@article{UBHD-69278611, author={Adolph, Jonas E. and Fleischhack, Gudrun and Tschirner, Sebastian and Rink, Lydia and Dittes, Christine and Mikasch, Ruth and Dammann, Philipp and Mynarek, Martin and Obrecht-Sturm, Denise and Rutkowski, Stefan and Bison, Brigitte and Warmuth-Metz, Monika and Pietsch, Torsten and Pfister, Stefan and Pajtler, Kristian Wilfried and Milde, Till and Kortmann, Rolf-Dieter and Dietzsch, Stefan and Timmermann, Beate and Tippelt, Stephan}, title={Radiotherapy for recurrent medulloblastoma in children and adolescents}, subtitle={survival after re-irradiation and first-time irradiation}, year={2024}, pages={1-13}, language={eng}, issn={2072-6694}, volume={16}, note={Gesehen am 02.12.2024}, journal={Cancers}, doi={10.3390/cancers16111955}, } @article{UBHD-68495293, author={B{\"a}chli, Heidi and Ecker, Jonas and Tilburg, Cornelis M. van and Sturm, Dominik and Selt, Florian and Sahm, Felix and K{\"o}lsche, Christian and Grund, Kerstin and Sutter, Christian and Witt, Hendrik and Herold-Mende, Christel and Deimling, Andreas von and Jones, David T. W. and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Molecular diagnostics in pediatric brain tumors}, subtitle={impact on diagnosis and clinical decision-making - a selected case series}, year={2018}, pages={305-313}, language={eng}, issn={1439-3824}, volume={230}, number={06}, note={Gesehen am 02.03.2020}, journal={Klinische P{\"a}diatrie}, doi={10.1055/a-0637-9653}, } @article{UBHD-68305724, author={Bai, Alfa H. C. and Milde, Till and Remke, Marc and Rolli, Claudio Gavino and Hielscher, Thomas and Kool, Marcel and Jugold, Manfred and Bazhin, Alexandr V. and Eichm{\"u}ller, Stefan B. and Kulozik, Andreas and Pscherer, Armin and Benner, Axel and Witt, Olaf and Korshunov, Andrey and Lichter, Peter and Pfister, Stefan}, title={MicroRNA-182 promotes leptomeningeal spread of non-Sonic Hedgehog-medulloblastoma}, year={2012}, pages={529-538}, language={eng}, issn={1432-0533}, volume={123}, number={4}, note={First online: 02 December 2011 ; Gesehen am 18.09.2018}, journal={Acta neuropathologica}, doi={10.1007/s00401-011-0924-x}, } @article{UBHD-68423343, author={Bandopadhayay, Pratiti and Milde, Till and Pfister, Stefan}, title={Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma}, year={2019}, pages={16 S.}, language={eng}, issn={2041-1723}, volume={10(2019) Article number: 2400}, number={16 Seiten}, note={Weitere Verfasser: Federica Piccioni, Ryan O’Rourke, Patricia Ho, Elizabeth M. Gonzalez, Graham Buchan, Kenin Qian, Gabrielle Gionet, Emily Girard, Margo Coxon, Matthew G. Rees, Lisa Brenan, Frank Dubois, Ofer Shapira, Noah F. Greenwald, Melanie Pages, Amanda Balboni Iniguez, Brenton R. Paolella, Alice Meng, Claire Sinai, Giovanni Roti, Neekesh V. Dharia, Amanda Creech, Benjamin Tanenbaum, Prasidda Khadka, Adam Tracy, Hong L. Tiv, Andrew L. Hong, Shannon Coy, Rumana Rashid, Jia-Ren Lin, Glenn S. Cowley, Fred C. Lam, Amy Goodale, Yenarae Lee, Kathleen Schoolcraft, Francisca Vazquez, William C. Hahn, Aviad Tsherniak, James E. Bradner, Michael B. Yaffe, Till Milde, Stefan M. Pfister, Jun Qi, Monica Schenone, Steven A. Carr, Keith L. Ligon, Mark W. Kieran, Sandro Santagata, James M. Olson, Prafulla C. Gokhale, Jacob D. Jaffe, David E. Root, Kimberly Stegmaier, Cory M. Johannessen, Rameen Beroukhim ; Gesehen am 22.08.2019}, journal={Nature Communications}, doi={10.1038/s41467-019-10307-9}, } @article{UBHD-68664953, author={Bender, Sebastian and Tang, Yujie and Lindroth, Anders and Hovestadt, Volker and Jones, David T. W. and Kool, Marcel and Zapatka, Marc and Northcott, Paul A. and Sturm, Dominik and Wei, Wang and Radlwimmer, Bernhard and Højfeldt, Jonas W. and Truffaux, Nathalène and Castel, David and Schubert, Simone and Ryzhova, Marina and Şeker-Cin, Huriye and Gronych, Jan and Johann, Pascal-David and Stark, Sebastian and Meyer, Jochen and Milde, Till and Schuhmann, Martin and Ebinger, Martin and Witt, Olaf and Deimling, Andreas von and Korshunov, Andrey and Lichter, Peter and Plass, Christoph and Pfister, Stefan}, title={Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas}, year={2013}, pages={660-672}, language={eng}, issn={1878-3686}, volume={24}, number={5}, note={Gesehen am 24.11.2020}, journal={Cancer cell}, doi={10.1016/j.ccr.2013.10.006}, } @article{UBHD-68286169, author={Bingel, Corinna and Sill, Martin and Peterziel, Heike and Milde, Till and Witt, Olaf and Oehme, Ina}, title={Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance}, year={2017}, pages={16 S.}, language={eng}, issn={2041-4889}, volume={8(2017}, note={Gesehen am 17.07.2018}, journal={Cell death & disease}, doi={10.1038/cddis.2017.398}, } @article{UBHD-68341774, author={Buhl, Juliane and Selt, Florian and Hielscher, Thomas and Ecker, Jonas and Sahm, Felix and Ridinger, Johannes and Usta, Diren and Wefers, Annika K. and Remke, Marc and Pusch, Stefan and Oehme, Ina and Tilburg, Cornelis M. van and Kool, Marcel and Deimling, Andreas von and Herold-Mende, Christel and Korshunov, Andrey and Pfister, Stefan and Jones, David T. W. and Witt, Olaf and Milde, Till}, title={The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma}, year={2019}, pages={1851-1866}, language={eng}, issn={1557-3265}, volume={25}, number={6}, note={Published first: December 7, 2018 ; Gesehen am 18.12.2018}, journal={Clinical cancer research}, doi={10.1158/1078-0432.CCR-18-1965}, } @article{UBHD-68237229, author={Capper, David and Jones, David T. W. and Schrimpf, Daniel and Sturm, Dominik and K{\"o}lsche, Christian and Sahm, Felix and Reuss, David and Reinhardt, Annekathrin and Wefers, Annika K. and Huang, Kristin and Pajtler, Kristian Wilfried and Schweizer, Leonille and Stichel, Damian and Selt, Florian and Witt, Hendrik and Milde, Till and Witt, Olaf and Scheurlen, Wolfram and Geisenberger, Christoph and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and H{\"a}nggi, Daniel and Kulozik, Andreas and Benner, Axel and Bendszus, Martin and Debus, J{\"u}rgen and Platten, Michael and Unterberg, Andreas and Wick, Wolfgang and Karajannis, Matthias A. and Mittelbronn, Michel Guy André and Acker, Till and Hartmann, Christian and Aldape, Kenneth and Sch{\"u}ller, Ulrich and Buslei, Rolf and Lichter, Peter and Kool, Marcel and Herold-Mende, Christel and Deimling, Andreas von and Pfister, Stefan and M{\"u}ller, Hermann L.}, title={DNA methylation-based classification of central nervous system tumours}, year={2018}, pages={469-474}, language={eng}, issn={1476-4687}, volume={555}, number={7697}, note={Gesehen am 28.03.2018}, journal={Nature}, doi={10.1038/nature26000}, } @article{UBHD-68374101, author={Capper, David and Sahm, Felix and Jones, David T. W. and Schrimpf, Daniel and Reuss, David and K{\"o}lsche, Christian and Reinhardt, Annekathrin and Wefers, Annika K. and Huang, Kristin and Sievers, Philipp and Ebrahimi, Azadeh and H{\"a}nggi, Daniel and Unterberg, Andreas and Platten, Michael and Wick, Wolfgang and Witt, Olaf and Milde, Till and Korshunov, Andrey and Pfister, Stefan and Deimling, Andreas von}, title={Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics}, subtitle={the Heidelberg experience}, year={2018}, pages={181-210}, language={eng}, issn={1432-0533}, volume={136}, number={2}, note={Published online: 2 July 2018 ; Gesehen am 29.03.2019}, journal={Acta neuropathologica}, doi={10.1007/s00401-018-1879-y}, } @article{UBHD-68467061, author={Daskalakis, Michael and Brocks, David and Sheng, Yi-Hua and Islam, Md Saiful and Ressnerova, Alzbeta and Assenov, Yassen and Milde, Till and Oehme, Ina and Witt, Olaf and Goyal, Ashihs and K{\"u}hn, Alexander and Hartmann, Mark and Weichenhan, Dieter and Jung, Manfred and Plass, Christoph}, title={Reactivation of endogenous retroviral elements via treatment with DNMT- and HDAC-inhibitors}, year={2018}, pages={811-822}, language={eng}, issn={1551-4005}, volume={17}, number={7}, note={Gesehen am 10.12.2019}, journal={Cell cycle}, doi={10.1080/15384101.2018.1442623}, } @article{UBHD-68568632, author={Deng, Maximilian and Sill, Martin and Sturm, Dominik and Stichel, Damian and Witt, Hendrik and Ecker, Jonas and Wittmann, A. and Schittenhelm, J. and Ebinger, M. and Schuhmann, M. U. and Figarella‐Branger, D. and Aronica, E. and Staszewski, O. and Preusser, M. and Haberler, C. and Lauten, M. and Sch{\"u}ller, U. and Hartmann, C. and Snuderl, M. and Dunham, C. and Jabado, N. and Wesseling, P. and Deckert, M. and Keyvani, K. and Gottardo, N. and Giangaspero, F. and Hoff, K. von and Ellison, D. W. and Pietsch, T. and Herold-Mende, Christel and Milde, Till and Witt, Olaf and Kool, Marcel and Korshunov, Andrey and Wick, Wolfgang and Deimling, Andreas von and Pfister, Stefan and Jones, David T. W. and Sahm, Felix}, title={Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) - a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14}, year={2020}, pages={422-430}, language={eng}, issn={1365-2990}, volume={46}, number={5}, note={First published: 23 December 2019 ; Gesehen am 21.04.2020}, journal={Neuropathology & applied neurobiology}, doi={10.1111/nan.12590}, url={https://doi.org/10.1111/nan.12590}, library={UB}, } @article{UBHD-68898709, author={Deng, Maximilian and Sturm, Dominik and Pfaff, Elke and Sill, Martin and Stichel, Damian and Balasubramanian, Gnana Prakash and Tippelt, Stephan and Kramm, Christof and Donson, Andrew M. and Green, Adam L. and Jones, Chris and Schittenhelm, Jens and Ebinger, Martin and Schuhmann, Martin U. and Jones, Barbara Christine and Tilburg, Cornelis M. van and Wittmann, Andrea and Golanov, Andrey and Ryzhova, Marina and Ecker, Jonas and Milde, Till and Witt, Olaf and Sahm, Felix and Reuss, David and Sumerauer, David and Zamecnik, Josef and Korshunov, Andrey and Deimling, Andreas von and Pfister, Stefan and Jones, David T. W.