway are involved in betulinic acid-induced eNOS activation}, year={2016}, pages={13 S.}, language={eng}, issn={1420-3049}, volume={21(2016}, note={Gesehen am 19.05.2020}, journal={Molecules}, doi={10.3390/molecules21080973}, } @article{UBHD-68420677, author={Hohmann, Nicolas and Mikus, Gerd and Haefeli, Walter E. and Schwenger, Vedat and Weiß, Johanna}, title={A follow-up report on potential drug interactions with clementines}, subtitle={two single case experiments show no effect on CYP3A-dependent midazolam clearance}, year={2019}, pages={54-58}, language={eng}, issn={1879-0720}, volume={133}, note={Gesehen am 14.08.2019}, journal={European journal of pharmaceutical sciences}, doi={10.1016/j.ejps.2019.03.013}, } @article{UBHD-68635189, author={Hohmann, Nicolas and Kocheise, Franziska and Carls, Alexandra and Burhenne, J{\"u}rgen and Haefeli, Walter E. and Mikus, Gerd}, title={Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans}, year={2015}, pages={278-285}, language={eng}, issn={1365-2125}, volume={79}, number={2}, note={Accepted article published online 2 September 2014 ; Gesehen am 07.09.2020}, journal={British journal of clinical pharmacology}, doi={10.1111/bcp.12502}, } @article{UBHD-68772058, author={Hohmann, Nicolas and Bozorgmehr, Farastuk and Christopoulos, Petros and Mikus, Gerd and Blank, Antje and Burhenne, J{\"u}rgen and Thomas, Michael and Haefeli, Walter E.}, title={Pharmacoenhancement of low crizotinib plasma concentrations in patients with anaplastic lymphoma kinase-positive non-small cell lung cancer using the CYP3A inhibitor cobicistat}, year={2021}, pages={487-491}, language={eng}, issn={1752-8062}, volume={14}, number={2}, note={First published: 22 November 2020 ; Gesehen am 19.08.2021}, journal={Clinical and translational science}, doi={10.1111/cts.12921}, url={https://doi.org/10.1111/cts.12921}, library={UB}, } @article{UBHD-68014760, author={Hohmann, Nicolas and Halama, Birte and Siller, Nelly and Mikus, Gerd and Haefeli, Walter E.}, title={Response to "Can CYP3A activity be evaluated for drug interaction using a nanogram dose of probe drug?"}, subtitle={Evaluation of CYP3A activity with microdoses of midazolam}, year={2014}, pages={490-491}, language={eng}, issn={1532-6535}, volume={95}, number={5}, note={Gesehen am 05.08.2016}, journal={Clinical pharmacology & therapeutics}, doi={10.1038/clpt.2014.28}, } @article{UBHD-68485715, author={Hohmann, Nicolas and Maus, Anna Sabina and Carls, Alexandra and Haefeli, Walter E. and Mikus, Gerd}, title={St. John’s wort treatment in women bears risks beyond pharmacokinetic drug interactions}, year={2016}, pages={1013-1015}, language={eng}, issn={1432-0738}, volume={90}, number={4}, note={Published online: 12 May 2015 ; Gesehen am 06.02.2020}, journal={Archives of toxicology}, doi={10.1007/s00204-015-1532-7}, } @article{UBHD-68069519, author={Hohmann, Nicolas and Reinhard, Raphael and Schnaidt, Sven and Witt, Lukas and Carls, Alexandra and Burhenne, J{\"u}rgen and Mikus, Gerd and Haefeli, Walter E.