@article{UBHD-68944838, author={Becker, Jonas and Stanifer, Megan and Leist, Sarah Rebecca and Stolp-Rast{\"a}tter, Bettina and Maiakovska, Olena and West, Ande and Wiedtke, Ellen and B{\"o}rner, Kathleen and Ghanem, Ali and Ambiel, Ina and Tse, Longping Victor and Fackler, Oliver Till and Baric, Ralph Steven and Boulant, Steeve and Grimm, Dirk}, title={Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors}, year={2022}, pages={2005-2023}, language={eng}, issn={1525-0024}, volume={30}, number={5 vom: Mai}, note={Gesehen am 20.07.2022}, journal={Molecular therapy}, doi={10.1016/j.ymthe.2022.01.024}, } @article{UBHD-69002424, author={Beer, Shelly and Bellovin, David I and Lee, Joyce and Komatsubara, Kimberly and Wang, Lora S and Koh, Huishan and B{\"o}rner, Kathleen and Storm, Theresa A and Davis, Corrine R and Kay, Mark A and Felsher, Dean W and Grimm, Dirk}, title={Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice}, year={2010}, pages={161-170}, language={eng}, issn={1525-0024}, volume={18}, number={1}, note={Published online 20 October 2009 ; Gesehen am 04.01.2023}, journal={Molecular therapy}, doi={10.1038/mt.2009.222}, } @article{UBHD-68330261, author={Bejarano Acuña, David Alejandro and B{\"o}rner, Kathleen and M{\"u}ller, Barbara and Kr{\"a}usslich, Hans-Georg}, title={Detailed characterization of early HIV-1 replication dynamics in primary human macrophages}, year={2018}, pages={25 S.}, language={eng}, issn={1999-4915}, volume={10(2018}, note={Gesehen am 20.11.2018}, journal={Viruses}, doi={10.3390/v10110620}, url={http://dx.doi.org/10.3390/v10110620}, library={UB}, } @article{UBHD-68407585, author={Bejarano Acuña, David Alejandro and Peng, Ke and Laketa, Vibor and B{\"o}rner, Kathleen and Jost, Katharina Laurence and Lucic, Bojana and Lusic, Marina and M{\"u}ller, Barbara and Kr{\"a}usslich, Hans-Georg}, title={HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex}, year={2019}, pages={31 S.}, language={eng}, issn={2050-084X}, volume={8(2019) Artikel-Nummer e41800}, number={31 Seiten}, note={Gesehen am 11.07.2019}, journal={eLife}, doi={10.7554/eLife.41800}, } @article{UBHD-67840403, author={B{\"o}rner, Kathleen and Beneke, J{\"u}rgen and Hausmann, Michael and Hamprecht, Fred and Erfle, Holger and Kaderali, Lars and Kr{\"a}usslich, Hans-Georg and Lehmann, Maik J. and Hermle, Johannes and Sommer, Christoph and Knapp, Bettina and Glass, B{\"a}rbel and Kunkel, Julian and Torralba, Gloria Collados and Reymann, J{\"u}rgen and Beil, Nina}, title={From experimental setup to bioinformatics}, subtitle={an RNAi screening platform to identify host factors involved in HIV-1 replication}, year={2010}, pages={39-49}, language={eng}, issn={1860-7314}, volume={5}, number={1}, note={Gesehen am 02.07.2015}, journal={Biotechnology journal}, doi={10.1002/biot.200900226}, } @book{UBHD-67354377, author={B{\"o}rner, Kathleen}, title={Identification of new cellular interaction partners of HIV-1 using RNAi}, year={2012}, pages={XI, 159 S.