}, title={Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B}, year={2021}, pages={1-11}, language={eng}, issn={2041-1723}, volume={12}, number={Artikel-ID 5530}, note={Published 20 September 2021 ; Gesehen am 23.03.2022}, journal={Nature Communications}, doi={10.1038/s41467-021-25708-y}, } @article{UBHD-68897196, author={Dittes, Christine and Adolph, Jonas E. and Tippelt, Stephan and Mikasch, Ruth and Obrecht, Denise and Mynarek, Martin and Rutkowski, Stefan and Pfister, Stefan and Milde, Till and Witt, Olaf and Bison, Brigitte and Warmuth-Metz, Monika and Kortmann, Rolf-Dieter and Dietzsch, Stefan and Pietsch, Torsten and Timmermann, Beate and Str{\"a}ter, Ronald and Bode, Udo and Faldum, Andreas and Kwiecien, Robert and Fleischhack, Gudrun}, title={Local and systemic therapy of recurrent medulloblastomas in children and adolescents}, subtitle={results of the P-HIT-REZ 2005 study}, year={2022}, pages={1-24}, language={eng}, issn={2072-6694}, volume={14}, note={Gesehen am 22.03.2022}, journal={Cancers}, doi={10.3390/cancers14030471}, } @article{UBHD-68959384, author={Ebrahimi, Azadeh and Korshunov, Andrey and Reifenberger, Guido and Capper, David and Felsberg, Joerg and Trisolini, Elena and Pollo, Bianca and Calatozzolo, Chiara and Prinz, Marco and Staszewski, Ori and Schweizer, Leonille and Schittenhelm, Jens Florian and Harter, Patrick N. and Paulus, Werner and Thomas, Christian and Kohlhof-Meinecke, Patricia and Seiz-Rosenhagen, Marcel and Milde, Till and Casalini, Belén and Suwala, Abigail Kora and Wefers, Annika K. and Reinhardt, Annekathrin and Sievers, Philipp and Kramm, Christof M. and Etminan, Nima and Unterberg, Andreas and Wick, Wolfgang and Herold-Mende, Christel and Sturm, Dominik and Pfister, Stefan and Sill, Martin and Jones, David T. W. and Schrimpf, Daniel and Reuss, David and Aldape, Kenneth and Abdullaev, Zied and Sahm, Felix and Deimling, Andreas von and Stichel, Damian}, title={Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival}, year={2022}, pages={1-10}, language={eng}, issn={2051-5960}, volume={10}, number={Artikel-ID 5}, note={Gesehen am 01.09.2022}, journal={Acta Neuropathologica Communications}, doi={10.1186/s40478-021-01308-1}, } @article{UBHD-69106183, author={Ecker, Jonas and Selt, Florian and Sturm, Dominik and Sill, Martin and Korshunov, Andrey and Hirsch, Steffen and Capper, David and Dikow, Nicola and Sutter, Christian and M{\"u}ller, Carina and Sigaud, Romain and Eggert, Angelika and Simon, Thorsten and Niehues, Tim and Deimling, Andreas von and Pajtler, Kristian Wilfried and Tilburg, Cornelis M. van and Jones, David T. W. and Sahm, Felix and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Corrigendum to ‘Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry’ [Eur J Cancer 180 (2023) 71-84]}, year={2023}, pages={200-201}, language={eng}, issn={1879-0852}, volume={184(2023) vom: Mai}, note={Online verf{\"u}gbar: 21. M{\"a}rz 2023, Artikelversion: 11. April 2023 ; Gesehen am 03.08.2023}, journal={European journal of cancer}, doi={10.1016/j.ejca.2023.02.024}, } @article{UBHD-69054224, author={Ecker, Jonas and Selt, Florian and Sturm, Dominik and Sill, Martin and Korshunov, Andrey and Hirsch, Steffen and Capper, David and Dikow, Nicola and Sutter, Christian and M{\"u}ller, Carina and Sigaud, Romain and Eggert, Angelika and Simon, Thorsten and Niehues, Tim and Deimling, Andreas von and Pajtler, Kristian Wilfried and Tilburg, Cornelis M. van and Jones, David T. W. and Sahm, Felix and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Molecular diagnostics enables detection of actionable targets}, subtitle={the Pediatric Targeted Therapy 2.0 registry}, year={2023}, pages={71-84}, language={eng}, issn={1879-0852}, volume={180(2023) vom: Feb.}, note={Online ver{\"o}ffentlicht am 25. November 2022, Artikelversion vom 19. Dezember 2022 ; Gesehen am 22.11.2023}, journal={European journal of cancer}, doi={10.1016/j.ejca.2022.11.015}, } @article{UBHD-68746998, author={Ecker, Jonas and Thatikonda, Venu and Sigismondo, Gianluca and Selt, Florian and Valinciute, Gintvile and Oehme, Ina and M{\"u}ller, Carina and Buhl, Juliane and Ridinger, Johannes and Usta, Diren and Qin, Nan and Tilburg, Cornelis M. van and Herold-Mende, Christel and Remke, Marc and Sahm, Felix and Westermann, Frank and Kool, Marcel and Wechsler-Reya, Robert J. and Chavez, Lukas and Krijgsveld, Jeroen and J{\"a}ger, Natalie and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma}, year={2021}, pages={226-239}, language={eng}, issn={1523-5866}, volume={23}, number={2 vom: Feb.}, note={Gesehen am 10.06.2021 ; First published: 21 August 2020}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noaa191}, } @book{UBHD-67968247, author={Ecker, Jonas and Korshunov, Andrey and Kiss, Judit and Selt, Florian and Deubzer, Hedwig and Deimling, Andreas von and Kulozik, Andreas and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma}, publisher={BioMed Central}, address={London}, year={2016}, pages={1 Online-Ressource (14 Seiten)}, language={eng}, note={Wissenschaftlicher Aufsatz. - Aus: Acta Neuropathologica Communications, 3 (UNSPECIFIED), Nr. 22. pp. 1-14. ISSN 2051-5960}, doi={10.1186/s40478-015-0201-7}, url={https://nbn-resolving.org/urn:nbn:de:bsz:16-heidok-194764}, library={UB}, } @article{UBHD-68706904, author={Endersby, Raelene and Whitehouse, Jacqueline and Pribnow, Allison and Kuchibhotla, Mani and Hii, Hilary and Carline, Brooke and Gande, Suresh and Stripay, Jennifer and Ancliffe, Mathew and Howlett, Meegan and Schoep, Tobias and George, Courtney and Andradas, Clara and Dyer, Patrick and Schluck, Marjolein and Patterson, Brett and Tacheva-Gigorova, Silvia K. and Cooper, Matthew N. and Robinson, Giles and Stewart, Clinton and Pfister, Stefan and Kool, Marcel and Milde, Till and Gajjar, Amar and Johns, Terrance and Wechsler-Reya, Robert J. and Roussel, Martine F. and Gottardo, Nicholas G.}, title={Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma}, year={2021}, pages={1-16}, language={eng}, issn={1946-6242}, volume={13}, note={Gesehen am 04.03.2021}, journal={Science translational medicine}, doi={10.1126/scitranslmed.aba7401}, } @article{UBHD-68638102, author={Fabian, Johannes and Lodrini, Marco and Oehme, Ina and Schier, Marie Catherine and Thole, Theresa Maria and Hielscher, Thomas and Kopp-Schneider, Annette and Opitz, Lennart and Capper, David and Deimling, Andreas von and Rettig, Inga Edeltraud and Milde, Till and Mahlknecht, Ulrich Rudolph and Westermann, Frank and Popanda, Odilia and Roels, Frederik and Hero, Barbara and Berthold, Frank and Fischer, Matthias and Kulozik, Andreas and Witt, Olaf and Deubzer, Hedwig}, title={GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3}, year={2014}, pages={2604-2616}, language={eng}, issn={1538-7445}, volume={74}, number={9}, note={Gesehen am 16.09.2020}, journal={Cancer research}, doi={10.1158/0008-5472.CAN-13-1904}, } @article{UBHD-69347739, author={Filippidou, Maria and Glentis, Stavros and Rigatou, Efthymia and Sievers, Philipp and Selt, Florian and Dimitriadis, Efthymios and Perari, Panagiota and Binenbaum, Ilona and Avgerinou, Georgia and Tilburg, Cornelis M. van and Jones, David T. W. and Sahm, Felix and Milde, Till and Witt, Olaf and Pfister, Stefan and Gr{\"u}newald, Thomas G. P. and Stefanaki, Kalliopi and Kattamis, Antonis}, title={Soft tissue undifferentiated sarcoma carrying a novel Onecut1::Nutm1 fusion}, subtitle={letter to the editor}, year={2025}, pages={1-4}, language={eng}, issn={1545-5017}, volume={72}, note={Online verf{\"u}gbar: 06. November 2024 ; Gesehen am 23.05.2025}, journal={Pediatric blood & cancer}, doi={10.1002/pbc.31427}, } @book{UBHD-69140233, author={Jungkunz, Martin and Cornelius, Kai and Schickhardt, Christoph and Dikow, Nicola and Winkler, Eva C. and Brors, Benedikt and Fr{\"o}hling, Stefan and Greulich-Bode, Karin Maria and Idler, Irina and Lichter, Peter and Milde, Till and Pfister, Stefan and Schaaf, Christian P. and Wiemann, Stefan}, title={Position paper on the return of additional genetic findings in minors}, publisher={Marsilius-Kolleg}, address={Heidelberg}, year={2023}, pages={1 Online-Ressource (120 Seiten)}, language={eng}, number={ARRAY(0x555ca9e2b670)}, series={Forum Marsilius-Kolleg}, note={Gesehen am 06.11.2023}, url={https://doi.org/10.11588/fmk.2023.23.100566}, library={UB}, } @book{UBHD-69139948, author={Jungkunz, Martin and Cornelius, Kai and Schickhardt, Christoph and Dikow, Nicola and Winkler, Eva C. and Brors, Benedikt and Fr{\"o}hling, Stefan and Greulich-Bode, Karin Maria and Idler, Irina and Lichter, Peter and Milde, Till and Pfister, Stefan and Schaaf, Christian P. and Wiemann, Stefan}, organization={Projektgruppe EURAT}, title={Stellungnahme zur R{\"u}ckmeldung genetischer Zusatzbefunde Minderj{\"a}hriger}, publisher={Marsilius-Kolleg}, address={Heidelberg}, year={2023}, pages={1 Online-Ressource (130 Seiten)}, language={ger}, number={ARRAY(0x555ca9dd96b8)}, series={Forum Marsilius-Kolleg}, note={Gesehen am 06.11.2023}, doi={10.11588/fmk.2023.23.98739}, url={https://doi.org/10.11588/fmk.2023.23.98739}, library={UB}, } @article{UBHD-69114482, author={Funke, Viktoria and Walter, Carolin and Melcher, Viktoria and Wei, Lanying and Sandmann, Sarah and Hotfilder, Marc and Varghese, Julian and J{\"a}ger, Natalie and Kool, Marcel and Jones, David T. W. and Pfister, Stefan and Milde, Till and Mynarek, Martin and Rutkowski, Stefan and Seggewiss, Jochen and Jeising, Daniela and de Faria, Flavia W. and Marquardt, Thorsten and Albert, Thomas K. and Sch{\"u}ller, Ulrich and Kerl, Kornelius}, title={Group-specific cellular metabolism in Medulloblastoma}, year={2023}, pages={1-16}, language={eng}, issn={1479-5876}, volume={21}, number={Artikel-ID 363}, note={Gesehen am 21.11.2023}, journal={Journal of translational medicine}, doi={10.1186/s12967-023-04211-6}, } @article{UBHD-68896635, author={Gatzweiler, Charlotte and Ridinger, Johannes and Herter, Sonja and Gerloff, Xenia F. and ElHarouni, Dina and Berker, Yannick and Imle, Roland and Schmitt, Lukas and Kreth, Sina and Stainczyk, Sabine and Ayhan, Simay and Najafi, Sara and Krunic, Damir and Frese, Karen S. and Meder, Benjamin and Reuss, David and Fiesel, Petra and Schramm, Kathrin and Blattner-Johnson, Mirjam and Jones, David T. W. and Banito, Ana and Westermann, Frank and Oppermann, Sina and Milde, Till and Peterziel, Heike and Witt, Olaf and Oehme, Ina}, title={Functional therapeutic target validation using pediatric zebrafish xenograft models}, year={2022}, pages={1-24}, language={eng}, issn={2072-6694}, volume={14}, note={Gesehen am 29.03.2022}, journal={Cancers}, doi={10.3390/cancers14030849}, } @article{UBHD-68904387, author={Ghasemi, David R. and Fleischhack, Gudrun and Milde, Till and Pajtler, Kristian Wilfried}, title={The current landscape of targeted clinical trials in non-WNT/non-SHH medulloblastoma}, year={2022}, pages={1-22}, language={eng}, issn={2072-6694}, volume={14}, note={This article belongs to the Special issue: Medulloblastoma systemic therapy clinical trials and their foundations ; Gesehen am 06.04.2022}, journal={Cancers}, doi={10.3390/cancers14030679}, } @article{UBHD-68635490, author={Gojo, Johannes and H{\"u}bner, Jens-Martin and Pajtler, Kristian Wilfried and Milde, Till and Pfister, Stefan and Kool, Marcel}, title={Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma}, year={2020}, pages={44-59.e9}, language={eng}, issn={1878-3686}, volume={38}, number={1}, note={Gesehen am 08.09.2020}, journal={Cancer cell}, doi={10.1016/j.ccell.2020.06.004}, } @article{UBHD-68942846, author={Gronych, Jan and Korshunov, Andrey and Bageritz, Josephine and Milde, Till and Jugold, Manfred and Hambardzumyan, Dolores and Remke, Marc and Hartmann, Christian and Witt, Hendrik and Jones, David T. W. and Witt, Olaf and Heiland, Sabine and Bendszus, Martin and Holland, Eric C. and Pfister, Stefan and Lichter, Peter}, title={An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice}, year={2011}, pages={1344-1348}, language={eng}, issn={1558-8238}, volume={121}, number={4}, note={Gesehen am 15.07.2022}, journal={The journal of clinical investigation}, doi={10.1172/JCI44656}, } @article{UBHD-69295603, author={Heipertz, Anna-Elisa and Pajtler, Kristian Wilfried and Pfaff, Elke and Schramm, Kathrin and Blattner-Johnson, Mirjam and Milde, Till and Jones, Barbara Christine and Zuliani, Cecilia and Hutter, Caroline and Lohi, Olli and Kattamis, Antonis and Dachowska-Kalwak, Iwona and Nilsson, Anna and Gerber, Nicolas U. and Langenberg, Karin and Goemans, Bianca F. and Zwaan, C. Michel and Molenaar, Jan J. and J{\"a}ger, Natalie and Dirksen, Uta and Witt, Ruth and Pfister, Stefan and Jones, David T. W. and Kopp-Schneider, Annette and Witt, Olaf and Tilburg, Cornelis M. van}, title={Outcome of children and adolescents with relapsed/refractory/progressive malignancies treated with molecularly informed targeted drugs in the pediatric precision oncology registry INFORM}, year={2023}, pages={1-12}, language={eng}, issn={2473-4284}, note={Gesehen am 29.01.2025}, journal={JCO precision oncology}, doi={10.1200/PO.23.00015}, } @article{UBHD-67970363, author={Hovestadt, Volker and Jones, David T. W. and Kool, Marcel