@article{UBHD-68805211, author={Adolph, Jonas E. and Fleischhack, Gudrun and Mikasch, Ruth and Zeller, Julia and Warmuth-Metz, Monika and Bison, Brigitte and Mynarek, Martin and Rutkowski, Stefan and Sch{\"u}ller, Ulrich and von Hoff, Katja and Obrecht, Denise and Pietsch, Torsten and Pfister, Stefan and Pajtler, Kristian Wilfried and Witt, Olaf and Witt, Hendrik and Kortmann, Rolf-Dieter and Timmermann, Beate and Krauß, J{\"u}rgen and Fr{\"u}hwald, Michael C and Faldum, Andreas and Kwiecien, Robert and Bode, Udo and Tippelt, Stephan}, title={Local and systemic therapy of recurrent ependymoma in children and adolescents}, subtitle={short- and long-term results of the E-HIT-REZ 2005 study}, year={2021}, pages={1012-1023}, language={eng}, issn={1523-5866}, volume={23}, number={6}, note={Advance Access date 17 December 2020 ; Gesehen am 25.11.2021}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noaa276}, } @article{UBHD-69163336, author={Ameline, Baptiste and Kovac, Michal and Nathrath, Michaela and Barenboim, Maxim and Witt, Olaf and Krieg, Andreas H. and Baumhoer, Daniel}, title={Overactivation of the IGF signalling pathway in osteosarcoma}, subtitle={a potential therapeutic target?}, year={2021}, pages={165-172}, language={eng}, issn={2056-4538}, volume={7}, number={2 vom: M{\"a}rz}, note={Gesehen am 19.1.2024}, journal={The journal of pathology: clinical research}, doi={10.1002/cjp2.191}, } @article{UBHD-68495293, author={B{\"a}chli, Heidi and Ecker, Jonas and Tilburg, Cornelis M. van and Sturm, Dominik and Selt, Florian and Sahm, Felix and K{\"o}lsche, Christian and Grund, Kerstin and Sutter, Christian and Witt, Hendrik and Herold-Mende, Christel and Deimling, Andreas von and Jones, David T. W. and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Molecular diagnostics in pediatric brain tumors}, subtitle={impact on diagnosis and clinical decision-making - a selected case series}, year={2018}, pages={305-313}, language={eng}, issn={1439-3824}, volume={230}, number={06}, note={Gesehen am 02.03.2020}, journal={Klinische P{\"a}diatrie}, doi={10.1055/a-0637-9653}, } @article{UBHD-68305724, author={Bai, Alfa H. C. and Milde, Till and Remke, Marc and Rolli, Claudio Gavino and Hielscher, Thomas and Kool, Marcel and Jugold, Manfred and Bazhin, Alexandr V. and Eichm{\"u}ller, Stefan B. and Kulozik, Andreas and Pscherer, Armin and Benner, Axel and Witt, Olaf and Korshunov, Andrey and Lichter, Peter and Pfister, Stefan}, title={MicroRNA-182 promotes leptomeningeal spread of non-Sonic Hedgehog-medulloblastoma}, year={2012}, pages={529-538}, language={eng}, issn={1432-0533}, volume={123}, number={4}, note={First online: 02 December 2011 ; Gesehen am 18.09.2018}, journal={Acta neuropathologica}, doi={10.1007/s00401-011-0924-x}, } @article{UBHD-68893301, author={Barenboim, Maxim and Kovac, Michal and Ameline, Baptiste and Jones, David T. W. and Witt, Olaf and Bielack, Stefan and Burdach, Stefan and Baumhoer, Daniel and Nathrath, Michaela}, title={DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma}, year={2021}, pages={1-24}, language={eng}, issn={1553-7358}, volume={17}, note={Gesehen am 09.03.2022}, journal={PLoS Computational Biology}, doi={10.1371/journal.pcbi.1009562}, } @article{UBHD-68191833, author={Bender, Sebastian and Pfaff, Elke and Sturm, Dominik and Jones, Barbara Christine and Tilburg, Cornelis M. van and Milford, David and Heiland, Sabine and Kalle, Christof von and Kulozik, Andreas and Unterberg, Andreas and Witt, Olaf and Deimling, Andreas von and Capper, David and Brors, Benedikt and Herold-Mende, Christel and Korshunov, Andrey and Eils, Roland and Pfister, Stefan}, title={Recurrent MET fusion genes represent a drug target in pediatric glioblastoma}, year={2016}, pages={1314-1322}, language={eng}, issn={1546-170X}, volume={22}, number={11}, note={Gesehen am 17.11.2017}, journal={Nature medicine}, doi={10.1038/nm.4204}, } @article{UBHD-68664953, author={Bender, Sebastian and Tang, Yujie and Lindroth, Anders and Hovestadt, Volker and Jones, David T. W. and Kool, Marcel and Zapatka, Marc and Northcott, Paul A. and Sturm, Dominik and Wei, Wang and Radlwimmer, Bernhard and Højfeldt, Jonas W. and Truffaux, Nathalène and Castel, David and Schubert, Simone and Ryzhova, Marina and Şeker-Cin, Huriye and Gronych, Jan and Johann, Pascal-David and Stark, Sebastian and Meyer, Jochen and Milde, Till and Schuhmann, Martin and Ebinger, Martin and Witt, Olaf and Deimling, Andreas von and Korshunov, Andrey and Lichter, Peter and Plass, Christoph and Pfister, Stefan}, title={Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas}, year={2013}, pages={660-672}, language={eng}, issn={1878-3686}, volume={24}, number={5}, note={Gesehen am 24.11.2020}, journal={Cancer cell}, doi={10.1016/j.ccr.2013.10.006}, } @article{UBHD-68637659, author={Benesch, Martin and Bartelheim, Kerstin and Fleischhack, G. and Gruhn, Bernd and Schlegel, Paul-Gerhardt and Witt, Olaf and Stachel, Klaus Daniel and Hauch, Holger and Urban, Christian and Quehenberger, F. and Massimino, M. and Pietsch, T. and Hasselblatt, Martin and Giangaspero, F. and Kordes, Uwe and Schneppenheim, Reinhard and Hauser, Peter and Klingebiel, Thomas and Fr{\"u}hwald, Michael}, title={High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT)}, subtitle={a report from the European Rhabdoid Registry (EU-RHAB)}, year={2014}, pages={370-375}, language={eng}, issn={1476-5365}, volume={49}, number={3}, note={Gesehen am 16.09.2020}, journal={Bone marrow transplantation}, doi={10.1038/bmt.2013.208}, } @article{UBHD-68286169, author={Bingel, Corinna and Sill, Martin and Peterziel, Heike and Milde, Till and Witt, Olaf and Oehme, Ina}, title={Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance}, year={2017}, pages={16 S.}, language={eng}, issn={2041-4889}, volume={8(2017}, note={Gesehen am 17.07.2018}, journal={Cell death & disease}, doi={10.1038/cddis.2017.398}, } @article{UBHD-69041452, author={Blattmann, Claudia and Oertel, Susanne and Ehemann, Volker and Thiemann, Markus and Huber, Peter E. and Bischof, Marc and Witt, Olaf and Deubzer, Hedwig and Kulozik, Andreas and Debus, J{\"u}rgen and Weber, Klaus-Josef}, title={Enhancement of radiation response in osteosarcoma and rhabomyosarcoma cell lines by histone deacetylase inhibition}, year={2010}, pages={237-245}, language={eng}, issn={1879-355X}, volume={78}, number={1}, note={Gesehen am 14.02.2023}, journal={International journal of radiation oncology, biology, physics}, doi={10.1016/j.ijrobp.2010.03.010}, } @article{UBHD-69227263, author={Bouffet, Eric and Hansford, Jordan R. and Garrè, Maria Luisa and Hara, Junichi and Plant-Fox, Ashley and Aerts, Isabelle and Locatelli, Franco and van der Lugt, Jasper and Papusha, Ludmila and Sahm, Felix and Tabori, Uri and Cohen, Kenneth J. and Packer, Roger J. and Witt, Olaf and Sandalic, Larissa and Bento Pereira da Silva, Ana and Russo, Mark and Hargrave, Darren R.}, title={Dabrafenib plus Trametinib in pediatric glioma with BRAF V600 mutations}, year={2023}, pages={1108-1120}, language={eng}, issn={1533-4406}, volume={389}, number={12}, note={Online ver{\"o}ffentlicht: 20. September 2023 ; Gesehen am 28.06.2024}, journal={The New England journal of medicine}, doi={10.1056/NEJMoa2303815}, } @article{UBHD-68670336, author={Brockmann, Markus and Poon, Evon and Berry, Teeara and Carstensen, Anne and Deubzer, Hedwig and Rycak, Lukas and Jamin, Yann and Thway, Khin and Robinson, Simon P. and Roels, Frederik and Witt, Olaf and Fischer, Matthias and Chesler, Louis and Eilers, Martin}, title={Small molecule inhibitors of Aurora-A induce proteasomal degradation of N-Myc in childhood neuroblastoma}, year={2013}, pages={75-89}, language={eng}, issn={1878-3686}, volume={24}, number={1}, note={Gesehen am 08.12.2020}, journal={Cancer cell}, doi={10.1016/j.ccr.2013.05.005}, } @article{UBHD-68295715, author={Brocks, David and Schott, Johanna and Oehme, Ina and Witt, Olaf and Mallm, Jan-Philipp and Rippe, Karsten and Stoecklin, Georg}, title={DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats}, year={2017}, pages={1052-1060}, language={eng}, issn={1546-1718}, volume={49}, number={7}, note={Gesehen am 15.08.2018}, journal={Nature genetics}, doi={10.1038/ng.3889}, } @article{UBHD-68341774, author={Buhl, Juliane and Selt, Florian and Hielscher, Thomas and Ecker, Jonas and Sahm, Felix and Ridinger, Johannes and Usta, Diren and Wefers, Annika K. and Remke, Marc and Pusch, Stefan and Oehme, Ina and Tilburg, Cornelis M. van and Kool, Marcel and Deimling, Andreas von and Herold-Mende, Christel and Korshunov, Andrey and Pfister, Stefan and Jones, David T. W. and Witt, Olaf and Milde, Till}, title={The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma}, year={2019}, pages={1851-1866}, language={eng}, issn={1557-3265}, volume={25}, number={6}, note={Published first: December 7, 2018 ; Gesehen am 18.12.2018}, journal={Clinical cancer research}, doi={10.1158/1078-0432.CCR-18-1965}, } @article{UBHD-68237229, author={Capper, David and Jones, David T. W. and Schrimpf, Daniel and Sturm, Dominik and K{\"o}lsche, Christian and Sahm, Felix and Reuss, David and Reinhardt, Annekathrin and Wefers, Annika K. and Huang, Kristin and Pajtler, Kristian Wilfried and Schweizer, Leonille and Stichel, Damian and Selt, Florian and Witt, Hendrik and Milde, Till and Witt, Olaf and Scheurlen, Wolfram and Geisenberger, Christoph and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and H{\"a}nggi, Daniel and Kulozik, Andreas and Benner, Axel and Bendszus, Martin and Debus, J{\"u}rgen and Platten, Michael and Unterberg, Andreas and Wick, Wolfgang and Karajannis, Matthias A. and Mittelbronn, Michel Guy André and Acker, Till and Hartmann, Christian and Aldape, Kenneth and Sch{\"u}ller, Ulrich and Buslei, Rolf and Lichter, Peter and Kool, Marcel and Herold-Mende, Christel and Deimling, Andreas von and Pfister, Stefan and M{\"u}ller, Hermann L.}, title={DNA methylation-based classification of central nervous system tumours}, year={2018}, pages={469-474}, language={eng}, issn={1476-4687}, volume={555}, number={7697}, note={Gesehen am 28.03.2018}, journal={Nature}, doi={10.1038/nature26000}, } @article{UBHD-68374101, author={Capper, David and Sahm, Felix and Jones, David T. W. and Schrimpf, Daniel and Reuss, David and K{\"o}lsche, Christian and Reinhardt, Annekathrin and Wefers, Annika K. and Huang, Kristin and Sievers, Philipp and Ebrahimi, Azadeh and H{\"a}nggi, Daniel and Unterberg, Andreas and Platten, Michael and Wick, Wolfgang and Witt, Olaf and Milde, Till and Korshunov, Andrey and Pfister, Stefan and Deimling, Andreas von}, title={Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics}, subtitle={the Heidelberg experience}, year={2018}, pages={181-210}, language={eng}, issn={1432-0533}, volume={136}, number={2}, note={Published online: 2 July 2018 ; Gesehen am 29.03.2019}, journal={Acta neuropathologica}, doi={10.1007/s00401-018-1879-y}, } @article{UBHD-68104765, author={Chakrabarti, Alokta and Witt, Olaf}, title={HDAC8}, subtitle={a multifaceted target for therapeutic interventions}, year={2015}, pages={481-492}, language={eng}, issn={1873-3735}, volume={36}, number={7}, note={Gesehen am 30.03.2017}, journal={Trends in pharmacological sciences}, doi={10.1016/j.tips.2015.04.013}, } @article{UBHD-68217734, author={Chakrabarti, Alokta and Witt, Olaf}, title={Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases}, year={2016}, pages={1609-1634}, language={eng}, issn={1756-8927}, volume={8}, number={13}, note={Gesehen am 06.02.2018}, journal={Future medicinal chemistry}, doi={10.4155/fmc-2016-0117}, } @article{UBHD-68635981, author={Clarke, Matthew and Karremann, Michael and Korshunov, Andrey and Jones, Barbara Christine and Sturm, Dominik and Witt, Olaf and Deimling, Andreas von and Pfister, Stefan and Sahm, Felix and Capper, David and Jones, David T. W.}, title={Infant high-grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes}, year={2020}, pages={942-963}, language={eng}, issn={2159-8290}, volume={10}, number={7}, note={Gesehen am 09.09.2020}, journal={Cancer discovery}, doi={10.1158/2159-8290.CD-19-1030}, } @article{UBHD-68300352, author={Combs, Stephanie and Eitz, Kerstin Anne and Herfarth, Klaus and Jensen, Alexandra and Oertel, Susanne and Blattmann, Claudia and Ecker, Swantje and H{\"o}ss, Angelika and Martin, Eike and Witt, Olaf and J{\"a}kel, Oliver and Kulozik, Andreas and Debus, J{\"u}rgen}, title={Treatment of pediatric patients and young adults with particle therapy at the Heidelberg Ion Therapy Center (HIT)}, subtitle={establishment of workflow and initial clinical data}, year={2012}, pages={9 S.