@article{UBHD-68378165, author={Abdul-Razak, Hayder and Gabriel, Richard and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Schmidt, Michael}, title={Molecular evidence of genome editing in a mouse model of immunodeficiency}, year={2018}, pages={13 S.}, language={eng}, issn={2045-2322}, volume={8(2018) Artikel-Nummer 8214}, number={13 Seiten}, note={Gesehen am 02.04.2019}, journal={Scientific reports}, doi={10.1038/s41598-018-26439-9}, } @article{UBHD-67436521, author={Abel, Ulrich and Deichmann, Annette and Nowrouzi, Ali and Gabriel, Richard and Bartholom{\"a}, Cynthia C. and Glimm, Hanno and Kalle, Christof von and Schmidt, Manfred}, title={Analyzing the number of common integration sites of viral vectors}, subtitle={new methods and computer programs}, year={2011}, pages={8 S.}, language={eng}, issn={1932-6203}, volume={6(2011}, note={Gesehen am 26.06.2013}, journal={PLOS ONE}, doi={10.1371/journal.pone.0024247}, } @article{UBHD-68081318, author={Alaee, Farhang and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred}, title={Biodistribution of LV-TSTA transduced rat bone marrow cells used for “ex-vivo” regional gene therapy for bone repair}, year={2015}, pages={481-491}, language={eng}, issn={1875-5631}, volume={15}, number={5}, note={Gesehen am 07.02.2017}, journal={Current gene therapy}, doi={10.2174/1566523215666150812120229}, } @article{UBHD-67994479, author={Bartholom{\"a}, Cynthia C. and Kutschera, Ina and Kalle, Christof von and Schmidt, Manfred}, title={Integration-deficient lentiviral vectors expressing codon-optimized R338L human FIX restore normal hemostasis in hemophilia B mice}, year={2014}, pages={567-574}, language={eng}, issn={1525-0024}, volume={22}, number={3}, note={Gesehen am 10.06.2016}, journal={Molecular therapy}, doi={10.1038/mt.2013.188}, } @article{UBHD-67436524, author={Bartholom{\"a}, Cynthia C. and Arens, Anne and Balaggan, Kamaljit S. and Yáñez-Muñoz, Rafael J. and Montini, Eugenio and Howe, Steven J. and Paruzynski, Anna and Korn, Bernhard and Appelt, Jens-Uwe and MacNeil, Angus and Cesana, Daniela and Abel, Ulrich and Glimm, Hanno and Naldini, Luigi and Ali, Robin R. and Thrasher, Adrian J. and Kalle, Christof von and Schmidt, Manfred}, title={Lentiviral vector integration profiles differ in rodent postmitotic tissues}, year={2011}, pages={703-710}, language={eng}, issn={1525-0016}, volume={19}, number={4}, journal={Molecular therapy}, } @article{UBHD-68879816, author={Bartholom{\"a}, Cynthia C. and Arens, Anne and Balaggan, Kamaljit S. and Yáñez-Muñoz, Rafael J. and Montini, Eugenio and Howe, Steven J. and Paruzynski, Anna and Korn, Bernhard and Appelt, Jens-Uwe and MacNeil, Angus and Cesana, Daniela and Abel, Ulrich and Glimm, Hanno and Naldini, Luigi and Ali, Robin R. and Thrasher, Adrian J. and Kalle, Christof von and Schmidt, Manfred}, title={Lentiviral vector integration profiles differ in rodent postmitotic tissues}, year={2011}, pages={703-710}, language={eng}, issn={1525-0024}, volume={19}, number={4 vom: Apr.}, note={First published online: 14 December 2016 ; Gesehen am 17.02.2022}, journal={Molecular therapy}, doi={10.1038/mt.2011.19}, } @article{UBHD-68898712, author={Biasco, Luca and Ambrosi, Alessandro and Pellin, Danilo and Bartholom{\"a}, Cynthia C. and Brigida, Immacolata and Roncarolo, Maria Grazia and Di Serio, Clelia and Kalle, Christof von and Schmidt, Manfred and Aiuti, Alessandro}, title={Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell}, year={2011}, pages={89-101}, language={eng}, issn={1757-4684}, volume={3}, number={2}, note={Gesehen am 23.03.2022}, journal={EMBO molecular medicine}, doi={10.1002/emmm.201000108}, } @article{UBHD-68898768, author={Biffi, Alessandra