}, language={eng}, note={Zsfassung in engl. und dt. Sprache}, school={Heidelberg, Univ., Diss., 2012}, library={UB [Signatur: 2013 U 88]}, } @article{UBHD-68703981, author={B{\"o}rner, Kathleen and Kienle, Eike and Huang, Lin-Ya and Weinmann, Jonas and Sacher, Anna and Bayer, Philipp and St{\"u}llein, Christian and Fakhiri, Julia and Zimmermann, Laura and Westhaus, Adrian and Beneke, J{\"u}rgen and Beil, Nina and Wiedtke, Ellen and Schmelas, Carolin and Miltner, Dominik and Rau, Alexander and Erfle, Holger and Kr{\"a}usslich, Hans-Georg and M{\"u}ller, Martin and Agbandje-McKenna, Mavis and Grimm, Dirk}, title={Pre-arrayed Pan-AAV peptide display libraries for rapid single-round screening}, year={2020}, pages={1016-1032}, language={eng}, issn={1525-0024}, volume={28}, number={4}, note={Gesehen am 25.02.2021}, journal={Molecular therapy}, doi={10.1016/j.ymthe.2020.02.009}, } @article{UBHD-67823756, author={B{\"o}rner, Kathleen and Erfle, Holger and Bartenschlager, Ralf and Boutros, Michael and Binder, Marco and Kr{\"a}usslich, Hans-Georg and Grimm, Dirk and Niopek, Dominik and Willemsen, Joschka and Sch{\"u}rmann, Nina and Mockenhaupt, Stefan and Serva, Andrius and Hiet, Marie-Sophie and Wiedtke, Ellen and Starkuviene-Erfle, Vytaute}, title={Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines}, year={2013}, pages={22 S.}, language={eng}, issn={1362-4962}, volume={41(2013}, note={Gesehen am 29.05.2015}, journal={Nucleic acids research}, doi={10.1093/nar/gkt836}, } @article{UBHD-68334927, author={Bubeck, Felix and Hoffmann, Mareike and Bietz, Andreas and Waldhauer, Max and B{\"o}rner, Kathleen and Fakhiri, Julia and Schmelas, Carolin and Dietz, Laura and Grimm, Dirk and Eils, Roland and Niopek, Dominik}, title={Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9}, year={2018}, pages={924-927}, language={eng}, issn={1548-7105}, volume={15}, number={11}, note={Das PDF enth{\"a}lt 4 Seiten Text und 6 Seiten Anhang ; Gesehen am 03.12.2018}, journal={Nature methods}, doi={10.1038/s41592-018-0178-9}, } @article{UBHD-69255815, author={Bundschuh, Christian and Weidner, Niklas Maximilian and Klein, Julian and Rausch, Tobias and Azevedo, Nayara and Telzerow, Anja and Mallm, Jan-Philipp and Kim, Heeyoung and Steiger, Simon and Seufert, Isabelle and B{\"o}rner, Kathleen and Bauer, Katharina and H{\"u}bschmann, Daniel and Jost, Katharina Laurence and Parthé, Sylvia and Schnitzler, Paul and Boutros, Michael and Rippe, Karsten and M{\"u}ller, Barbara and Bartenschlager, Ralf and Kr{\"a}usslich, Hans-Georg and Benes, Vladimir}, title={Evolution of SARS-CoV-2 in the Rhine-Neckar/Heidelberg region 01/2021-07/2023}, year={2024}, pages={[1]-18}, language={eng}, issn={1567-7257}, volume={119(2024) vom: Apr.}, number={Artikel-ID 105577}, note={Online ver{\"o}ffentlicht: 23. Februar 2024 ; Gesehen am 24.09.2024}, journal={Infection, genetics and evolution}, doi={10.1016/j.meegid.2024.105577}, } @article{UBHD-68648451, author={Carnero, Elena and Barriocanal, Marina and Segura, Victor and Guruceaga, Elizabeth and Prior, Celia and B{\"o}rner, Kathleen and Grimm, Dirk and Fortes, Puri}, title={Type I interferon regulates the expression of long non-coding RNAs}, year={2014}, pages={1-14}, language={eng}, issn={1664-3224}, volume={5}, number={Artikel-ID 548}, note={Gesehen am 14.10.2020}, journal={Frontiers in immunology}, doi={10.3389/fimmu.2014.00548}, } @article{UBHD-68751488, author={Deckert, Andreas and Anders, Simon and De Allegri, Manuela and Nguyen, Hoa Thi and Souares-Coutant, Aurélia and McMahon-R{\"o}ssle, Shannon A. and B{\"o}rner, Kathleen and Meurer, Matthias and Herbst, Konrad and Sand, Matthias and K{\"o}ppel, Lisa and Siems, Tobias and Brugnara, Lucia and Brenner, Stephan and Burk, Robin and Lou, Dan and Kirrmaier, Daniel and Duan, Yuanqiang and Ovchinnikova, Svetlana and Marx, Michael and Kr{\"a}usslich, Hans-Georg and Knop, Michael and B{\"a}rnighausen, Till and Denkinger, Claudia M.