}, language={eng}, issn={1748-717X}, volume={7(2012) Artikel-Nummer 170}, number={9 Seiten}, note={Gesehen am 30.08.2018}, journal={Radiation oncology}, doi={10.1186/1748-717X-7-170}, } @article{UBHD-68467061, author={Daskalakis, Michael and Brocks, David and Sheng, Yi-Hua and Islam, Md Saiful and Ressnerova, Alzbeta and Assenov, Yassen and Milde, Till and Oehme, Ina and Witt, Olaf and Goyal, Ashihs and K{\"u}hn, Alexander and Hartmann, Mark and Weichenhan, Dieter and Jung, Manfred and Plass, Christoph}, title={Reactivation of endogenous retroviral elements via treatment with DNMT- and HDAC-inhibitors}, year={2018}, pages={811-822}, language={eng}, issn={1551-4005}, volume={17}, number={7}, note={Gesehen am 10.12.2019}, journal={Cell cycle}, doi={10.1080/15384101.2018.1442623}, } @article{UBHD-68568632, author={Deng, Maximilian and Sill, Martin and Sturm, Dominik and Stichel, Damian and Witt, Hendrik and Ecker, Jonas and Wittmann, A. and Schittenhelm, J. and Ebinger, M. and Schuhmann, M. U. and Figarella‐Branger, D. and Aronica, E. and Staszewski, O. and Preusser, M. and Haberler, C. and Lauten, M. and Sch{\"u}ller, U. and Hartmann, C. and Snuderl, M. and Dunham, C. and Jabado, N. and Wesseling, P. and Deckert, M. and Keyvani, K. and Gottardo, N. and Giangaspero, F. and Hoff, K. von and Ellison, D. W. and Pietsch, T. and Herold-Mende, Christel and Milde, Till and Witt, Olaf and Kool, Marcel and Korshunov, Andrey and Wick, Wolfgang and Deimling, Andreas von and Pfister, Stefan and Jones, David T. W. and Sahm, Felix}, title={Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) - a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14}, year={2020}, pages={422-430}, language={eng}, issn={1365-2990}, volume={46}, number={5}, note={First published: 23 December 2019 ; Gesehen am 21.04.2020}, journal={Neuropathology & applied neurobiology}, doi={10.1111/nan.12590}, url={https://doi.org/10.1111/nan.12590}, library={UB}, } @article{UBHD-68898709, author={Deng, Maximilian and Sturm, Dominik and Pfaff, Elke and Sill, Martin and Stichel, Damian and Balasubramanian, Gnana Prakash and Tippelt, Stephan and Kramm, Christof and Donson, Andrew M. and Green, Adam L. and Jones, Chris and Schittenhelm, Jens and Ebinger, Martin and Schuhmann, Martin U. and Jones, Barbara Christine and Tilburg, Cornelis M. van and Wittmann, Andrea and Golanov, Andrey and Ryzhova, Marina and Ecker, Jonas and Milde, Till and Witt, Olaf and Sahm, Felix and Reuss, David and Sumerauer, David and Zamecnik, Josef and Korshunov, Andrey and Deimling, Andreas von and Pfister, Stefan and Jones, David T. W.}, title={Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B}, year={2021}, pages={1-11}, language={eng}, issn={2041-1723}, volume={12}, number={Artikel-ID 5530}, note={Published 20 September 2021 ; Gesehen am 23.03.2022}, journal={Nature Communications}, doi={10.1038/s41467-021-25708-y}, } @article{UBHD-67322240, author={Deubzer, Hedwig and Schier, Marie Catherine and Oehme, Ina and Lodrini, Marco and Witt, Olaf}, title={HDAC11 is a novel drug target in carcinomas}, year={2013}, pages={2200-2208}, language={eng}, issn={1097-0215}, volume={132}, number={9}, note={Online 1 Oct 2012 ; Gesehen am 14.12.2020}, journal={International journal of cancer}, doi={10.1002/ijc.27876}, } @article{UBHD-68897196, author={Dittes, Christine and Adolph, Jonas E. and Tippelt, Stephan and Mikasch, Ruth and Obrecht, Denise and Mynarek, Martin and Rutkowski, Stefan and Pfister, Stefan and Milde, Till and Witt, Olaf and Bison, Brigitte and Warmuth-Metz, Monika and Kortmann, Rolf-Dieter and Dietzsch, Stefan and Pietsch, Torsten and Timmermann, Beate and Str{\"a}ter, Ronald and Bode, Udo and Faldum, Andreas and Kwiecien, Robert and Fleischhack, Gudrun}, title={Local and systemic therapy of recurrent medulloblastomas in children and adolescents}, subtitle={results of the P-HIT-REZ 2005 study}, year={2022}, pages={1-24}, language={eng}, issn={2072-6694}, volume={14}, note={Gesehen am 22.03.2022}, journal={Cancers}, doi={10.3390/cancers14030471}, } @article{UBHD-68299976, author={Dovzhanskiy, Dmitriy I. and Arnold, Stefanie M. and Hackert, Thilo and Oehme, Ina and Witt, Olaf and Felix, Klaus M. and Giese, Nathalia and Werner, Jens}, title={Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer}, year={2012}, pages={9 S.}, language={eng}, issn={1471-2407}, volume={12(2012) Artikel-Nummer 226}, number={9 Seiten}, note={Gesehen am 29.08.2018}, journal={BMC cancer}, doi={10.1186/1471-2407-12-226}, } @article{UBHD-69106183, author={Ecker, Jonas and Selt, Florian and Sturm, Dominik and Sill, Martin and Korshunov, Andrey and Hirsch, Steffen and Capper, David and Dikow, Nicola and Sutter, Christian and M{\"u}ller, Carina and Sigaud, Romain and Eggert, Angelika and Simon, Thorsten and Niehues, Tim and Deimling, Andreas von and Pajtler, Kristian Wilfried and Tilburg, Cornelis M. van and Jones, David T. W. and Sahm, Felix and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Corrigendum to ‘Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry’ [Eur J Cancer 180 (2023) 71-84]}, year={2023}, pages={200-201}, language={eng}, issn={1879-0852}, volume={184(2023) vom: Mai}, note={Online verf{\"u}gbar: 21. M{\"a}rz 2023, Artikelversion: 11. April 2023 ; Gesehen am 03.08.2023}, journal={European journal of cancer}, doi={10.1016/j.ejca.2023.02.024}, } @article{UBHD-69054224, author={Ecker, Jonas and Selt, Florian and Sturm, Dominik and Sill, Martin and Korshunov, Andrey and Hirsch, Steffen and Capper, David and Dikow, Nicola and Sutter, Christian and M{\"u}ller, Carina and Sigaud, Romain and Eggert, Angelika and Simon, Thorsten and Niehues, Tim and Deimling, Andreas von and Pajtler, Kristian Wilfried and Tilburg, Cornelis M. van and Jones, David T. W. and Sahm, Felix and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Molecular diagnostics enables detection of actionable targets}, subtitle={the Pediatric Targeted Therapy 2.0 registry}, year={2023}, pages={71-84}, language={eng}, issn={1879-0852}, volume={180(2023) vom: Feb.}, note={Online ver{\"o}ffentlicht am 25. November 2022, Artikelversion vom 19. Dezember 2022 ; Gesehen am 22.11.2023}, journal={European journal of cancer}, doi={10.1016/j.ejca.2022.11.015}, } @article{UBHD-68746998, author={Ecker, Jonas and Thatikonda, Venu and Sigismondo, Gianluca and Selt, Florian and Valinciute, Gintvile and Oehme, Ina and M{\"u}ller, Carina and Buhl, Juliane and Ridinger, Johannes and Usta, Diren and Qin, Nan and Tilburg, Cornelis M. van and Herold-Mende, Christel and Remke, Marc and Sahm, Felix and Westermann, Frank and Kool, Marcel and Wechsler-Reya, Robert J. and Chavez, Lukas and Krijgsveld, Jeroen and J{\"a}ger, Natalie and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma}, year={2021}, pages={226-239}, language={eng}, issn={1523-5866}, volume={23}, number={2 vom: Feb.}, note={Gesehen am 10.06.2021 ; First published: 21 August 2020}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noaa191}, } @book{UBHD-67968247, author={Ecker, Jonas and Korshunov, Andrey and Kiss, Judit and Selt, Florian and Deubzer, Hedwig and Deimling, Andreas von and Kulozik, Andreas and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma}, publisher={BioMed Central}, address={London}, year={2016}, pages={1 Online-Ressource (14 Seiten)}, language={eng}, note={Wissenschaftlicher Aufsatz. - Aus: Acta Neuropathologica Communications, 3 (UNSPECIFIED), Nr. 22. pp. 1-14. ISSN 2051-5960}, doi={10.1186/s40478-015-0201-7}, url={https://nbn-resolving.org/urn:nbn:de:bsz:16-heidok-194764}, library={UB}, } @article{UBHD-68377942, author={Erkek, Serap and Johann, Pascal-David and Zapatka, Marc and Sturm, Dominik and Jones, David T. W. and Korshunov, Andrey and Wolf, Stephan and Mallm, Jan-Philipp and Witt, Olaf and Kulozik, Andreas and Korbel, Jan Oliver and Lichter, Peter and Eils, Roland and Chavez, Lukas and Pfister, Stefan and Kool, Marcel}, editor={Northcott, Michael}, title={Comprehensive analysis of chromatin states in atypical teratoid/rhabdoid tumor identifies diverging roles for SWI/SNF and polycomb in gene regulation}, year={2019}, pages={25 S.}, language={eng}, issn={1878-3686}, volume={35(2019}, note={Available online 27 December 2018 ; Gesehen am 08.05.2019}, journal={Cancer cell}, doi={10.1016/j.ccell.2018.11.014}, } @article{UBHD-68638102, author={Fabian, Johannes and Lodrini, Marco and Oehme, Ina and Schier, Marie Catherine and Thole, Theresa Maria and Hielscher, Thomas and Kopp-Schneider, Annette and Opitz, Lennart and Capper, David and Deimling, Andreas von and Rettig, Inga Edeltraud and Milde, Till and Mahlknecht, Ulrich Rudolph and Westermann, Frank and Popanda, Odilia and Roels, Frederik and Hero, Barbara and Berthold, Frank and Fischer, Matthias and Kulozik, Andreas and Witt, Olaf and Deubzer, Hedwig}, title={GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3}, year={2014}, pages={2604-2616}, language={eng}, issn={1538-7445}, volume={74}, number={9}, note={Gesehen am 16.09.2020}, journal={Cancer research}, doi={10.1158/0008-5472.CAN-13-1904}, } @article{UBHD-68404559, author={Fabian, Johannes and Althoff, Kristina and Lodrini, Marco and Patil, Nitin and Abba, Mohammed L. and Thole, Theresa Maria and Schweizer, Leonille and Mechtersheimer, Gunhild and Deimling, Andreas von and Erb, Ulrike and Z{\"o}ller, Margot and Allgayer, Heike and Kulozik, Andreas and Witt, Olaf and Schulte, Johannes Hubertus and Deubzer, Hedwig}, title={MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma}, year={2016}, pages={66344-66359}, language={eng}, issn={1949-2553}, volume={7}, number={41}, note={Gesehen am 04.07.2019}, journal={OncoTarget}, doi={10.18632/oncotarget.11662}, } @article{UBHD-68631909, author={Fangusaro, Jason R. and Witt, Olaf and Hernáiz Driever, Pablo and Bag, Asim K. and de Blank, Peter and Kadom, Nadja and Kilburn, Lindsay and Lober, Robert M. and Robison, Nathan J. and Fisher, Michael J. and Packer, Roger J. and Young Poussaint, Tina and Papusha, Ludmila and Avula, Shivaram and Brandes, Alba A. and Bouffet, Eric and Bowers, Daniel and Artemov, Anton and Chintagumpala, Murali and Zurakowski, David and van den Bent, Martin and Bison, Brigitte and Yeom, Kristen W. and Taal, Walter and Warren, Katherine E.}, title={Response assessment in paediatric low-grade glioma}, subtitle={recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group : imaging guidelines for paediatric brain tumours 1}, year={2020}, pages={e305-e316}, language={eng}, issn={1474-5488}, volume={21}, number={6}, note={Gesehen am 27.08.2020}, journal={The lancet}, doi={10.1016/S1470-2045(20)30064-4}, } @article{UBHD-69347739, author={Filippidou, Maria and Glentis, Stavros and Rigatou, Efthymia and Sievers, Philipp and Selt, Florian and Dimitriadis, Efthymios and Perari, Panagiota and Binenbaum, Ilona and Avgerinou, Georgia and Tilburg, Cornelis M. van and Jones, David T. W. and Sahm, Felix and Milde, Till and Witt, Olaf and Pfister, Stefan and Gr{\"u}newald, Thomas G. P. and Stefanaki, Kalliopi and Kattamis, Antonis}, title={Soft tissue undifferentiated sarcoma carrying a novel Onecut1::Nutm1 fusion}, subtitle={letter to the editor}, year={2025}, pages={1-4}, language={eng}, issn={1545-5017}, volume={72}, note={Online verf{\"u}gbar: 06. November 2024 ; Gesehen am 23.05.2025}, journal={Pediatric blood & cancer}, doi={10.1002/pbc.31427}, } @book{UBHD-68020731, author={Fogarasi, Andras and Witt, Olaf}, title={EFFECTS}, subtitle={an expanded access program of everolimus for patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex}, publisher={BioMed Central; Springer}, address={London; Berlin; Heidelberg}, year={2016}, pages={1 Online-Ressource (9 Seiten)}, language={eng}, note={Wissenschaftlicher Aufsatz. - Aus: BMC Neurology, 16 (2016), Nr. 126. pp. 1-9. ISSN 1471-2377}, doi={10.1186/s12883-016-0658-4}, url={https://nbn-resolving.org/urn:nbn:de:bsz:16-heidok-217701}, library={UB}, } @article{UBHD-68235486, author={Fogarasi, Andras and Witt, Olaf}, title={EFFECTS}, subtitle={an expanded access program of everolimus for patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex}, year={2016}, language={eng}, issn={1471-2377}, volume={16(2016) Artikel-Nummer 126}, number={9 Seiten}, note={Gesehen am 22.03.2018}, journal={BMC neurology}, doi={10.1186/s12883-016-0658-4}, } @article{UBHD-68735204, author={Franz, David N. and Belousova, Elena and Sparagana, Steven and Bebin, E Martina and Frost, Michael and Kuperman, Rachel and Witt, Olaf and Kohrman, Michael H and Flamini, J Robert and Wu, Joyce Y and Curatolo, Paolo and de Vries, Petrus J and Whittemore, Vicky H and Thiele, Elizabeth A and Ford, James P and Shah, Gaurav and Cauwel, Helene and Lebwohl, David and Sahmoud, Tarek and Jozwiak, Sergiusz}, title={Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1)}, subtitle={a multicentre, randomised, placebo-controlled phase 3 trial}, year={2013}, pages={125-132}, language={eng}, volume={381}, number={9861}, note={Published Online November 14, 2012 ; Gesehen am 07.05.2021}, journal={The lancet}, doi={10.1016/S0140-6736(12)61134-9}, } @article{UBHD-68649631, author={Franz, David N. and Witt, Olaf}, title={Everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis complex}, subtitle={2-year open-label extension of the randomised EXIST-1 study}, year={2014}, pages={1513-1520}, language={eng}, issn={1474-5488}, volume={15}, number={13}, note={Gesehen am 16.10.2020}, journal={The lancet}, doi={10.1016/S1470-2045(14)70489-9}, } @article{UBHD-68580299, author={Franz, David N. and Belousova, Elena and Sparagana, Steven and Bebin, E. Martina and Frost, Michael D. and Kuperman, Rachel and Witt, Olaf and Kohrman, Michael H. and Flamini, J. Robert and Wu, Joyce Y. and Curatolo, Paolo and Vries, Petrus J. de and Berkowitz, Noah and Niolat, Julie and Jóźwiak, Sergiusz}, title={Long-term use of everolimus in patients with tuberous sclerosis complex}, subtitle={final results from the EXIST-1 study}, year={2016}, pages={13 S.