@article{UBHD-68942692, author={Cornean, Alex and Gierten, Jakob and Welz, Bettina and Mateo, Juan L. and Thumberger, Thomas and Wittbrodt, Joachim}, title={Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction}, year={2022}, pages={1-34}, language={eng}, issn={2050-084X}, volume={11}, number={Artikel-ID e72124}, note={Gesehen am 15.07.2022}, journal={eLife}, doi={10.7554/eLife.72124}, } @incollection{UBHD-69185996, author={Cornean, Alex and Gierten, Jakob and Welz, Bettina and Mateo, Juan L. and Thumberger, Thomas and Wittbrodt, Joachim}, title={Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction}, year={2021}, pages={1-63}, language={eng}, note={Gesehen am 27.02.2024}, booktitle={bioRxiv beta}, doi={10.1101/2021.07.26.453883}, } @article{UBHD-69145687, author={Doering, Lino and Cornean, Alex and Thumberger, Thomas and Benjaminsen, Jørgen and Wittbrodt, Beate and Kellner, Tanja and Hammouda, Omar T. and Gorenflo, Matthias and Wittbrodt, Joachim and Gierten, Jakob}, title={CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease}, year={2023}, pages={1-14}, language={eng}, issn={1754-8411}, volume={16}, note={Online ver{\"o}ffentlicht: 16. August 2023 ; Gesehen am 23.11.2023}, journal={Disease models & mechanisms}, doi={10.1242/dmm.049811}, } @incollection{UBHD-69185977, author={Fitzgerald, Tomas and Brettell, Ian and Leger, Adrien and Wolf, Nadeshda and Kusminski, Natalja and Monahan, Jack and Barton, Carl and Herder, Cathrin and Aadepu, Narendar and Gierten, Jakob and Becker, Clara and Hammouda, Omar and Hasel, Eva Mareike and Lischik, Colin Q. and Lust, Katharina and Suzuki, Risa and Tsingos, Erika and Tavhelidse-Suck, Tinatini and Thumberger, Thomas and Watson, Philip and Welz, Bettina and Khouja, Nadia and Naruse, Kiyoshi and Birney, Ewan and Wittbrodt, Joachim and Loosli, Felix}, title={The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel}, year={2021}, pages={1-34}, language={eng}, note={Gesehen am 27.02.2024}, booktitle={bioRxiv beta}, doi={10.1101/2021.05.17.444412}, } @article{UBHD-68906928, author={Fitzgerald, Tomas and Brettell, Ian and Leger, Adrien and Wolf, Nadeshda and Kusminski, Natalja and Monahan, Jack and Barton, Carl and Herder, Cathrin and Aadepu, Narendar and Gierten, Jakob and Becker, Clara and Hammouda, Omar and Hasel, Eva Mareike and Lischik, Colin Q. and Lust, Katharina and Sokolova, Natalia and Suzuki, Risa and Tsingos, Erika and Tavhelidse-Suck, Tinatini and Thumberger, Thomas and Watson, Philip and Welz, Bettina and Khouja, Nadia and Naruse, Kiyoshi and Birney, Ewan and Wittbrodt, Joachim and Loosli, Felix}, title={The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel}, year={2022}, pages={1-32}, language={eng}, issn={1474-760X}, volume={23}, number={Artikel-ID 59}, note={Gesehen am 12.04.2022}, journal={Genome biology}, doi={10.1186/s13059-022-02623-z}, } @article{UBHD-68641257, author={Gierten, Jakob and Pylatiuk, Christian and Hammouda, Omar and Schock, Christian and Stegmaier, Johannes and Wittbrodt, Joachim and Gehrig, Jochen and Loosli, Felix}, title={Automated high-throughput heartbeat quantification in medaka and zebrafish embryos under physiological conditions}, year={2020}, pages={12 S.