}, title={Effectiveness and cost-effectiveness of four different strategies for SARS-CoV-2 surveillance in the general population (CoV-Surv Study)}, subtitle={a structured summary of a study protocol for a cluster-randomised, two-factorial controlled trial}, year={2021}, pages={1-4}, language={eng}, issn={1468-6694 and 1745-6215}, volume={22}, number={Artikel-ID 39}, note={Gesehen am 22.06.2021}, journal={Trials}, doi={10.1186/s13063-020-04982-z}, } @article{UBHD-68872953, author={Deckert, Andreas and Anders, Simon and De Allegri, Manuela and Nguyen, Hoa Thi and Souares-Coutant, Aurélia and McMahon-R{\"o}ssle, Shannon A. and Meurer, Matthias and Burk, Robin and Sand, Matthias and K{\"o}ppel, Lisa and Maier-Hein, Lena and Roß, Tobias and Adler, Tim and Siems, Tobias and Brugnara, Lucia and Brenner, Stephan and Herbst, Konrad and Kirrmaier, Daniel and Duan, Yuanqiang and Ovchinnikova, Svetlana and B{\"o}rner, Kathleen and Marx, Michael and Kr{\"a}usslich, Hans-Georg and Knop, Michael and B{\"a}rnighausen, Till and Denkinger, Claudia M.}, title={Effectiveness and cost-effectiveness of four different strategies for SARS-CoV-2 surveillance in the general population (CoV-Surv Study)}, subtitle={study protocol for a two-factorial randomized controlled multi-arm trial with cluster sampling}, year={2021}, pages={1-9}, language={eng}, issn={1468-6694 and 1745-6215}, volume={22}, number={Artikel-ID 656}, note={Gesehen am 01.02.2022}, journal={Trials}, doi={10.1186/s13063-021-05619-5}, url={https://doi.org/10.1186/s13063-021-05619-5}, library={UB}, } @article{UBHD-68563783, author={Eichhoff, Anna Marei and B{\"o}rner, Kathleen and Albrecht, Birte and Sch{\"a}fer, Waldemar and Baum, Natalie and Haag, Friedrich and K{\"o}rbelin, Jakob and Trepel, Martin and Braren, Ingke and Grimm, Dirk and Adriouch, Sahil and Koch-Nolte, Friedrich}, title={Nanobody-Enhanced targeting of AAV gene therapy vectors}, year={2019}, pages={211-220}, language={eng}, issn={2329-0501}, volume={15}, note={Gesehen am 14.04.2020}, journal={Molecular therapy}, doi={10.1016/j.omtm.2019.09.003}, } @article{UBHD-67821460, author={Engeland, Christine Elisabeth and B{\"o}rner, Kathleen and Kr{\"a}usslich, Hans-Georg}, title={Proteome analysis of the HIV-1 gag interactome}, year={2014}, pages={194-206}, language={eng}, issn={1096-0341}, volume={460/61}, note={Gesehen am 22.05.2015}, journal={Virology}, doi={10.1016/j.virol.2014.04.038}, } @article{UBHD-68406924, author={Fanucchi, Stephanie and B{\"o}rner, Kathleen and Grimm, Dirk}, title={Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments}, year={2019}, pages={138-150}, language={eng}, issn={1546-1718}, volume={51}, number={1}, note={Published online: 10 December 2018 ; Gesehen am 10.07.2019}, journal={Nature genetics}, doi={10.1038/s41588-018-0298-2}, } @article{UBHD-69079564, author={Grimm, Dirk and Wang, Lora and Lee, Joyce and Sch{\"u}rmann, Nina and Gu, Shuo and B{\"o}rner, Kathleen and Storm, Theresa A. and Kay, Mark A.