@article{UBHD-68283604, author={Brenner, Thorsten and Schmitt, Felix and Demirel, Serdar and Salgado, Eduardo and Celi de la Torre, Juan Antonio and G{\"o}ring, Martin and Bruckner, Thomas and B{\"o}ckler, Dittmar and Weigand, Markus A. and Hofer, Stefan and Attigah, Nicolas}, title={The role of unfractionated heparin for the antiaggregatory effect of aspirin in patients undergoing carotid endarterectomy}, subtitle={results of an observational clinical study}, year={2017}, pages={19-27}, language={eng}, issn={1708-539X}, volume={25}, number={1}, note={First published: March 17, 2016 ; Gesehen am 09.07.2018}, journal={Vascular}, doi={10.1177/1708538116638961}, } @book{UBHD-68403079, author={Salgado, Eduardo}, organization={Universit{\"a}t Heidelberg}, title={Cell death biomarkers as early predictors for delayed graft function in patients following kidney transplantation}, address={Heidelberg}, year={2018}, pages={54 Bl{\"a}tter}, language={ger}, school={Dissertation, Ruprecht-Karls-Universit{\"a}t Heidelberg, 2019}, library={UB [Signatur: 2019 U 454]}, } @article{UBHD-68560596, author={Schmitt, Felix and Salgado, Eduardo and Hetto, Janina and Schmoch, Thomas and Uhle, Florian and Fleming, Thomas and Zemva, Johanna and Kihm, Lars Philipp and Nußhag, Christian and Morath, Christian and Zeier, Martin and Bruckner, Thomas and Mehrabi, Arianeb and Nawroth, Peter Paul and Weigand, Markus A. and Hofer, Stefan and Brenner, Thorsten}, title={Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury inpatients following kidney transplantation}, subtitle={results of an observational pilot study}, year={2018}, pages={751-760}, language={eng}, issn={1432-2277}, volume={31}, number={7}, note={Published online 30 March 2018 ; Gesehen am 02.04.2020 ; A prolonged cold ischaemia time (CIT) is suspected to be associated with anincreased ischaemia and reperfusion injury (IRI) resulting in an increaseddamage to the graft. In total, 91 patients were evaluated for a delayed graftfunction within 7 days after kidney transplantation (48 deceased, 43 livingdonors). Blood and urine samples were collected before, immediately afterthe operation, and 1, 3, 5, 7 and 10 days later. Plasma and/or urine levels oftotal keratin 18 (total K18), caspase-cleaved keratin 18 (cc K18), the solublereceptor for advanced glycation end products (sRAGE), tissue inhibitor ofmetalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding pro-tein-7 (IGFBP7) were measured. As a result of prolonged CIT and increasedIRI, deceased donor transplantations were shown to suffer from a more dis-tinct cell cycle arrest and necrotic cell death. Plasmatic total K18 and urinaryTIMP-2 and IGFBP7 were therefore demonstrated to be of value for thedetection of a delayed graft function (DGF), as they improved the diagnosticperformance of a routinely used clinical scoring system. Plasmatic total K18and urinary TIMP-2 and IGFBP7 measurements are potentially suitable forearly identification of patients at high risk for a DGF following kidney trans-plantation from deceased or living donors}, journal={Transplant international}, doi={10.1111/tri.13148}, }