@article{UBHD-68665930, author={Altmeyer, Markus and Amtmann, Eberhard and Heyl, Carina and Marschner, Aline and Scheidig, Axel J. and Klein, Christian D.}, title={Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases}, year={2014}, pages={5310-5314}, language={eng}, issn={1464-3405}, volume={24}, number={22}, note={Gesehen am 26.11.2020}, journal={Bioorganic & medicinal chemistry letters}, doi={10.1016/j.bmcl.2014.09.047}, } @article{UBHD-68987824, author={Altmeyer, Markus and Marschner, Aline and Schiffmann, Rolf and Klein, Christian D.}, title={Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors}, year={2010}, pages={4038-4044}, language={eng}, issn={1464-3405}, volume={20}, number={14}, note={Gesehen am 22.11.2022}, journal={Bioorganic & medicinal chemistry letters}, doi={10.1016/j.bmcl.2010.05.093}, } @article{UBHD-68590129, author={Bastos Lima, Allan and Behnam, Mira A. M. and El Sherif, Yasmin and Nitsche, Christoph and Vechi, Sergio and Klein, Christian D.}, title={Dual inhibitors of the dengue and West Nile virus NS2B-NS3 proteases}, subtitle={synthesis, biological evaluation and docking studies of novel peptide-hybrids}, year={2015}, pages={5748-5755}, language={eng}, issn={1464-3391}, volume={23}, number={17}, note={Gesehen am 23.06.2020}, journal={Bioorganic & medicinal chemistry}, doi={10.1016/j.bmc.2015.07.012}, } @article{UBHD-69162580, author={Behnam, Mira A. M. and Basché, Thomas and Klein, Christian D.}, title={2,2′-Bithiophene as sensor tag for ligand-protein binding assays based on F{\"o}rster resonance energy transfer}, year={2023}, pages={1-7}, language={eng}, issn={1096-0309}, volume={682}, number={Artikel-ID 115335}, note={Gesehen am 17.01.2024}, journal={Analytical biochemistry}, doi={10.1016/j.ab.2023.115335}, } @article{UBHD-69314986, author={Behnam, Mira A. M. and Klein, Christian D.}, title={Alternate recognition by dengue protease}, subtitle={proteolytic and binding assays provide functional evidence beyond an induced-fit}, year={2024}, pages={15-27}, language={eng}, volume={227(2024) vom: Dez.}, note={Online verf{\"u}gbar: 11. Juni 2024, Artikelversion: 3. Dezember 2024 ; Gesehen am 05.03.2025}, journal={Biochimie}, doi={10.1016/j.biochi.2024.06.002}, } @article{UBHD-68647886, author={Behnam, Mira A. M. and Klein, Christian D.}, title={Conformational selection in the flaviviral NS2B-NS3 protease}, year={2020}, pages={117-125}, language={eng}, volume={174}, note={Gesehen am 13.10.2020}, journal={Biochimie}, doi={10.1016/j.biochi.2020.04.014}, } @article{UBHD-68634789, author={Behnam, Mira A. M. and Nitsche, Christoph and Vechi, Sergio and Klein, Christian D.}, title={C-Terminal residue optimization and fragment merging}, subtitle={discovery of a potent peptide-hybrid inhibitor of Dengue protease}, year={2014}, pages={1037-1042}, language={eng}, issn={1948-5875}, volume={5}, number={9}, note={Gesehen am 04.09.2020}, journal={ACS medicinal chemistry letters}, doi={10.1021/ml500245v}, } @article{UBHD-68623866, author={Behnam, Mira A. M. and Graf, Dominik Korbinian and Bartenschlager, Ralf and Zlotos, Darius P. and Klein, Christian D.}, title={Discovery of nanomolar dengue and West Nile virus protease inhibitors containing a 4-benzyloxyphenylglycine residue}, year={2015}, pages={9354-9370}, language={eng}, issn={1520-4804}, volume={58}, number={23}, note={Gesehen am 04.08.2020}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.5b01441}, } @article{UBHD-68802718, author={Behnam, Mira A. M. and Klein, Christian D.}, title={Inhibitor potency and assay conditions}, subtitle={a case study on SARS-CoV-2 main protease}, year={2021}, pages={1-2}, language={eng}, issn={1091-6490}, volume={118}, note={Gesehen am 17.11.2021}, journal={Proceedings of the National Academy of Sciences of the United States of America}, doi={10.1073/pnas.2106095118}, } @article{UBHD-68573228, author={Behnam, Mira A. M. and Nitsche, Christoph and Boldescu, Veaceslav and Klein, Christian D.