}, language={eng}, issn={2045-2322}, volume={10(2020) Artikel-Nummer 2046}, number={12 Seiten}, note={Gesehen am 29.09.2020}, journal={Scientific reports}, doi={10.1038/s41598-020-58563-w}, } @book{UBHD-68457889, author={Gierten, Jakob and Pylatiuk, Christian and Hammouda, Omar and Schock, Christian and Stegmaier, Johannes and Wittbrodt, Joachim and Gehrig, Jochen and Loosli, Felix}, title={Automated high-throughput heart rate measurement in medaka and zebrafish embryos under physiological conditions}, address={Karlsruhe}, year={2019}, pages={1 Online-Ressource (39 Seiten)}, language={eng}, doi={10.1101/548594}, } @book{UBHD-68457963, author={Gierten, Jakob}, organization={Universit{\"a}t Heidelberg}, title={Genome-wide analysis of quantitative cardiac traits in medaka inbred strains}, address={Heidelberg}, year={2019}, pages={xiv, 147 Seiten}, language={eng}, school={Dissertation, Ruperto Carola University Heidelberg, 2019}, library={UB [Signatur: 2019 U 979]}, } @article{UBHD-69051051, author={Gierten, Jakob and Ficker, Eckhard and Bloehs, Ramona and Schweizer, Patrick Alexander and Zitron, Edgar and Scholz, Eberhard P. and Karle, Christoph and Katus, Hugo and Thomas, Dierk}, title={The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone}, year={2010}, pages={261-270}, language={eng}, issn={1432-1912}, volume={381}, number={3}, note={Published online: 24 September 2009 ; Im Titel ist 2P tiefgestellt ; Gesehen am 13.03.2023}, journal={Naunyn-Schmiedeberg's archives of pharmacology}, doi={10.1007/s00210-009-0454-4}, } @article{UBHD-68260783, author={Gierten, Jakob and Hassel, David and Schweizer, Patrick Alexander and Becker, R{\"u}diger and Katus, Hugo and Thomas, Dierk}, title={Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels}, year={2012}, pages={33-41}, language={eng}, issn={1872-8006}, volume={1818}, number={1}, note={Available online 21 September 2011 ; Im Titel ist "2P" tiefgestellt und "+" hochgestellt ; Gesehen am 13.06.2018}, journal={Biochimica et biophysica acta}, doi={10.1016/j.bbamem.2011.09.015}, } @incollection{UBHD-69182759, author={Gierten, Jakob and Welz, Bettina and Fitzgerald, Tomas and Thumberger, Thomas and Hummel, Oliver and Leger, Adrien and Weber, Philipp and Hassel, David and H{\"u}bner, Norbert and Birney, Ewan and Wittbrodt, Joachim}, title={Natural genetic variation quantitatively regulates heart rate and dimension}, year={2023}, pages={1-21}, language={eng}, note={Gesehen am 15.02.2024}, booktitle={bioRxiv beta}, doi={10.1101/2023.09.01.555906}, } @article{UBHD-69348433, author={Gierten, Jakob and Welz, Bettina and Fitzgerald, Tomas and Thumberger, Thomas and Agarwal, Rashi and Hummel, Oliver and Leger, Adrien and Weber, Philipp and Naruse, Kiyoshi and Hassel, David and H{\"u}bner, Norbert and Birney, Ewan and Wittbrodt, Joachim}, title={Natural genetic variation quantitatively regulates heart rate and dimension}, year={2025}, pages={1-12}, language={eng}, issn={2041-1723}, volume={16}, number={Artikel-ID 4062}, note={Gesehen am 27.05.2025}, journal={Nature Communications}, doi={10.1038/s41467-025-59425-7}, } @book{UBHD-68048074, author={Gierten, Jakob}, title={Regulationsmechanismen und physiologischer Stellenwert der kardialen Zwei-Porendom{\"a}nen-Kaliumkan{\"a}le K 2P 3.1 und K 2P 10.1}, address={Heidelberg}, year={2015}, pages={153 Bl{\"a}tter}, language={ger}, school={Dissertation, Ruprecht-Karls-Universit{\"a}t Heidelberg, 2016}, library={UB [Signatur: 2016 U 