and Bartholom{\"a}, Cynthia C. and Cesana, Daniela and Cartier, Natalie and Aubourg, Patrik and Ranzani, Marco and Cesani, Martina and Benedicenti, Fabrizio and Plati, Tiziana and Rubagotti, Enrico and Merella, Stefania and Capotondo, Alessia and Sgualdino, Jacopo and Zanetti, Gianluigi and Kalle, Christof von and Schmidt, Manfred and Naldini, Luigi and Montini, Eugenio}, title={Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection}, year={2011}, pages={5332-5339}, language={eng}, issn={1528-0020}, volume={117}, number={20}, note={Gesehen am 23.03.2022}, journal={Blood}, doi={10.1182/blood-2010-09-306761}, } @article{UBHD-68167907, author={Cantore, Alessio and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred}, title={Liver-directed lentiviral gene therapy in a dog model of hemophilia B}, year={2015}, pages={12 S.}, language={eng}, issn={1946-6242}, volume={7(2015}, note={Gesehen am 20.09.2017}, journal={Science translational medicine}, doi={10.1126/scitranslmed.aaa1405}, } @article{UBHD-69010630, author={Cattoglio, Claudia and Maruggi, Giulietta and Bartholom{\"a}, Cynthia C. and Malani, Nirav and Pellin, Danilo and Cocchiarella, Fabienne and Magnani, Zulma and Ciceri, Fabio and Ambrosi, Alessandro and Kalle, Christof von and Bushman, Frederic D. and Bonini, Chiara and Schmidt, Manfred and Mavilio, Fulvio and Recchia, Alessandra}, title={High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion}, year={2010}, pages={1-14}, language={eng}, issn={1932-6203}, volume={5}, note={Gesehen am 26.01.2023}, journal={PLOS ONE}, doi={10.1371/journal.pone.0015688}, } @article{UBHD-67924038, author={Cesana, Daniela and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Schmidt, Manfred}, title={Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo}, year={2014}, pages={774-785}, language={eng}, issn={1525-0024}, volume={22}, number={4}, note={Gesehen am 12.01.2016}, journal={Molecular therapy}, doi={10.1038/mt.2014.3}, } @article{UBHD-67436527, author={Deichmann, Annette and Bartholom{\"a}, Cynthia C. and Gabriel, Richard and Glimm, Hanno and Abel, Ulrich}, title={Insertion sites in encrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy}, year={2011}, pages={2031-2039}, language={eng}, issn={1525-0016}, volume={19}, number={11}, journal={Molecular therapy}, } @article{UBHD-68913891, author={Deichmann, Annette and Brugman, Martijn H and Bartholom{\"a}, Cynthia C. and Schwarzwaelder, Kerstin and Verstegen, Monique MA and Howe, Steven J and Arens, Anne and Ott, Marion G and Hoelzer, Dieter and Seger, Reinhard and Grez, Manuel and Hacein-Bey-Abina, Salima and Cavazzana-Calvo, Marina and Fischer, Alain and Paruzynski, Anna and Gabriel, Richard and Glimm, Hanno and Abel, Ulrich and Cattoglio, Claudia and Mavilio, Fulvio and Cassani, Barbara and Aiuti, Alessandro and Dunbar, Cynthia E and Baum, Christopher and Gaspar, H Bobby and Thrasher, Adrian J and Kalle, Christof von and Schmidt, Manfred and Wagemaker, Gerard}, title={Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after ´gammaretroviral vector gene therapy}, year={2011}, pages={2031-2039}, language={eng}, issn={1525-0024}, volume={19}, number={11}, note={Gesehen am 03.05.2022}, journal={Molecular therapy}, doi={10.1038/mt.2011.178}, } @article{UBHD-68683848, author={Eißmann, Moritz and Melzer, I. M. and Fernández, S. B. M. and Michel, G. and Hrabě de Angelis, M. and Hoefler, G. and Finkenwirth, P. and Jauch, Anna and Schoell, Brigitte and Grez, M. and Schmidt, Martina and Bartholom{\"a}, Cynthia C. and Newrzela, S. and Haetscher, N. and Rieger, M. A. and Zachskorn, C. and Mittelbronn, M. and Z{\"o}rnig, M.