}, title={Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver}, year={2010}, pages={3106-3119}, language={eng}, issn={1558-8238}, volume={120}, number={9}, note={Gesehen am 25.05.2023}, journal={The journal of clinical investigation}, doi={10.1172/JCI43565}, } @article{UBHD-68259162, author={Große, Stefanie and B{\"o}rner, Kathleen and Fakhiri, Julia and Laketa, Vibor and Wiedtke, Ellen and Gunkel, Manuel and Grimm, Dirk}, title={Relevance of assembly-activating protein for adeno-associated virus vector production and capsid protein stability in mammalian and insect cells}, year={2017}, pages={20 S.}, language={eng}, issn={1098-5514}, volume={91(2017}, note={Posted online 2 August 2017 ; Gesehen am 08.06.2018}, journal={Journal of virology}, doi={10.1128/JVI.01198-17}, } @article{UBHD-68651142, author={Hentzschel, Franziska and B{\"o}rner, Kathleen and Heiß, Kirsten and Knapp, Bettina and Sattler, Julia M. and Kaderali, Lars and M{\"u}ller, Ann-Kristin and Grimm, Dirk}, title={AAV8-mediated In Vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated Malarial parasites}, year={2014}, pages={2130-2141}, language={eng}, issn={1525-0024}, volume={22}, number={12}, note={Gesehen am 21.10.2020}, journal={Molecular therapy}, doi={10.1038/mt.2014.172}, } @article{UBHD-68401833, author={Herrmann, Anne-Kathrin and Große, Stefanie and B{\"o}rner, Kathleen and Kr{\"a}mer, Chiara and Wiedtke, Ellen and Gunkel, Manuel and Grimm, Dirk}, title={Impact of the assembly-activating protein on molecular evolution of synthetic adeno-associated virus capsids}, year={2019}, pages={21-35}, language={eng}, issn={1557-7422}, volume={30}, number={1}, note={Gesehen am 26.06.2019}, journal={Human gene therapy}, doi={10.1089/hum.2018.085}, } @article{UBHD-68470832, author={Hoffmann, Mareike and Aschenbrenner, Sabine and Große, Stefanie and Rapti, Kleopatra and Domenger, Claire and Fakhiri, Julia and Mastel, Manuel and B{\"o}rner, Kathleen and Eils, Roland and Grimm, Dirk and Niopek, Dominik}, title={Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins}, year={2019}, pages={15 S.}, language={eng}, issn={1362-4962}, volume={47(2019}, note={Gesehen am 03.01.2020}, journal={Nucleic acids research}, doi={10.1093/nar/gkz271}, } @article{UBHD-68875291, author={Joachim, Alexander and Dewald, Felix and Suárez, Isabelle and Zemlin, Michael and Lang, Isabelle and Stutz, Regine and Marthaler, Anna and Bosse, Hans-Martin and L{\"u}bke, Nadine and M{\"u}nch, Juliane and Bernard, Marie-Annett and Jeltsch, Kathrin and T{\"o}nshoff, Burkhard and Weidner, Niklas Maximilian and Kr{\"a}usslich, Hans-Georg and Birzele, Lena and H{\"u}bner, Johannes and Schmied, Patricia and Meyer-B{\"u}hn, Melanie and Horemheb-Rubio, Gibran and Cornely, Oliver A. and Haverkamp, Heinz and Wiesm{\"u}ller, Gerhard and F{\"a}tkenheuer, Gerd and Hero, Barbara and Kaiser, Rolf and D{\"o}tsch, J{\"o}rg and Rybniker, Jan and Cosgun, Z{\"u}lf{\"u} C. and H{\"u}nseler, Christoph and Sch{\"o}nenkorb, Jana and Wurm, Juliane and Klein, Florian and Heger, Eva and Knops, Elena and Sierra-Aragón, Saleta and