}, title={The medicinal chemistry of dengue virus}, year={2016}, pages={5622-5649}, language={eng}, issn={1520-4804}, volume={59}, number={12}, note={Gesehen am 05.05.2020}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.5b01653}, } @article{UBHD-68878262, author={Behnam, Mira A. M. and Klein, Christian D.}, title={On track to tackle dengue}, subtitle={History and future of NS4B ligands}, year={2021}, pages={1735-1737}, language={eng}, issn={1934-6069}, volume={29}, number={12}, note={Gesehen am 15.02.2022}, journal={Cell host and microbe}, doi={10.1016/j.chom.2021.11.010}, } @article{UBHD-68573230, author={Behnam, Mira A. M. and Sundermann, Tom R. and Klein, Christian D.}, title={Solid phase synthesis of C-terminal boronic acid peptides}, year={2016}, pages={2016-2019}, language={eng}, issn={1523-7052}, volume={18}, number={9}, note={Gesehen am 05.05.2020}, journal={Organic letters}, doi={10.1021/acs.orglett.6b00625}, } @article{UBHD-68805543, author={Behrouz, Somayeh and K{\"u}hl, Nikos and Klein, Christian D.}, title={A facile approach towards amidinophenylalanine derivatives as building blocks for the synthesis of non-natural peptides and peptidomimetics}, year={2021}, pages={1-7}, language={eng}, issn={1873-3581}, volume={81}, number={Artikel-ID 153342}, note={Gesehen am 26.11.2021}, journal={Tetrahedron letters}, doi={10.1016/j.tetlet.2021.153342}, } @article{UBHD-69078957, author={Behrouz, Somayeh and K{\"u}hl, Nikos and Klein, Christian D.}, title={N-sulfonyl peptide-hybrids as a new class of dengue virus protease inhibitors}, year={2023}, pages={1-14}, language={eng}, issn={1768-3254}, volume={251(2023) vom: M{\"a}rz}, number={Artikel-ID 115227}, note={Online verf{\"u}gbar 1. M{\"a}rz 2023, Artikelversion 7. M{\"a}rz 2023 ; Gesehen am 24.05.2023}, journal={European journal of medicinal chemistry}, doi={10.1016/j.ejmech.2023.115227}, } @article{UBHD-68299964, author={Boldescu, Veaceslav and Behnam, Mira A. M. and Klein, Christian D.}, title={Broad-spectrum agents for flaviviral infections}, subtitle={dengue, Zika and beyond}, year={2017}, pages={565-586}, language={eng}, issn={1474-1784}, volume={16}, number={8}, note={Gesehen am 29.08.2018}, journal={Nature reviews}, doi={10.1038/nrd.2017.33}, } @article{UBHD-68571272, author={Calcagno, Sarah and Klein, Christian D.}, title={N-Terminal methionine processing by the zinc-activated Plasmodium falciparum methionine aminopeptidase 1b}, year={2016}, pages={7091-7102}, language={eng}, issn={1432-0614}, volume={100}, number={16}, note={Gesehen am 28.04.2020}, journal={Applied microbiology and biotechnology}, doi={10.1007/s00253-016-7470-3}, } @article{UBHD-68572131, author={Chen, Wan-Na and Nitsche, Christoph and Pilla, Kala Bharath and Graham, Bim and Huber, Thomas and Klein, Christian D. and Otting, Gottfried}, title={Sensitive NMR approach for determining the binding mode of tightly binding ligand molecules to protein targets}, year={2016}, pages={4539-4546}, language={eng}, issn={1520-5126}, volume={138}, number={13}, note={Gesehen am 30.04.2020}, journal={Journal of the American Chemical Society}, doi={10.1021/jacs.6b00416}, } @article{UBHD-68560522, author={Dokla, Eman M. E. and Abutaleb, Nader S. and Milik, Sandra N. and Li, Daoyi and El-Baz, Karim and Shalaby, Menna-Allah W. and Al-Karaki, Rawan and Nasr, Maha and Klein, Christian D. and Abouzid, Khaled A. M. and Seleem, Mohamed N.}, title={Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria}, year={2020}, pages={1-9}, language={eng}, issn={1768-3254}, volume={186(2020) Artikel-Nummer 111850}, note={Available online 5 November 2019 ; Gesehen am 02.04.2020}, journal={European journal of medicinal chemistry}, doi={10.1016/j.ejmech.2019.111850}, } @article{UBHD-68491098, author={Dražić, Tonko and Leuthold, Mila and Klein, Christian D.