}, title={Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms}, year={2013}, pages={2586-2591}, language={eng}, issn={1476-5594}, volume={32}, number={20}, note={ Epub July 2, 2012 ; Gesehen am 26.01.2021}, journal={Oncogene}, doi={10.1038/onc.2012.263}, } @article{UBHD-67977734, author={Gabriel, Richard and Kutschera, Ina and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Schmidt, Manfred}, title={Linear amplification mediated PCR}, subtitle={localization of genetic elements and characterization of unknown flanking DNA}, year={2014}, pages={1 Online-Ressource (1 Videodatei, 11:57 min)}, language={eng}, issn={1940-087X}, volume={(2014}, note={Enth{\"a}lt auch Textversion ; Gesehen am 12.05.2016 ; Wissenschaftlicher Film. Deutschland. 2014}, journal={JoVE}, doi={10.3791/51543}, } @article{UBHD-69093647, author={Gabriel, Richard and Lombardo, Angelo and Arens, Anne and Miller, Jeffrey C. and Genovese, Pietro and K{\"a}ppel, Christine and Nowrouzi, Ali and Bartholom{\"a}, Cynthia C. and Wang, Jianbin and Friedman, Geoffrey and Holmes, Michael C. and Gregory, Philip D. and Glimm, Hanno and Schmidt, Manfred and Naldini, Luigi and Kalle, Christof von}, title={An unbiased genome-wide analysis of zinc-finger nuclease specificity}, year={2011}, pages={816-823}, language={eng}, issn={1546-1696}, volume={29}, number={9 vom: Sept.}, note={Gesehen am 05.07.2023}, journal={Nature biotechnology}, doi={10.1038/nbt.1948}, } @article{UBHD-69142573, author={Gama-Norton, Leonor and Herrmann, S. and Schucht, R. and Coroadinha, A. S. and L{\"o}w, R. and Alves, P. M. and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred and Baum, C. and Schambach, A. and Hauser, H. and Wirth, D.}, title={Retroviral vector performance in defined chromosomal loci of modular packaging cell lines}, year={2010}, pages={979-991}, language={eng}, issn={1557-7422}, volume={21}, number={8 vom: Aug.}, note={Gesehen am 14.11.2023}, journal={Human gene therapy}, doi={10.1089/hum.2009.089}, } @article{UBHD-67970363, author={Hovestadt, Volker and Jones, David T. W. and Kool, Marcel and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Eils, J{\"u}rgen and Milde, Till and Witt, Olaf and Scheurlen, Wolfram and Brors, Benedikt and Eils, Roland and Korshunov, Andrey and Zapatka, Marc and Pfister, Stefan and Lichter, Peter}, title={Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing}, year={2014}, pages={537-541}, language={eng}, issn={1476-4687}, volume={510}, number={7506}, note={Gesehen am 21.04.2016}, journal={Nature}, doi={10.1038/nature13268}, } @article{UBHD-68573696, author={Jones, David T. W. and J{\"a}ger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor and Hovestadt, Volker and St{\"u}tz, Adrian M. and Rausch, Tobias and Warnatz, Hans-J{\"o}rg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina Valesca and Şeker-Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Andrea and Remke, Marc and Witt, Hendrik and Hutter, Sonja and Tzaridis, Theophilos-Dimitrios and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D. and Wang, Qi and Lasitschka, B{\"a}rbel and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred and Kalle, Christof von and Ast, Volker and Lawerenz, Christian and Eils, J{\"u}rgen and Kabbe, Rolf and Benes, Vladimir and Sluis, Peter van and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J. and Russell, Robert B. and Coco, Simona and Paolo Tonini, Gian and Sch{\"u}ller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Andreas and Herold-Mende, Christel and Milde, Till and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Maass, Eberhard and R{\"o}ssler, Jochen and Ebinger, Martin and Schuhmann, Martin