}, language={eng}, issn={1932-6203}, volume={11(2016}, note={Gesehen am 25.05.2020}, journal={PLOS ONE}, doi={10.1371/journal.pone.0158476}, } @article{UBHD-68896635, author={Gatzweiler, Charlotte and Ridinger, Johannes and Herter, Sonja and Gerloff, Xenia F. and ElHarouni, Dina and Berker, Yannick and Imle, Roland and Schmitt, Lukas and Kreth, Sina and Stainczyk, Sabine and Ayhan, Simay and Najafi, Sara and Krunic, Damir and Frese, Karen S. and Meder, Benjamin and Reuss, David and Fiesel, Petra and Schramm, Kathrin and Blattner-Johnson, Mirjam and Jones, David T. W. and Banito, Ana and Westermann, Frank and Oppermann, Sina and Milde, Till and Peterziel, Heike and Witt, Olaf and Oehme, Ina}, title={Functional therapeutic target validation using pediatric zebrafish xenograft models}, year={2022}, pages={1-24}, language={eng}, issn={2072-6694}, volume={14}, note={Gesehen am 29.03.2022}, journal={Cancers}, doi={10.3390/cancers14030849}, } @article{UBHD-68415013, author={Géraldy, Magalie and Morgen, Michael and Ridinger, Johannes and Oehme, Ina and Witt, Olaf}, title={Selective inhibition of histone deacetylase 10}, subtitle={hydrogen bonding to the gatekeeper residue is implicated}, year={2019}, pages={4426-4443}, language={eng}, issn={1520-4804}, volume={62}, number={9}, note={Gesehen am 01.08.2019}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.8b01936}, } @article{UBHD-68758125, author={Gnekow, Astrid K. and Kandels, Daniela and Pietsch, Torsten and Bison, Brigitte and Warmuth-Metz, Monika and Thomale, Ulrich W. and Kortmann, Rolf-D. and Timmermann, Beate and Driever, Pablo Hernàiz and Witt, Olaf and Schmidt, René and Spix, Claudia}, title={Doubling recruitment of pediatric low-grade Glioma within two decades does not change outcome}, subtitle={report from the german LGG studies}, year={2021}, pages={107-122}, language={eng}, issn={1439-3824}, volume={233}, number={03}, note={Gesehen am 09.07.2021}, journal={Klinische P{\"a}diatrie}, doi={10.1055/a-1471-5897}, } @article{UBHD-68448882, author={Goebel, Anna-Maria and Witt, Olaf}, title={Natural history of pediatric low-grade glioma disease}, subtitle={first multi-state model analysis}, year={2019}, pages={6314-6326}, language={eng}, issn={1837-9664}, volume={10}, number={25}, note={Gesehen am 31.10.2019}, journal={Journal of cancer}, doi={10.7150/jca.33463}, } @article{UBHD-69306546, author={Gorodezki, David and Chiang, Jason and Viaene, Angela N. and Sievers, Philipp and Schmid, Simone and Holzer, Ursula and Paulsen, Frank and Schuhmann, Martin U. and Witt, Olaf and Schittenhelm, Jens and Ebinger, Martin}, title={A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity}, year={2024}, pages={1-10}, language={eng}, issn={2051-5960}, volume={12(2024) vom: Juni}, number={Artikel-ID 101}, note={Gesehen am 20.02.2025}, journal={Acta Neuropathologica Communications}, doi={10.1186/s40478-024-01817-9}, } @article{UBHD-68570567, author={Gr{\"o}bner, Susanne and Jones, Barbara Christine and Buchhalter, Ivo and Johann, Pascal-David and Balasubramanian, Gnana Prakash and Bender, Sebastian and Hutter, Barbara and Sturm, Dominik and Pfaff, Elke and H{\"u}bschmann, Daniel and Heinold, Michael and Eils, J{\"u}rgen and Kulozik, Andreas and Witt, Hendrik and Witt, Olaf and Tilburg, Cornelis M. van and Klingebiel, Thomas and Brors, Benedikt and Pajtler, Kristian Wilfried and Kool, Marcel and Korbel, Jan Oliver and Schlesner, Matthias and Eils, Roland and Jones, David T. W. and Lichter, Peter and Zapatka, Marc and Pfister, Stefan}, title={Author correction: The landscape of genomic alterations across childhood cancers}, year={2018}, pages={E10-E10}, language={eng}, issn={1476-4687}, volume={559}, number={7714}, note={Gesehen am 27.04.2020}, journal={Nature}, doi={10.1038/s41586-018-0167-2}, } @article{UBHD-68227032, author={Gr{\"o}bner, Susanne and Jones, Barbara Christine and Buchhalter, Ivo and Johann, Pascal-David and Balasubramanian, Gnana Prakash and Bender, Sebastian and Sturm, Dominik and Pfaff, Elke and H{\"u}bschmann, Daniel and Heinold, Michael and Eils, J{\"u}rgen and Kulozik, Andreas and Witt, Hendrik and Tilburg, Cornelis M. van and Pajtler, Kristian Wilfried and Kool, Marcel and Eils, Roland and Jones, David T. W. and Lichter, Peter and Zapatka, Marc and Korshunov, Andrey and Witt, Olaf and Pfister, Stefan}, title={The landscape of genomic alterations across childhood cancers}, year={2018}, pages={321-327}, language={eng}, issn={1476-4687}, volume={555}, note={Author correction: Susanne N. Gr{\"o}bner, Barbara C. Worst, Joachim Weischenfeldt, Ivo Buchhalter, Kortine Kleinheinz, Vasilisa A. Rudneva, Pascal D. Johann, Gnana Prakash Balasubramanian, Maia Segura-Wang, Sebastian Brabetz, Sebastian Bender, Barbara Hutter, Dominik Sturm, Elke Pfaff, Daniel H{\"u}bschmann, Gideon Zipprich, Michael Heinold, J{\"u}rgen Eils, Christian Lawerenz, Serap Erkek, Sander Lambo, Sebastian Waszak, Claudia Blattmann, Arndt Borkhardt, Michaela Kuhlen, Angelika Eggert, Simone Fulda, Manfred Gessler, Jenny Wegert, Roland Kappler, Daniel Baumhoer, Stefan Burdach, Renate Kirschner-Schwabe, Udo Kontny, Andreas E. Kulozik, Dietmar Lohmann, Simone Hettmer, Cornelia Eckert, Stefan Bielack, Michaela Nathrath, Charlotte Niemeyer, G{\"u}nther H. Richter, Johannes Schulte, Reiner Siebert, Frank Westermann, Jan J. Molenaar, Gilles Vassal, Hendrik Witt, ICGC PedBrain-Seq Project, ICGC MMML-Seq Project, Birgit Burkhardt, Christian P. Kratz, Olaf Witt, Cornelis M. van Tilburg, Christof M. Kramm, Gudrun Fleischhack, Uta Dirksen, Stefan Rutkowski, Michael Fr{\"u}hwald, Katja von Hoff, Stephan Wolf, Thomas Klingebiel, Ewa Koscielniak, Pablo Landgraf, Jan Koster, Adam C. Resnick, Jinghui Zhang, Yanling Liu, Xin Zhou, Angela J. Waanders, Danny A. Zwijnenburg, Pichai Raman, Benedikt Brors, Ursula D. Weber, Paul A. Northcott, Kristian W. Pajtler, Marcel Kool, Rosario M. Piro, Jan O. Korbel, Matthias Schlesner, Roland Eils, David T.W. Jones, Peter Lichter, Lukas Chavez, Marc Zapatka & Stefan M. Pfister ; Gesehen am 06.03.2018}, journal={Nature}, doi={10.1038/nature25480}, } @article{UBHD-68942846, author={Gronych, Jan and Korshunov, Andrey and Bageritz, Josephine and Milde, Till and Jugold, Manfred and Hambardzumyan, Dolores and Remke, Marc and Hartmann, Christian and Witt, Hendrik and Jones, David T. W. and Witt, Olaf and Heiland, Sabine and Bendszus, Martin and Holland, Eric C. and Pfister, Stefan and Lichter, Peter}, title={An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice}, year={2011}, pages={1344-1348}, language={eng}, issn={1558-8238}, volume={121}, number={4}, note={Gesehen am 15.07.2022}, journal={The journal of clinical investigation}, doi={10.1172/JCI44656}, } @article{UBHD-69355257, author={Hansford, Jordan R. and Bouche, Gauthier and Ramaswamy, Vijay and Jabado, Nada and Fonseca, Adriana and Moloney, Sam and Gottardo, Nicholas G. and Robinson, Giles W. and Gajjar, Amar and Tinkle, Christopher L. and Fisher, Paul G. and Foreman, Nicholas and Ashley, David M. and Ziegler, David S. and Eisenstat, David D. and Massimino, Maura and Witt, Olaf and Bartels, Ute and Rutkowski, Stefan and Hargrave, Darren and Fouladi, Maryam and Pfister, Stefan and Bouffet, Eric}, title={Comments and controversies in oncology}, subtitle={the tribulations of trials developing ONC201}, year={2024}, pages={4126-4129}, language={eng}, issn={1527-7755}, volume={42}, number={35 vom: Dez.}, note={Online ver{\"o}ffentlicht: 07. August 2024 ; Gesehen am 11.06.2025}, journal={Journal of clinical oncology}, doi={10.1200/JCO.24.00709}, } @article{UBHD-68243554, author={Heimburg, Tino and Witt, Olaf}, title={Structure-based design and biological characterization of selective histone deacetylase 8 (HDAC8) inhibitors with anti-neuroblastoma activity}, year={2017}, pages={10188-10204}, language={eng}, issn={1520-4804}, volume={60}, number={24}, note={Gesehen am 17.04.2018}, journal={Journal of medicinal chemistry}, doi={10.1021/acs.jmedchem.7b01447}, } @article{UBHD-69295603, author={Heipertz, Anna-Elisa and Pajtler, Kristian Wilfried and Pfaff, Elke and Schramm, Kathrin and Blattner-Johnson, Mirjam and Milde, Till and Jones, Barbara Christine and Zuliani, Cecilia and Hutter, Caroline and Lohi, Olli and Kattamis, Antonis and Dachowska-Kalwak, Iwona and Nilsson, Anna and Gerber, Nicolas U. and Langenberg, Karin and Goemans, Bianca F. and Zwaan, C. Michel and Molenaar, Jan J. and J{\"a}ger, Natalie and Dirksen, Uta and Witt, Ruth and Pfister, Stefan and Jones, David T. W. and Kopp-Schneider, Annette and Witt, Olaf and Tilburg, Cornelis M. van}, title={Outcome of children and adolescents with relapsed/refractory/progressive malignancies treated with molecularly informed targeted drugs in the pediatric precision oncology registry INFORM}, year={2023}, pages={1-12}, language={eng}, issn={2473-4284}, note={Gesehen am 29.01.2025}, journal={JCO precision oncology}, doi={10.1200/PO.23.00015}, } @article{UBHD-67855355, author={H{\"o}rner-Rieber, Juliane and Witt, Olaf and Behnisch, Wolfgang and Kulozik, Andreas and Debus, J{\"u}rgen}, title={Treatment tolerance of particle therapy in pediatric patients}, year={2015}, pages={1049-1055}, language={eng}, issn={1651-226X}, volume={54}, number={7}, note={Gesehen am 05.08.2015}, journal={Acta oncologica}, doi={10.3109/0284186X.2014.998273}, } @article{UBHD-68578657, author={Holzapfel, Johannes and Kandels, Daniela and Schmidt, René and Pietsch, Torsten and Warmuth‐Metz, Monika and Bison, Brigitte and Krauss, J{\"u}ergen and Kortmann, Rolf-Dieter and Timmermann, Beate and Thomale, Ulrich-Wilhelm and Albert, Michael H. and Driever, Pablo Hernáiz and Witt, Olaf and Gnekow, Astrid K.}, title={Favorable prognosis in pediatric brainstem low-grade glioma}, subtitle={Report from the German SIOP-LGG 2004 cohort}, year={2020}, pages={3385-3396}, language={eng}, issn={1097-0215}, volume={146}, number={12}, note={Online 27 November 2019 ; Gesehen am 18.05.2020}, journal={International journal of cancer}, doi={10.1002/ijc.32734}, } @article{UBHD-68569809, author={Hong, David S. and DuBois, Steven G and Kummar, Shivaani and Farago, Anna F and Albert, Catherine M and Rohrberg, Kristoffer S and Tilburg, Cornelis M. van and Nagasubramanian, Ramamoorthy and Berlin, Jordan D and Federman, Noah and Mascarenhas, Leo and Geoerger, Birgit and Dowlati, Afshin and Pappo, Alberto S and Bielack, Stefan and Doz, François and McDermott, Ray and Patel, Jyoti D and Schilder, Russell J and Tahara, Makoto and Pfister, Stefan and Witt, Olaf and Ladanyi, Marc and Rudzinski, Erin R and Nanda, Shivani and Childs, Barrett H and Laetsch, Theodore W and Hyman, David M and Drilon, Alexander}, title={Larotrectinib in patients with TRK fusion-positive solid tumours}, subtitle={a pooled analysis of three phase 1/2 clinical trials}, year={2020}, pages={531-540}, language={eng}, issn={1474-5488}, volume={21}, number={4}, note={Gesehen am 23.04.2020}, journal={The lancet}, doi={10.1016/S1470-2045(19)30856-3}, } @article{UBHD-67970363, author={Hovestadt, Volker and Jones, David T. W. and Kool, Marcel and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Eils, J{\"u}rgen and Milde, Till and Witt, Olaf and Scheurlen, Wolfram and Brors, Benedikt and Eils, Roland and Korshunov, Andrey and Zapatka, Marc and Pfister, Stefan and Lichter, Peter}, title={Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing}, year={2014}, pages={537-541}, language={eng}, issn={1476-4687}, volume={510}, number={7506}, note={Gesehen am 21.04.2016}, journal={Nature}, doi={10.1038/nature13268}, } @article{UBHD-68443432, author={Hutter, Sonja and Witt, Olaf and Pfister, Stefan}, title={No correlation between NF1 mutation position and risk of optic pathway glioma in 77 unrelated NF1 patients}, year={2016}, pages={469-475}, language={eng}, issn={1432-1203}, volume={135}, number={5}, note={Im Titel ist "NF1" in NF1 mutation kursiv geschrieben ; Gesehen am 22.10.2019}, journal={Human genetics}, doi={10.1007/s00439-016-1646-x}, } @article{UBHD-68937062, author={Jacob, Karine and Quang-Khuong, Dongh-Anh and Jones, David T. W. and Witt, Hendrik and Lambert, Sally and Albrecht, Steffen and Witt, Olaf and Vezina, Catherine and Shirinian, Margret and Faury, Damien and Garami, Miklos and Hauser, Peter and Klekner, Almos and Bognar, Laszlo and Farmer, Jean-Pierre and Montes, Jose-Luis and Atkinson, Jeffrey and Hawkins, Cynthia and Korshunov, Andrey and Collins, V. Peter and Pfister, Stefan and Tabori, Uri and Jabado, Nada}, title={Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas}, year={2011}, pages={4650-4660}, language={eng}, issn={1557-3265}, volume={17}, number={14}, note={Gesehen am 04.07.2022}, journal={Clinical cancer research}, doi={10.1158/1078-0432.CCR-11-0127}, } @article{UBHD-68436861, author={J{\"a}nsch, Niklas and Witt, Olaf and Oehme, Ina}, title={The enzyme activity of histone deacetylase 8 is modulated by a redox-switch}, year={2019}, pages={60-67}, language={eng}, issn={2213-2317}, volume={20}, note={Available online 27 September 2018 ; Gesehen am 09.10.2019}, journal={Redox Biology}, doi={10.1016/j.redox.2018.09.013}, } @article{UBHD-68215366, author={Jones, Barbara Christine and Tilburg, Cornelis M. van and Balasubramanian, Gnana Prakash and Fiesel, Petra and Witt, Ruth and Freitag, Angelika and Boudalil, Miream and Hutter, Barbara and Taylor, Lenka A. and Sutter, Christian and Bartram, Claus R. and Milde, Till and Pfaff, Elke and Kulozik, Andreas and Brors, Benedikt and Deimling, Andreas von and Capper, David and Pfister, Stefan and Witt, Olaf}, title={Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study}, year={2016}, pages={91-101}, language={eng}, issn={1879-0852}, volume={65}, note={Gesehen am 31.01.2018}, journal={European journal of cancer}, doi={10.1016/j.ejca.2016.06.009}, } @article{UBHD-68297000, author={Jones, David T. W. and Witt, Olaf and Pfister, Stefan}, title={BRAF V600E status alone is not sufficient as a prognostic biomarker in pediatric low-grade glioma}, year={2018}, pages={96}, language={eng}, issn={1527-7755}, volume={36}, number={1}, note={Published online November 15, 2017 ; Gesehen am 20.08.2018}, journal={Journal of clinical oncology}, doi={10.1200/JCO.2017.75.8987}, } @article{UBHD-68573696, author={Jones, David T. W. and J{\"a}ger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor and Hovestadt, Volker and St{\"u}tz, Adrian M. and Rausch, Tobias and Warnatz, Hans-J{\"o}rg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina Valesca and Şeker-Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Andrea and Remke, Marc and Witt, Hendrik and Hutter, Sonja and Tzaridis, Theophilos-Dimitrios and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D. and Wang, Qi and Lasitschka, B{\"a}rbel and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred and Kalle, Christof von and Ast, Volker and Lawerenz, Christian and Eils, J{\"u}rgen and Kabbe, Rolf and Benes, Vladimir and Sluis, Peter van and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J. and