Kretschmer, Alina Chloé and Sprute, Rosanne and Kossow, Annelene and Hellmich, Martin and Shah-Hosseini, Kija and Weiss, Michael and Goedicke-Fritz, Sybelle and Kaiser, Elisabeth and Meyer, Sascha and Seiwert, Nastasja and Smola, Sigrun and Pfuhl, Thorsten and Lohse, Stefan and Schupp, Anna-Kathrin and Timm, J{\"o}rg and Gr{\"o}ne, Nehle and Lesmann, Hellen and Bredahl, Renate and Schneble, Lukas and Turinsky, Martin and Patry, Christian and Hoffmann, Georg F. and M{\"u}ller, Barbara and B{\"o}rner, Kathleen and Schnitzler, Paul and Heuser, Anke-Mareil and Welker, Andreas and von Both, Ulrich and Kern, Anna}, title={Pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools}, subtitle={a cluster randomised trial}, year={2021}, pages={1-10}, language={eng}, issn={2589-5370}, volume={39}, number={Artikel-ID 101082}, note={The B-FAST study group: Z{\"u}lf{\"u} C. Cosgun, Lukas Schneble, Martin Turinsky, Christian Patry, Georg F. Hoffmann, Barbara M{\"u}ller, Kathleen B{\"o}rner, Paul Schnitzler, Anke-Mareil Heuser, Andreas Welker [und 27 weitere] ; Gesehen am 08.02.2022}, journal={EClinicalMedicine}, doi={10.1016/j.eclinm.2021.101082}, } @article{UBHD-68298533, author={Kienle, Eike and Senís Herrero, Elena and B{\"o}rner, Kathleen and Niopek, Dominik and Wiedtke, Ellen and Große, Stefanie and Grimm, Dirk}, title={Engineering and evolution of synthetic Adeno-associated virus (AAV) gene therapy vectors via DNA family shuffling}, year={2012}, pages={1 Online-Ressource (1 Videodatei, 21:55 min) S.}, language={eng}, issn={1940-087X}, volume={(2012}, note={Enth{\"a}lt auch Textversion ; Gesehen am 23.08.2018 ; Wissenschaftlicher Film. Deutschland. 2012}, journal={JoVE}, doi={10.3791/3819}, } @article{UBHD-68668519, author={Klein, Steffen and M{\"u}ller, Thorsten G. and Khalid, Dina and Sonntag-Buck, Vera and Heuser, Anke-Mareil and Glass, B{\"a}rbel and Meurer, Matthias and Morales, Ivonne and Schillak, Angelika and Freistaedter, Andrew and Ambiel, Ina and Winter, Sophie L. and Zimmermann, Liv and Naumoska, Tamara and Bubeck, Felix and Kirrmaier, Daniel and Ullrich, Stephanie and Barreto Miranda, Isabel and Anders, Simon and Grimm, Dirk and Schnitzler, Paul and Knop, Michael and Kr{\"a}usslich, Hans-Georg and Dao Thi, Viet Loan and B{\"o}rner, Kathleen and Chlanda, Petr}, title={SARS-CoV-2 RNA extraction using magnetic beads for rapid large-scale testing by RT-qPCR and RT-LAMP}, year={2020}, pages={13 S.}, language={eng}, issn={1999-4915}, volume={12(2020}, note={Gesehen am 03.12.2020}, journal={Viruses}, doi={10.3390/v12080863}, } @article{UBHD-68324691, author={Kunze, Christine and B{\"o}rner, Kathleen and Kienle, Eike and Grimm, Dirk}, title={Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes}, year={2018}, pages={413-427}, language={eng}, issn={1098-1136}, volume={66}, number={2}, note={First published: 09 November 2017 ; Gesehen am 05.11.2018}, journal={Glia}, doi={10.1002/glia.23254}, } @article{UBHD-68896315, author={Michels, Alexander and Frank, Annika M. and G{\"u}nther, Dorothee M. and Mataei, Mehryad and B{\"o}rner, Kathleen and Grimm, Dirk and Hartmann, Jessica and Buchholz, Christian J.}, title={Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8}, year={2021}, pages={334-347}, language={eng}, issn={2329-0501}, volume={23(2021) vom: Dez.