and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Eils, J{\"u}rgen and Milde, Till and Witt, Olaf and Scheurlen, Wolfram and Brors, Benedikt and Eils, Roland and Korshunov, Andrey and Zapatka, Marc and Pfister, Stefan and Lichter, Peter}, title={Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing}, year={2014}, pages={537-541}, language={eng}, issn={1476-4687}, volume={510}, number={7506}, note={Gesehen am 21.04.2016}, journal={Nature}, doi={10.1038/nature13268}, } @article{UBHD-68492095, author={Johann, Pascal-David and Sturm, Dominik and Korshunov, Andrey and Gr{\"o}schel, Stefan and Ge{\"o}rg, Christina and Capper, David and Deimling, Andreas von and Milde, Till and Witt, Olaf and Kulozik, Andreas and Pfister, Stefan}, title={Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes}, year={2016}, pages={379-393}, language={eng}, issn={1878-3686}, volume={29}, number={3}, note={Gesehen am 21.02.2020}, journal={Cancer cell}, doi={10.1016/j.ccell.2016.02.001}, } @article{UBHD-68215366, author={Jones, Barbara Christine and Tilburg, Cornelis M. van and Balasubramanian, Gnana Prakash and Fiesel, Petra and Witt, Ruth and Freitag, Angelika and Boudalil, Miream and Hutter, Barbara and Taylor, Lenka A. and Sutter, Christian and Bartram, Claus R. and Milde, Till and Pfaff, Elke and Kulozik, Andreas and Brors, Benedikt and Deimling, Andreas von and Capper, David and Pfister, Stefan and Witt, Olaf}, title={Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study}, year={2016}, pages={91-101}, language={eng}, issn={1879-0852}, volume={65}, note={Gesehen am 31.01.2018}, journal={European journal of cancer}, doi={10.1016/j.ejca.2016.06.009}, } @article{UBHD-68573696, author={Jones, David T. W. and J{\"a}ger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor and Hovestadt, Volker and St{\"u}tz, Adrian M. and Rausch, Tobias and Warnatz, Hans-J{\"o}rg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina Valesca and Şeker-Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Andrea and Remke, Marc and Witt, Hendrik and Hutter, Sonja and Tzaridis, Theophilos-Dimitrios and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D. and Wang, Qi and Lasitschka, B{\"a}rbel and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred and Kalle, Christof von and Ast, Volker and Lawerenz, Christian and Eils, J{\"u}rgen and Kabbe, Rolf and Benes, Vladimir and Sluis, Peter van and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J. and Russell, Robert B. and Coco, Simona and Paolo Tonini, Gian and Sch{\"u}ller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Andreas and Herold-Mende, Christel and Milde, Till and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Maass, Eberhard and R{\"o}ssler, Jochen and Ebinger, Martin and Schuhmann, Martin U. and Fr{\"u}hwald, Michael and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and Bueren, André von and Williamson, Dan and Clifford, Steven C. and McCabe, Martin G. and Peter Collins, V. and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, J{\"o}rg and Reifenberger, Guido and Northcott, Paul A. and Taylor, Michael D. and Meyerson, Matthew and Pomeroy, Scott L. and Yaspo, Marie-Laure and Korbel, Jan Oliver and Korshunov, Andrey and Eils, Roland and Pfister, Stefan and Lichter, Peter}, title={Dissecting the genomic complexity underlying medulloblastoma}, year={2012}, pages={100-105}, language={eng}, issn={0028-0836}, volume={488}, number={7409 vom: 20. Juni}, journal={Nature}, } @article{UBHD-68296998, author={Jones, David T. W. and J{\"a}ger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor and Hovestadt, Volker and St{\"u}tz, Adrian M. and Rausch, Tobias and Warnatz, Hans-J{\"o}rg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina Valesca and Şeker-Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Andrea and Remke, Marc and Witt, Hendrik and Hutter, Sonja and Tzaridis, Theophilos-Dimitrios and Weischenfeldt, Joachim and Zapatka, Marc and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred and Kalle, Christof von and Ast, Volker and Lawerenz, Christian and Eils, J{\"u}rgen and Betts, Matthew J. and Russell, Robert B. and Roggendorf, Wolfgang and Unterberg, Andreas and Herold-Mende, Christel and Milde, Till and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Rutkowski, Stefan and Bueren, André von and Brors, Benedikt and Korbel, Jan Oliver and Korshunov, Andrey and Eils, Roland and Pfister, Stefan and Lichter, Peter}, title={Dissecting the genomic complexity underlying medulloblastoma}, year={2012}, pages={100-105}, language={eng}, issn={1476-4687}, volume={488}, number={7409}, note={Gesehen am 20.08.2018}, journal={Nature}, doi={10.1038/nature11284}, } @article{UBHD-68485493, author={Jones, David T. W. and Banito, Ana and Gr{\"u}newald, Thomas G. P. and Haber, Michelle and J{\"a}ger, Natalie and Kool, Marcel and Milde, Till and Molenaar, Jan J. and Nabbi, Arash and Pugh, Trevor and Schleiermacher, Gudrun and Smith, Malcolm A. and Westermann, Frank and Pfister, Stefan}, title={Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours}, year={2019}, pages={420-438}, language={eng}, issn={1474-1768}, volume={19}, number={8}, note={Gesehen am 06.02.2020}, journal={Nature reviews}, doi={10.1038/s41568-019-0169-x}, } @article{UBHD-69322486, author={Kastellan, Svenja and Kalb, Reinhard and Sajjad, Bia and McReynolds, Lisa J. and Giri, Neelam and Samuel, David and Milde, Till and Elbracht, Miriam and Holzhauer, Susanne and Niewisch, Marena R. and Kratz, Christian P.}, title={Germline biallelic BRCA2 pathogenic variants and medulloblastoma}, subtitle={an international cohort study}, year={2024}, pages={1-5}, language={eng}, issn={1756-8722}, volume={17}, number={Artikel-ID 26}, note={Gesehen am 26.03.2025}, journal={Journal of hematology & oncology}, doi={10.1186/s13045-024-01547-4}, } @article{UBHD-69092243, author={Keck, Michaela-Kristina and Sill, Martin and Stichel, Damian and Sievers, Philipp and Wefers, Annika K. and Sturm, Dominik and Schramm, Kathrin and Selt, Florian and Ecker, Jonas and Milde, Till and Deimling, Andreas von and Pfister, Stefan and Sahm, Felix and Jones, David T. W.}, title={Amplification of the PLAG-family genes - PLAGL1 and PLAGL2 - is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification}, year={2023}, pages={49-69}, language={eng}, issn={1432-0533}, volume={145}, number={1}, note={Online ver{\"o}ffentlicht: 27. November 2022 ; Gesehen am 06.12.2023}, journal={Acta neuropathologica}, doi={10.1007/s00401-022-02516-2}, } @article{UBHD-69150257, author={Keck, Michaela-Kristina and Sill, Martin and Stichel, Damian and Sievers, Philipp and Wefers, Annika K. and Sturm, Dominik and Schramm, Kathrin and Selt, Florian and Ecker, Jonas and Milde, Till and Deimling, Andreas von and Pfister, Stefan and Sahm, Felix and Jones, David T. W.}, title={Correction to: Amplification of the PLAG-family genes - PLAGL1 and PLAGL2 - is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification}, year={2023}, pages={511-514}, language={eng}, issn={1432-0533}, volume={145}, number={4}, note={Online ver{\"o}ffentlicht am 14. Februar 2023 ; Gesehen am 06.12.2023}, journal={Acta neuropathologica}, doi={10.1007/s00401-023-02538-4}, } @article{UBHD-69323093, author={Kocher, Daniela and Cao, Lei and Guiho, Romain and Langhammer, Melanie and Lai, Yun-Lu and Becker, Pauline and Hamdi, Hiba and Friedel, Dennis and Selt, Florian and Vonh{\"o}ren, David and Zaman, Julia and Valinciute, Gintvile and Herter, Sonja and Picard, Daniel and Rettenmeier, Johanna and Maaß, Kendra K. and Pajtler, Kristian Wilfried and Remke, Marc and Deimling, Andreas von and Pusch, Stefan and Pfister, Stefan and Oehme, Ina and Jones, David T. W. and Halbach, Sebastian and Brummer, Tilman and Martinez-Barbera, Juan Pedro and Witt, Olaf and Milde, Till and Sigaud, Romain}, title={Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines}, year={2024}, pages={317-332}, language={eng}, issn={1573-7373}, volume={168}, number={2 vom: Juni}, note={Gesehen am 28.03.2025}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-024-04672-9}, } @article{UBHD-68462522, author={K{\"o}lsche, Christian and Schrimpf, Daniel and Sahm, Felix and Reuss, David and Hou, Yanghao and Sturm, Dominik and Ecker, Jonas and Milde, Till and Pfister, Stefan and Mechtersheimer, Gunhild and Jones, David T. W. and Deimling, Andreas von}, title={Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations}, year={2018}, pages={327-337}, language={eng}, issn={1432-0533}, volume={136}, number={2}, note={Gesehen am 02.12.2019}, journal={Acta neuropathologica}, doi={10.1007/s00401-018-1871-6}, } @article{UBHD-68708346, author={K{\"o}lsche, Christian and Schrimpf, Daniel and Stichel, Damian and Sill, Martin and Sahm, Felix and Reuss, David and Jones, Barbara Christine and Heilig, Christoph E. and Horak, Peter and Stark, Sebastian and Johann, Pascal-David and Selt, Florian and Ecker, Jonas and Sturm, Dominik and Pajtler, Kristian Wilfried and Reinhardt, Annekathrin and Wefers, Annika K. and Sievers, Philipp and Suwala, Abigail Kora and Fernández Klett, Francisco and Casalini, Belén and Korshunov, Andrey and Kommoss, Felix and Kriegsmann, Mark and Milde, Till and Witt, Olaf and Kulozik, Andreas and Kool, Marcel and Gr{\"u}newald, Thomas G. P. and Wick, Wolfgang and Platten, Michael and Unterberg, Andreas and Uhl, Matthias and Abdollahi, Amir and Debus, J{\"u}rgen and Lehner, Burkhard and Schirmacher, Peter and Stenzinger, Albrecht and Brors, Benedikt and Glimm, Hanno and Hohenberger, Peter and Mechtersheimer, Gunhild and Jones, David T. W. and Fr{\"o}hling, Stefan and Pfister, Stefan and Deimling, Andreas von}, title={Sarcoma classification by DNA methylation profiling}, year={2021}, pages={1-10}, language={eng}, issn={2041-1723}, volume={12}, number={Artikel-ID 498}, note={Gesehen am 09.03.2021}, journal={Nature Communications}, doi={10.1038/s41467-020-20603-4}, } @article{UBHD-69183509, author={Kolodziejczak, Anna and Guerrini-Rousseau, Lea and Planchon, Julien Masliah and Ecker, Jonas and Selt, Florian and Mynarek, Martin and Obrecht-Sturm, Denise and Sill, Martin and Autry, Robert J. and Stutheit-Zhao, Eric and Hirsch, Steffen and Amouyal, Elsa and Dufour, Christelle and Ayrault, Olivier and Torrejon, Jacob and Waszak, Sebastian Martin and Ramaswamy, Vijay and Pentikainen, Virve and Demir, Haci Ahmet and Clifford, Steven C. and Schwalbe, Ed C. and Massimi, Luca and Snuderl, Matija and Galbraith, Kristyn and Karajannis, Matthias A. and Hill, Katherine and Li, Bryan K. and Walsh, Mike and White, Christine L. and Redmond, Shelagh and Loizos, Loizou and Jakob, Marcus and Kordes, Uwe and Schmid, Irene and Hauer, Julia Christina and Blattmann, Claudia and Filippidou, Maria and Piccolo, Gianluca and Scheurlen, Wolfram and Farrag, Ahmed and Grund, Kerstin and Sutter, Christian and Pietsch, Torsten and Frank, Stephan and Schewe, Denis Martin and Malkin, David and Weyl Ben-Arush, Myriam and Sehested, Astrid and Wong, Tai-Tong and Wu, Kuo-Sheng and Liu, Yen-Lin and Carceller, Fernando and Mueller, Sabine and Stoller, Schuyler and Taylor, Michael D. and Tabori, Uri and Bouffet, Eric and Kool, Marcel and Sahm, Felix and Deimling, Andreas von and Korshunov, Andrey and Hoff, Katja von and Kratz, Christian Peter and Sturm, Dominik and Jones, David T. W. and Rutkowski, Stefan and Tilburg, Cornelis M. van and Witt, Olaf and Bougeard, Gaëlle and Pajtler, Kristian Wilfried and Pfister, Stefan and Bourdeaut, Franck and Milde, Till}, title={Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome}, year={2023}, pages={2273-2286}, language={eng}, issn={1523-5866}, volume={25}, number={12 vom: Dez.