Russell, Robert B. and Coco, Simona and Paolo Tonini, Gian and Sch{\"u}ller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Andreas and Herold-Mende, Christel and Milde, Till and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Maass, Eberhard and R{\"o}ssler, Jochen and Ebinger, Martin and Schuhmann, Martin U. and Fr{\"u}hwald, Michael and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and Bueren, André von and Williamson, Dan and Clifford, Steven C. and McCabe, Martin G. and Peter Collins, V. and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, J{\"o}rg and Reifenberger, Guido and Northcott, Paul A. and Taylor, Michael D. and Meyerson, Matthew and Pomeroy, Scott L. and Yaspo, Marie-Laure and Korbel, Jan Oliver and Korshunov, Andrey and Eils, Roland and Pfister, Stefan and Lichter, Peter}, title={Dissecting the genomic complexity underlying medulloblastoma}, year={2012}, pages={100-105}, language={eng}, issn={0028-0836}, volume={488}, number={7409 vom: 20. Juni}, journal={Nature}, } @article{UBHD-68296998, author={Jones, David T. W. and J{\"a}ger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor and Hovestadt, Volker and St{\"u}tz, Adrian M. and Rausch, Tobias and Warnatz, Hans-J{\"o}rg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina Valesca and Şeker-Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Andrea and Remke, Marc and Witt, Hendrik and Hutter, Sonja and Tzaridis, Theophilos-Dimitrios and Weischenfeldt, Joachim and Zapatka, Marc and Bartholom{\"a}, Cynthia C. and Schmidt, Manfred and Kalle, Christof von and Ast, Volker and Lawerenz, Christian and Eils, J{\"u}rgen and Betts, Matthew J. and Russell, Robert B. and Roggendorf, Wolfgang and Unterberg, Andreas and Herold-Mende, Christel and Milde, Till and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Rutkowski, Stefan and Bueren, André von and Brors, Benedikt and Korbel, Jan Oliver and Korshunov, Andrey and Eils, Roland and Pfister, Stefan and Lichter, Peter}, title={Dissecting the genomic complexity underlying medulloblastoma}, year={2012}, pages={100-105}, language={eng}, issn={1476-4687}, volume={488}, number={7409}, note={Gesehen am 20.08.2018}, journal={Nature}, doi={10.1038/nature11284}, } @article{UBHD-68296999, author={Jones, David T. W. and Witt, Olaf and Pfister, Stefan}, title={MAPK pathway activation in pilocytic astrocytoma}, year={2012}, pages={1799-1811}, language={eng}, issn={1420-9071}, volume={69}, number={11}, note={Published online: 13 December 2011 ; Gesehen am 20.08.2018 ; Published online: 13 December 2011}, journal={Cellular and molecular life sciences}, doi={10.1007/s00018-011-0898-9}, } @article{UBHD-68430746, author={Josupeit, Rafael and Herold-Mende, Christel and Witt, Olaf and Lacroix, Jeannine}, title={Pediatric and adult high-grade glioma stem cell culture models are permissive to lytic infection with parvovirus H-1}, year={2016}, pages={1-21}, language={eng}, issn={1999-4915}, volume={8}, note={Gesehen am 17.09.2019}, journal={Viruses}, doi={10.3390/v8050138}, } @article{UBHD-69310489, author={Kelety, Tibor and Thomale, Ulrich-Wilhelm and Kandels, Daniela and Schuhmann, Martin U. and El Damaty, Ahmed and Krauss, J{\"u}rgen and Fr{\"u}hwald, Michael and Driever, Pablo Hernáiz and Witt, Olaf and Bison, Brigitte and Warmuth-Metz, Monika and Pietsch, Torsten and Schmidt, René and Gnekow, Astrid K.}, title={Adaption of neurosurgical resection patterns for pediatric low-grade glioma spanning two decades - report from the German LGG-studies 1996-2018}, year={2024}, pages={1-19}, language={eng}, issn={2045-7634}, volume={13}, note={Online ver{\"o}ffentlicht: 24. Juni 2024 ; Gesehen am 26.02.2025}, journal={Cancer medicine}, doi={10.1002/cam4.7417}, } @article{UBHD-69178437, author={Kilburn, Lindsay B. and Khuong-Quang, Dong-Anh and Hansford, Jordan R. and Landi, Daniel and van der Lugt, Jasper and Leary, Sarah E. S. and Driever, Pablo Hernáiz and Bailey, Simon and Perreault, Sébastien and McCowage, Geoffrey and Waanders, Angela J. and Ziegler, David S. and Witt, Olaf and Baxter, Patricia A. and Kang, Hyoung Jin and Hassall, Timothy E. and Han, Jung Woo and Hargrave, Darren R. and Franson, Andrea T. and Yalon Oren, Michal and Toledano, Helen and Larouche, Valérie and Kline, Cassie and Abdelbaki, Mohamed S. and Jabado, Nada and Gottardo, Nicholas G. and Gerber, Nicolas U. and Whipple, Nicholas S. and Segal, Devorah and Chi, Susan N. and Oren, Liat and Tan, Enrica E. K. and M{\"u}ller, Sabine and Cornelio, Izzy and McLeod, Lisa and Zhao, Xin and Walter, Ashley and Da Costa, Daniel and Manley, Peter and Blackman, Samuel C. and Packer, Roger J. and Nysom, Karsten}, title={The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma}, subtitle={the phase 2 FIREFLY-1 trial}, year={2024}, pages={207-217}, language={eng}, issn={1546-170X}, volume={30}, number={1 vom: Jan.}, note={Ver{\"o}ffentlicht: 17. November 2023 ; Gesehen am 07.02.2024}, journal={Nature medicine}, doi={10.1038/s41591-023-02668-y}, } @article{UBHD-69323093, author={Kocher, Daniela and Cao, Lei and Guiho, Romain and Langhammer, Melanie and Lai, Yun-Lu and Becker, Pauline and Hamdi, Hiba and Friedel, Dennis and Selt, Florian and Vonh{\"o}ren, David and Zaman, Julia and Valinciute, Gintvile and Herter, Sonja and Picard, Daniel and Rettenmeier, Johanna and Maaß, Kendra K. and Pajtler, Kristian Wilfried and Remke, Marc and Deimling, Andreas von and Pusch, Stefan and Pfister, Stefan and Oehme, Ina and Jones, David T. W. and Halbach, Sebastian and Brummer, Tilman and Martinez-Barbera, Juan Pedro and Witt, Olaf and Milde, Till and Sigaud, Romain}, title={Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines}, year={2024}, pages={317-332}, language={eng}, issn={1573-7373}, volume={168}, number={2 vom: Juni}, note={Gesehen am 28.03.2025}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-024-04672-9}, } @article{UBHD-68708346, author={K{\"o}lsche, Christian and Schrimpf, Daniel and Stichel, Damian and Sill, Martin and Sahm, Felix and Reuss, David and Jones, Barbara Christine and Heilig, Christoph E. and Horak, Peter and Stark, Sebastian and Johann, Pascal-David and Selt, Florian and Ecker, Jonas and Sturm, Dominik and Pajtler, Kristian Wilfried and Reinhardt, Annekathrin and Wefers, Annika K. and Sievers, Philipp and Suwala, Abigail Kora and Fernández Klett, Francisco and Casalini, Belén and Korshunov, Andrey and Kommoss, Felix and Kriegsmann, Mark and Milde, Till and Witt, Olaf and Kulozik, Andreas and Kool, Marcel and Gr{\"u}newald, Thomas G. P. and Wick, Wolfgang and Platten, Michael and Unterberg, Andreas and Uhl, Matthias and Abdollahi, Amir and Debus, J{\"u}rgen and Lehner, Burkhard and Schirmacher, Peter and Stenzinger, Albrecht and Brors, Benedikt and Glimm, Hanno and Hohenberger, Peter and Mechtersheimer, Gunhild and Jones, David T. W. and Fr{\"o}hling, Stefan and Pfister, Stefan and Deimling, Andreas von}, title={Sarcoma classification by DNA methylation profiling}, year={2021}, pages={1-10}, language={eng}, issn={2041-1723}, volume={12}, number={Artikel-ID 498}, note={Gesehen am 09.03.2021}, journal={Nature Communications}, doi={10.1038/s41467-020-20603-4}, } @article{UBHD-68616781, author={Koeneke, Emily and Witt, Olaf and Oehme, Ina}, title={HDAC Family members intertwined in the regulation of autophagy}, subtitle={a druggable vulnerability in aggressive tumor entities}, year={2015}, pages={135-168}, language={eng}, issn={2073-4409}, volume={4}, number={2}, note={Gesehen am 14.07.2020}, journal={Cells}, doi={10.3390/cells4020135}, } @article{UBHD-68753849, author={K{\"o}rholz, Katharina and Ridinger, Johannes and Krunic, Damir and Najafi, Sara and Gerloff, Xenia F. and Frese, Karen S. and Meder, Benjamin and Peterziel, Heike and Vega-Rubín-de-Celis, Silvia and Witt, Olaf and Oehme, Ina}, title={Broad-spectrum HDAC inhibitors promote autophagy through FOXO transcription factors in neuroblastoma}, year={2021}, pages={1-18}, language={eng}, issn={2073-4409}, volume={10}, note={Gesehen am 29.06.2021}, journal={Cells}, doi={10.3390/cells10051001}, } @article{UBHD-68465624, author={Kolbinger, Fiona and Ridinger, Johannes and Heimburg, Tino and Bayer, Theresa Yasmin Charlotte and Sippl, Wolfgang and Gunkel, Nikolas and Westermann, Frank and Witt, Olaf and Oehme, Ina}, title={The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines}, year={2018}, pages={2649-2664}, language={eng}, issn={1432-0738}, volume={92}, number={8}, journal={Archives of toxicology}, doi={10.1007/s00204-018-2234-8}, } @article{UBHD-69183509, author={Kolodziejczak, Anna and Guerrini-Rousseau, Lea and Planchon, Julien Masliah and Ecker, Jonas and Selt, Florian and Mynarek, Martin and Obrecht-Sturm, Denise and Sill, Martin and Autry, Robert J. and Stutheit-Zhao, Eric and Hirsch, Steffen and Amouyal, Elsa and Dufour, Christelle and Ayrault, Olivier and Torrejon, Jacob and Waszak, Sebastian Martin and Ramaswamy, Vijay and Pentikainen, Virve and Demir, Haci Ahmet and Clifford, Steven C. and Schwalbe, Ed C. and Massimi, Luca and Snuderl, Matija and Galbraith, Kristyn and Karajannis, Matthias A. and Hill, Katherine and Li, Bryan K. and Walsh, Mike and White, Christine L. and Redmond, Shelagh and Loizos, Loizou and Jakob, Marcus and Kordes, Uwe and Schmid, Irene and Hauer, Julia Christina and Blattmann, Claudia and Filippidou, Maria and Piccolo, Gianluca and Scheurlen, Wolfram and Farrag, Ahmed and Grund, Kerstin and Sutter, Christian and Pietsch, Torsten and Frank, Stephan and Schewe, Denis Martin and Malkin, David and Weyl Ben-Arush, Myriam and Sehested, Astrid and Wong, Tai-Tong and Wu, Kuo-Sheng and Liu, Yen-Lin and Carceller, Fernando and Mueller, Sabine and Stoller, Schuyler and Taylor, Michael D. and Tabori, Uri and Bouffet, Eric and Kool, Marcel and Sahm, Felix and Deimling, Andreas von and Korshunov, Andrey and Hoff, Katja von and Kratz, Christian Peter and Sturm, Dominik and Jones, David T. W. and Rutkowski, Stefan and Tilburg, Cornelis M. van and Witt, Olaf and Bougeard, Gaëlle and Pajtler, Kristian Wilfried and Pfister, Stefan and Bourdeaut, Franck and Milde, Till}, title={Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome}, year={2023}, pages={2273-2286}, language={eng}, issn={1523-5866}, volume={25}, number={12 vom: Dez.}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noad114}, } @article{UBHD-68392383, author={Kopp-Schneider, Annette and Witt, Ruth and Witt, Olaf and Abel, Ulrich}, title={Monitoring futility and efficacy in phase II trials with Bayesian posterior distributions—A calibration approach}, year={2019}, pages={488-502}, language={eng}, issn={1521-4036}, volume={61}, number={3}, note={Gesehen am 23.05.2019 ; First published: 02 September 2018}, journal={Biometrical journal}, doi={10.1002/bimj.201700209}, } @article{UBHD-69054561, author={Korshunov, Andrey and Remke, Marc and Gessi, Marco and Ryzhova, Marina and Hielscher, Thomas and Witt, Hendrik and Tobias, Vivienne and Buccoliero, Anna Maria and Sardi, Iacopo and Gardiman, Marina Paola and Bonnin, Jose and Scheithauer, Bernd and Kulozik, Andreas and Witt, Olaf and Mork, Sverre and Deimling, Andreas von and Wiestler, Otmar D. and Giangaspero, Felice and Rosenblum, Marc and Pietsch, Torsten and Lichter, Peter and Pfister, Stefan}, title={Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes}, year={2010}, pages={253-260}, language={eng}, issn={1432-0533}, volume={120}, number={2}, note={Gesehen am 22.03.2023}, journal={Acta neuropathologica}, doi={10.1007/s00401-010-0688-8}, } @article{UBHD-68134428, author={Korshunov, Andrey and Sturm, Dominik and Capper, David and Meyer, Jochen and Schrimpf, Daniel and Milde, Till and Witt, Olaf and Kulozik, Andreas and Deimling, Andreas von and Pfister, Stefan}, title={Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers}, year={2015}, pages={669-678}, language={eng}, issn={1432-0533}, volume={129}, number={5}, note={Gesehen am 05.07.2017}, journal={Acta neuropathologica}, doi={10.1007/s00401-015-1405-4}, } @article{UBHD-69054605, author={Korshunov, Andrey and Witt, Hendrik and Hielscher, Thomas and Benner, Axel and Remke, Marc and Ryzhova, Marina and Milde, Till and Bender, Sebastian and Wittmann, Andrea and Sch{\"o}ttler, Anna and Kulozik, Andreas and Witt, Olaf and Deimling, Andreas von and Lichter, Peter and Pfister, Stefan}, title={Molecular staging of intracranial ependymoma in children and adults}, year={2010}, pages={3182-3190}, language={eng}, issn={1527-7755}, volume={28}, number={19 vom: Juli}, note={Gesehen am 22.03.2023}, journal={Journal of clinical oncology}, doi={10.1200/JCO.2009.27.3359}, } @article{UBHD-69100908, author={Kuhlen, Michaela and Golas, Mariola Monika and Schaller, Tina and Stadler, Nicole and Maier, Felicitas and Witt, Olaf and Fr{\"u}hwald, Michael}, title={Beyond germline genetic testing - heterozygous pathogenic variants in PMS2 in two children with Osteosarcoma and Ependymoma}, year={2023}, pages={1-6}, language={eng}, issn={1897-4287}, volume={21}, number={Artikel-ID 8}, note={Ver{\"o}ffentlicht: 12. Juni 2023 ; Gesehen am 25.07.2023}, journal={Hereditary cancer in clinical practice}, doi={10.1186/s13053-023-00254-4}, } @article{UBHD-67822519, author={Lacroix, Jeannine and Sturm, Dominik and Bender, Sebastian and Pfister, Stefan and Witt, Olaf and Witt, Hendrik}, title={Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis}, year={2014}, pages={703-716}, language={eng}, issn={1097-0215}, volume={134}, number={3}, note={Gesehen am 27.05.2015}, journal={International journal of cancer}, doi={10.1002/ijc.28386}, } @article{UBHD-69050016, author={Lacroix, Jeannine and Leuchs, Barbara and Li, Junwei and Hristov, Georgi and Deubzer, Hedwig E. and Kulozik, Andreas and Rommelaere, Jean and Schlehofer, J{\"o}rg R. and