876]}, } @article{UBHD-68895368, author={Hammouda, Omar and Wu, Meng Yue and Kaul, Verena and Gierten, Jakob and Thumberger, Thomas and Wittbrodt, Joachim}, title={In vivo identification and validation of novel potential predictors for human cardiovascular diseases}, year={2021}, pages={1-20}, language={eng}, issn={1932-6203}, volume={16}, note={Gesehen am 16.03.2022}, journal={PLOS ONE}, doi={10.1371/journal.pone.0261572}, } @incollection{UBHD-69185991, author={Hammouda, Omar and Wu, Meng Yue and Kaul, Verena and Gierten, Jakob and Thumberger, Thomas and Wittbrodt, Joachim}, title={In vivo identification and validation of novel potential predictors for human cardiovascular diseases}, year={2021}, pages={1-42}, language={eng}, note={Gesehen am 27.02.2024}, booktitle={bioRxiv beta}, doi={10.1101/2021.02.03.429563}, } @article{UBHD-68914022, author={Leger, Adrien and Brettell, Ian and Monahan, Jack and Barton, Carl and Wolf, Nadeshda and Kusminski, Natalja and Herder, Cathrin and Aadepu, Narendar and Becker, Clara and Gierten, Jakob and Hammouda, Omar T. and Hasel, Eva and Lischik, Colin and Lust, Katharina and Sokolova, Natalia and Suzuki, Risa and Tavhelidse-Suck, Tinatini and Thumberger, Thomas and Tsingos, Erika and Watson, Philip and Welz, Bettina and Naruse, Kiyoshi and Loosli, Felix and Wittbrodt, Joachim and Birney, Ewan and Fitzgerald, Tomas}, title={Genomic variations and epigenomic landscape of the medaka inbred Kiyosu-Karlsruhe (MIKK) panel}, year={2022}, pages={1-24}, language={eng}, issn={1474-760X}, volume={23}, number={Artikel-ID 58}, note={Gesehen am 03.05.2022}, journal={Genome biology}, doi={10.1186/s13059-022-02602-4}, } @article{UBHD-69186008, author={Meyer, Hannah V. and Dawes, Timothy J. W. and Serrani, Marta and Bai, Wenjia and Tokarczuk, Paweł and Cai, Jiashen and de Marvao, Antonio and Henry, Albert and Lumbers, R. Thomas and Gierten, Jakob and Thumberger, Thomas and Wittbrodt, Joachim and Ware, James S. and Rueckert, Daniel and Matthews, Paul M. and Prasad, Sanjay K. and Costantino, Maria L. and Cook, Stuart A. and Birney, Ewan and O’Regan, Declan P.}, title={Genetic and functional insights into the fractal structure of the heart}, year={2020}, pages={589-594}, language={eng}, issn={1476-4687}, volume={584}, number={7822}, note={Gesehen am 27.02.2024}, journal={Nature}, doi={10.1038/s41586-020-2635-8}, } @article{UBHD-67670440, author={Rahm, Ann-Kathrin and Wiedmann, Felix Tobias and Gierten, Jakob and Schmidt, Constanze and Schweizer, Patrick Alexander and Becker, R{\"u}diger and Katus, Hugo and Thomas, Dierk}, title={Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels}, year={2014}, pages={291-300}, language={eng}, issn={1432-1912}, volume={387}, number={3}, note={Published online: 6 December 2013 ; Gesehen am 05.09.2014}, journal={Naunyn-Schmiedeberg's archives of pharmacology}, doi={10.1007/s00210-013-0945-1}, } @article{UBHD-68329163, author={Rahm, Ann-Kathrin and Gierten, Jakob and Kisselbach, Jana and Staudacher, Ingo and Staudacher, Kathrin and Schweizer, Patrick Alexander and Becker, R{\"u}diger and Katus, Hugo and Thomas, Dierk}, title={PKC-dependent activation of human K2P18.1 K+ channels}, year={2012}, pages={764-773}, language={eng}, issn={1476-5381}, volume={166}, number={2}, note={First published: 13 December 2011 ; Im Titel ist "2P" tiefgestellt ; Gesehen am 