}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noad114}, } @article{UBHD-67928856, author={Kool, Marcel and Milde, Till and Witt, Hendrik and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Unterberg, Andreas and Herold-Mende, Christel and Kulozik, Andreas and Deimling, Andreas von and Scheurlen, Wolfram and Pfister, Stefan}, title={Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition}, year={2014}, pages={393-405}, language={eng}, issn={1878-3686}, volume={25}, number={3}, note={Gesehen am 22.01.2016}, journal={Cancer cell}, doi={10.1016/j.ccr.2014.02.004}, } @article{UBHD-68134428, author={Korshunov, Andrey and Sturm, Dominik and Capper, David and Meyer, Jochen and Schrimpf, Daniel and Milde, Till and Witt, Olaf and Kulozik, Andreas and Deimling, Andreas von and Pfister, Stefan}, title={Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers}, year={2015}, pages={669-678}, language={eng}, issn={1432-0533}, volume={129}, number={5}, note={Gesehen am 05.07.2017}, journal={Acta neuropathologica}, doi={10.1007/s00401-015-1405-4}, } @article{UBHD-69054605, author={Korshunov, Andrey and Witt, Hendrik and Hielscher, Thomas and Benner, Axel and Remke, Marc and Ryzhova, Marina and Milde, Till and Bender, Sebastian and Wittmann, Andrea and Sch{\"o}ttler, Anna and Kulozik, Andreas and Witt, Olaf and Deimling, Andreas von and Lichter, Peter and Pfister, Stefan}, title={Molecular staging of intracranial ependymoma in children and adults}, year={2010}, pages={3182-3190}, language={eng}, issn={1527-7755}, volume={28}, number={19 vom: Juli}, note={Gesehen am 22.03.2023}, journal={Journal of clinical oncology}, doi={10.1200/JCO.2009.27.3359}, } @article{UBHD-68712562, author={Kratz, Christian Peter and Milde, Till and Pajtler, Kristian Wilfried}, title={Predisposition to cancer in children and adolescents}, year={2021}, pages={142-154}, language={eng}, issn={2352-4650}, volume={5}, number={2}, note={Gesehen am 15.03.2021}, journal={The lancet child & adolescent health}, doi={10.1016/S2352-4642(20)30275-3}, } @article{UBHD-69313521, author={Lenga, Pavlina and K{\"u}hlwein, Daniel and Grutza, Martin and Issa, Mohammed and Hinz, Felix and Sahm, Felix and Selt, Florian and Milde, Till and G{\"u}nther, Patrick and Unterberg, Andreas and Krieg, Sandro and El Damaty, Ahmed}, title={Decoding pediatric spinal tumors}, subtitle={a single-center retrospective case series on etiology, presentation, therapeutic strategies, and outcomes}, year={2024}, pages={1-12}, language={eng}, issn={1437-2320}, volume={47}, number={Artikel-ID 557}, note={Gesehen am 28.02.2025}, journal={Neurosurgical review}, doi={10.1007/s10143-024-02770-w}, } @article{UBHD-68620670, author={Liu, Lu and Milde, Till and Haefeli, Walter E. and Witt, Olaf and Burhenne, J{\"u}rgen}, title={Quantification of vorinostat and its main metabolites in plasma and intracellular vorinostat in PBMCs by liquid chromatography coupled to tandem mass spectrometry and its relation to histone deacetylase activity in human blood}, year={2014}, pages={212-221}, language={eng}, issn={1873-376X}, volume={964}, note={Gesehen am 24.07.2020}, journal={Journal of chromatography}, doi={10.1016/j.jchromb.2014.02.014}, } @article{UBHD-68739690, author={Lodrini, Marco and Oehme, Ina and Schr{\"o}der, Christina and Milde, Till and Schier, Marie Catherine and Kopp-Schneider, Annette and Schulte, Johannes H. and Fischer, Matthias and De Preter, Katleen and Pattyn, Filip and Castoldi, Mirco and Muckenthaler, Martina and Kulozik, Andreas and Westermann, Frank and Witt, Olaf and Deubzer, Hedwig}, title={MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma}, year={2013}, pages={6018-6033}, language={eng}, issn={1362-4962}, volume={41}, number={12}, note={Gesehen am 19.05.2021}, journal={Nucleic acids research}, doi={10.1093/nar/gkt346}, } @article{UBHD-68747382, author={Mack, Stephen C. and Witt, Hendrik and Wang, Xin and Milde, Till and Yao, Yuan and Bertrand, Kelsey C. and Korshunov, Andrey and Pfister, Stefan and Taylor, Michael D.}, title={Emerging insights into the ependymoma epigenome}, year={2013}, pages={206-209}, language={eng}, issn={1750-3639}, volume={23}, number={2 vom: M{\"a}rz}, note={Gesehen am 11.06.2021}, journal={Brain pathology}, doi={10.1111/bpa.12020}, } @article{UBHD-68639644, author={Mack, Stephen C. and J{\"a}ger, Natalie and Jones, David T. W. and Sill, Martin and Stark, Sebastian and Şeker-Cin, Huriye and Johann, Pascal-David and Bender, Silke and Milde, Till and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Kool, Marcel and Korbel, Jan Oliver and Eils, Roland and Lichter, Peter and Pfister, Stefan}, title={Epigenomic alterations define lethal CIMP-positive ependymomas of infancy}, year={2014}, pages={445-453}, language={eng}, issn={1476-4687}, volume={506}, number={7489}, note={Gesehen am 23.09.2020}, journal={Nature}, doi={10.1038/nature13108}, } @article{UBHD-68289802, author={Mack, Stephen C. and Pajtler, Kristian Wilfried and Chavez, Lukas and Okonechnikov, Konstantin and Erkek, Serap and Zapatka, Marc and Milde, Till and Witt, Hendrik and Jones, David T. W. and Lichter, Peter and Korshunov, Andrey and Pfister, Stefan and Kool, Marcel}, title={Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling}, year={2018}, pages={101-105}, language={eng}, issn={1476-4687}, volume={553}, number={7686}, note={Published 20 December 2017 ; Published online 20 December 2017 ; Gesehen am 27.07.2018}, journal={Nature}, doi={10.1038/nature25169}, } @article{UBHD-69113128, author={Marquardt, Viktoria and Theruvath, Johanna and Pauck, David and Picard, Daniel and Qin, Nan and Bl{\"u}mel, Lena and Maue, Mara and Bartl, Jasmin and Ahmadov, Ulvi and Langini, Maike and Meyer, Frauke-Dorothee and Cole, Allison and Cruz-Cruz, Joselyn and Graef, Claus M. and W{\"o}lfl, Matthias and Milde, Till and Witt, Olaf and Erdreich-Epstein, Anat and Leprivier, Gabriel and Kahlert, Ulf and Stefanski, Anja and St{\"u}hler, Kai and Keir, Stephen T. and Bigner, Darell D. and Hauer, Julia and Beez, Thomas and Knobbe-Thomsen, Christiane B. and Fischer, Ute and Felsberg, J{\"o}rg and Hansen, Finn K. and Vibhakar, Rajeev and Venkatraman, Sujatha and Cheshier, Samuel H. and Reifenberger, Guido and Borkhardt, Arndt and Kurz, Thomas and Remke, Marc and Mitra, Siddhartha}, title={Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation}, year={2023}, pages={1-16}, language={eng}, issn={2051-1426}, volume={11}, note={Online ver{\"o}ffentlicht: 13. Januar 2023 ; Gesehen am 16.08.2023}, journal={Journal for ImmunoTherapy of Cancer}, doi={10.1136/jitc-2022-005871}, } @article{UBHD-68874734, author={Mayr, Lisa and Guntner, Armin S. and Madlener, Sibylle and Schmook, Maria T. and Peyrl, Andreas and Azizi, Amedeo A. and Dieckmann, Karin and Reisinger, Dominik and Stepien, Natalia M. and Schramm, Kathrin and Laemmerer, Anna and Jones, David T. W. and Ecker, Jonas and Sahm, Felix and Milde, Till and Pajtler, Kristian Wilfried and Blattner-Johnson, Mirjam and Strbac, Miroslav and Dorfer, Christian and Czech, Thomas and Kirchhofer, Dominik and Gabler, Lisa and Berger, Walter and Haberler, Christine and M{\"u}llauer, Leonhard and Buchberger, Wolfgang and Slavc, Irene and L{\"o}tsch-Gojo, Daniela and Gojo, Johannes}, title={Cerebrospinal fluid penetration and combination therapy of entrectinib for disseminated ROS1/NTRK-fusion positive pediatric high-grade glioma}, year={2020}, pages={1-17}, language={eng}, issn={2043-7749}, volume={10}, note={Gesehen am 09.02.2022}, journal={International Journal of Person Centered Medicine}, doi={10.3390/jpm10040290}, } @article{UBHD-69143642, author={Milde, Till and Fangusaro, Jason R. and Fisher, Michael J and Hawkins, Cynthia and Rodriguez, Fausto J and Tabori, Uri and Witt, Olaf and Zhu, Yuan and Gutmann, David H}, title={Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation}, year={2023}, pages={1920-1931}, language={eng}, issn={1523-5866}, volume={25}, number={11 vom: Nov.}, note={Gesehen am 16.11.2023 ; Online verf{\"u}gbar: 21. September 2023}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noad125}, } @article{UBHD-68333887, author={Milde, Till and Hielscher, Thomas and Witt, Hendrik and Kool, Marcel and Deubzer, Hedwig and Oehme, Ina and Lodrini, Marco and Benner, Axel and Deimling, Andreas von and Kulozik, Andreas and Pfister, Stefan and Witt, Olaf and Korshunov, Andrey}, title={Nestin expression identifies ependymoma patients with poor outcome}, year={2012}, pages={848-860}, language={eng}, issn={1750-3639}, volume={22}, number={6}, note={Gesehen am 29.11.2018}, journal={Brain pathology}, doi={10.1111/j.1750-3639.2012.00600.x}, } @article{UBHD-68955714, author={Milde, Till and Kleber, Susanne and Korshunov, Andrey and Witt, Hendrik and Hielscher, Thomas and Koch, Philipp and Kopp, Hans-Georg and Jugold, Manfred and Deubzer, Hedwig E. and Oehme, Ina and Lodrini, Marco and Gr{\"o}ne, Hermann-Josef and Benner, Axel and Br{\"u}stle, Oliver and Gilbertson, Richard J. and Deimling, Andreas von and Kulozik, Andreas and Pfister, Stefan and Martín-Villalba, Ana and Witt, Olaf}, title={A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat}, year={2011}, pages={1-14}, language={eng}, issn={1432-0533}, volume={122}, note={Gesehen am 19.08.2022}, journal={Acta neuropathologica}, doi={10.1007/s00401-011-0866-3}, } @article{UBHD-68333891, author={Milde, Till and Lodrini, Marco and Korshunov, Andrey and Kool, Marcel and Pfister, Stefan and Kulozik, Andreas and Witt, Olaf and Deubzer, Hedwig}, title={HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment}, year={2012}, pages={335-348}, language={eng}, issn={1573-7373}, volume={110}, number={3}, note={Gesehen am 29.11.2018}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-012-0978-1}, } @article{UBHD-69069402, author={Milde, Till and Oehme, Ina and Korshunov, Andrey and Kopp-Schneider, Annette and Remke, Marc and Northcott, Paul and Deubzer, Hedwig and Lodrini, Marco and Taylor, Michael D. and Deimling, Andreas von and Pfister, Stefan and Witt, Olaf}, title={HDAC5 and HDAC9 in medulloblastoma}, subtitle={novel markers for risk stratification and role in tumor cell growth}, year={2010}, pages={3240-3252}, language={eng}, issn={1557-3265}, volume={16}, number={12}, note={Gesehen am 26.04.2023}, journal={Clinical cancer research}, doi={10.1158/1078-0432.CCR-10-0395}, } @book{UBHD-67944749, author={Milde, Till}, title={P{\"a}diatrische Hirntumore}, subtitle={Subgruppen-spezifische Modelle, Biomarker und epigenetische Therapieans{\"a}tze}, address={Heidelberg}, year={2015}, pages={57 Seiten, circa 60 ungez{\"a}hlte Seiten}, language={eng}, note={Enth{\"a}lt Zeitschriftenaufs{\"a}tze ; Zusammenfassung in deutscher Sprache}, school={Habilitationsschrift, Medizinische Fakult{\"a}t Heidelberg der Ruprecht-Karls-Universit{\"a}t, 2015}, library={UB [Signatur: 2016 U 224]}, } @article{UBHD-68866810, author={Milde, Till and Rodriguez, Fausto J and Barnholtz-Sloan, Jill S and Patil, Nirav and Eberhart, Charles G and Gutmann, David H}, title={Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas}, year={2021}, pages={1634-1646}, language={eng}, issn={1523-5866}, volume={23}, number={10 vom: Okt.