Witt, Olaf}, title={Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells}, year={2010}, pages={1230-1239}, language={eng}, issn={1097-0215}, volume={127}, number={5}, note={Gesehen am 09.03.2023}, journal={International journal of cancer}, doi={10.1002/ijc.25168}, } @article{UBHD-69050011, author={Lacroix, Jeannine and Witt, Olaf and Schlehofer, J{\"o}rg R. and Rommelaere, Jean}, title={Therapeutic exploitation of oncolytic viruses in pediatric oncology}, year={2010}, pages={1015-1027}, language={eng}, issn={2013-0368}, volume={35}, number={12}, note={Gesehen am 09.03.2023}, journal={Drugs of the future}, doi={10.1358/dof.2010.035.012.1521419}, } @article{UBHD-68955706, author={Ley, Sebastian and Ley-Zaporozhan, Julia and G{\"u}nther, Patrick and Deubzer, Hedwig and Witt, Olaf and Schenk, Jens-Peter}, title={Neuroblastoma imaging}, year={2011}, pages={217-225}, language={eng}, issn={1438-9010}, volume={183}, number={03}, note={Online-Publikation: 17.12.2010 ; Gesehen am 19.08.2022}, journal={R{\"o}Fo}, doi={10.1055/s-0029-1245903}, } @article{UBHD-68620670, author={Liu, Lu and Milde, Till and Haefeli, Walter E. and Witt, Olaf and Burhenne, J{\"u}rgen}, title={Quantification of vorinostat and its main metabolites in plasma and intracellular vorinostat in PBMCs by liquid chromatography coupled to tandem mass spectrometry and its relation to histone deacetylase activity in human blood}, year={2014}, pages={212-221}, language={eng}, issn={1873-376X}, volume={964}, note={Gesehen am 24.07.2020}, journal={Journal of chromatography}, doi={10.1016/j.jchromb.2014.02.014}, } @article{UBHD-68220110, author={Lodrini, Marco and Witt, Olaf and Deubzer, Hedwig}, title={Minichromosome maintenance complex is a critical node in the miR-183 signaling network of MYCN-amplified neuroblastoma cells}, year={2016}, pages={2178-2186}, language={eng}, issn={1535-3907}, volume={15}, number={7}, note={Gesehen am 14.02.2018}, journal={Journal of proteome research}, doi={10.1021/acs.jproteome.6b00134}, } @article{UBHD-68739690, author={Lodrini, Marco and Oehme, Ina and Schr{\"o}der, Christina and Milde, Till and Schier, Marie Catherine and Kopp-Schneider, Annette and Schulte, Johannes H. and Fischer, Matthias and De Preter, Katleen and Pattyn, Filip and Castoldi, Mirco and Muckenthaler, Martina and Kulozik, Andreas and Westermann, Frank and Witt, Olaf and Deubzer, Hedwig}, title={MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma}, year={2013}, pages={6018-6033}, language={eng}, issn={1362-4962}, volume={41}, number={12}, note={Gesehen am 19.05.2021}, journal={Nucleic acids research}, doi={10.1093/nar/gkt346}, } @article{UBHD-68639644, author={Mack, Stephen C. and J{\"a}ger, Natalie and Jones, David T. W. and Sill, Martin and Stark, Sebastian and Şeker-Cin, Huriye and Johann, Pascal-David and Bender, Silke and Milde, Till and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Kool, Marcel and Korbel, Jan Oliver and Eils, Roland and Lichter, Peter and Pfister, Stefan}, title={Epigenomic alterations define lethal CIMP-positive ependymomas of infancy}, year={2014}, pages={445-453}, language={eng}, issn={1476-4687}, volume={506}, number={7489}, note={Gesehen am 23.09.2020}, journal={Nature}, doi={10.1038/nature13108}, } @article{UBHD-69113128, author={Marquardt, Viktoria and Theruvath, Johanna and Pauck, David and Picard, Daniel and Qin, Nan and Bl{\"u}mel, Lena and Maue, Mara and Bartl, Jasmin and Ahmadov, Ulvi and Langini, Maike and Meyer, Frauke-Dorothee and Cole, Allison and Cruz-Cruz, Joselyn and Graef, Claus M. and W{\"o}lfl, Matthias and Milde, Till and Witt, Olaf and Erdreich-Epstein, Anat and Leprivier, Gabriel and Kahlert, Ulf and Stefanski, Anja and St{\"u}hler, Kai and Keir, Stephen T. and Bigner, Darell D. and Hauer, Julia and Beez, Thomas and Knobbe-Thomsen, Christiane B. and Fischer, Ute and Felsberg, J{\"o}rg and Hansen, Finn K. and Vibhakar, Rajeev and Venkatraman, Sujatha and Cheshier, Samuel H. and Reifenberger, Guido and Borkhardt, Arndt and Kurz, Thomas and Remke, Marc and Mitra, Siddhartha}, title={Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation}, year={2023}, pages={1-16}, language={eng}, issn={2051-1426}, volume={11}, note={Online ver{\"o}ffentlicht: 13. Januar 2023 ; Gesehen am 16.08.2023}, journal={Journal for ImmunoTherapy of Cancer}, doi={10.1136/jitc-2022-005871}, } @article{UBHD-68575840, author={Mascelli, Samantha and Nozza, Paolo and Jones, David T. W. and Colin, Carole and Pistorio, Angela and Milanaccio, Claudia and Ravegnani, Marcello and Consales, Alessandro and Witt, Olaf and Morana, Giovanni and Cama, Armando and Capra, Valeria and Biassoni, Roberto and Pfister, Stefan and Figarella-Branger, Dominique and Garrè, Maria Luisa and Raso, Alessandro}, title={TP53 codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma}, year={2016}, pages={47918-47926}, language={eng}, issn={1949-2553}, volume={7}, number={30}, note={Gesehen am 12.05.2020}, journal={OncoTarget}, doi={10.18632/oncotarget.10295}, } @article{UBHD-69143642, author={Milde, Till and Fangusaro, Jason R. and Fisher, Michael J and Hawkins, Cynthia and Rodriguez, Fausto J and Tabori, Uri and Witt, Olaf and Zhu, Yuan and Gutmann, David H}, title={Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation}, year={2023}, pages={1920-1931}, language={eng}, issn={1523-5866}, volume={25}, number={11 vom: Nov.}, note={Gesehen am 16.11.2023 ; Online verf{\"u}gbar: 21. September 2023}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noad125}, } @article{UBHD-68333887, author={Milde, Till and Hielscher, Thomas and Witt, Hendrik and Kool, Marcel and Deubzer, Hedwig and Oehme, Ina and Lodrini, Marco and Benner, Axel and Deimling, Andreas von and Kulozik, Andreas and Pfister, Stefan and Witt, Olaf and Korshunov, Andrey}, title={Nestin expression identifies ependymoma patients with poor outcome}, year={2012}, pages={848-860}, language={eng}, issn={1750-3639}, volume={22}, number={6}, note={Gesehen am 29.11.2018}, journal={Brain pathology}, doi={10.1111/j.1750-3639.2012.00600.x}, } @article{UBHD-68955714, author={Milde, Till and Kleber, Susanne and Korshunov, Andrey and Witt, Hendrik and Hielscher, Thomas and Koch, Philipp and Kopp, Hans-Georg and Jugold, Manfred and Deubzer, Hedwig E. and Oehme, Ina and Lodrini, Marco and Gr{\"o}ne, Hermann-Josef and Benner, Axel and Br{\"u}stle, Oliver and Gilbertson, Richard J. and Deimling, Andreas von and Kulozik, Andreas and Pfister, Stefan and Martín-Villalba, Ana and Witt, Olaf}, title={A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat}, year={2011}, pages={1-14}, language={eng}, issn={1432-0533}, volume={122}, note={Gesehen am 19.08.2022}, journal={Acta neuropathologica}, doi={10.1007/s00401-011-0866-3}, } @article{UBHD-68333891, author={Milde, Till and Lodrini, Marco and Korshunov, Andrey and Kool, Marcel and Pfister, Stefan and Kulozik, Andreas and Witt, Olaf and Deubzer, Hedwig}, title={HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment}, year={2012}, pages={335-348}, language={eng}, issn={1573-7373}, volume={110}, number={3}, note={Gesehen am 29.11.2018}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-012-0978-1}, } @article{UBHD-69069402, author={Milde, Till and Oehme, Ina and Korshunov, Andrey and Kopp-Schneider, Annette and Remke, Marc and Northcott, Paul and Deubzer, Hedwig and Lodrini, Marco and Taylor, Michael D. and Deimling, Andreas von and Pfister, Stefan and Witt, Olaf}, title={HDAC5 and HDAC9 in medulloblastoma}, subtitle={novel markers for risk stratification and role in tumor cell growth}, year={2010}, pages={3240-3252}, language={eng}, issn={1557-3265}, volume={16}, number={12}, note={Gesehen am 26.04.2023}, journal={Clinical cancer research}, doi={10.1158/1078-0432.CCR-10-0395}, } @incollection{UBHD-68585127, author={Milde, Till and Witt, Olaf and Pfister, Stefan and Witt, Hendrik}, title={Ependymoma}, year={2015}, pages={67-75}, language={eng}, isbn={9781493918300}, note={First online: 04 November 2014 ; Gesehen am 08.06.2020}, booktitle={Molecular Pathology of Nervous System Tumors}, editor={Zagzag, David}, doi={10.1007/978-1-4939-1830-0_5}, } @article{UBHD-68792687, author={M{\"u}ller, Michael and R{\"o}sch, Lisa and Najafi, Sara and Gatzweiler, Charlotte and Ridinger, Johannes and Gerloff, Xenia F. and Jones, David T. W. and Baßler, Jochen and Kreth, Sina and Stainczyk, Sabine and Frese, Karen S. and Meder, Benjamin and Westermann, Frank and Milde, Till and Peterziel, Heike and Witt, Olaf and Oehme, Ina}, title={Combining APR-246 and HDAC-inhibitors}, subtitle={a novel targeted treatment option for neuroblastoma}, year={2021}, pages={1-23}, language={eng}, issn={2072-6694}, volume={13}, note={Gesehen am 22.10.2021}, journal={Cancers}, doi={10.3390/cancers13174476}, } @article{UBHD-69295852, author={M{\"u}ller, Sabine and Fangusaro, Jason and Thomas, Arzu Onar and Jacques, Thomas S and Bandopadhayay, Pratiti and de Blank, Peter and Packer, Roger J and Fouladi, Maryam and van Meeteren, Antoinette Schouten and Jones, David T. W. and Perry, Arie and Nakano, Yoshiko and Hargrave, Darren and Riedl, David and Robison, Nathan J and Partanen, Marita and Fisher, Michael J and Witt, Olaf}, title={Consensus framework for conducting phase I/II clinical trials for children, adolescents, and young adults with pediatric low-grade glioma}, subtitle={guidelines established by the International Pediatric Low-Grade Glioma Coalition Clinical Trial Working Group}, year={2024}, pages={407-416}, language={eng}, issn={1523-5866}, volume={26}, number={3 vom: M{\"a}rz}, note={26 December 2023 ; Gesehen am 29.01.2025}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noad227}, } @article{UBHD-69155230, author={Mynarek, Martin and Obrecht-Sturm, Denise and Sill, Martin and Sturm, Dominik and Kloth-Stachnau, Katja and Selt, Florian and Ecker, Jonas and Hoff, Katja von and Juhnke, Bj{\"o}rn-Ole and Goschzik, Tobias and Pietsch, Torsten and Bockmayr, Michael and Kool, Marcel and Deimling, Andreas von and Witt, Olaf and Sch{\"u}ller, Ulrich and Benesch, Martin and Gerber, Nicolas U. and Sahm, Felix and Jones, David T. W. and Korshunov, Andrey and Pfister, Stefan and Rutkowski, Stefan and Milde, Till}, title={Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts}, year={2023}, pages={97-112}, language={eng}, issn={1432-0533}, volume={145}, number={1}, note={Gesehen am 20.12.2023}, journal={Acta neuropathologica}, doi={10.1007/s00401-022-02522-4}, } @article{UBHD-67959025, author={Northcott, Paul A. and Bartholom{\"a}, Cynthia C. and Kalle, Christof von and Scheurlen, Wolfram and Kulozik, Andreas and Deimling, Andreas von and Witt, Olaf and Korshunov, Andrey and Pfister, Stefan}, title={Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma}, year={2014}, pages={428-434}, language={eng}, issn={1476-4687}, volume={511}, number={7510}, note={Gesehen am 21.03.2016}, journal={Nature}, doi={10.1038/nature13379}, } @article{UBHD-68254461, author={Northcott, Paul A. and Paramasivam, Nagarajan and Heinold, Michael and H{\"u}bschmann, Daniel and Herold-Mende, Christel and Witt, Olaf and Milde, Till and Deimling, Andreas von and Capper, David and Brors, Benedikt and Eils, Roland}, title={The whole-genome landscape of medulloblastoma subtypes}, year={2017}, pages={311-317}, language={eng}, issn={1476-4687}, volume={547}, number={7663}, note={Das PDF enth{\"a}lt abweichend von der Seitenangabe 20 Seiten, incl. Anhang ; Gesehen am 24.05.2018}, journal={Nature}, doi={10.1038/nature22973}, } @article{UBHD-67458702, author={Oehme, Ina and Linke, Jan-Peter and B{\"o}ck, Barbara and Milde, Till and Lodrini, Marco and Hartenstein, Bettina and Rettig, Inga Edeltraud and Eckert, Christian and Roth, Wilfried and Kool, Marcel and Kaden, Sylvia and Gr{\"o}ne, Hermann-Josef and Schulte, Johannes Hubertus and Lindner, Sven and Hamacher-Brady, Anne and Brady, Nathan and Deubzer, Hedwig and Witt, Olaf}, title={Histone deacetylase 10 promotes autophagy-mediated cell survival}, year={2013}, pages={E2592-E2601}, language={eng}, issn={0027-8424}, volume={110}, number={28}, journal={Proceedings of the National Academy of Sciences of the United States of America}, } @article{UBHD-68805961, author={Oehme, Ina and Linke, Jan-Peter and B{\"o}ck, Barbara and Milde, Till and Lodrini, Marco and Hartenstein, Bettina and Rettig, Inga Edeltraud and Eckert, Christian and Roth, Wilfried and Kool, Marcel and Kaden, Sylvia and Gr{\"o}ne, Hermann-Josef and Schulte, Johannes Hubertus and Lindner, Sven and Hamacher-Brady, Anne and Brady, Nathan and Deubzer, Hedwig and Witt, Olaf}, title={Histone deacetylase 10 promotes autophagy-mediated cell survival}, year={2013}, pages={E2592-E2601}, language={eng}, issn={1091-6490}, volume={110}, number={28}, note={Gesehen am 29.11.2021}, journal={Proceedings of the National Academy of Sciences of the United States of America}, doi={10.1073/pnas.1300113110}, } @article{UBHD-68805986, author={Oehme, Ina and Lodrini, Marco and Brady, Nathan and Witt, Olaf}, title={Histone deacetylase 10-promoted autophagy as a druggable point of interference to improve the treatment response of advanced neuroblastomas}, year={2013}, pages={2163-2165}, language={eng}, issn={1554-8635}, volume={9}, number={12}, note={Gesehen am 29.11.2021}, journal={Autophagy}, doi={10.4161/auto.26450}, } @article{UBHD-69280318, author={O’Hare, Patricia and Cooney, Tabitha and de Blank, Peter and Gutmann, David H and Kieran, Mark and Milde, Till and Fangusaro, Jason and Fisher, Michael and Avula, Shivaram and Packer, Roger and Fukuoka, Kohei and Mankad, Kshitij and M{\"u}ller, Sabine and Waanders, Angela J and Opocher, Enrico and Bouffet, Eric and Raabe, Eric and Werle, Natacha Entz and Azizi, Amedeo A and Robison, Nathan J and Hernáiz Driever, Pablo and Russo, Mark and Schouten, Netteke and Tilburg, Cornelis M. van and Sehested, Astrid and Grill, Jacques and Bandopadhayay, Pratiti and Kilday, John-Paul and Witt, Olaf and Ashley, David M and Ertl-Wagner, Birgit Betina and Tabori, Uri and Hargrave, Darren R.