}, title={Peptide-β-lactam inhibitors of Dengue and West Nile virus NS2B-NS3 protease display two distinct binding modes}, year={2020}, pages={140-156}, language={eng}, issn={1520-4804}, volume={63}, number={1}, note={Published online 5 December 2019 ; Gesehen am 19.02.2020}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.9b00759}, } @article{UBHD-68802738, author={Dražić, Tonko and K{\"u}hl, Nikos and Gottscheber, Nicole and Hacker, Christina N. and Klein, Christian D.}, title={The spectrum between substrates and inhibitors}, subtitle={Pinpointing the binding mode of dengue protease ligands with modulated basicity and hydrophobicity}, year={2021}, pages={1-16}, language={eng}, issn={1464-3391}, volume={48}, number={Artikel-ID 116412}, note={Gesehen am 17.11.2021}, journal={Bioorganic & medicinal chemistry}, doi={10.1016/j.bmc.2021.116412}, } @article{UBHD-69039723, author={F{\"o}rster, Sebastian and Persch, Elke and Tverskoy, Olena and Rominger, Frank and Helmchen, G{\"u}nter and Klein, Christian D. and {\"O}zata, Başak and Br{\"u}gger, Britta}, title={Syntheses and biological properties of brefeldin analogues}, year={2011}, pages={878-891}, language={eng}, issn={1099-0690}, volume={2011}, number={5 vom: Feb.}, note={Online ver{\"o}ffentlicht: Dezember 30, 2010 ; Gesehen am 09.02.2023}, journal={European journal of organic chemistry}, doi={10.1002/ejoc.201001297}, } @article{UBHD-68647824, author={Hinkes, Stefan and K{\"a}mmerer, Severin and Klein, Christian D.}, title={Diversity-oriented synthesis of peptide-boronic acids by a versatile building-block approach}, year={2020}, pages={9898-9903}, language={eng}, issn={2041-6539}, volume={11}, number={36}, note={Gesehen am 13.10.2020}, journal={Chemical science}, doi={10.1039/D0SC03999C}, } @article{UBHD-68438276, author={Hinkes, Stefan and Klein, Christian D.}, title={Virtues of volatility}, subtitle={a facile transesterification approach to boronic acids}, year={2019}, pages={3048-3052}, language={eng}, issn={1523-7052}, volume={21}, number={9}, note={Gesehen am 10.10.2019}, journal={Organic letters}, doi={10.1021/acs.orglett.9b00584}, } @article{UBHD-68406959, author={Jakob, Alexander and Sundermann, Tom R. and Klein, Christian D.}, title={Backbone modifications in peptidic inhibitors of flaviviral proteases}, year={2019}, pages={1913-1917}, language={eng}, issn={1464-3405}, volume={29}, number={15}, note={Gesehen am 10.07.2019}, journal={Bioorganic & medicinal chemistry letters}, doi={10.1016/j.bmcl.2019.05.054}, } @article{UBHD-68625690, author={J{\"o}st, Christian and Nitsche, Christoph and Scholz, Therese and Roux, Lionel and Klein, Christian D.}, title={Promiscuity and selectivity in covalent enzyme inhibition}, subtitle={a systematic study of electrophilic fragments}, year={2014}, pages={7590-7599$10}, language={eng}, issn={1520-4804}, volume={57}, number={18}, note={Gesehen am 07.08.2020}, journal={Journal of medicinal chemistry}, doi={10.1021/jm5006918}, } @article{UBHD-68766964, author={Klein, Christian D.}, title={[Rezension von: Small molecule medicinal chemistry]}, year={2017}, pages={1101}, language={eng}, issn={1860-7187}, volume={12}, number={13}, note={Gesehen am 04.08.2021}, journal={ChemMedChem}, doi={10.1002/cmdc.201700060}, } @article{UBHD-68749325, author={K{\"u}hl, Nikos and Leuthold, Mila and Behnam, Mira A. M. and Klein, Christian D.}, title={Beyond basicity}, subtitle={discovery of nonbasic DENV-2 protease inhibitors with potent activity in cell culture}, year={2021}, pages={4567-4587}, language={eng}, issn={1520-4804}, volume={64}, number={8}, note={Gesehen am 16.06.2021}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.0c02042}, } @article{UBHD-68983009, author={K{\"u}hl, Nikos and Lang, Johannes and Leuthold, Mila and Klein, Christian D.