}, note={Gesehen am 15.01.2022}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noab138}, } @incollection{UBHD-68585127, author={Milde, Till and Witt, Olaf and Pfister, Stefan and Witt, Hendrik}, title={Ependymoma}, year={2015}, pages={67-75}, language={eng}, isbn={9781493918300}, note={First online: 04 November 2014 ; Gesehen am 08.06.2020}, booktitle={Molecular Pathology of Nervous System Tumors}, editor={Zagzag, David}, doi={10.1007/978-1-4939-1830-0_5}, } @article{UBHD-68792687, author={M{\"u}ller, Michael and R{\"o}sch, Lisa and Najafi, Sara and Gatzweiler, Charlotte and Ridinger, Johannes and Gerloff, Xenia F. and Jones, David T. W. and Baßler, Jochen and Kreth, Sina and Stainczyk, Sabine and Frese, Karen S. and Meder, Benjamin and Westermann, Frank and Milde, Till and Peterziel, Heike and Witt, Olaf and Oehme, Ina}, title={Combining APR-246 and HDAC-inhibitors}, subtitle={a novel targeted treatment option for neuroblastoma}, year={2021}, pages={1-23}, language={eng}, issn={2072-6694}, volume={13}, note={Gesehen am 22.10.2021}, journal={Cancers}, doi={10.3390/cancers13174476}, } @article{UBHD-69155230, author={Mynarek, Martin and Obrecht-Sturm, Denise and Sill, Martin and Sturm, Dominik and Kloth-Stachnau, Katja and Selt, Florian and Ecker, Jonas and Hoff, Katja von and Juhnke, Bj{\"o}rn-Ole and Goschzik, Tobias and Pietsch, Torsten and Bockmayr, Michael and Kool, Marcel and Deimling, Andreas von and Witt, Olaf and Sch{\"u}ller, Ulrich and Benesch, Martin and Gerber, Nicolas U. and Sahm, Felix and Jones, David T. W. and Korshunov, Andrey and Pfister, Stefan and Rutkowski, Stefan and Milde, Till}, title={Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts}, year={2023}, pages={97-112}, language={eng}, issn={1432-0533}, volume={145}, number={1}, note={Gesehen am 20.12.2023}, journal={Acta neuropathologica}, doi={10.1007/s00401-022-02522-4}, } @article{UBHD-68959677, author={Mynarek, Martin and Milde, Till and Padovani, Laetitia and Janssens, Geert O. and Kwiecien, Robert and Mosseri, Veronique and Clifford, Steven C. and Doz, François and Rutkowski, Stefan}, title={SIOP PNET5 MB trial}, subtitle={history and concept of a molecularly stratified clinical trial of risk-adapted therapies for standard-risk medulloblastoma}, year={2021}, pages={1-16}, language={eng}, issn={2072-6694}, volume={13}, note={Gesehen am 02.09.2022}, journal={Cancers}, doi={10.3390/cancers13236077}, } @article{UBHD-68935700, author={Nemes, Karolina and Johann, Pascal-David and Steinb{\"u}gl, Mona and Gruhle, Miriam and Bens, Susanne and Kachanov, Denis and Teleshova, Margarita and Hauser, Peter and Simon, Thorsten and Tippelt, Stephan and Eberl, Wolfgang and Chada, Martin and Lopez, Vicente Santa-Maria and Grigull, Lorenz and Hernáiz-Driever, Pablo and Eyrich, Matthias and Pears, Jane and Milde, Till and Reinhard, Harald and Leipold, Alfred and van de Wetering, Marianne and Gil-da-Costa, Maria João and Ebetsberger-Dachs, Georg and Kerl, Kornelius and Lemmer, Andreas and Boztug, Heidrun and Furtw{\"a}ngler, Rhoikos and Kordes, Uwe and Vokuhl, Christian and Hasselblatt, Martin and Bison, Brigitte and Kr{\"o}ncke, Thomas and Melchior, Patrick and Timmermann, Beate and Gerss, Joachim and Siebert, Reiner and Fr{\"u}hwald, Michael C.}, title={Infants and newborns with atypical teratoid rhabdoid tumors (ATRT) and extracranial malignant rhabdoid tumors (eMRT) in the EU-RHAB Registry}, subtitle={a unique and challenging population}, year={2022}, pages={1-16}, language={eng}, issn={2072-6694}, volume={14}, note={Published: 27 April 2022 ; Gesehen am 29.06.2022}, journal={Cancers}, doi={10.3390/cancers14092185}, } @article{UBHD-68254461, author={Northcott, Paul A. and Paramasivam, Nagarajan and Heinold, Michael and H{\"u}bschmann, Daniel and Herold-Mende, Christel and Witt, Olaf and Milde, Till and Deimling, Andreas von and Capper, David and Brors, Benedikt and Eils, Roland}, title={The whole-genome landscape of medulloblastoma subtypes}, year={2017}, pages={311-317}, language={eng}, issn={1476-4687}, volume={547}, number={7663}, note={Das PDF enth{\"a}lt abweichend von der Seitenangabe 20 Seiten, incl. Anhang ; Gesehen am 24.05.2018}, journal={Nature}, doi={10.1038/nature22973}, } @article{UBHD-67458702, author={Oehme, Ina and Linke, Jan-Peter and B{\"o}ck, Barbara and Milde, Till and Lodrini, Marco and Hartenstein, Bettina and Rettig, Inga Edeltraud and Eckert, Christian and Roth, Wilfried and Kool, Marcel and Kaden, Sylvia and Gr{\"o}ne, Hermann-Josef and Schulte, Johannes Hubertus and Lindner, Sven and Hamacher-Brady, Anne and Brady, Nathan and Deubzer, Hedwig and Witt, Olaf}, title={Histone deacetylase 10 promotes autophagy-mediated cell survival}, year={2013}, pages={E2592-E2601}, language={eng}, issn={0027-8424}, volume={110}, number={28}, journal={Proceedings of the National Academy of Sciences of the United States of America}, } @article{UBHD-68805961, author={Oehme, Ina and Linke, Jan-Peter and B{\"o}ck, Barbara and Milde, Till and Lodrini, Marco and Hartenstein, Bettina and Rettig, Inga Edeltraud and Eckert, Christian and Roth, Wilfried and Kool, Marcel and Kaden, Sylvia and Gr{\"o}ne, Hermann-Josef and Schulte, Johannes Hubertus and Lindner, Sven and Hamacher-Brady, Anne and Brady, Nathan and Deubzer, Hedwig and Witt, Olaf}, title={Histone deacetylase 10 promotes autophagy-mediated cell survival}, year={2013}, pages={E2592-E2601}, language={eng}, issn={1091-6490}, volume={110}, number={28}, note={Gesehen am 29.11.2021}, journal={Proceedings of the National Academy of Sciences of the United States of America}, doi={10.1073/pnas.1300113110}, } @article{UBHD-69280318, author={O’Hare, Patricia and Cooney, Tabitha and de Blank, Peter and Gutmann, David H and Kieran, Mark and Milde, Till and Fangusaro, Jason and Fisher, Michael and Avula, Shivaram and Packer, Roger and Fukuoka, Kohei and Mankad, Kshitij and M{\"u}ller, Sabine and Waanders, Angela J and Opocher, Enrico and Bouffet, Eric and Raabe, Eric and Werle, Natacha Entz and Azizi, Amedeo A and Robison, Nathan J and Hernáiz Driever, Pablo and Russo, Mark and Schouten, Netteke and Tilburg, Cornelis M. van and Sehested, Astrid and Grill, Jacques and Bandopadhayay, Pratiti and Kilday, John-Paul and Witt, Olaf and Ashley, David M and Ertl-Wagner, Birgit Betina and Tabori, Uri and Hargrave, Darren R.}, title={Resistance, rebound, and recurrence regrowth patterns in pediatric low-grade glioma treated by MAPK inhibition}, subtitle={a modified Delphi approach to build international consensus-based definitions : international pediatric low-grade glioma coalition}, year={2024}, pages={1357-1366}, language={eng}, issn={1523-5866}, volume={26}, number={8 vom: Aug.}, note={Ver{\"o}ffentlicht: 14 May 2024 ; Gesehen am 04.12.2024}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noae074}, } @article{UBHD-69151862, author={Okonechnikov, Konstantin and Camg{\"o}z, Aylin and Chapman, Owen and Wani, Sameena and Park, Donglim Esther and H{\"u}bner, Jens-Martin and Chakraborty, Abhijit and Pagadala, Meghana and Bump, Rosalind and Chandran, Sahaana and Kraft, Katerina and Acuna-Hidalgo, Rocio and Reid, Derek and Sikkink, Kristin and Mauermann, Monika and Juarez, Edwin F. and Jenseit, Anne and Robinson, James T. and Pajtler, Kristian Wilfried and Milde, Till and J{\"a}ger, Natalie and Fiesel, Petra and Morgan, Ling and Sridhar, Sunita and Coufal, Nicole G. and Levy, Michael and Malicki, Denise and Hobbs, Charlotte and Kingsmore, Stephen and Nahas, Shareef and Snuderl, Matija and Crawford, John and Wechsler-Reya, Robert J. and Davidson, Tom Belle and Cotter, Jennifer and Michaiel, George and Fleischhack, Gudrun and Mundlos, Stefan and Schmitt, Anthony and Carter, Hannah and Michealraj, Kulandaimanuvel Antony and Kumar, Sachin A. and Taylor, Michael D. and Rich, Jeremy and Buchholz, Frank and Mesirov, Jill P. and Pfister, Stefan and Ay, Ferhat and Dixon, Jesse R. and Kool, Marcel and Chavez, Lukas}, title={3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma}, year={2023}, pages={1-16}, language={eng}, issn={2041-1723}, volume={14}, number={Artikel-ID 2300}, note={Online ver{\"o}ffentlicht: 21. April 2023 ; Gesehen am 12.12.2023}, journal={Nature Communications}, doi={10.1038/s41467-023-38044-0}, } @article{UBHD-69276307, author={Okonechnikov, Konstantin and Schrimpf, Daniel and Koster, Jan and Sievers, Philipp and Milde, Till and Sahm, Felix and Jones, David T. W. and Deimling, Andreas von and Pfister, Stefan and Kool, Marcel and Korshunov, Andrey}, title={Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations}, year={2024}, pages={1-11}, language={eng}, issn={1432-0533}, volume={147}, number={Artikel-ID 95}, note={Gesehen am 25.11.2024}, journal={Acta neuropathologica}, doi={10.1007/s00401-024-02746-6}, } @article{UBHD-69344141, author={Okonechnikov, Konstantin and Joshi, Piyush and K{\"o}rber, Verena and Rademacher, Anne and Bortolomeazzi, Michele and Mallm, Jan-Philipp and Vaillant, Jan and da Silva, Patricia Benites Goncalves and Statz, Britta and Sepp, Mari and Sarropoulos, Ioannis and Yamada, Tetsuya and Wittmann, Andrea and Schramm, Kathrin and Blattner-Johnson, Mirjam and Fiesel, Petra and Jones, Barbara Christine and J{\"a}ger, Natalie and Milde, Till and Pajtler, Kristian Wilfried and Tilburg, Cornelis M. van and Witt, Olaf and Bochennek, Konrad and Weber, Katharina Johanna and Nonnenmacher, Lisa and Reimann, Christian and Ghasemi, David R. and Sch{\"u}ller, Ulrich and Mynarek, Martin and Rutkowski, Stefan and Jones, David T. W. and Korshunov, Andrey and Rippe, Karsten and Westermann, Frank and Thongjuea, Supat and H{\"o}fer, Thomas and Kaessmann, Henrik and Kutscher, Lena and Pfister, Stefan}, title={Oncogene aberrations drive medulloblastoma progression, not initiation}, year={2025}, pages={34 S.}, language={eng}, issn={1476-4687}, note={Gesehen am 13.05.2025}, journal={Nature}, doi={10.1038/s41586-025-08973-5}, } @article{UBHD-69006827, author={Peterziel, Heike and Jamaladdin, Nora and ElHarouni, Dina and Gerloff, Xenia F. and Herter, Sonja and Fiesel, Petra and Berker, Yannick and Blattner-Johnson, Mirjam and Schramm, Kathrin and Jones, Barbara Christine and Reuss, David and Turunen, Laura and Friedenauer, Aileen and Holland-Letz, Tim and Sill, Martin and Weiser, Lena and Previti, A. Christopher and Balasubramanian, Gnanaprakash and Gerber, Nicolas U. and Gojo, Johannes and Hutter, Caroline and Øra, Ingrid and Lohi, Olli and Kattamis, Antonis and de Wilde, Bram and Westermann, Frank and Tippelt, Stephan and Graf, Norbert and Nathrath, Michaela and Sparber-Sauer, Monika and Sehested, Astrid and Kramm, Christof M. and Dirksen, Uta and Kallioniemi, Olli and Pfister, Stefan and Tilburg, Cornelis M. van and Jones, David T. W. and Saarela, Jani and Pieti{\"a}inen, Vilja and J{\"a}ger, Natalie and Schlesner, Matthias and Kopp-Schneider, Annette and Oppermann, Sina and Milde, Till and Witt, Olaf and Oehme, Ina}, title={Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM}, year={2022}, pages={1-17}, language={eng}, issn={2397-768X}, volume={6}, number={Artikel-ID 94}, note={Gesehen am 17.01.2023}, journal={npj precision oncology}, doi={10.1038/s41698-022-00335-y}, } @article{UBHD-68428360, author={Pfaff, Elke and El Damaty, Ahmed and Jones, Barbara Christine and Stark, Sebastian and Witt, Hendrik and Pajtler, Kristian Wilfried and Tilburg, Cornelis M. van and Milde, Till and Jakobs, Martin and D{\"u}rken, Matthias and Karremann, Michael and Herold-Mende, Christel and Kiening, Karl and Lichter, Peter and Pfister, Stefan and Jones, David T. W. and B{\"a}chli, Heidi and Witt, Olaf}, title={Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine}, subtitle={the INFORM study experience}, year={2019}, pages={27-35}, language={eng}, issn={1879-0852}, volume={114}, note={Gesehen am 09.09.2019}, journal={European journal of cancer}, doi={10.1016/j.ejca.2019.03.019}, } @article{UBHD-68992245, author={Pfaff, Elke and Remke, Marc and Sturm, Dominik and Benner, Axel and Witt, Hendrik and Milde, Till and von Bueren, André O. and Jorch, Norbert and Graf, Norbert and Kulozik, Andreas and Witt, Olaf and Scheurlen, Wolfram and Deimling, Andreas von and Rutkowski, Stefan and Taylor, Michael D. and Tabori, Uri and Lichter, Peter and Korshunov, Andrey and Pfister, Stefan}, title={Reply to J.C. Lindsey et al}, year={2011}, pages={e348-e349}, language={eng}, issn={1527-7755}, volume={29}, number={12}, note={Gesehen am 02.12.2022}, journal={Journal of clinical oncology}, doi={10.1200/JCO.2010.34.1545}, } @article{UBHD-69070098, author={Pfaff, Elke and Remke, Marc and Sturm, Dominik and Benner, Axel and Witt, Hendrik and Milde, Till and von Bueren, André O. and Wittmann, Andrea and Sch{\"o}ttler, Anna and Jorch, Norbert and Graf, Norbert and Kulozik, Andreas and Witt, Olaf and Scheurlen, Wolfram and Deimling, Andreas von and Rutkowski, Stefan and Taylor, Michael D. and Tabori, Uri and Lichter, Peter and Korshunov, Andrey and Pfister, Stefan}, title={TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma}, year={2010}, pages={5188-5196}, language={eng}, issn={1527-7755}, volume={28}, number={35 vom: Nov.