}, title={Resistance, rebound, and recurrence regrowth patterns in pediatric low-grade glioma treated by MAPK inhibition}, subtitle={a modified Delphi approach to build international consensus-based definitions : international pediatric low-grade glioma coalition}, year={2024}, pages={1357-1366}, language={eng}, issn={1523-5866}, volume={26}, number={8 vom: Aug.}, note={Ver{\"o}ffentlicht: 14 May 2024 ; Gesehen am 04.12.2024}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noae074}, } @article{UBHD-69344141, author={Okonechnikov, Konstantin and Joshi, Piyush and K{\"o}rber, Verena and Rademacher, Anne and Bortolomeazzi, Michele and Mallm, Jan-Philipp and Vaillant, Jan and da Silva, Patricia Benites Goncalves and Statz, Britta and Sepp, Mari and Sarropoulos, Ioannis and Yamada, Tetsuya and Wittmann, Andrea and Schramm, Kathrin and Blattner-Johnson, Mirjam and Fiesel, Petra and Jones, Barbara Christine and J{\"a}ger, Natalie and Milde, Till and Pajtler, Kristian Wilfried and Tilburg, Cornelis M. van and Witt, Olaf and Bochennek, Konrad and Weber, Katharina Johanna and Nonnenmacher, Lisa and Reimann, Christian and Ghasemi, David R. and Sch{\"u}ller, Ulrich and Mynarek, Martin and Rutkowski, Stefan and Jones, David T. W. and Korshunov, Andrey and Rippe, Karsten and Westermann, Frank and Thongjuea, Supat and H{\"o}fer, Thomas and Kaessmann, Henrik and Kutscher, Lena and Pfister, Stefan}, title={Oncogene aberrations drive medulloblastoma progression, not initiation}, year={2025}, pages={1062-1072}, language={eng}, issn={1476-4687}, volume={642}, number={8069}, note={Gesehen am 13.05.2025}, journal={Nature}, doi={10.1038/s41586-025-08973-5}, } @article{UBHD-68248916, author={Packer, Roger J. and Pfister, Stefan and Witt, Olaf}, title={Pediatric low-grade gliomas}, subtitle={implications of the biologic era}, year={2017}, pages={750-761}, language={eng}, issn={1523-5866}, volume={19}, number={6}, note={Gesehen am 03.05.2018}, journal={Neuro-Oncology}, doi={10.1093/neuonc/now209}, } @article{UBHD-68145535, author={Pajtler, Kristian Wilfried and Witt, Hendrik and Capper, David and Schweizer, Leonille and Kulozik, Andreas and Witt, Olaf and Deimling, Andreas von and Lichter, Peter and Kool, Marcel and Pfister, Stefan}, title={Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups}, year={2015}, pages={728-743}, language={eng}, issn={1878-3686}, volume={27}, number={5}, note={Gesehen am 02.08.2017}, journal={Cancer cell}, doi={10.1016/j.ccell.2015.04.002}, } @article{UBHD-69151490, author={Pant, Shubham and Schuler, Martin and Iyer, Gopa and Witt, Olaf and Doi, Toshihiko and Qin, Shukui and Tabernero, Josep and Reardon, David A and Massard, Christophe and Minchom, Anna and Lugowska, Iwona and Carranza, Omar and Arnold, Dirk and Gutierrez, Martin and Winter, Helen and Stuyckens, Kim and Crow, Lauren and Najmi, Saltanat and Hammond, Constance and Thomas, Shibu and Santiago-Walker, Ademi and Triantos, Spyros and Sweiti, Hussein and Loriot, Yohann}, title={Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR)}, subtitle={an international, single-arm, phase 2 study}, year={2023}, pages={925-935}, language={eng}, issn={1474-5488}, volume={24}, number={8 vom: Aug.}, note={Online verf{\"u}gbar: 1. August 2023 ; Gesehen am 11.12.2023}, journal={The lancet}, doi={10.1016/S1470-2045(23)00275-9}, } @article{UBHD-69007662, author={Pearson, Andrew D. J. and Allen, Carl and Fangusaro, Jason and Hutter, Caroline and Witt, Olaf and Weiner, Susan and Reaman, Gregory and Russo, Mark and Bandopadhayay, Pratiti and Ahsan, Sama and Barone, Amy and Barry, Elly and de Rojas, Teresa and Fisher, Michael and Fox, Elizabeth and Bender, Julia Glade and Gore, Lia and Hargrave, Darren and Hawkins, Doug and Kreider, Brent and Langseth, Abraham J. and Lesa, Giovanni and Ligas, Franca and Marotti, Marcelo and Marshall, Lynley V. and Nasri, Kahina and Norga, Koen and Nysom, Karsten and Pappo, Alberto and Rossato, Gianluca and Scobie, Nicole and Smith, Malcolm and Stieglitz, Elliot and Weigel, Brenda and Weinstein, Amy and Viana, Ruth and Karres, Dominik and Vassal, Gilles}, title={Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors}, subtitle={ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration}, year={2022}, pages={120-142}, language={eng}, issn={1879-0852}, volume={177}, note={Dateiversion vom 3. November 2022 ; Gesehen am 18.01.2023}, journal={European journal of cancer}, doi={10.1016/j.ejca.2022.09.036}, } @article{UBHD-69006827, author={Peterziel, Heike and Jamaladdin, Nora and ElHarouni, Dina and Gerloff, Xenia F. and Herter, Sonja and Fiesel, Petra and Berker, Yannick and Blattner-Johnson, Mirjam and Schramm, Kathrin and Jones, Barbara Christine and Reuss, David and Turunen, Laura and Friedenauer, Aileen and Holland-Letz, Tim and Sill, Martin and Weiser, Lena and Previti, A. Christopher and Balasubramanian, Gnanaprakash and Gerber, Nicolas U. and Gojo, Johannes and Hutter, Caroline and Øra, Ingrid and Lohi, Olli and Kattamis, Antonis and de Wilde, Bram and Westermann, Frank and Tippelt, Stephan and Graf, Norbert and Nathrath, Michaela and Sparber-Sauer, Monika and Sehested, Astrid and Kramm, Christof M. and Dirksen, Uta and Kallioniemi, Olli and Pfister, Stefan and Tilburg, Cornelis M. van and Jones, David T. W. and Saarela, Jani and Pieti{\"a}inen, Vilja and J{\"a}ger, Natalie and Schlesner, Matthias and Kopp-Schneider, Annette and Oppermann, Sina and Milde, Till and Witt, Olaf and Oehme, Ina}, title={Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM}, year={2022}, pages={1-17}, language={eng}, issn={2397-768X}, volume={6}, number={Artikel-ID 94}, note={Gesehen am 17.01.2023}, journal={npj precision oncology}, doi={10.1038/s41698-022-00335-y}, } @article{UBHD-68741539, author={Pfaff, Elke and Adam de Beaumais, Tiphaine and Marchais, Antonin and Tilburg, Cornelis M. van and Blattner-Johnson, Mirjam and Dirksen, Uta and Øra, Ingrid and Geoerger, Birgit and Schleiermacher, Gudrun and Pfister, Stefan and Witt, Olaf and Jones, David T. W. and Vassal, Gilles}, title={NTRK alterations in pediatric high-risk malignancies identified through European clinical sequencing programs constitute promising drug targets}, year={2021}, pages={450-454}, language={eng}, issn={2473-4284}, volume={5}, note={Gesehen am 27.05.2021}, journal={JCO precision oncology}, doi={10.1200/PO.20.00417}, } @article{UBHD-68428360, author={Pfaff, Elke and El Damaty, Ahmed and Jones, Barbara Christine and Stark, Sebastian and Witt, Hendrik and Pajtler, Kristian Wilfried and Tilburg, Cornelis M. van and Milde, Till and Jakobs, Martin and D{\"u}rken, Matthias and Karremann, Michael and Herold-Mende, Christel and Kiening, Karl and Lichter, Peter and Pfister, Stefan and Jones, David T. W. and B{\"a}chli, Heidi and Witt, Olaf}, title={Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine}, subtitle={the INFORM study experience}, year={2019}, pages={27-35}, language={eng}, issn={1879-0852}, volume={114}, note={Gesehen am 09.09.2019}, journal={European journal of cancer}, doi={10.1016/j.ejca.2019.03.019}, } @article{UBHD-68992245, author={Pfaff, Elke and Remke, Marc and Sturm, Dominik and Benner, Axel and Witt, Hendrik and Milde, Till and von Bueren, André O. and Jorch, Norbert and Graf, Norbert and Kulozik, Andreas and Witt, Olaf and Scheurlen, Wolfram and Deimling, Andreas von and Rutkowski, Stefan and Taylor, Michael D. and Tabori, Uri and Lichter, Peter and Korshunov, Andrey and Pfister, Stefan}, title={Reply to J.C. Lindsey et al}, year={2011}, pages={e348-e349}, language={eng}, issn={1527-7755}, volume={29}, number={12}, note={Gesehen am 02.12.2022}, journal={Journal of clinical oncology}, doi={10.1200/JCO.2010.34.1545}, } @article{UBHD-69070098, author={Pfaff, Elke and Remke, Marc and Sturm, Dominik and Benner, Axel and Witt, Hendrik and Milde, Till and von Bueren, André O. and Wittmann, Andrea and Sch{\"o}ttler, Anna and Jorch, Norbert and Graf, Norbert and Kulozik, Andreas and Witt, Olaf and Scheurlen, Wolfram and Deimling, Andreas von and Rutkowski, Stefan and Taylor, Michael D. and Tabori, Uri and Lichter, Peter and Korshunov, Andrey and Pfister, Stefan}, title={TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma}, year={2010}, pages={5188-5196}, language={eng}, issn={1527-7755}, volume={28}, number={35 vom: Nov.}, note={Gesehen am 28.04.2023}, journal={Journal of clinical oncology}, doi={10.1200/JCO.2010.31.1670}, } @article{UBHD-69150189, author={Rahmanzade, Ramin and Pfaff, Elke and Banan, Rouzbeh and Sievers, Philipp and Suwala, Abigail Kora and Hinz, Felix and Bogumil, Henri and Cherkezov, Asan and Kaan, Aras Fuat and Schrimpf, Daniel and Friedel, Dennis and G{\"o}bel, Kirsten and Keller, Felix and Saenz-Sardà, Xavier and Lossos, Alexander and Sill, Martin and Witt, Olaf and Sakowitz, Oliver and Korshunov, Andrey and Reuss, David and Etminan, Nima and Unterberg, Andreas and Ratliff, Miriam and Herold-Mende, Christel and Wick, Wolfgang and Pfister, Stefan and Deimling, Andreas von and Jones, David T. W. and Sahm, Felix}, title={Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics}, year={2023}, pages={853-856}, language={eng}, issn={1432-0533}, volume={146}, number={6}, note={Online ver{\"o}ffentlicht: 30. September 2023 ; Gesehen am 06.12.2023}, journal={Acta neuropathologica}, doi={10.1007/s00401-023-02638-1}, } @article{UBHD-68243553, author={Rausch, Tobias and Remke, Marc and Wang, Qi and Witt, Hendrik and Bender, Sebastian and Pleier, Sabrina Valesca and Beck, Christian and Deimling, Andreas von and Eils, Roland and Kulozik, Andreas and Witt, Olaf and Korshunov, Andrey and Pfister, Stefan}, title={Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations}, year={2012}, pages={59-71}, language={eng}, issn={1097-4172}, volume={148}, number={1}, note={Gesehen am 17.04.2018}, journal={Cell}, doi={10.1016/j.cell.2011.12.013}, } @article{UBHD-68638234, author={Rettig, Inga Edeltraud and Koeneke, Emily and Trippel, Franziska and Mueller, Wolf C. and Burhenne, J{\"u}rgen and Kopp-Schneider, Annette and Fabian, Johannes and Schober, Andreas and Fernekorn, Uta and Deimling, Andreas von and Deubzer, Hedwig and Milde, Till and Witt, Olaf and Oehme, Ina}, title={Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation}, year={2015}, pages={14 S.}, language={eng}, issn={2041-4889}, volume={Bd. 6}, journal={Cell death & disease}, doi={10.1038/cddis.2015.24}, } @article{UBHD-68488050, author={Ridinger, Johannes and Gunkel, Nikolas and Peterziel, Heike and Schmezer, Peter and Hamacher-Brady, Anne and Witt, Olaf and Oehme, Ina}, title={Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance}, year={2018}, pages={17 S.}, language={eng}, issn={2045-2322}, volume={8(2018) Artikel-Nummer 10039}, number={17 Seiten}, note={Gesehen am 12.02.2020}, journal={Scientific reports}, doi={10.1038/s41598-018-28265-5}, } @article{UBHD-68964867, author={Rieken, Stefan and Mohr, Angela and Habermehl, Daniel and Welzel, Thomas and Lindel, Katja and Witt, Olaf and Kulozik, Andreas and Wick, Wolfgang and Debus, J{\"u}rgen and Combs, Stephanie E.}, title={Outcome and prognostic factors of radiation therapy for medulloblastoma}, year={2011}, pages={e7-e13}, language={eng}, issn={1879-355X}, volume={81}, number={3}, note={Gesehen am 16.09.2022}, journal={International journal of radiation oncology, biology, physics}, doi={10.1016/j.ijrobp.2010.12.042}, } @article{UBHD-69077303, author={Rieken, Stefan and Gaiser, Timo and Mohr, Angela and Welzel, Thomas and Witt, Olaf and Kulozik, Andreas and Wick, Wolfgang and Debus, J{\"u}rgen and Combs, Stephanie}, title={Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept}, year={2010}, pages={1-10}, language={eng}, issn={1471-2407}, volume={10}, number={Artikel-ID 450}, note={Gesehen am 19.05.2023}, journal={BMC cancer}, doi={10.1186/1471-2407-10-450}, } @article{UBHD-68274796, author={Ripperger, Tim and Kulozik, Andreas and Pajtler, Kristian Wilfried and Witt, Olaf and Pfister, Stefan}, title={Childhood cancer predisposition syndromes}, subtitle={a concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology}, year={2017}, pages={1017-1037}, language={eng}, issn={1552-4833}, volume={173}, number={4}, note={First published: 07 February 2017 ; Gesehen am 27.06.2017}, journal={American journal of medical genetics}, doi={10.1002/ajmg.a.38142}, } @article{UBHD-69085831, author={Rokes, Christopher Alan and Remke, Mark and Guha-Thakurta, Nandita and Witt, Olaf and Korshunov, Andrey and Pfister, Stephan and Wolff, Johannes E.}, title={Sorafenib plus valproic acid for infant spinal glioblastoma}, year={2010}, pages={511-514}, language={eng}, issn={1536-3678}, volume={32}, number={6 vom: Aug.