16.11.2018}, journal={British journal of pharmacology}, doi={10.1111/j.1476-5381.2011.01813.x}, } @article{UBHD-68286568, author={Seyler, Claudia and Duthil-Straub, Elvenn and Zitron, Edgar and Gierten, Jakob and Scholz, Eberhard P. and Fink, Rainer and Karle, Christoph and Becker, R{\"u}diger and Katus, Hugo and Thomas, Dierk}, title={TASK1 (K2P3.1) K+ channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation}, year={2012}, pages={1467-1475}, language={eng}, issn={1476-5381}, volume={165}, number={5}, note={Published online: 27 July 2011 ; 2P ist im Titel tief- und das Pluszeichen hochgestellt ; Gesehen am 18.07.2018}, journal={British journal of pharmacology}, doi={10.1111/j.1476-5381.2011.01626.x}, } @article{UBHD-68406871, author={Staudacher, Ingo and Seehausen, Sebastian and Gierten, Jakob and Illg, Claudius and Schweizer, Patrick Alexander and Katus, Hugo and Thomas, Dierk}, title={Cloning and characterization of zebrafish K2P13.1 (THIK-1) two-pore-domain K+ channels}, year={2019}, pages={96-104}, language={eng}, issn={1095-8584}, volume={126}, note={Available online 22 November 2018 ; Gesehen am 10.07.2019 ; Im Titel ist "2P" in K2P13.1 tiefgestellt ; Im Titel ist "+" in K+ hochgestellt}, journal={Journal of molecular and cellular cardiology}, doi={10.1016/j.yjmcc.2018.11.013}, } @article{UBHD-68568611, author={Staudacher, Ingo and Illg, Claudius and Gierten, Jakob and Seehausen, Sebastian and Schweizer, Patrick Alexander and Katus, Hugo and Thomas, Dierk}, title={Identification and functional characterization of zebrafish K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels}, year={2018}, pages={94-102}, language={eng}, issn={1879-0712}, volume={831}, note={Gesehen am 21.04.2020 ; Im Titel ist "2P" in K2P13.1 tiefgestellt ; Im Titel ist "+" in K+ hochgestellt}, journal={European journal of pharmacology}, doi={10.1016/j.ejphar.2018.05.007}, } @article{UBHD-68753850, author={Wagner, Nils and Beuttenmueller, Fynn and Norlin, Nils and Gierten, Jakob and Boffi, Juan Carlos and Wittbrodt, Joachim and Weigert, Martin and Hufnagel, Lars and Prevedel, Robert and Kreshuk, Anna}, title={Deep learning-enhanced light-field imaging with continuous validation}, year={2021}, pages={557-563}, language={eng}, issn={1548-7105}, volume={18}, number={5}, note={13 Seiten Anhang ; Gesehen am 29.06.2021}, journal={Nature methods}, doi={10.1038/s41592-021-01136-0}, } @article{UBHD-68400989, author={Wagner, Nils and Gierten, Jakob and Wittbrodt, Joachim}, title={Instantaneous isotropic volumetric imaging of fast biological processes}, year={2019}, pages={497-200}, language={eng}, issn={1548-7105}, volume={16}, number={6}, note={Gesehen am 25.06.2019}, journal={Nature methods}, doi={10.1038/s41592-019-0393-z}, } @incollection{UBHD-69346918, author={Welz, Bettina and Pierotti, Saul and Fitzgerald, Tomas and Thumberger, Thomas and Suzuki, Risa and Watson, Philip and Fuß, Jana and Cordeiro da Trindade, Tiago and Defranoux, Fanny and Ferreira, Márcio Soares and Naruse, Kiyoshi and Gierten, Jakob and Loosli, Felix and Wittbrodt, Joachim and Birney, Ewan}, title={Discovery and characterisation of gene by environment and epistatic genetic effects in a vertebrate model}, year={2025}, pages={1-43}, language={eng}, note={Gesehen am 21.05.2025}, booktitle={bioRxiv beta}, doi={10.1101/2025.04.24.650462}, }