}, title={Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteases}, year={2022}, pages={1-14}, language={eng}, issn={1768-3254}, volume={240}, number={Artikel-ID 114585}, note={Gesehen am 08.11.2022}, journal={European journal of medicinal chemistry}, doi={10.1016/j.ejmech.2022.114585}, } @article{UBHD-68640015, author={K{\"u}hl, Nikos and Graf, Dominik Korbinian and Bock, Josephine and Behnam, Mira A. M. and Leuthold, Mila and Klein, Christian D.}, title={A new class of Dengue and west Nile virus protease inhibitors with submicromolar activity in reporter gene DENV-2 protease and viral replication assays}, year={2020}, pages={8179-8197}, language={eng}, issn={1520-4804}, volume={63}, number={15}, note={Gesehen am 24.09.2020}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.0c00413}, } @article{UBHD-69338243, author={Lang, Johannes and Dutta, Sudip Kumar and Leuthold, Mila and Reichert, Lisa and K{\"u}hl, Nikos and Martina, Byron and Klein, Christian D.}, title={Antiviral drug discovery with an optimized biochemical dengue protease assay}, subtitle={Improved predictive power for antiviral efficacy}, year={2025}, pages={1-12}, language={eng}, issn={1872-9096}, volume={234(2025) vom: Feb.}, number={Artikel-ID 106053}, note={Gesehen am 23.04.2025}, journal={Antiviral research}, doi={10.1016/j.antiviral.2024.106053}, } @article{UBHD-68588684, author={Lei, Jian and Hansen, Guido and Nitsche, Christoph and Klein, Christian D. and Zhang, Linlin and Hilgenfeld, Rolf}, title={Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor}, year={2016}, pages={503-505}, language={eng}, issn={1095-9203}, volume={353}, number={6298}, note={Gesehen am 18.06.2020}, journal={Science}, doi={10.1126/science.aag2419}, } @article{UBHD-68305750, author={Liang, Chen and Behnam, Mira A. M. and Sundermann, Tom R. and Klein, Christian D.}, title={Phenylglycine racemization in Fmoc-based solid-phase peptide synthesis}, subtitle={stereochemical stability is achieved by choice of reaction conditions}, year={2017}, pages={2325-2329}, language={eng}, issn={1873-3581}, volume={58}, number={24}, note={Gesehen am 18.09.2018}, journal={Tetrahedron letters}, doi={10.1016/j.tetlet.2017.04.047}, } @article{UBHD-68292844, author={Mahawaththa, Mithun C. and Klein, Christian D.}, title={Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease}, year={2017}, pages={141-147}, language={eng}, issn={1872-9096}, volume={142}, note={Gesehen am 07.08.2018}, journal={Antiviral research}, doi={10.1016/j.antiviral.2017.03.011}, } @article{UBHD-68585171, author={Marschner, Aline and Klein, Christian D.}, title={Metal promiscuity and metal-dependent substrate preferences of Trypanosoma brucei methionine aminopeptidase 1}, year={2015}, pages={35-43}, language={eng}, volume={115}, note={Gesehen am 08.06.2020}, journal={Biochimie}, doi={10.1016/j.biochi.2015.04.012}, } @article{UBHD-68574457, author={Mauceri, Daniela and Buchthal, Bettina and Hemstedt, Thekla Joana and Weiss, Ursula and Klein, Christian D. and Bading, Hilmar}, title={Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage}, year={2020}, pages={8616-8623}, language={eng}, issn={1091-6490}, volume={117}, number={15}, note={Gesehen am 07.05.2018}, journal={Proceedings of the National Academy of Sciences of the United States of America}, doi={10.1073/pnas.2001563117}, } @article{UBHD-68333432, author={Mendgen, Thomas and Steuer, Christian and Klein, Christian D.}, title={Privileged scaffolds or promiscuous binders}, subtitle={a comparative study on rhodanines and related heterocycles in medicinal chemistry}, year={2012}, pages={743-753}, language={eng}, issn={1520-4804}, volume={55}, number={2}, note={Publication Date (Web): 14 November 2011 ; Gesehen am 28.11.2018}, journal={Journal of medicinal chemistry}, doi={10.1021/jm201243p}, } @article{UBHD-69065403, author={Mendgen, Thomas and Scholz, Therese and Klein, Christian D.