}, note={Gesehen am 28.04.2023}, journal={Journal of clinical oncology}, doi={10.1200/JCO.2010.31.1670}, } @book{UBHD-68594472, author={Pfister, Stefan and Milde, Till}, organization={Zentrum f{\"u}r Kinder- und Jugendmedizin / Klinik f{\"u}r Kinderheilkunde III: Onkologie, H{\"a}matologie, Immunologie und Pneumologie}, title={Schlussbericht zum CancerSys-Verbundprojekt „MYC-NET - Aufkl{\"a}rung der Mechanismen MYC-getriebener Therapieresistenz neuroectodermaler Tumore“}, subtitle={Laufzeit des Vorhabens: 01.03.2012-28.02.2015}, publisher={Universit{\"a}tsklinikum Heidelberg, Abteilung P{\"a}diatrische H{\"a}matologie und Onkologie}, address={Heidelberg}, year={2015}, pages={13 Bl{\"a}tter, 1 ungez{\"a}hltes Blatt}, language={ger}, note={F{\"o}rderkennzeichen BMBF 0316076B. - Verbund-Nummer 01109385 ; Titel auf dem Berichtsblatt: CancerSys-Verbundprojekt: MYC-NET - Aufkl{\"a}rung der Mechanismen MYC-getriebener Therapieresistenz neuroectodermaler Tumore, Teilprojekt Pr{\"a}klinische Validierung (TP4) ; "Autor(en): Pfister, Stefan; Milde, Till" - Berichtsblatt ; "Durchf{\"u}hrende Institution(en): Universit{\"a}tsklinik Heidelberg, ZKJM, Abteilung f{\"u}r H{\"a}matologie, Onkologie, Immunologie und Pneumologie, INF 430, 69120 Heidelberg" - Berichtsblatt ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource k{\"o}nnen nicht ausgeschlossen werden}, keywords={Neuroblastom / Systembiologie / Genregulation / Myc}, } @book{UBHD-68594474, author={Pfister, Stefan and Milde, Till}, organization={Zentrum f{\"u}r Kinder- und Jugendmedizin / Klinik f{\"u}r Kinderheilkunde III: Onkologie, H{\"a}matologie, Immunologie und Pneumologie}, title={Schlussbericht zum CancerSys-Verbundprojekt „MYC-NET - Aufkl{\"a}rung der Mechanismen MYC-getriebener Therapieresistenz neuroectodermaler Tumore“}, subtitle={Laufzeit des Vorhabens: 01.03.2012-28.02.2015}, publisher={Universit{\"a}tsklinikum Heidelberg, Abteilung P{\"a}diatrische H{\"a}matologie und Onkologie}, address={Heidelberg}, year={2015}, pages={1 Online-Ressource (14 Seiten, 657,76 KB)}, language={ger}, note={F{\"o}rderkennzeichen BMBF 0316076B. - Verbund-Nummer 01109385 ; Titel auf dem Berichtsblatt: CancerSys-Verbundprojekt: MYC-NET - Aufkl{\"a}rung der Mechanismen MYC-getriebener Therapieresistenz neuroectodermaler Tumore, Teilprojekt Pr{\"a}klinische Validierung (TP4) ; "Autor(en): Pfister, Stefan; Milde, Till" - Berichtsblatt ; "Durchf{\"u}hrende Institution(en): Universit{\"a}tsklinik Heidelberg, ZKJM, Abteilung f{\"u}r H{\"a}matologie, Onkologie, Immunologie und Pneumologie, INF 430, 69120 Heidelberg" - Berichtsblatt ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource k{\"o}nnen nicht ausgeschlossen werden}, doi={10.2314/GBV:872584631}, keywords={Neuroblastom / Systembiologie / Genregulation / Myc}, } @book{UBHD-69316526, author={Jungkunz, Martin and Cornelius, Kai and Schickhardt, Christoph and Dikow, Nicola and Winkler, Eva C. and Brors, Benedikt and Fr{\"o}hling, Stefan and Greulich-Bode, Karin Maria and Idler, Irina and Lichter, Peter and Milde, Till and Pfister, Stefan and Schaaf, Christian P. and Wiemann, Stefan}, organization={Projektgruppe EURAT}, title={Stellungnahme zur R{\"u}ckmeldung genetischer Zusatzbefunde Minderj{\"a}hriger}, subtitle={Heidelberg, Oktober 2023}, publisher={Sektion f{\"u}r Translationale Medizinethik}, address={Heidelberg}, year={2023}, pages={130 Seiten}, language={ger}, } @article{UBHD-68426784, author={Ramaswamy, Vijay and Milde, Till and Pfister, Stefan}, title={Risk stratification of childhood medulloblastoma in the molecular era}, subtitle={the current consensus}, year={2016}, pages={821-831}, language={eng}, issn={1432-0533}, volume={131}, number={6}, note={Gesehen am 04.09.2019}, journal={Acta neuropathologica}, doi={10.1007/s00401-016-1569-6}, } @article{UBHD-68241403, author={Ratnaparkhe, Manasi and Jauch, Anna and Korshunov, Andrey and Milde, Till and Kunz, Joachim and Kulozik, Andreas and Jones, Barbara Christine and Pfister, Stefan}, title={Genomic profiling of acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis}, year={2017}, pages={2048-2056}, language={eng}, issn={1476-5551}, volume={31}, number={10}, note={Gesehen am 10.04.2018 ; Im Titel ist "ATM" kursiv geschrieben}, journal={Leukemia}, doi={10.1038/leu.2017.55}, } @article{UBHD-68638234, author={Rettig, Inga Edeltraud and Koeneke, Emily and Trippel, Franziska and Mueller, Wolf C. and Burhenne, J{\"u}rgen and Kopp-Schneider, Annette and Fabian, Johannes and Schober, Andreas and Fernekorn, Uta and Deimling, Andreas von and Deubzer, Hedwig and Milde, Till and Witt, Olaf and Oehme, Ina}, title={Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation}, year={2015}, pages={14 S.}, language={eng}, issn={2041-4889}, volume={Bd. 6}, journal={Cell death & disease}, doi={10.1038/cddis.2015.24}, } @article{UBHD-68873371, author={Rusert, Jessica M. and Juarez, Edwin F. and Brabetz, Sebastian and Jensen, James and Garancher, Alexandra and Chau, Lianne Q. and Tacheva-Grigorova, Silvia K. and Wahab, Sameerah and Udaka, Yoko T. and Finlay, Darren and Şeker-Cin, Huriye and Reardon, Brendan and Gr{\"o}bner, Susanne and Serrano, Jonathan and Ecker, Jonas and Qi, Lin and Kogiso, Mari and Du, Yuchen and Baxter, Patricia A. and Henderson, Jacob J. and Berens, Michael E. and Vuori, Kristiina and Milde, Till and Cho, Yoon-Jae and Li, Xiao-Nan and Olson, James M. and Reyes, Iris and Snuderl, Matija and Wong, Terence C. and Dimmock, David P. and Nahas, Shareef A. and Malicki, Denise and Crawford, John R. and Levy, Michael L. and Allen, Eliezer M. Van and Pfister, Stefan and Tamayo, Pablo and Kool, Marcel and Mesirov, Jill P. and Wechsler-Reya, Robert J.}, title={Functional precision medicine identifies new therapeutic candidates for medulloblastoma}, year={2020}, pages={5393-5407}, language={eng}, issn={1538-7445}, volume={80}, number={23}, note={Gesehen am 02.02.2022}, journal={Cancer research}, doi={10.1158/0008-5472.CAN-20-1655}, } @article{UBHD-68431902, author={Saffari, Afshin and Br{\"o}sse, Ines and Tilburg, Cornelis M. van and Hoffmann, Georg F. and K{\"o}lker, Stefan and Witt, Olaf and Milde, Till and Ziegler, Andreas and Syrbe, Steffen}, title={Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age - a multicenter retrospective study}, year={2019}, pages={1-13}, language={eng}, issn={1750-1172}, volume={14}, number={Artikel-ID 96}, note={Gesehen am 20.09.2019}, journal={Orphanet journal of rare diseases}, doi={10.1186/s13023-019-1077-6}, url={https://doi.org/10.1186/s13023-019-1077-6}, library={UB}, } @book{UBHD-68412598, author={Saffari, Afshin and Br{\"o}sse, Ines and Tilburg, Cornelis M. van and Hoffmann, Georg F. and K{\"o}lker, Stefan and Witt, Olaf and Milde, Till and Ziegler, Andreas and Syrbe, Steffen}, title={Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age}, subtitle={a multicenter retrospective study}, publisher={BioMed Central}, address={London}, year={2019}, pages={1 Online-Ressource}, language={eng}, note={In: Orphanet journal of rare diseases, 14 (2019), Nr. 96. pp. 1-13. ISSN 1750-1172}, url={https://nbn-resolving.org/urn:nbn:de:bsz:16-heidok-264004}, library={UB}, } @article{UBHD-68426790, author={Sahm, Felix and Schrimpf, Daniel and Reinhardt, Annekathrin and Reuss, David and Capper, David and K{\"o}lsche, Christian and Korshunov, Andrey and Wiestler, Benedikt and Milde, Till and Selt, Florian and Sturm, Dominik and Wick, Antje and Witt, Olaf and Platten, Michael and Herold-Mende, Christel and Unterberg, Andreas and Pfister, Stefan and Wick, Wolfgang and Deimling, Andreas von}, editor={Jungk, Christine}, title={Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets}, year={2016}, pages={903-910}, language={eng}, issn={1432-0533}, volume={131}, number={6}, note={Published online: 15 December 2015 ; Gesehen am 04.09.2019}, journal={Acta neuropathologica}, doi={10.1007/s00401-015-1519-8}, } @article{UBHD-69243309, author={Sandmann, Christoph and Syrbe, Steffen and Hebe, Joachim and Kreft, Jannis and Stark, Sebastian and Milde, Till and V{\"o}lkers, Mirko and Hoffmann, Georg F. and Gorenflo, Matthias and Kovacevic, Alexander}, title={Long-term use of everolimus for refractory arrhythmia in a child with tuberous sclerosis complex}, year={2024}, pages={1-6}, language={eng}, issn={1552-4833}, volume={194}, note={Online ver{\"o}ffentlicht: 21. Dezember 2023 ; Gesehen am 14.08.2024}, journal={American journal of medical genetics}, doi={10.1002/ajmg.a.63508}, keywords={Tuber{\"o}se Hirnsklerose}, } @article{UBHD-68253603, author={Schmidt, Christin and Selt, Florian and Herold-Mende, Christel and Witt, Olaf and Milde, Till and Pfister, Stefan and Korshunov, Andrey and Kool, Marcel}, title={Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients}, year={2017}, pages={1607-1617}, language={eng}, issn={1523-5866}, volume={19}, number={12}, note={Gesehen am 22.05.2018}, journal={Neuro-Oncology}, doi={10.1093/neuonc/nox093}, } @article{UBHD-69098316, author={Schmidt, Stephanie and Kovacs, Edina and Usta, Diren and Behnisch, Rouven and Sahm, Felix and Haux-Nettesheim, Daniel and Witt, Olaf and Milde, Till and Unterberg, Andreas and El Damaty, Ahmed}, title={Cerebellar mutism syndrome ater posterior fossa tumor surgery in children}, subtitle={a retrospective single-center study}, year={2023}, pages={e622-e628}, language={eng}, issn={1878-8769}, volume={173(2023) vom: Mai}, note={Online ver{\"o}ffentlicht: 4. M{\"a}rz 2023 ; Gesehen am 17.07.2023}, journal={World neurosurgery}, doi={10.1016/j.wneu.2023.02.117}, } @article{UBHD-69331755, author={Schwalbe, Edward C. and Lindsey, Janet C. and Danilenko, Marina and Hill, Rebecca M. and Crosier, Stephen and Ryan, Sarra and Williamson, Daniel and Castle, Jemma and Hicks, Debbie and Kool, Marcel and Milde, Till and Korshunov, Andrey and Pfister, Stefan and Bailey, Simon and Clifford, Steven C.