}, note={Gesehen am 15.06.2023}, journal={Journal of pediatric hematology - oncology}, doi={10.1097/MPH.0b013e3181d74702}, } @article{UBHD-68431902, author={Saffari, Afshin and Br{\"o}sse, Ines and Tilburg, Cornelis M. van and Hoffmann, Georg F. and K{\"o}lker, Stefan and Witt, Olaf and Milde, Till and Ziegler, Andreas and Syrbe, Steffen}, title={Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age - a multicenter retrospective study}, year={2019}, pages={1-13}, language={eng}, issn={1750-1172}, volume={14}, number={Artikel-ID 96}, note={Gesehen am 20.09.2019}, journal={Orphanet journal of rare diseases}, doi={10.1186/s13023-019-1077-6}, url={https://doi.org/10.1186/s13023-019-1077-6}, library={UB}, } @book{UBHD-68412598, author={Saffari, Afshin and Br{\"o}sse, Ines and Tilburg, Cornelis M. van and Hoffmann, Georg F. and K{\"o}lker, Stefan and Witt, Olaf and Milde, Till and Ziegler, Andreas and Syrbe, Steffen}, title={Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age}, subtitle={a multicenter retrospective study}, publisher={BioMed Central}, address={London}, year={2019}, pages={1 Online-Ressource}, language={eng}, note={In: Orphanet journal of rare diseases, 14 (2019), Nr. 96. pp. 1-13. ISSN 1750-1172}, url={https://nbn-resolving.org/urn:nbn:de:bsz:16-heidok-264004}, library={UB}, } @article{UBHD-68426790, author={Sahm, Felix and Schrimpf, Daniel and Reinhardt, Annekathrin and Reuss, David and Capper, David and K{\"o}lsche, Christian and Korshunov, Andrey and Wiestler, Benedikt and Milde, Till and Selt, Florian and Sturm, Dominik and Wick, Antje and Witt, Olaf and Platten, Michael and Herold-Mende, Christel and Unterberg, Andreas and Pfister, Stefan and Wick, Wolfgang and Deimling, Andreas von}, editor={Jungk, Christine}, title={Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets}, year={2016}, pages={903-910}, language={eng}, issn={1432-0533}, volume={131}, number={6}, note={Published online: 15 December 2015 ; Gesehen am 04.09.2019}, journal={Acta neuropathologica}, doi={10.1007/s00401-015-1519-8}, } @article{UBHD-68225740, author={Scheer, Carina and Witt, Olaf}, title={Hematologic response to vorinostat treatment in relapsed myeloid leukemia of Down syndrome}, year={2016}, pages={1677-1679}, language={eng}, issn={1545-5017}, volume={63}, number={9}, note={Gesehen am 01.03.2018}, journal={Pediatric blood & cancer}, doi={10.1002/pbc.26062}, } @article{UBHD-68253603, author={Schmidt, Christin and Selt, Florian and Herold-Mende, Christel and Witt, Olaf and Milde, Till and Pfister, Stefan and Korshunov, Andrey and Kool, Marcel}, title={Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients}, year={2017}, pages={1607-1617}, language={eng}, issn={1523-5866}, volume={19}, number={12}, note={Gesehen am 22.05.2018}, journal={Neuro-Oncology}, doi={10.1093/neuonc/nox093}, } @article{UBHD-67661408, author={Schmidt, René and Witt, Olaf}, title={Adaptive designs with arbitrary dependence structure}, year={2014}, pages={86-106}, language={eng}, issn={1521-4036}, volume={56}, number={1}, note={Gesehen am 15.08.2014}, journal={Biometrical journal}, doi={10.1002/bimj.201200234}, } @article{UBHD-69098316, author={Schmidt, Stephanie and Kovacs, Edina and Usta, Diren and Behnisch, Rouven and Sahm, Felix and Haux-Nettesheim, Daniel and Witt, Olaf and Milde, Till and Unterberg, Andreas and El Damaty, Ahmed}, title={Cerebellar mutism syndrome ater posterior fossa tumor surgery in children}, subtitle={a retrospective single-center study}, year={2023}, pages={e622-e628}, language={eng}, issn={1878-8769}, volume={173(2023) vom: Mai}, note={Online ver{\"o}ffentlicht: 4. M{\"a}rz 2023 ; Gesehen am 17.07.2023}, journal={World neurosurgery}, doi={10.1016/j.wneu.2023.02.117}, } @article{UBHD-68251886, author={Schwartzentruber, Jeremy and Korshunov, Andrey and Jones, David T. W. and Sturm, Dominik and T{\"o}njes, Martje and Hovestadt, Volker and Kool, Marcel and Korbel, Jan Oliver and Kulozik, Andreas and Zapatka, Marc and Deimling, Andreas von and Witt, Hendrik and Milde, Till and Witt, Olaf and Lichter, Peter and Plass, Christoph and Pfister, Stefan}, title={Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma}, year={2012}, pages={226-231}, language={eng}, issn={1476-4687}, volume={482}, number={7384}, note={Gesehen am 14.05.2018}, journal={Nature}, doi={10.1038/nature10833}, } @article{UBHD-69293300, author={Seiboldt, Till and Zeiser, Constantia and Nguyen, Duy and Çeliky{\"u}rekli, Simay and Herter, Sonja and Najafi, Sara and Stroh-Dege, Alexandra and Meulenbroeks, Chris and Mack, Norman and Salem-Altintas, Rabia and Westermann, Frank and Schlesner, Matthias and Milde, Till and Kool, Marcel and Holland-Letz, Tim and Vogler, Meike and Peterziel, Heike and Witt, Olaf and Oehme, Ina}, title={Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours}, year={2024}, pages={763-777}, language={eng}, issn={1532-1827}, volume={131}, number={4}, note={Gesehen am 22.01.2025}, journal={British journal of cancer}, doi={10.1038/s41416-024-02740-5}, } @article{UBHD-68280852, author={Selt, Florian and Buhl, Juliane and Sahm, Felix and Capper, David and Korshunov, Andrey and Usta, Diren and Brabetz, Sebastian and Ridinger, Johannes and Ecker, Jonas and Oehme, Ina and B{\"a}chli, Heidi and Deimling, Andreas von and Pfister, Stefan and Jones, David T. W. and Witt, Olaf and Milde, Till}, title={Establishment and application of a novel patient-derived KIAA1549}, subtitle={BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing}, year={2017}, pages={11460-11479}, language={eng}, issn={1949-2553}, volume={8}, number={7}, note={Published online: December 17, 2016 ; Gesehen am 04.07.2018}, journal={OncoTarget}, doi={10.18632/oncotarget.14004}, } @article{UBHD-69163993, author={Selt, Florian and El Damaty, Ahmed and Schuhmann, Martin U. and Sigaud, Romain and Ecker, Jonas and Sievers, Philipp and Kocher, Daniela and Herold-Mende, Christel and Oehme, Ina and Deimling, Andreas von and Pfister, Stefan and Sahm, Felix and Jones, David T. W. and Witt, Olaf and Milde, Till}, title={Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T}, subtitle={evaluation of a modeling workflow}, year={2023}, pages={467-478}, language={eng}, issn={1573-7373}, volume={165}, number={3 vom: Nov.}, note={Gesehen am 22.01.2024}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-023-04500-6}, } @article{UBHD-68213910, author={Selt, Florian and Korshunov, Andrey and Capper, David and Witt, Hendrik and Tilburg, Cornelis M. van and Witt, Ruth and Sahm, Felix and Reuss, David and K{\"o}lsche, Christian and Deimling, Andreas von and Kulozik, Andreas and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Pediatric targeted therapy}, subtitle={clinical feasibility of personalized diagnostics in children with relapsed and progressive tumors}, year={2016}, pages={506-516}, language={eng}, issn={1750-3639}, volume={26}, number={4}, note={Gesehen am 26.01.2018}, journal={Brain pathology}, doi={10.1111/bpa.12326}, } @article{UBHD-69307525, author={Selt, Florian and Tilburg, Cornelis M. van and Bison, Brigitte and Sievers, Philipp and Harting, Inga and Ecker, Jonas and Pajtler, Kristian W. and Sahm, Felix and Bahr, Annabelle and Simon, Michèle and Jones, David T. W. and Well, Lennart and Mautner, Victor-Felix and Capper, David and Hernáiz Driever, Pablo and Gnekow, Astrid and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Response to trametinib treatment in progressive pediatric low-grade glioma patients}, year={2020}, pages={499-510}, language={eng}, issn={1573-7373}, volume={149(2020) vom: Sept.}, note={Gesehen am 24.02.2025}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-020-03640-3}, } @article{UBHD-68452719, author={Shen, Jing and Najafi, Sara and St{\"a}ble, Sina and Fabian, Johannes and Koeneke, Emily and Kolbinger, Fiona R. and Wrobel, Jagoda and Meder, Benjamin and Distel, Martin and Heimburg, Tino and Sippl, Wolfgang and Jung, Manfred and Peterziel, Heike and Kranz, Dominique and Boutros, Michael and Westermann, Frank and Witt, Olaf and Oehme, Ina}, title={A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment}, year={2018}, pages={2053-2070}, language={eng}, issn={1476-5403}, volume={25}, journal={Cell death and differentiation}, doi={10.1038/s41418-018-0080-0}, } @article{UBHD-69106612, author={Sievers, Philipp and Stichel, Damian and Sill, Martin and Schrimpf, Daniel and Sturm, Dominik and Selt, Florian and Ecker, Jonas and Kazdal, Daniel and Miele, Evelina and Kranendonk, Mariëtte E. G. and Tops, Bastiaan B. J. and Kohlhof-Meinecke, Patricia and Beschorner, Rudi and Kramm, Christof M. and Hasselblatt, Martin and Reifenberger, Guido and Capper, David and Wesseling, Pieter and Stenzinger, Albrecht and Milde, Till and Korshunov, Andrey and Witt, Olaf and Pfister, Stefan and Wick, Wolfgang and Deimling, Andreas von and Jones, David T. W. and Sahm, Felix}, title={GOPC}, subtitle={ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types}, year={2021}, pages={1065-1069}, language={eng}, issn={1432-0533}, volume={142}, number={6}, note={Gesehen am 04.08.2023}, journal={Acta neuropathologica}, doi={10.1007/s00401-021-02369-1}, url={https://doi.org/10.1007/s00401-021-02369-1}, library={UB}, } @article{UBHD-68760358, author={Sievers, Philipp and Sill, Martin and Schrimpf, Daniel and Stichel, Damian and Reuss, David and Sturm, Dominik and Hench, J{\"u}rgen and Frank, Stephan and Krskova, Lenka and Vicha, Ales and Zapotocky, Michal and Bison, Brigitte and Castel, David and Grill, Jacques and Debily, Marie-Anne and Harter, Patrick N and Snuderl, Matija and Kramm, Christof M and Reifenberger, Guido and Korshunov, Andrey and Jabado, Nada and Wesseling, Pieter and Wick, Wolfgang and Solomon, David A and Perry, Arie and Jacques, Thomas S and Jones, Chris and Witt, Olaf and Pfister, Stefan and Deimling, Andreas von and Jones, David T. W. and Sahm, Felix}, title={A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR}, year={2021}, pages={34-43}, language={eng}, issn={1523-5866}, volume={23}, number={1}, note={Advance access date 1 November 2020 ; Gesehen am 15.07.2021}, journal={Neuro-Oncology}, doi={10.1093/neuonc/noaa251}, } @article{UBHD-69154744, author={Sigaud, Romain and Albert, Thomas K. and Hess, Caroline and Hielscher, Thomas and Winkler, Nadine and Kocher, Daniela and Walter, Carolin and M{\"u}nter, Daniel and Selt, Florian and Usta, Diren and Ecker, Jonas and Brentrup, Angela and Hasselblatt, Martin and Thomas, Christian and Varghese, Julian and Capper, David and Thomale, Ulrich W. and Hernáiz Driever, Pablo and Simon, Michèle and Horn, Svea and Herz, Nina Annika and Koch, Arend and Sahm, Felix and Hamelmann, Stefan and Faria-Andrade, Augusto and Jabado, Nada and Schuhmann, Martin U. and Schouten-van Meeteren, Antoinette Y. N. and Hoving, Eelco and Brummer, Tilman and Tilburg, Cornelis M. van and Pfister, Stefan and Witt, Olaf and Jones, David T. W. and Kerl, Kornelius and Milde, Till}, title={MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas}, year={2023}, pages={1-21}, language={eng}, issn={2041-1723}, volume={14}, number={Artikel-ID 4533}, note={Gesehen am 19.12.2023}, journal={Nature Communications}, doi={10.1038/s41467-023-40235-8}, } @article{UBHD-68704401, author={Stainczyk, Sabine and Sieverling, Lina and Nadler-Holly, Michal and Ziehm, Matthias and Toprak, Umut H. and Herrmann, Carl and Ishaque, Naveed and Okonechnikov, Konstantin and Gartlgruber, Moritz and Park, Young-Gyu and Wecht, Elisa Maria and Savelyeva, Larissa and Henrich, Kai-Oliver and Rosswog, Carolina and Fischer, Matthias and Hero, Barbara and Jones, David T. W. and Pfaff, Elke and Witt, Olaf and Pfister, Stefan and Volckmann, Richard and Koster, Jan and Kiesel, Katharina and Rippe, Karsten and Taschner-Mandl, Sabine and Ambros, Peter and Brors, Benedikt and Selbach, Matthias and Feuerbach, Lars and Westermann, Frank}, title={Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome}, year={2021}, pages={1-18}, language={eng}, issn={2041-1723}, volume={12}, number={Artikel-ID 1269}, note={Gesehen am 26.02.2021}, journal={Nature Communications}, doi={10.1038/s41467-021-21247-8}, } @article{UBHD-68460169, author={Stichel, Damian and Schrimpf, Daniel and Casalini, Belén and Wefers, Annika K. and Sievers, Philipp and K{\"o}lsche, Christian and Reuss, David and Reinhardt, Annekathrin and Fernández Klett, Francisco and Keßler, Tobias and Sturm, Dominik and Ecker, Jonas and Milde, Till and Herold-Mende, Christel and Witt, Olaf and Pfister, Stefan and Wick, Wolfgang and Jones, David T. W. and Deimling, Andreas von and Sahm, Felix}, title={Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions}, year={2019}, pages={827-835}, language={eng}, issn={1432-0533}, volume={138}, number={5}, note={Gesehen am 26.11.2019}, journal={Acta neuropathologica}, doi={10.1007/s00401-019-02039-3}, } @article{UBHD-67494942, author={Sturm, Dominik and Witt, Hendrik and Jones, David T. W. and Konermann, Carolin and Pfaff, Elke and Bender, Sebastian and Kool, Marcel and Becker, Natalia and Hielscher, Thomas and Radlwimmer, Bernhard and Komorowski, Gregor von and D{\"u}rken, Matthias and Kulozik, Andreas and Deimling, Andreas von and Herold-Mende, Christel and Unterberg, Andreas and Wiestler, Benedikt and Wick, Wolfgang and Milde, Till and Witt, Olaf and Korshunov, Andrey and Lichter, Peter and Pfister, Stefan}, title={Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma}, year={2012}, pages={425-437}, language={eng}, issn={1878-3686}, volume={22}, number={4}, note={Gesehen am 31.10.2018}, journal={Cancer cell}, doi={10.1016/j.ccr.2012.08.024}, } @article{UBHD-69053691, author={Sturm, Dominik and Capper, David and Andreiuolo, Felipe and Gessi, Marco and K{\"o}lsche, Christian and Reinhardt, Annekathrin and Sievers, Philipp and Wefers, Annika K. and Ebrahimi, Azadeh and Suwala, Abigail Kora and Gielen, Gerrit H. and Sill, Martin and Schrimpf, Daniel and Stichel, Damian and Hovestadt, Volker and Daenekas, Bjarne and Rode, Agata and Hamelmann, Stefan and Previti, A. Christopher and J{\"a}ger, Natalie and Buchhalter, Ivo and Blattner-Johnson, Mirjam and Jones, Barbara Christine and Warmuth-Metz, Monika and Bison, Brigitte and Grund, Kerstin and Sutter, Christian and Hirsch, Steffen and Dikow, Nicola and Witt, Olaf and Deimling, Andreas von and M{\"u}ller, Hermann L. and Pietsch, Torsten and Sahm, Felix and Pfister, Stefan and Jones, David T. W.