}, title={Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans}, year={2016}, pages={2241-2247}, language={eng}, issn={1460-2091}, volume={71}, number={8}, note={Gesehen am 05.01.2017}, journal={The journal of antimicrobial chemotherapy}, doi={10.1093/jac/dkw125}, } @article{UBHD-68068839, author={Hohmann, Nicolas and Haefeli, Walter E. and Mikus, Gerd}, title={Use of microdose phenotyping to individualise dosing of patients}, year={2015}, pages={893-900}, language={eng}, issn={1179-1926}, volume={54}, number={9}, note={Gesehen am 03.01.2017}, journal={Clinical pharmacokinetics}, doi={10.1007/s40262-015-0278-y}, } @article{UBHD-68936787, author={Neuman, Manuela G. and Seitz, Helmut K. and Teschke, Rolf and Malnick, Stephen and Johnson-Davis, Kamisha L. and Cohen, Lawrence B. and German, Anit and Hohmann, Nicolas and Moreira, Bernhardo and Moussa, George and Opris, Mihai}, title={Molecular, viral and clinical features of alcohol- and non-alcohol-induced liver injury}, year={2022}, pages={1294-1315}, language={eng}, issn={1467-3045}, volume={44}, number={3 vom: M{\"a}rz}, note={Gesehen am 02.07.2022}, journal={Current issues in molecular biology}, doi={10.3390/cimb44030087}, } @article{UBHD-68299578, author={Niethammer, Andreas Gerhard and Mikus, Gerd and Knebel, Phillip and Hohmann, Nicolas and Leowardi-Bauer, Christine and Beckhove, Philipp and Akhisaroglu, Mustafa and Ge, Yingzi and Grenacher, Lars and B{\"u}chler, Markus W. and Koch, Moritz and Weitz, J{\"u}rgen and Haefeli, Walter E. and Schmitz-Winnenthal, Friedrich Hubertus}, title={Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer}, year={2012}, pages={8 S.}, language={eng}, issn={1471-2407}, volume={12(2012) Artikel-Nummer 361}, number={8 Seiten}, note={Gesehen am 28.08.2018}, journal={BMC cancer}, doi={10.1186/1471-2407-12-361}, } @article{UBHD-68069055, author={Outeiro, Noémi and Hohmann, Nicolas and Mikus, Gerd}, title={No increased risk of ketoconazole toxicity in drug-drug interaction studies}, year={2016}, pages={1203-1211}, language={eng}, issn={1552-4604}, volume={56}, number={10}, note={Gesehen am 04.01.2017}, journal={Journal of clinical pharmacology}, doi={10.1002/jcph.795}, } @article{UBHD-68262742, author={Schmitz-Winnenthal, Friedrich Hubertus and Hohmann, Nicolas and Friedrich, Tobias and Mikus, Gerd and Weitz, J{\"u}rgen and Ulrich, Alexis and B{\"u}chler, Markus W. and Pianka, Frank and Klaiber, Ulla and Diener, Markus K. and Leowardi-Bauer, Christine and Schimmack, Simon and Peters, Leila and Springfeld, Christoph and Knebel, Phillip and Schmidt, Thomas and Ge, Yingzi and Stamova, Slava and Podola, Lilli and Haefeli, Walter E. and Grenacher, Lars and Beckhove, Philipp}, title={Anti-angiogenic activity of VXM01, an oral T-cell vaccine against VEGF receptor 2, in patients with advanced pancreatic cancer}, subtitle={a randomized, placebo-controlled, phase 1 trial}, year={2015}, pages={13 S.}, language={eng}, issn={2162-402X}, volume={4(2015}, note={Gesehen am 01.12.2016}, journal={OncoImmunology}, doi={10.1080/2162402X.2014.1001217}, } @article{UBHD-68561940, author={Schmitz-Winnenthal, Friedrich Hubertus and Hohmann, Nicolas and Schmidt, Thomas and Podola, Lilli and Friedrich, Tobias and Lubenau, Heinz and Springer, Marco and Wieckowski, Sébastien and Breiner, Klaus M. and Mikus, Gerd and B{\"u}chler, Markus W. and Keller, Anne-Valérie and Koc, Ruhan and Springfeld, Christoph and Knebel, Phillip and Bucur, Mariana and Grenacher, Lars and Haefeli, Walter E. and Beckhove, Philipp}, title={A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer}, year={2018}, pages={13 S.