}, title={Structure-activity relationships of tulipalines, tuliposides, and related compounds as inhibitors of MurA}, year={2010}, pages={5757-5762}, language={eng}, issn={1464-3405}, volume={20}, number={19}, note={Gesehen am 14.04.2023}, journal={Bioorganic & medicinal chemistry letters}, doi={10.1016/j.bmcl.2010.07.139}, } @article{UBHD-68953622, author={Milik, Sandra and Abdel-Aziz, Amal Kamal and El-Hendawy, Morad M. and El-Gogary, Riham I. and Saadeldin, Mona Kamal and Minucci, Saverio and Klein, Christian D. and Abouzid, Khaled A. M.}, title={Insights into the design of inhibitors of the EGFR family with anticancer activity overcoming resistance}, subtitle={a case of optimizing thieno[2,3-d]pyrimidine-based EGFR inhibitors}, year={2022}, pages={1-13}, language={eng}, issn={1872-8014}, volume={1259}, number={Artikel-ID 132724}, note={Gesehen am 15.08.2022}, journal={Journal of molecular structure}, doi={10.1016/j.molstruc.2022.132724}, } @book{UBHD-68875552, title={Monoclonal antibodies}, edition={First edition}, publisher={MDPI}, address={Basel ; Beijing ; Wuhan ; Barcelona ; Belgrade}, year={2018}, pages={1 Online-Ressource (viii, 224 Seiten)}, language={eng}, isbn={978-3-03842-876-3}, note={This edition is a reprint of the special issue published online in the open access journal Antibodies (ISSN 2073-4468) from 2017-2018 (available at: http://www.mdpi.com/journal/antibodies/special_issues/moloclonal_antibodies)}, } @article{UBHD-68636712, author={Morgen, Michael and J{\"o}st, Christian and Malz, Mona and Janowski, Robert and Niessing, Dierk and Klein, Christian D. and Gunkel, Nikolas and Miller, Aubry K.}, title={Spiroepoxytriazoles are fumagillin-like irreversible inhibitors of MetAP2 with potent cellular activity}, year={2016}, pages={1001-1011}, language={eng}, issn={1554-8937}, volume={11}, number={4}, note={Published online 2015 ; Gesehen am 11.09.2020}, journal={ACS chemical biology}, doi={10.1021/acschembio.5b00755}, } @article{UBHD-68255667, author={Nitsche, Christoph and Klein, Christian D.}, title={Aqueous microwave-assisted one-pot synthesis of N-substituted rhodanines}, year={2012}, pages={5197-5201}, language={eng}, issn={1873-3581}, volume={53}, number={39}, note={Gesehen am 29.05.2018}, journal={Tetrahedron letters}, doi={10.1016/j.tetlet.2012.07.002}, } @article{UBHD-68969074, author={Nitsche, Christoph and Steuer, Christian and Klein, Christian D.}, title={Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases}, year={2011}, pages={7318-7337}, language={eng}, issn={1464-3391}, volume={19}, number={24}, note={Gesehen am 28.09.2022}, journal={Bioorganic & medicinal chemistry}, doi={10.1016/j.bmc.2011.10.061}, } @article{UBHD-68614256, author={Nitsche, Christoph and Klein, Christian D.}, title={Biochemistry and medicinal chemistry of the dengue virus protease}, year={2014}, pages={11348-11381}, language={eng}, issn={1520-6890}, volume={114}, number={22}, note={Gesehen am 07.07.2020}, journal={Chemical reviews}, doi={10.1021/cr500233q}, } @article{UBHD-68430726, author={Nitsche, Christoph and Leuthold, Mila and Klein, Christian D.}, title={De Novo discovery of nonstandard macrocyclic peptides as noncompetitive inhibitors of the Zika Virus NS2B-NS3 protease}, year={2019}, pages={168-174}, language={eng}, issn={1948-5875}, volume={10}, number={2}, note={Gesehen am 17.09.2019}, journal={ACS medicinal chemistry letters}, doi={10.1021/acsmedchemlett.8b00535}, } @incollection{UBHD-68805272, author={Nitsche, Christoph and Klein, Christian D.}, title={Fluorimetric and HPLC-based dengue virus protease assays using a FRET substrate}, year={2013}, pages={221-236}, language={eng}, isbn={9781627034845}, note={Gesehen am 25.11.2021}, booktitle={Antiviral methods and protocols}, editor={Gong, Edwin Yunhao}, doi={10.1007/978-1-62703-484-5_18}, } @article{UBHD-68250391, author={Nitsche, Christoph and Weigel, Lena and Graf, Dominik Korbinian and Bartenschlager, Ralf and Klein, Christian D.