U. and Fr{\"u}hwald, Michael and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and Bueren, André von and Williamson, Dan and Clifford, Steven C. and McCabe, Martin G. and Peter Collins, V. and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, J{\"o}rg and Reifenberger, Guido and Northcott, Paul A. and Taylor, Michael D. and Meyerson, Matthew and Pomeroy, Scott L. and Yaspo, Marie-Laure and Korbel, Jan Oliver and Korshunov, Andrey and Eils, Roland and Pfister, Stefan and Lichter, Peter}, title={Dissecting the genomic complexity underlying medulloblastoma}, year={2012}, pages={100-105}, language={eng}, issn={0028-0836}, volume={488}, number={7409 vom: 20. Juni}, journal={Nature}, } @article{UBHD-68296998, author={Jones, David T. W. and J{\"a}ger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor and Hovestadt, Volker and St{\"u}tz, Adrian M. and Rausch, Tobias and Warnatz, Hans-J{\"o}rg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina Valesca and Şeker-Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Andrea and Remke, Marc and Witt, Hendrik and Hutter, Sonja and Tzaridis, Theophilos-Dimitrios and Weischenfeldt, Joachim and Zapatka, Marc and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred and Kalle, Christof von and Ast, Volker and Lawerenz, Christian and Eils, J{\"u}rgen and Betts, Matthew J. and Russell, Robert B. and Roggendorf, Wolfgang and Unterberg, Andreas and Herold-Mende, Christel and Milde, Till and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Rutkowski, Stefan and Bueren, André von and Brors, Benedikt and Korbel, Jan Oliver and Korshunov, Andrey and Eils, Roland and Pfister, Stefan and Lichter, Peter}, title={Dissecting the genomic complexity underlying medulloblastoma}, year={2012}, pages={100-105}, language={eng}, issn={1476-4687}, volume={488}, number={7409}, note={Gesehen am 20.08.2018}, journal={Nature}, doi={10.1038/nature11284}, } @article{UBHD-68939889, author={Kang, Hyoung Jin and Bartholom{\"a}, Cynthia C. and Paruzynski, Anna and Arens, Anne and Kim, Sujeong and Yu, Seung Shin and Hong, Youngtae and Joo, Chang-Wan and Yoon, Nam-Kyung and Rhim, Jung-Woo and Kim, Joong Gon and Kalle, Christof von and Schmidt, Manfred and Kim, Sunyoung and Ahn, Hyo Seop}, title={Retroviral gene therapy for X-linked chronic granulomatous disease}, subtitle={results from phase I/II trial}, year={2011}, pages={2092-2101}, language={eng}, issn={1525-0024}, volume={19}, number={11}, note={Gesehen am 11.07.2022}, journal={Molecular therapy}, doi={10.1038/mt.2011.166}, } @article{UBHD-67928856, author={Kool, Marcel and Milde, Till and Witt, Hendrik and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Unterberg, Andreas and Herold-Mende, Christel and Kulozik, Andreas and Deimling, Andreas von and Scheurlen, Wolfram and Pfister, Stefan}, title={Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition}, year={2014}, pages={393-405}, language={eng}, issn={1878-3686}, volume={25}, number={3}, note={Gesehen am 22.01.2016}, journal={Cancer cell}, doi={10.1016/j.ccr.2014.02.004}, } @article{UBHD-68052573, author={Negre, Olivier and Bartholom{\"a}, Cynthia C. and Deichmann, Annette and Fronza, Raffaele and Schmidt, Manfred and Kalle, Christof von}, title={Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease}, year={2015}, pages={64-81}, language={eng}, issn={1875-5631}, volume={15}, number={1}, note={Gesehen am 18.11.2016}, journal={Current gene therapy}, doi={10.2174/1566523214666141127095336}, } @article{UBHD-68627845, author={Negre, Olivier and Bartholom{\"a}, Cynthia C. and Deichmann, Annette and Fronza, Raffaele and Schmidt, Manfred and Kalle, Christof