}, title={Molecular and clinical heterogeneity within MYC-family amplified medulloblastoma is associated with survival outcomes}, subtitle={a multicenter cohort study}, year={2025}, pages={222-236}, language={eng}, issn={1523-5866}, volume={27}, number={1}, note={Online verf{\"u}gbar: 08. Oktober 2024 ; Gesehen am 16.04.2025}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noae178}, } @article{UBHD-68251886, author={Schwartzentruber, Jeremy and Korshunov, Andrey and Jones, David T. W. and Sturm, Dominik and T{\"o}njes, Martje and Hovestadt, Volker and Kool, Marcel and Korbel, Jan Oliver and Kulozik, Andreas and Zapatka, Marc and Deimling, Andreas von and Witt, Hendrik and Milde, Till and Witt, Olaf and Lichter, Peter and Plass, Christoph and Pfister, Stefan}, title={Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma}, year={2012}, pages={226-231}, language={eng}, issn={1476-4687}, volume={482}, number={7384}, note={Gesehen am 14.05.2018}, journal={Nature}, doi={10.1038/nature10833}, } @article{UBHD-69293300, author={Seiboldt, Till and Zeiser, Constantia and Nguyen, Duy and Çeliky{\"u}rekli, Simay and Herter, Sonja and Najafi, Sara and Stroh-Dege, Alexandra and Meulenbroeks, Chris and Mack, Norman and Salem-Altintas, Rabia and Westermann, Frank and Schlesner, Matthias and Milde, Till and Kool, Marcel and Holland-Letz, Tim and Vogler, Meike and Peterziel, Heike and Witt, Olaf and Oehme, Ina}, title={Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours}, year={2024}, pages={763-777}, language={eng}, issn={1532-1827}, volume={131}, number={4}, note={Gesehen am 22.01.2025}, journal={British journal of cancer}, doi={10.1038/s41416-024-02740-5}, } @article{UBHD-68280852, author={Selt, Florian and Buhl, Juliane and Sahm, Felix and Capper, David and Korshunov, Andrey and Usta, Diren and Brabetz, Sebastian and Ridinger, Johannes and Ecker, Jonas and Oehme, Ina and B{\"a}chli, Heidi and Deimling, Andreas von and Pfister, Stefan and Jones, David T. W. and Witt, Olaf and Milde, Till}, title={Establishment and application of a novel patient-derived KIAA1549}, subtitle={BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing}, year={2017}, pages={11460-11479}, language={eng}, issn={1949-2553}, volume={8}, number={7}, note={Published online: December 17, 2016 ; Gesehen am 04.07.2018}, journal={OncoTarget}, doi={10.18632/oncotarget.14004}, } @article{UBHD-69163993, author={Selt, Florian and El Damaty, Ahmed and Schuhmann, Martin U. and Sigaud, Romain and Ecker, Jonas and Sievers, Philipp and Kocher, Daniela and Herold-Mende, Christel and Oehme, Ina and Deimling, Andreas von and Pfister, Stefan and Sahm, Felix and Jones, David T. W. and Witt, Olaf and Milde, Till}, title={Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T}, subtitle={evaluation of a modeling workflow}, year={2023}, pages={467-478}, language={eng}, issn={1573-7373}, volume={165}, number={3 vom: Nov.}, note={Gesehen am 22.01.2024}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-023-04500-6}, } @article{UBHD-68213910, author={Selt, Florian and Korshunov, Andrey and Capper, David and Witt, Hendrik and Tilburg, Cornelis M. van and Witt, Ruth and Sahm, Felix and Reuss, David and K{\"o}lsche, Christian and Deimling, Andreas von and Kulozik, Andreas and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Pediatric targeted therapy}, subtitle={clinical feasibility of personalized diagnostics in children with relapsed and progressive tumors}, year={2016}, pages={506-516}, language={eng}, issn={1750-3639}, volume={26}, number={4}, note={Gesehen am 26.01.2018}, journal={Brain pathology}, doi={10.1111/bpa.12326}, } @article{UBHD-69307525, author={Selt, Florian and Tilburg, Cornelis M. van and Bison, Brigitte and Sievers, Philipp and Harting, Inga and Ecker, Jonas and Pajtler, Kristian W. and Sahm, Felix and Bahr, Annabelle and Simon, Michèle and Jones, David T. W. and Well, Lennart and Mautner, Victor-Felix and Capper, David and Hernáiz Driever, Pablo and Gnekow, Astrid and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Response to trametinib treatment in progressive pediatric low-grade glioma patients}, year={2020}, pages={499-510}, language={eng}, issn={1573-7373}, volume={149(2020) vom: Sept.}, note={Gesehen am 24.02.2025}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-020-03640-3}, } @article{UBHD-69106612, author={Sievers, Philipp and Stichel, Damian and Sill, Martin and Schrimpf, Daniel and Sturm, Dominik and Selt, Florian and Ecker, Jonas and Kazdal, Daniel and Miele, Evelina and Kranendonk, Mariëtte E. G. and Tops, Bastiaan B. J. and Kohlhof-Meinecke, Patricia and Beschorner, Rudi and Kramm, Christof M. and Hasselblatt, Martin and Reifenberger, Guido and Capper, David and Wesseling, Pieter and Stenzinger, Albrecht and Milde, Till and Korshunov, Andrey and Witt, Olaf and Pfister, Stefan and Wick, Wolfgang and Deimling, Andreas von and Jones, David T. W. and Sahm, Felix}, title={GOPC}, subtitle={ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types}, year={2021}, pages={1065-1069}, language={eng}, issn={1432-0533}, volume={142}, number={6}, note={Gesehen am 04.08.2023}, journal={Acta neuropathologica}, doi={10.1007/s00401-021-02369-1}, url={https://doi.org/10.1007/s00401-021-02369-1}, library={UB}, } @article{UBHD-69154744, author={Sigaud, Romain and Albert, Thomas K. and Hess, Caroline and Hielscher, Thomas and Winkler, Nadine and Kocher, Daniela and Walter, Carolin and M{\"u}nter, Daniel and Selt, Florian and Usta, Diren and Ecker, Jonas and Brentrup, Angela and Hasselblatt, Martin and Thomas, Christian and Varghese, Julian and Capper, David and Thomale, Ulrich W. and Hernáiz Driever, Pablo and Simon, Michèle and Horn, Svea and Herz, Nina Annika and Koch, Arend and Sahm, Felix and Hamelmann, Stefan and Faria-Andrade, Augusto and Jabado, Nada and Schuhmann, Martin U. and Schouten-van Meeteren, Antoinette Y. N. and Hoving, Eelco and Brummer, Tilman and Tilburg, Cornelis M. van and Pfister, Stefan and Witt, Olaf and Jones, David T. W. and Kerl, Kornelius and Milde, Till}, title={MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas}, year={2023}, pages={1-21}, language={eng}, issn={2041-1723}, volume={14}, number={Artikel-ID 4533}, note={Gesehen am 19.12.2023}, journal={Nature Communications}, doi={10.1038/s41467-023-40235-8}, } @article{UBHD-69355058, author={Sigaud, Romain and Brummer, Tilman and Kocher, Daniela and Milde, Till and Selt, Florian}, title={MOST wanted}, subtitle={navigating the MAPK-OIS-SASP-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models}, year={2024}, pages={3209-3221}, language={eng}, issn={1433-0350}, volume={40}, number={10 vom: Okt.}, note={Online verf{\"u}gbar: 25 May 2024 ; Gesehen am 10.06.2025}, journal={Child's nervous system}, doi={10.1007/s00381-024-06463-z}, } @article{UBHD-68460169, author={Stichel, Damian and Schrimpf, Daniel and Casalini, Belén and Wefers, Annika K. and Sievers, Philipp and K{\"o}lsche, Christian and Reuss, David and Reinhardt, Annekathrin and Fernández Klett, Francisco and Keßler, Tobias and Sturm, Dominik and Ecker, Jonas and Milde, Till and Herold-Mende, Christel and Witt, Olaf and Pfister, Stefan and Wick, Wolfgang and Jones, David T. W. and Deimling, Andreas von and Sahm, Felix}, title={Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions}, year={2019}, pages={827-835}, language={eng}, issn={1432-0533}, volume={138}, number={5}, note={Gesehen am 26.11.2019}, journal={Acta neuropathologica}, doi={10.1007/s00401-019-02039-3}, } @article{UBHD-67494942, author={Sturm, Dominik and Witt, Hendrik and Jones, David T. W. and Konermann, Carolin and Pfaff, Elke and Bender, Sebastian and Kool, Marcel and Becker, Natalia and Hielscher, Thomas and Radlwimmer, Bernhard and Komorowski, Gregor von and D{\"u}rken, Matthias and Kulozik, Andreas and Deimling, Andreas von and Herold-Mende, Christel and Unterberg, Andreas and Wiestler, Benedikt and Wick, Wolfgang and Milde, Till and Witt, Olaf and Korshunov, Andrey and Lichter, Peter and Pfister, Stefan}, title={Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma}, year={2012}, pages={425-437}, language={eng}, issn={1878-3686}, volume={22}, number={4}, note={Gesehen am 31.10.2018}, journal={Cancer cell}, doi={10.1016/j.ccr.2012.08.024}, } @article{UBHD-68443888, author={Sturm, Dominik and Orr, Brent A. and Toprak, Umut and Hovestadt, Volker and Jones, David T. W. and Capper, David and Sill, Martin and Buchhalter, Ivo and Northcott, Paul A. and Leis, Irina and Ryzhova, Marina and K{\"o}lsche, Christian and Pfaff, Elke and Allen, Sariah J. and Balasubramanian, Gnana Prakash and Jones, Barbara Christine and Pajtler, Kristian Wilfried and Brabetz, Sebastian and Johann, Pascal-David and Sahm, Felix and Reimand, J{\"u}ri and Mackay, Alan and Carvalho, Diana M. and Remke, Marc and Phillips, Joanna J. and Perry, Arie and Cowdrey, Cynthia and Drissi, Rachid and Fouladi, Maryam and Giangaspero, Felice and Łastowska, Maria and Grajkowska, Wiesława and Scheurlen, Wolfram and Pietsch, Torsten and Hagel, Christian and Gojo, Johannes and L{\"o}tsch, Daniela and Berger, Walter and Slavc, Irene and Haberler, Christine and Jouvet, Anne and Holm, Stefan and Hofer, Silvia and Prinz, Marco and Keohane, Catherine and Fried, Iris and Mawrin, Christian and Scheie, David and Mobley, Bret C. and Schniederjan, Matthew J. and Santi, Mariarita and Buccoliero, Anna M. and Dahiya, Sonika and Kramm, Christof M. and Bueren, André von and Hoff, Katja von and Rutkowski, Stefan and Herold-Mende, Christel and Fr{\"u}hwald, Michael and Milde, Till and Hasselblatt, Martin and Wesseling, Pieter and R{\"o}ßler, Jochen and Sch{\"u}ller, Ulrich and Ebinger, Martin and Schittenhelm, Jens Florian and Frank, Stephan and Grobholz, Rainer and Vajtai, Istvan and Schneppenheim, Reinhard and Zitterbart, Karel and Collins, V. Peter and Aronica, Eleonora and Varlet, Pascale and Puget, Stephanie and Dufour, Christelle and Grill, Jacques and Figarella-Branger, Dominique and Wolter, Marietta and Schuhmann, Martin Ulrich and Shalaby, Tarek and Grotzer, Michael and Meter, Timothy van and Felsberg, J{\"o}rg and Reifenberger, Guido and Snuderl, Matija and Forrester, Lynn Ann and Koster, Jan and Versteeg, Rogier and Volckmann, Richard and Sluis, Peter van and Wolf, Stephan and Mikkelsen, Tom and Gajjar, Amar and Aldape, Kenneth and Moore, Andrew S. and Taylor, Michael D. and Jones, Chris and Jabado, Nada and Karajannis, Matthias A. and Eils, Roland and Schlesner, Matthias and Lichter, Peter and Deimling, Andreas von and Pfister, Stefan and Ellison, David W. and Korshunov, Andrey and Kool, Marcel}, title={New brain tumor entities emerge from molecular classification of CNS-PNETs}, year={2016}, pages={1060-1072}, language={eng}, issn={1097-4172}, volume={164}, number={5}, note={Gesehen am 23.10.2019}, journal={Cell}, doi={10.1016/j.cell.2016.01.015}, } @article{UBHD-68747001, author={Tilburg, Cornelis M. van and Witt, Ruth and Heiss, Melanie and Pajtler, Kristian Wilfried and Plass, Christoph and Poschke, Isabel and Platten, Michael and Harting, Inga and Sedlaczek, Oliver and Freitag, Angelika and Meyrath, David and Taylor, Lenka A. and Balasubramanian, Gnana Prakash and J{\"a}ger, Natalie and Pfaff, Elke and Jones, Barbara Christine and Milde, Till and Pfister, Stefan and Jones, David T. W. and Kopp-Schneider, Annette and Witt, Olaf}, title={INFORM2 NivEnt}, subtitle={the first trial of the INFORM2 biomarker driven phase I/II trial series : the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies}, year={2020}, pages={1-12}, language={eng}, issn={1471-2407}, volume={20(2020) vom: Juni}, number={Artikel-ID 