Cholinergic plasticity of ocillating neuronal assemblies in mouse hippocampal slices

• Verfasst von: Zylla, Maura Magdalena [VerfasserIn]
• Verfasst von: Reichinnek, Susanne [VerfasserIn]
• Verfasst von: Zhang, Xiaomin [VerfasserIn]
• Verfasst von: Draguhn, Andreas [VerfasserIn]
• Verfasst von: Both, Martin [VerfasserIn]
• Titel: Cholinergic plasticity of ocillating neuronal assemblies in mouse hippocampal slices
• Verf.angabe: Maura M. Zylla, Xiaomin Zhang, Susanne Reichinnek, Andreas Draguhn, Martin Both
• E-Jahr: 2013
• Jahr: November 18, 2013
• Umfang: 11 S.
• Fussnoten: Gesehen am 17.12.2024
• Titel Quelle: Enthalten in: PLOS ONE
• Ort Quelle: San Francisco, California, US : PLOS, 2006
• Jahr Quelle: 2013
• Band/Heft Quelle: 8(2013), 11 vom: Nov., Artikel-ID e80718, Seite 1-11
• ISSN Quelle: 1932-6203
• DOI: doi:10.1371/journal.pone.0080718
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Action potentials
• Sach-SW: Atropine
• Sach-SW: Carbachol
• Sach-SW: Cholinergics
• Sach-SW: Hippocampus
• Sach-SW: Neuronal plasticity
• Sach-SW: Neurons
• Sach-SW: Synaptic plasticity
• K10plus-PPN: 1485303281

Abstract

The mammalian hippocampus expresses several types of network oscillations which entrain neurons into transiently stable assemblies. These groups of co-active neurons are believed to support the formation, consolidation and recall of context-dependent memories. Formation of new assemblies occurs during theta- and gamma-oscillations under conditions of high cholinergic activity. Memory consolidation is linked to sharp wave-ripple oscillations (SPW-R) during decreased cholinergic tone. We hypothesized that increased cholinergic tone supports plastic changes of assemblies while low cholinergic tone favors their stability. Coherent spatiotemporal network patterns were measured during SPW-R activity in mouse hippocampal slices. We compared neuronal activity within the oscillating assemblies before and after a transient phase of carbachol-induced gamma oscillations. Single units maintained their coupling to SPW-R throughout the experiment and could be re-identified after the transient phase of gamma oscillations. However, the frequency of SPW-R-related unit firing was enhanced after muscarinic stimulation. At the network level, these changes resulted in altered patterns of extracellularly recorded SPW-R waveforms. In contrast, recording of ongoing SPW-R activity without intermittent cholinergic stimulation revealed remarkably stable repetitive activation of assemblies. These results show that activation of cholinergic receptors induces plasticity at the level of oscillating hippocampal assemblies, in line with the different role of gamma- and SPW-R network activity for memory formation and -consolidation, respectively.