}, title={Peptide-boronic acid inhibitors of flaviviral proteases}, subtitle={medicinal chemistry and structural biology}, year={2017}, pages={511-516}, language={eng}, issn={1520-4804}, volume={60}, number={1}, note={Online erschienen: November 28, 2016 ; Gesehen am 08.05.2018}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.6b01021}, } @article{UBHD-68259868, author={Nitsche, Christoph and Behnam, Mira A. M. and Steuer, Christian and Klein, Christian D.}, title={Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease}, year={2012}, pages={72-79}, language={eng}, issn={1872-9096}, volume={94}, number={1}, note={Gesehen am 11.06.2018}, journal={Antiviral research}, doi={10.1016/j.antiviral.2012.02.008}, } @article{UBHD-67700748, author={Nitsche, Christoph and Schreier, Verena Natalie and Behnam, Mira A. M. and Kumar, Anil and Bartenschlager, Ralf and Klein, Christian D.}, title={Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture}, year={2013}, pages={8389-8403}, language={eng}, issn={1520-4804}, volume={56}, number={21}, note={Gesehen am 07.11.2014}, journal={Journal of medicinal chemistry}, doi={10.1021/jm400828u}, } @article{UBHD-68646224, author={Oosten, Luuk N. van and Klein, Christian D.}, title={Machine learning in mass spectrometry}, subtitle={A MALDI-TOF MS approach to phenotypic antibacterial screening}, year={2020}, pages={8849-8856}, language={eng}, issn={1520-4804}, volume={63}, number={16}, note={Gesehen am 08.10.2020}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.0c00040}, } @article{UBHD-68647896, author={Osman, Noha and Ligresti, Alessia and Klein, Christian D. and Allarà, Marco and Rabbito, Alessandro and Di Marzo, Vincenzo and Abouzid, Khaled A. and Abadi, Ashraf H.}, title={Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands}, subtitle={the structural elements controlling binding affinity, selectivity and functionality}, year={2016}, pages={619-634}, language={eng}, issn={1768-3254}, volume={122}, note={Gesehen am 13.10.2020}, journal={European journal of medicinal chemistry}, doi={10.1016/j.ejmech.2016.07.012}, } @article{UBHD-68618539, author={Osman, Noha and Mahmoud, Amr H. and Klein, Christian D. and Allarà, Marco and Marzo, Vincenzo Di and Abouzid, Khaled M. and Abadi, Ashraf H.}, title={Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB2-selective ligands}, year={2014}, pages={1571-1576}, language={eng}, issn={2040-2511}, volume={5}, number={10}, note={Im Titel ist "2" in CB2 tiefgestellt ; Gesehen am 20.07.2020}, journal={MedChemComm}, doi={10.1039/C4MD00232F}, } @article{UBHD-68294931, author={Poręba, Marcin and Marschner, Aline and Klein, Christian D.}, title={S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors}, year={2012}, pages={704-710}, language={eng}, volume={94}, number={3}, note={Available online 7 November 2011 ; Gesehen am 13.08.2018}, journal={Biochimie}, doi={10.1016/j.biochi.2011.10.014}, } @article{UBHD-68442741, author={Richter, Michael and Leuthold, Mila and Graf, Dominik Korbinian and Bartenschlager, Ralf and Klein, Christian D.}, title={Prodrug activation by a viral protease}, subtitle={evaluating combretastatin peptide hybrids to selectively target infected cells}, year={2019}, pages={1115-1121}, language={eng}, issn={1948-5875}, volume={10}, number={8}, note={Gesehen am 21.10.2019}, journal={ACS medicinal chemistry letters}, doi={10.1021/acsmedchemlett.9b00058}, } @article{UBHD-68412337, author={Richter, Michael and Boldescu, Veaceslav and Graf, Dominik Korbinian and Bartenschlager, Ralf and Klein, Christian D.