}, note={Gesehen am 30.03.2022}, journal={Molecular therapy}, doi={10.1016/j.omtm.2021.09.014}, } @article{UBHD-68032793, author={M{\"u}ller, Stephanie and Huang, Xiaoyun and B{\"o}rner, Kathleen and Grimm, Dirk and Klingm{\"u}ller, Ursula}, title={T160-phosphorylated CDK2 defines threshold for HGF-dependent proliferation in primary hepatocytes}, year={2015}, pages={23 S.}, language={eng}, issn={1744-4292}, volume={11(2015}, note={Gesehen am 27.09.2016}, journal={Molecular systems biology}, doi={10.15252/msb.20156032}, } @article{UBHD-68312684, author={Nieto-Garai, Jon Ander and Glass, B{\"a}rbel and B{\"o}rner, Kathleen and Kr{\"a}usslich, Hans-Georg}, title={Lipidomimetic compounds act as HIV-1 entry inhibitors by altering viral membrane structure}, year={2018}, pages={18 S.}, language={eng}, issn={1664-3224}, volume={9}, number={Artikel-ID 1983}, note={Gesehen am 08.10.2018}, journal={Frontiers in immunology}, doi={10.3389/fimmu.2018.01983}, url={http://dx.doi.org/10.3389/fimmu.2018.01983}, library={UB}, } @article{UBHD-68283962, author={Santos, David M. Cordas dos and Eilers, Juliane and Orlova, Elena and B{\"o}rner, Kathleen and Grimm, Dirk and Muckenthaler, Martina and Kulozik, Andreas and Kunz, Joachim}, title={MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B}, year={2018}, language={eng}, issn={1471-2407}, volume={18(2018) Artikel-Nummer 663}, number={12 Seiten}, note={Gesehen am 10.07.2018}, journal={BMC cancer}, doi={10.1186/s12885-018-4525-0}, url={http://dx.doi.org/10.1186/s12885-018-4525-0}, library={UB}, } @book{UBHD-68295220, author={Santos, David M. Cordas dos and Eilers, Juliane and Orlova, Elena and B{\"o}rner, Kathleen and Grimm, Dirk and Muckenthaler, Martina and Kulozik, Andreas and Kunz, Joachim}, title={MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B}, publisher={BioMed Central ; Springer}, address={London ; Berlin ; Heidelberg}, year={2018}, pages={1 Online-Ressource (12 Seiten)}, language={eng}, note={Aus: BMC Cancer, 18 (2018), Nr. 663. pp. 1-12. ISSN 1471-2407}, doi={10.1186/s12885-018-4525-0}, url={https://nbn-resolving.org/urn:nbn:de:bsz:16-heidok-247558}, library={UB}, } @article{UBHD-68674408, author={Senís Herrero, Elena and Fatouros, Chronis and Große, Stefanie and Wiedtke, Ellen and Niopek, Dominik and M{\"u}ller, Ann-Kristin and B{\"o}rner, Kathleen and Grimm, Dirk}, title={CRISPR/Cas9-mediated genome engineering}, subtitle={an adeno-associated viral (AAV) vector toolbox}, year={2014}, pages={1402-1412}, language={eng}, issn={1860-7314}, volume={9}, number={11}, note={Gesehen am 17.12.2020}, journal={Biotechnology journal}, doi={10.1002/biot.201400046}, } @article{UBHD-68698544, author={Zila, Vojtech and Margiotta, Erica and Turoňová, Beata and M{\"u}ller, Thorsten G. and Zimmerli, Christian Eugen and Mattei, Simone and Allegretti, Matteo and B{\"o}rner, Kathleen and Rada, Jona and M{\"u}ller, Barbara and Lusic, Marina and Kr{\"a}usslich, Hans-Georg and Beck, Martin}, title={Cone-shaped HIV-1 capsids are transported through intact nuclear pores}, year={2021}, pages={33 Seiten}, language={eng}, issn={1097-4172}, volume={184}, note={Gesehen am 12.02.2021}, journal={Cell}, doi={10.1016/j.cell.2021.01.025}, }