von}, title={Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease}, year={2015}, pages={64-81}, language={eng}, issn={1875-5631}, volume={15}, number={1}, note={Gesehen am 17.08.2020}, journal={Current gene therapy}, doi={10.2174/1566523214666141127095336}, } @article{UBHD-67959025, author={Northcott, Paul A. and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Scheurlen, Wolfram and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Korshunov, Andrey and Pfister, Stefan}, title={Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma}, year={2014}, pages={428-434}, language={eng}, issn={1476-4687}, volume={511}, number={7510}, note={Gesehen am 21.03.2016}, journal={Nature}, doi={10.1038/nature13379}, } @article{UBHD-69089367, author={Paruzynski, Anna and Arens, Anne and Gabriel, Richard and Bartholom{\"a}, Cynthia C. and Scholz, Simone and Wang, Wei and Wolf, Stephan and Glimm, Hanno and Schmidt, Manfred and Kalle, Christof von}, title={Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing}, year={2010}, pages={1379-1395}, language={eng}, issn={1750-2799}, volume={5}, number={8}, note={Gesehen am 26.06.2023}, journal={Nature protocols}, doi={10.1038/nprot.2010.87}, } @article{UBHD-67860407, author={Saeed, Muhammad and Bartholom{\"a}, Cynthia C. and Knopf, Malaika and Kalle, Christof von and Schmidt, Manfred}, title={Comparison between several integrase-defective lentiviral vectors reveals increased integration of an HIV vector bearing a D167H mutant}, year={2014}, pages={12 S.}, language={eng}, issn={2162-2531}, volume={3(2014) Artikel-Nr.e213}, number={12S}, note={Gesehen am 18.08.2015}, journal={Molecular therapy}, doi={10.1038/mtna.2014.65}, } @article{UBHD-68286536, author={Scholz, Simone and Fronza, Raffaele and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Gil-Fariña, Irene and Schmidt, Manfred}, title={Lentiviral vector promoter is decisive for aberrant transcript formation}, year={2017}, pages={875-885}, language={eng}, issn={1557-7422}, volume={28}, number={10}, note={Online ahead of print: August 18, 2017 ; Gesehen am 18.07.2018}, journal={Human gene therapy}, doi={10.1089/hum.2017.162}, } @article{UBHD-67949827, author={Stephan, Christoph and Baldauf, Hanna-Mari and Barry, Joanne and Giordano, Frank Anton and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred and Maier-Laufs, Stephanie and Kaderali, Lars and Keppler, Oliver Till}, title={Impact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in treatment-naive patients}, year={2014}, pages={2809-2818}, language={eng}, issn={1460-2091}, volume={69}, number={10}, note={Gesehen am 01.03.2016}, journal={The journal of antimicrobial chemotherapy}, doi={10.1093/jac/dku213}, } @article{UBHD-68984054, author={Tolar, Jakub and Adair, Jennifer E and Antoniou, Michael and Bartholom{\"a}, Cynthia C. and Becker, Pamela S and Blazar, Bruce R and Bueren, Juan and Carroll, Thomas and Cavazzana-Calvo, Marina and Clapp, D Wade and Dalgleish, Robert and Galy, Anne and Gaspar, H Bobby and Hanenberg, Helmut and Kalle, Christof von and Kiem, Hans-Peter and Lindeman, Dirk and Naldini, Luigi and Navarro, Susana and Renella, Raffaele and Rio, Paula and Sevilla, Julián and Schmidt, Manfred and Verhoeyen, Els and Wagner, John E and Williams, David A and Thrasher, Adrian J}, title={Stem cell gene therapy for Fanconi anemia}, subtitle={report from the 1st International Fanconi anemia gene therapy working group meeting}, year={2011}, pages={1193-1198}, language={eng}, issn={1525-0024}, volume={19}, number={7 vom: Juli}, note={Gesehen am 10.11.2022 ; Erstmals am 14. Dezember 2016 online ver{\"o}ffentlicht}, journal={Molecular therapy}, doi={10.1038/mt.2011.78}, }