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Titel:Correlation of dynamic PET and gene array data in patients with gastrointestinal stromal tumors
Mitwirkende:Strauss, Ludwig G.   i
 Dimitrakopoulou-Strauss, Antonia   i
 Hohenberger, Peter   i
 Pan, Leyun   i
Verf.angabe:Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Dirk Koczan, Leyun Pan, and Peter Hohenberger
E-Jahr:2012
Jahr:04 Jun 2012
Umfang:5 S.
Fussnoten:Gesehen am 25.08.2020
Titel Quelle:In: The ScientificWorld journal
Ort Quelle:Boynton Beach, Fla. : [Verlag nicht ermittelbar], 2000
Jahr Quelle:2012
Band/Heft Quelle:(2012) Article ID 721313, 5 Seiten
ISSN Quelle:1537-744X
Abstract:Introduction. The results obtained with dynamic PET (dPET) were compared to gene expression data obtained in patients with gastrointestinal stromal tumors (GIST). The primary aim was to assess the association of the dPET results and gene expression data. Material and Methods. dPET was performed following the injection of F-18-fluorodeoxyglucose (FDG) in 22 patients with GIST. All patients were examined prior to surgery for staging purpose. Compartment and noncompartment models were used for the quantitative evaluation of the dPET examinations. Gene array data were based on tumor specimen obtained by surgery after the PET examinations. Results. The data analysis revealed significant correlations for the dPET parameters and the expression of zinc finger genes (znf43, znf85, znf91, znf189). Furthermore, the transport of FDG (k1) was associated with VEGF-A. The cell cycle gene cyclin-dependent kinase inhibitor 1C was correlated with the maximum tracer uptake (SUVmax) in the tumors. Conclusions. The data demonstrate a dependency of the tracer kinetics on genes associated with prognosis in GIST. Furthermore, angiogenesis and cell proliferation have an impact on the tracer uptake.
DOI:doi:10.1100/2012/721313
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/10.1100/2012/721313
 DOI: https://doi.org/10.1100/2012/721313
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1446098214
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