| Verfasst von: | Penzel, Roland [VerfasserIn]  |
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| | Sers, Christine [VerfasserIn] |
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| | Chen, Yuan [VerfasserIn] |
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| | Lehmann-Mühlenhoff, Ulrich [VerfasserIn] |
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| | Merkelbach-Bruse, Sabine [VerfasserIn] |
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| | Jung, Andreas [VerfasserIn] |
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| | Kirchner, Thomas [VerfasserIn] |
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| | Büttner, Reinhard [VerfasserIn] |
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| | Kreipe, Hans H. [VerfasserIn] |
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| | Petersen, Iver [VerfasserIn] |
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| | Dietel, Manfred [VerfasserIn] |
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| | Schirmacher, Peter [VerfasserIn] |
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| Titel: | EGFR mutation detection in NSCLC-assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC |
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| Verf.angabe: | hRoland Penzel, Christine Sers, Yuan Chen, Ulrich Lehmann-Mühlenhoff, Sabine Merkelbach-Bruse, Andreas Jung, Thomas Kirchner, Reinhard Büttner, Hans H. Kreipe, Iver Petersen, Manfred Dietel, Peter Schirmacher |
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| Jahr: | 2011 |
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| Umfang: | 4 S. |
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| Titel Quelle: | Enthalten in: Virchows Archiv |
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| Ort Quelle: | Berlin : Springer, 1994 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 458(2011), 1, Seite 95-98 |
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| ISSN Quelle: | 0945-6317 |
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| Abstract: | EGFR mutation testing in non-small cell lung cancer (NSCLC) is a novel and important molecular pathological diagnostic assay that is predictive of response to anti-epidermal growth factor receptor (EGFR) therapy. A comprehensive compilation of a large number of EGFR mutation analyses of the German Panel for Mutation Analyses in NSCLC demonstrates (a) a higher than previously reported mutation frequency outside the conventionally tested exons 19 and 21 and (b) an overall superiority of sequencing based assays over mutation-specific PCR. The implications for future diagnostic EGFR mutation testing are discussed. |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Online-Ausgabe: Penzel, Roland: EGFR mutation detection in NSCLC-assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC. - 2011 |
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| Sach-SW: | Carcinoma, Non-Small-Cell Lung |
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| | Early Detection of Cancer |
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| | ErbB Receptors |
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| | Exons |
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| | Genetic Testing |
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| | Germany |
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| | Health Planning Guidelines |
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| | Humans |
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| | Lung Neoplasms |
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| | Mutation |
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| | Single-Blind Method |
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| K10plus-PPN: | 1632996456 |
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| Verknüpfungen: | → Zeitschrift |
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EGFR mutation detection in NSCLC-assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC / Penzel, Roland [VerfasserIn]; 2011
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