}, title={Synthesis, biological evaluation, and molecular docking of combretastatin and colchicine derivatives and their hCE1-activated prodrugs as antiviral agents}, year={2019}, pages={469-483}, language={eng}, issn={1860-7187}, volume={14}, number={4}, note={Gesehen am 25.07.2019}, journal={ChemMedChem}, doi={10.1002/cmdc.201800641}, } @article{UBHD-68286533, author={Scholz, Therese and Heyl, Carina and Zimmermann, Stefan and Klein, Christian D.}, title={Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity}, year={2013}, pages={795-804}, language={eng}, issn={1464-3391}, volume={21}, number={3}, note={Available online 24 November 2012 ; Gesehen am 18.07.2018}, journal={Bioorganic & medicinal chemistry}, doi={10.1016/j.bmc.2012.11.018}, } @article{UBHD-68118383, author={Seehafer, Kai and Rominger, Frank and Helmchen, G{\"u}nter and Langhans, Markus and Robinson, David G. and {\"O}zata, Başak and Br{\"u}gger, Britta and Klein, Christian D.}, title={Synthesis and biological properties of novel brefeldin a analogues}, year={2013}, pages={5872-5884}, language={eng}, issn={1520-4804}, volume={56}, number={14}, note={Gesehen am 11.05.2017}, journal={Journal of medicinal chemistry}, doi={10.1021/jm400615g}, } @article{UBHD-68976973, author={Steuer, Christian and Gege, Christian and Fischl, Wolfgang and Heinonen, Karl H. and Bartenschlager, Ralf and Klein, Christian D.}, title={Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture}, year={2011}, pages={4067-4074}, language={eng}, issn={1464-3391}, volume={19}, number={13}, note={Gesehen am 21.10.2022}, journal={Bioorganic & medicinal chemistry}, doi={10.1016/j.bmc.2011.05.015}, } @article{UBHD-68409255, author={Sundermann, Tom R. and Dražić, Tonko and Klein, Christian D.}, title={Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors}, year={2019}, pages={187-194}, language={eng}, issn={1768-3254}, volume={176}, note={Gesehen am 16.07.2019}, journal={European journal of medicinal chemistry}, doi={10.1016/j.ejmech.2019.05.025}, } @article{UBHD-68593638, author={Weigel, Lena and Nitsche, Christoph and Graf, Dominik Korbinian and Bartenschlager, Ralf and Klein, Christian D.}, title={Phenylalanine and phenylglycine analogues as arginine mimetics in dengue protease inhibitors}, year={2015}, pages={7719-7733}, language={eng}, issn={1520-4804}, volume={58}, number={19}, note={Gesehen am 29.06.2020}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.5b00612}, } @article{UBHD-68299975, author={Weng, Zhibing and Graf, Dominik Korbinian and Klein, Christian D.}, title={Identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors}, year={2017}, pages={751-759}, language={eng}, issn={1768-3254}, volume={125}, note={Published online: 21 September 2016 ; Gesehen am 29.08.2018}, journal={European journal of medicinal chemistry}, doi={10.1016/j.ejmech.2016.09.063}, } @article{UBHD-69236802, author={Werner, Marius and Brinkhofer, Julian and Hammerm{\"u}ller, Leon and Heim, Thomas and Pham, Truc Lam and Huber, Jonas and Klein, Christian D. and Thomas, Franziska}, title={Peptide boronic acids by late-stage hydroboration on the solid phase}, year={2024}, pages={1-11}, language={eng}, issn={2198-3844}, volume={11}, note={Online ver{\"o}ffentlicht: 29. Mai 2024 ; Gesehen am 23.07.2024}, journal={Advanced science}, doi={10.1002/advs.202400640}, } @book{UBHD-69292384, author={Werner, Marius and Brinkhofer, Julian and Hammerm{\"u}ller, Leon and Heim, Thomas and Pham, Truc Lam and Huber, Jonas and Klein, Christian D. and Thomas, Franziska}, title={Peptide boronic acids by late-stage hydroboration on the solid phase [research data]}, publisher={Universit{\"a}t}, address={Heidelberg}, year={2025}, pages={1 Online Ressource (5 Files)}, language={eng}, note={Gef{\"o}rdert durch: Deutsche Forschungsgemeinschaft (DFG): 414261058; Deutsche Forschungsgemeinschaft (DFG) - Excellence Strategy: 2082/1 390761711 ; Gesehen am 20.01.2025}, doi={10.11588/data/G9NMGA}, url={https://doi.org/10.11588/data/G9NMGA}, library={UB}, }