}, language={eng}, issn={2162-402X}, volume={7 (2018}, note={Published online: 16 Jan 2018 ; Gesehen am 06.04.2020}, journal={OncoImmunology}, doi={10.1080/2162402X.2017.1303584}, } @article{UBHD-68721718, author={Siller, Nelly and Egerer, Gerlinde and Bochtler, Tilmann and Hohmann, Nicolas and Mikus, Gerd}, title={Normal CYP3A activity during arsenic trioxide therapy}, year={2014}, pages={1941-1942}, language={eng}, issn={1432-0584}, volume={93}, number={11}, note={Im Titel ist die Zahl "3" tief gestellt ; Gesehen am 09.04.2021}, journal={Annals of hematology}, doi={10.1007/s00277-014-2076-2}, } @article{UBHD-68803106, author={Suarez-Carmona, Meggy and Williams, Anja and Schreiber, Jutta and Hohmann, Nicolas and Pruefer, Ulrike and Krauß, J{\"u}rgen and J{\"a}ger, Dirk and Fr{\"o}mming, Anna and Beyer, Diana and Eulberg, Dirk and Jungelius, Jarf Ulf and Baumann, Matthias and Mangasarian, Aram and Halama, Niels}, title={Combined inhibition of CXCL12 and PD-1 in MSS colorectal and pancreatic cancer}, subtitle={modulation of the microenvironment and clinical effects}, year={2021}, pages={1-13}, language={eng}, issn={2051-1426}, volume={9}, note={Gesehen am 18.11.2021}, journal={Journal for ImmunoTherapy of Cancer}, doi={10.1136/jitc-2021-002505}, } @article{UBHD-68069050, author={Theile, Dirk and Hohmann, Nicolas and Kiemel, Dominik and Mikus, Gerd and Haefeli, Walter E. and Schwenger, Vedat and Weiß, Johanna}, title={Clementine juice has the potential for drug interactions}, subtitle={in vitro comparison with grapefruit and mandarin juice}, year={2017}, pages={247-256}, language={eng}, issn={1879-0720}, volume={97}, note={Gesehen am 04.01.2017}, journal={European journal of pharmaceutical sciences}, doi={10.1016/j.ejps.2016.11.021}, } @article{UBHD-68718705, author={Wagner, Lelia and Haefeli, Walter E. and Merle, Uta and Lorenz, Hanns-Martin and Hohmann, Nicolas and Weiß, Johanna and Theile, Dirk}, title={A nuclear factor kappa B reporter cell line used to evaluate ex vivo the net inflammatory effect of plasma samples from patients with rheumatoid arthritis, psoriasis, or COVID-19}, year={2021}, pages={1-6}, language={eng}, issn={1096-0023}, volume={138}, number={Artikel-ID 155399}, note={Available online 9 December 2020 ; Gesehen am 07.04.2021}, journal={Cytokine}, doi={10.1016/j.cyto.2020.155399}, } @article{UBHD-68069513, author={Witt, Lukas and Hohmann, Nicolas and Mikus, Gerd and Haefeli, Walter E. and Burhenne, J{\"u}rgen}, title={Ultrasensitive quantification of the CYP2E1 probe chlorzoxazone and its main metabolite 6-hydroxychlorzoxazone in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry after chlorzoxazone microdosing}, year={2016}, pages={207-213}, language={eng}, issn={1873-376X}, volume={1027}, note={Gesehen am 05.01.2017}, journal={Journal of chromatography}, doi={10.1016/j.jchromb.2016.05.049}, } @article{UBHD-69124550, author={Zhou, Xu and An, Jingyu and Kurilov, Roman and Brors, Benedikt and Hu, Kai and Peccerella, Teresa and R{\"o}ssler, Stephanie and Pf{\"u}tze, Katrin and Schulz, Angela and Wolf, Stephan and Hohmann, Nicolas and Theile, Dirk and Sauter, Max and Burhenne, J{\"u}rgen and Ei, Shigenori and Heger, Ulrike and Strobel, Oliver and Barry, Simon T. and Springfeld, Christoph and Tjaden, Christin and Bergmann, Frank and B{\"u}chler, Markus W. and Hackert, Thilo and Fortunato, Franco and Neoptolemos, John P. and Bailey, Peter}, title={Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC}, year={2023}, pages={1362-1381}, language={eng}, issn={2662-1347}, volume={4}, number={9}, note={Gesehen am 26.09.2023}, journal={Nature cancer}, doi={10.1038/s43018-023-00628-6}, }