523}, note={Gesehen am 10.06.2021}, journal={BMC cancer}, doi={10.1186/s12885-020-07008-8}, } @article{UBHD-69228579, author={Tilburg, Cornelis M. van and Kilburn, Lindsay B. and Perreault, Sébastien and Schmidt, Rene and Azizi, Amedeo A. and Cruz-Martínez, Ofelia and Zápotocký, Michal and Scheinemann, Katrin and Meeteren, Antoinette Y. N. Schouten-van and Sehested, Astrid and Opocher, Enrico and Driever, Pablo Hernáiz and Avula, Shivaram and Ziegler, David S. and Capper, David and Koch, Arend and Sahm, Felix and Qiu, Jiaheng and Tsao, Li-Pen and Blackman, Samuel C. and Manley, Peter and Milde, Till and Witt, Ruth and Jones, David T. W. and Hargrave, Darren and Witt, Olaf}, title={LOGGIC/FIREFLY-2}, subtitle={a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration}, year={2024}, pages={1-11}, language={eng}, issn={1471-2407}, volume={24}, number={Artikel-ID 147}, note={Gesehen am 01.07.2024}, journal={BMC cancer}, doi={10.1186/s12885-024-11820-x}, } @article{UBHD-68768470, author={Tilburg, Cornelis M. van and Pfaff, Elke and Pajtler, Kristian Wilfried and Langenberg, Karin and Fiesel, Petra and Jones, Barbara Christine and Balasubramanian, Gnana Prakash and Stark, Sebastian and Johann, Pascal-David and Blattner-Johnson, Mirjam and Schramm, Kathrin and Dikow, Nicola and Hirsch, Steffen and Sutter, Christian and Grund, Kerstin and Stackelberg, Arend von and Kulozik, Andreas and Lissat, Andrej and Borkhardt, Arndt and Meisel, Roland and Reinhardt, Dirk and Klusmann, Jan-Henning and Fleischhack, Gudrun and Tippelt, Stephan and Schweinitz, Dietrich von and Schmid, Irene and Kramm, Christof M. and Bueren, André von and Calaminus, Gabriele and Vorwerk, Peter and Graf, Norbert and Westermann, Frank and Fischer, Matthias and Eggert, Angelika and Burkhardt, Birgit and W{\"o}ßmann, Wilhelm and Nathrath, Michaela and Hecker-Nolting, Stefanie and Fr{\"u}hwald, Michael and Schneider, Dominik T. and Brecht, Ines B. and Ketteler, Petra and Fulda, Simone and Koscielniak, Ewa and Meister, Michael and Scheer, Monika and Hettmer, Simone and Schwab, Matthias and Tremmel, Roman and Øra, Ingrid and Hutter, Caroline and Gerber, Nicolas U. and Lohi, Olli and Kazanowska, Bernarda and Kattamis, Antonis and Filippidou, Maria and Goemans, Bianca and Zwaan, C. Michel and Milde, Till and J{\"a}ger, Natalie and Wolf, Stephan and Reuss, David and Sahm, Felix and Deimling, Andreas von and Dirksen, Uta and Freitag, Angelika and Witt, Ruth and Lichter, Peter and Kopp-Schneider, Annette and Jones, David T. W. and Molenaar, Jan J. and Capper, David and Pfister, Stefan and Witt, Olaf}, title={The pediatric precision oncology INFORM registry}, subtitle={clinical outcome and benefit for patients with very high-evidence targets}, year={2021}, pages={2764-2779}, language={eng}, issn={2159-8290}, volume={11}, number={11}, note={Gesehen am 30.07.2021}, journal={Cancer discovery}, doi={10.1158/2159-8290.CD-21-0094}, } @article{UBHD-68579599, author={Tilburg, Cornelis M. van and Milde, Till and Witt, Ruth and Ecker, Jonas and Hielscher, Thomas and Seitz, Angelika and Schenk, Jens-Peter and Buhl, Juliane and Riehl, Dennis and Fr{\"u}hwald, Michael and Pekrun, Arnulf and R{\"o}ssig, Claudia and Wieland, Regina Paula Franziska and Flotho, Christian and Kordes, Uwe and Gruhn, Bernd and Simon, Thorsten and Linderkamp, Christin and Sahm, Felix and Taylor, Lenka A. and Freitag, Angelika and Burhenne, J{\"u}rgen and Foerster, Kathrin and Meid, Andreas and Pfister, Stefan and Karapanagiotou-Schenkel, Irini and Witt, Olaf}, title={Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia}, year={2019}, pages={15 S.}, language={eng}, issn={1868-7083}, volume={11(2019) Artikel-Nummer 188}, number={15 Seiten}, note={Gesehen am 20.05.2020}, journal={Clinical epigenetics}, doi={10.1186/s13148-019-0775-1}, } @article{UBHD-68309694, author={Tilburg, Cornelis M. van and Selt, Florian and Sahm, Felix and B{\"a}chli, Heidi and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Response in a child with a BRAF V600E mutated desmoplastic infantile astrocytoma upon retreatment with vemurafenib}, year={2018}, pages={1-4}, language={eng}, issn={1545-5017}, volume={65}, note={First published: 12 December 2017 ; Gesehen am 27.09.2018}, journal={Pediatric blood & cancer}, doi={10.1002/pbc.26893}, } @article{UBHD-68202371, author={Tzaridis, Theophilos-Dimitrios and Milde, Till and Pajtler, Kristian Wilfried and Kulozik, Andreas and Witt, Olaf and Korshunov, Andrey and Pfister, Stefan and Witt, Hendrik}, title={Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA -positive ependymoma}, year={2016}, pages={61860-61873}, language={eng}, issn={1949-2553}, volume={7}, number={38}, note={Gesehen am 15.12.2017}, journal={OncoTarget}, doi={10.18632/oncotarget.11452}, } @article{UBHD-68647390, author={Usta, Diren and Sigaud, Romain and Buhl, Juliane and Selt, Florian and Marquardt, Viktoria and Pauck, David and Jansen, Jennifer and Pusch, Stefan and Ecker, Jonas and Hielscher, Thomas and Vollmer, Johanna and Sommerkamp, Alexander C. and Rubner, Tobias and Hargrave, Darren and Tilburg, Cornelis M. van and Pfister, Stefan and Jones, David T. W. and Remke, Marc and Brummer, Tilman and Witt, Olaf and Milde, Till}, title={A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells}, year={2020}, pages={1737-1750}, language={eng}, issn={1538-8514}, volume={19}, number={8}, note={Gesehen am 12.10.2020}, journal={Molecular cancer therapeutics}, doi={10.1158/1535-7163.MCT-19-1021}, } @article{UBHD-69157322, author={Vollmer, Johanna and Ecker, Jonas and Hielscher, Thomas and Valinciute, Gintvile and Ridinger, Johannes and Jamaladdin, Nora and Peterziel, Heike and Tilburg, Cornelis M. van and Oehme, Ina and Witt, Olaf and Milde, Till}, title={Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells}, year={2023}, pages={617-632}, language={eng}, issn={1573-7373}, volume={164}, number={3}, note={Online ver{\"o}ffentlicht: 3. Oktober 2023 ; Gesehen am 04.01.2024}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-023-04445-w}, } @article{UBHD-68588486, author={Waszak, Sebastian Martin and Buchhalter, Ivo and Kerssemakers, Jules and J{\"a}ger, Natalie and Sharma, Tanvi and Rausch, Tobias and Kool, Marcel and Sturm, Dominik and Jones, David T. W. and Milde, Till and Witt, Olaf and Korshunov, Andrey and Lichter, Peter and Korbel, Jan Oliver and Pfister, Stefan}, title={Germline elongator mutations in Sonic Hedgehog medulloblastoma}, year={2020}, pages={396-401}, language={eng}, issn={1476-4687}, volume={580}, number={7803}, note={Gesehen am 18.06.2020}, journal={Nature}, doi={10.1038/s41586-020-2164-5}, } @article{UBHD-68264794, author={Waszak, Sebastian Martin and Northcott, Paul A. and Buchhalter, Ivo and Sutter, Christian and Grund, Kerstin and Jones, David T. W. and Pajtler, Kristian Wilfried and Kool, Marcel and Sturm, Dominik and Milde, Till and Eils, Roland and Bartram, Claus R. and Lichter, Peter and Pfister, Stefan}, title={Spectrum and prevalence of genetic predisposition in medulloblastoma}, subtitle={a retrospective genetic study and prospective validation in a clinical trial cohort}, year={2018}, pages={785-798}, language={eng}, issn={1474-5488}, volume={19}, number={6}, note={Published online: May 9, 2018 ; Gesehen am 25.06.2018}, journal={The lancet}, doi={10.1016/S1470-2045(18)30242-0}, } @article{UBHD-68985044, author={Witt, Hendrik and Mack, Stephen C. and Ryzhova, Marina and Bender, Sebastian and Sill, Martin and Isserlin, Ruth and Benner, Axel and Hielscher, Thomas and Milde, Till and Remke, Marc and Jones, David T. W. and Northcott, Paul A. and Garzia, Livia and Bertrand, Kelsey C. and Wittmann, Andrea and Yao, Yuan and Roberts, Stephen S. and Massimi, Luca and Van Meter, Tim and Weiss, William A. and Gupta, Nalin and Grajkowska, Wiesia and Lach, Boleslaw and Cho, Yoon-Jae and Deimling, Andreas von and Kulozik, Andreas and Witt, Olaf and Bader, Gary D. and Hawkins, Cynthia E. and Tabori, Uri and Guha, Abhijit and Rutka, James T. and Lichter, Peter and Korshunov, Andrey and Taylor, Michael D. and Pfister, Stefan}, title={Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma}, year={2011}, pages={143-157}, language={eng}, issn={1878-3686}, volume={20}, number={2}, note={Gesehen am 14.11.2022}, journal={Cancer cell}, doi={10.1016/j.ccr.2011.07.007}, } @article{UBHD-68299279, author={Witt, Hendrik and Korshunov, Andrey and Pfister, Stefan and Milde, Till}, title={Molecular approaches to ependymoma}, subtitle={the next step(s)}, year={2012}, pages={745-750}, language={eng}, issn={1473-6551}, volume={25}, number={6}, note={Gesehen am 27.08.2018}, journal={Current opinion in neurology}, doi={10.1097/WCO.0b013e328359cdf5}, } @article{UBHD-68299286, author={Witt, Olaf and Milde, Till and Deubzer, Hedwig and Oehme, Ina and Kulozik, Andreas and Eisenmenger, Andreas and Abel, Ulrich and Karapanagiotou-Schenkel, Irini}, title={Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma or leukemia}, year={2012}, pages={398-403}, language={eng}, issn={1439-3824}, volume={224}, number={06}, note={Gesehen am 27.08.2018}, journal={Klinische P{\"a}diatrie}, doi={10.1055/s-0032-1323692}, } @article{UBHD-68687989, author={Wrobel, Jagoda and Najafi, Sara and Ayhan, Simay and Gatzweiler, Charlotte and Krunic, Damir and Ridinger, Johannes and Milde, Till and Westermann, Frank and Peterziel, Heike and Meder, Benjamin and Distel, Martin and Witt, Olaf and Oehme, Ina}, title={Rapid in vivo validation of HDAC inhibitor-based treatments in neuroblastoma zebrafish xenografts}, year={2020}, language={eng}, issn={1424-8247}, volume={13(2020}, note={Gesehen am 03.02.2021}, journal={Pharmaceuticals}, doi={10.3390/ph13110345}, } @article{UBHD-69195421, author={Zeuner, Simon and Vollmer, Johanna and Sigaud, Romain and Oppermann, Sina and Peterziel, Heike and ElHarouni, Dina and Oehme, Ina and Witt, Olaf and Milde, Till and Ecker, Jonas}, title={Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells}, year={2024}, pages={99-112}, language={eng}, issn={1573-7373}, volume={166}, note={Gesehen am 26.03.2024}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-023-04526-w}, } @article{UBHD-68795034, author={Zheng, Tuyu and Ghasemi, David R. and Okonechnikov, Konstantin and Korshunov, Andrey and Sill, Martin and Maass, Kendra K. and Silva, Patricia Benites Goncalves da and Ryzhova, Marina and Gojo, Johannes and Stichel, Damian and Arabzade, Amir and Kupp, Robert and Benzel, Julia and Taya, Shinichiro and Adachi, Toma and Shiraishi, Ryo and Gerber, Nicolas U. and Sturm, Dominik and Ecker, Jonas and Sievers, Philipp and Selt, Florian and Chapman, Rebecca and Haberler, Christine and Figarella-Branger, Dominique and Reifenberger, Guido and Fleischhack, Gudrun and Rutkowski, Stefan and Donson, Andrew M. and Ramaswamy, Vijay and Capper, David and Ellison, David W. and Herold-Mende, Christel and Sch{\"u}ller, Ulrich and Brandner, Sebastian and Driever, Pablo Hernáiz and Kros, Johan M. and Snuderl, Matija and Milde, Till and Grundy, Richard G. and Hoshino, Mikio and Mack, Stephen C. and Gilbertson, Richard J. and Jones, David T. W. and Kool, Marcel and Deimling, Andreas von and Pfister, Stefan and Sahm, Felix and Kawauchi, Daisuke and Pajtler, Kristian Wilfried}, title={Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas}, year={2021}, pages={2230-2247}, language={eng}, issn={2159-8290}, volume={11}, number={9}, note={Gesehen am 29.10.2021}, journal={Cancer discovery}, doi={10.1158/2159-8290.CD-20-0963}, }