}, title={Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology}, year={2023}, pages={917-926}, language={eng}, issn={1546-170X}, volume={29}, number={4}, note={Gesehen am 21.03.2023}, journal={Nature medicine}, doi={10.1038/s41591-023-02255-1}, } @article{UBHD-68593491, author={Tallen, Gesche and Witt, Olaf}, title={Strategies to improve the quality of survival for childhood brain tumour survivors}, year={2015}, pages={619-639}, language={eng}, issn={1532-2130}, volume={19}, number={6}, note={Gesehen am 29.06.2020}, journal={European journal of paediatric neurology}, doi={10.1016/j.ejpn.2015.07.011}, } @article{UBHD-68246671, author={Thole, Theresa Maria and Witt, Olaf and Deubzer, Hedwig}, title={Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival}, year={2017}, language={eng}, issn={2041-4889}, volume={8(2017) Artikel-Nummer e2635}, number={11 Seiten}, note={Gesehen am 25.04.2018}, journal={Cell death & disease}, doi={10.1038/cddis.2017.49}, } @article{UBHD-69007803, author={Thomale, Ulrich-Wilhelm and Gnekow, Astrid K. and Kandels, Daniela and Bison, Brigitte and Driever, Pablo Hernáiz and Witt, Olaf and Pietsch, Torsten and Koch, Arend and Capper, David and Kortmann, Rolf-Dieter and Timmermann, Beate and Harrabi, Semi B. and Simon, Michèle and El Damaty, Ahmed and Krauss, Juergen and Schuhmann, Martin U. and Aigner, Annette}, title={Long-term follow-up of surgical intervention pattern in pediatric low-grade gliomas}, subtitle={report from the German SIOP-LGG 2004 cohort}, year={2022}, pages={316-329}, language={eng}, issn={1933-0715}, volume={30}, number={3 vom: Sept.}, note={Publication date: 22 July 2022 ; Gesehen am 18.01.23}, journal={Journal of neurosurgery}, doi={10.3171/2022.6.PEDS22108}, } @article{UBHD-68747001, author={Tilburg, Cornelis M. van and Witt, Ruth and Heiss, Melanie and Pajtler, Kristian Wilfried and Plass, Christoph and Poschke, Isabel and Platten, Michael and Harting, Inga and Sedlaczek, Oliver and Freitag, Angelika and Meyrath, David and Taylor, Lenka A. and Balasubramanian, Gnana Prakash and J{\"a}ger, Natalie and Pfaff, Elke and Jones, Barbara Christine and Milde, Till and Pfister, Stefan and Jones, David T. W. and Kopp-Schneider, Annette and Witt, Olaf}, title={INFORM2 NivEnt}, subtitle={the first trial of the INFORM2 biomarker driven phase I/II trial series : the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies}, year={2020}, pages={1-12}, language={eng}, issn={1471-2407}, volume={20(2020) vom: Juni}, number={Artikel-ID 523}, note={Gesehen am 10.06.2021}, journal={BMC cancer}, doi={10.1186/s12885-020-07008-8}, } @article{UBHD-69228579, author={Tilburg, Cornelis M. van and Kilburn, Lindsay B. and Perreault, Sébastien and Schmidt, Rene and Azizi, Amedeo A. and Cruz-Martínez, Ofelia and Zápotocký, Michal and Scheinemann, Katrin and Meeteren, Antoinette Y. N. Schouten-van and Sehested, Astrid and Opocher, Enrico and Driever, Pablo Hernáiz and Avula, Shivaram and Ziegler, David S. and Capper, David and Koch, Arend and Sahm, Felix and Qiu, Jiaheng and Tsao, Li-Pen and Blackman, Samuel C. and Manley, Peter and Milde, Till and Witt, Ruth and Jones, David T. W. and Hargrave, Darren and Witt, Olaf}, title={LOGGIC/FIREFLY-2}, subtitle={a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration}, year={2024}, pages={1-11}, language={eng}, issn={1471-2407}, volume={24}, number={Artikel-ID 147}, note={Gesehen am 01.07.2024}, journal={BMC cancer}, doi={10.1186/s12885-024-11820-x}, } @article{UBHD-68768470, author={Tilburg, Cornelis M. van and Pfaff, Elke and Pajtler, Kristian Wilfried and Langenberg, Karin and Fiesel, Petra and Jones, Barbara Christine and Balasubramanian, Gnana Prakash and Stark, Sebastian and Johann, Pascal-David and Blattner-Johnson, Mirjam and Schramm, Kathrin and Dikow, Nicola and Hirsch, Steffen and Sutter, Christian and Grund, Kerstin and Stackelberg, Arend von and Kulozik, Andreas and Lissat, Andrej and Borkhardt, Arndt and Meisel, Roland and Reinhardt, Dirk and Klusmann, Jan-Henning and Fleischhack, Gudrun and Tippelt, Stephan and Schweinitz, Dietrich von and Schmid, Irene and Kramm, Christof M. and Bueren, André von and Calaminus, Gabriele and Vorwerk, Peter and Graf, Norbert and Westermann, Frank and Fischer, Matthias and Eggert, Angelika and Burkhardt, Birgit and W{\"o}ßmann, Wilhelm and Nathrath, Michaela and Hecker-Nolting, Stefanie and Fr{\"u}hwald, Michael and Schneider, Dominik T. and Brecht, Ines B. and Ketteler, Petra and Fulda, Simone and Koscielniak, Ewa and Meister, Michael and Scheer, Monika and Hettmer, Simone and Schwab, Matthias and Tremmel, Roman and Øra, Ingrid and Hutter, Caroline and Gerber, Nicolas U. and Lohi, Olli and Kazanowska, Bernarda and Kattamis, Antonis and Filippidou, Maria and Goemans, Bianca and Zwaan, C. Michel and Milde, Till and J{\"a}ger, Natalie and Wolf, Stephan and Reuss, David and Sahm, Felix and Deimling, Andreas von and Dirksen, Uta and Freitag, Angelika and Witt, Ruth and Lichter, Peter and Kopp-Schneider, Annette and Jones, David T. W. and Molenaar, Jan J. and Capper, David and Pfister, Stefan and Witt, Olaf}, title={The pediatric precision oncology INFORM registry}, subtitle={clinical outcome and benefit for patients with very high-evidence targets}, year={2021}, pages={2764-2779}, language={eng}, issn={2159-8290}, volume={11}, number={11}, note={Gesehen am 30.07.2021}, journal={Cancer discovery}, doi={10.1158/2159-8290.CD-21-0094}, } @article{UBHD-68579599, author={Tilburg, Cornelis M. van and Milde, Till and Witt, Ruth and Ecker, Jonas and Hielscher, Thomas and Seitz, Angelika and Schenk, Jens-Peter and Buhl, Juliane and Riehl, Dennis and Fr{\"u}hwald, Michael and Pekrun, Arnulf and R{\"o}ssig, Claudia and Wieland, Regina Paula Franziska and Flotho, Christian and Kordes, Uwe and Gruhn, Bernd and Simon, Thorsten and Linderkamp, Christin and Sahm, Felix and Taylor, Lenka A. and Freitag, Angelika and Burhenne, J{\"u}rgen and Foerster, Kathrin and Meid, Andreas and Pfister, Stefan and Karapanagiotou-Schenkel, Irini and Witt, Olaf}, title={Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia}, year={2019}, pages={15 S.}, language={eng}, issn={1868-7083}, volume={11(2019) Artikel-Nummer 188}, number={15 Seiten}, note={Gesehen am 20.05.2020}, journal={Clinical epigenetics}, doi={10.1186/s13148-019-0775-1}, } @article{UBHD-68309694, author={Tilburg, Cornelis M. van and Selt, Florian and Sahm, Felix and B{\"a}chli, Heidi and Pfister, Stefan and Witt, Olaf and Milde, Till}, title={Response in a child with a BRAF V600E mutated desmoplastic infantile astrocytoma upon retreatment with vemurafenib}, year={2018}, pages={1-4}, language={eng}, issn={1545-5017}, volume={65}, note={First published: 12 December 2017 ; Gesehen am 27.09.2018}, journal={Pediatric blood & cancer}, doi={10.1002/pbc.26893}, } @article{UBHD-68984076, author={Tsai, Jessica W. and Cejas, Paloma and Wang, Dayle K. and Patel, Smruti and Wu, David W. and Arounleut, Phonepasong and Wei, Xin and Zhou, Ningxuan and Syamala, Sudeepa and Dubois, Frank P.B. and Crane, Alexander and Pelton, Kristine and Vogelzang, Jayne and Sousa, Cecilia and Baguette, Audrey and Chen, Xiaolong and Condurat, Alexandra L. and Dixon-Clarke, Sarah E. and Zhou, Kevin N. and Lu, Sophie D. and Gonzalez, Elizabeth M. and Chacon, Madison S. and Digiacomo, Jeromy J. and Kumbhani, Rushil and Novikov, Dana and Hunter, J'Ya and Tsoli, Maria and Ziegler, David S. and Dirksen, Uta and J{\"a}ger, Natalie and Balasubramanian, Gnana Prakash and Kramm, Christof M. and Nathrath, Michaela and Bielack, Stefan and Baker, Suzanne J. and Zhang, Jinghui and McFarland, James M. and Getz, Gad and Aguet, François and Jabado, Nada and Witt, Olaf and Pfister, Stefan and Ligon, Keith L. and Hovestadt, Volker and Kleinman, Claudia L. and Long, Henry and Jones, David T. W. and Bandopadhayay, Pratiti and Phoenix, Timothy N.}, title={FOXR2 Is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits}, year={2022}, pages={2980-3001}, language={eng}, issn={1538-7445}, volume={82}, number={17}, note={Gesehen am 10.11.2022}, journal={Cancer research}, doi={10.1158/0008-5472.CAN-22-0671}, } @article{UBHD-68202371, author={Tzaridis, Theophilos-Dimitrios and Milde, Till and Pajtler, Kristian Wilfried and Kulozik, Andreas and Witt, Olaf and Korshunov, Andrey and Pfister, Stefan and Witt, Hendrik}, title={Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA -positive ependymoma}, year={2016}, pages={61860-61873}, language={eng}, issn={1949-2553}, volume={7}, number={38}, note={Gesehen am 15.12.2017}, journal={OncoTarget}, doi={10.18632/oncotarget.11452}, } @article{UBHD-68647390, author={Usta, Diren and Sigaud, Romain and Buhl, Juliane and Selt, Florian and Marquardt, Viktoria and Pauck, David and Jansen, Jennifer and Pusch, Stefan and Ecker, Jonas and Hielscher, Thomas and Vollmer, Johanna and Sommerkamp, Alexander C. and Rubner, Tobias and Hargrave, Darren and Tilburg, Cornelis M. van and Pfister, Stefan and Jones, David T. W. and Remke, Marc and Brummer, Tilman and Witt, Olaf and Milde, Till}, title={A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells}, year={2020}, pages={1737-1750}, language={eng}, issn={1538-8514}, volume={19}, number={8}, note={Gesehen am 12.10.2020}, journal={Molecular cancer therapeutics}, doi={10.1158/1535-7163.MCT-19-1021}, } @article{UBHD-68789263, author={Vassal, Gilles and Houghton, Peter J. and Pfister, Stefan and Smith, Malcolm A. and Caron, Huib N. and Li, Xiao-Nan and Shields, David J. and Witt, Olaf and Molenaar, Jan J. and Colombetti, Sara and Sch{\"u}ler, Julia and Stancato, Lou F.}, title={International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer}, year={2021}, pages={1462-1468}, language={eng}, issn={1538-8514}, volume={20}, number={8 vom: Aug.}, note={Gesehen am 12.10.2021}, journal={Molecular cancer therapeutics}, doi={10.1158/1535-7163.MCT-20-0394}, } @article{UBHD-69157322, author={Vollmer, Johanna and Ecker, Jonas and Hielscher, Thomas and Valinciute, Gintvile and Ridinger, Johannes and Jamaladdin, Nora and Peterziel, Heike and Tilburg, Cornelis M. van and Oehme, Ina and Witt, Olaf and Milde, Till}, title={Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells}, year={2023}, pages={617-632}, language={eng}, issn={1573-7373}, volume={164}, number={3}, note={Online ver{\"o}ffentlicht: 3. Oktober 2023 ; Gesehen am 04.01.2024}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-023-04445-w}, } @article{UBHD-68588486, author={Waszak, Sebastian Martin and Buchhalter, Ivo and Kerssemakers, Jules and J{\"a}ger, Natalie and Sharma, Tanvi and Rausch, Tobias and Kool, Marcel and Sturm, Dominik and Jones, David T. W. and Milde, Till and Witt, Olaf and Korshunov, Andrey and Lichter, Peter and Korbel, Jan Oliver and Pfister, Stefan}, title={Germline elongator mutations in Sonic Hedgehog medulloblastoma}, year={2020}, pages={396-401}, language={eng}, issn={1476-4687}, volume={580}, number={7803}, note={Gesehen am 18.06.2020}, journal={Nature}, doi={10.1038/s41586-020-2164-5}, } @article{UBHD-68403479, author={Weidenbusch, Bushra and Witt, Olaf}, title={Transcriptome based individualized therapy of refractory pediatric sarcomas}, subtitle={feasibility, tolerability and efficacy}, year={2018}, pages={20747-20760}, language={eng}, issn={1949-2553}, volume={9}, number={29}, note={Gesehen am 02.07.2019}, journal={OncoTarget}, doi={10.18632/oncotarget.25087}, } @article{UBHD-68794158, author={Weusthof, Katharina and L{\"u}ttich, Peggy and Regnery, Sebastian and K{\"o}nig, Laila and Bernhardt, Denise and Witt, Olaf and Herfarth, Klaus and Unterberg, Andreas and Jungk, Christine and Farnia, Benjamin and Combs, Stephanie and Debus, J{\"u}rgen and Rieken, Stefan and Harrabi, Semi B. and Adeberg, Sebastian}, title={Neurocognitive outcomes in pediatric patients following brain irradiation}, year={2021}, pages={1-16}, language={eng}, issn={2072-6694}, volume={13}, note={Gesehen am 27.10.2021}, journal={Cancers}, doi={10.3390/cancers13143538}, } @article{UBHD-68985044, author={Witt, Hendrik and Mack, Stephen C. and Ryzhova, Marina and Bender, Sebastian and Sill, Martin and Isserlin, Ruth and Benner, Axel and Hielscher, Thomas and Milde, Till and Remke, Marc and Jones, David T. W. and Northcott, Paul A. and Garzia, Livia and Bertrand, Kelsey C. and Wittmann, Andrea and Yao, Yuan and Roberts, Stephen S. and Massimi, Luca and Van Meter, Tim and Weiss, William A. and Gupta, Nalin and Grajkowska, Wiesia and Lach, Boleslaw and Cho, Yoon-Jae and Deimling, Andreas von and Kulozik, Andreas and Witt, Olaf and Bader, Gary D. and Hawkins, Cynthia E. and Tabori, Uri and Guha, Abhijit and Rutka, James T. and Lichter, Peter and Korshunov, Andrey and Taylor, Michael D. and Pfister, Stefan}, title={Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma}, year={2011}, pages={143-157}, language={eng}, issn={1878-3686}, volume={20}, number={2}, note={Gesehen am 14.11.2022}, journal={Cancer cell}, doi={10.1016/j.ccr.2011.07.007}, } @article{UBHD-68299286, author={Witt, Olaf and Milde, Till and Deubzer, Hedwig and Oehme, Ina and Kulozik, Andreas and Eisenmenger, Andreas and Abel, Ulrich and Karapanagiotou-Schenkel, Irini}, title={Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma or leukemia}, year={2012}, pages={398-403}, language={eng}, issn={1439-3824}, volume={224}, number={06}, note={Gesehen am 27.08.2018}, journal={Klinische P{\"a}diatrie}, doi={10.1055/s-0032-1323692}, } @article{UBHD-68687989, author={Wrobel, Jagoda and Najafi, Sara and Ayhan, Simay and Gatzweiler, Charlotte and Krunic, Damir and Ridinger, Johannes and Milde, Till and Westermann, Frank and Peterziel, Heike and Meder, Benjamin and Distel, Martin and Witt, Olaf and Oehme, Ina}, title={Rapid in vivo validation of HDAC inhibitor-based treatments in neuroblastoma zebrafish xenografts}, year={2020}, language={eng}, issn={1424-8247}, volume={13(2020}, note={Gesehen am 03.02.2021}, journal={Pharmaceuticals}, doi={10.3390/ph13110345}, } @article{UBHD-69195421, author={Zeuner, Simon and Vollmer, Johanna and Sigaud, Romain and Oppermann, Sina and Peterziel, Heike and ElHarouni, Dina and Oehme, Ina and Witt, Olaf and Milde, Till and Ecker, Jonas}, title={Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells}, year={2024}, pages={99-112}, language={eng}, issn={1573-7373}, volume={166}, note={Gesehen am 26.03.2024}, journal={Journal of neuro-oncology}, doi={10.1007/s11060-023-04526-w}, }