GABA metabolism and transport

• Verfasst von: Roth, Fabian C. [VerfasserIn]
• Verfasst von: Draguhn, Andreas [VerfasserIn]
• Titel: GABA metabolism and transport
• Titelzusatz: effects on synaptic efficacy
• Verf.angabe: Fabian C. Roth and Andreas Draguhn
• E-Jahr: 2012
• Jahr: 23 February 2012
• Umfang: 12 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 18.12.2024
• Titel Quelle: Enthalten in: Neural plasticity
• Ort Quelle: New York, NY : Hindawi, 1998
• Jahr Quelle: 2012
• Band/Heft Quelle: (2012), 1, Artikel-ID 805830, Seite 1-12
• ISSN Quelle: 1687-5443
• DOI: doi:10.1155/2012/805830
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 148607443X

Abstract

GABAergic inhibition is an important regulator of excitability in neuronal networks. In addition, inhibitory synaptic signals contribute crucially to the organization of spatiotemporal patterns of network activity, especially during coherent oscillations. In order to maintain stable network states, the release of GABA by interneurons must be plastic in timing and amount. This homeostatic regulation is achieved by several pre- and postsynaptic mechanisms and is triggered by various activity-dependent local signals such as excitatory input or ambient levels of neurotransmitters. Here, we review findings on the availability of GABA for release at presynaptic terminals of interneurons. Presynaptic GABA content seems to be an important determinant of inhibitory efficacy and can be differentially regulated by changing synthesis, transport, and degradation of GABA or related molecules. We will discuss the functional impact of such regulations on neuronal network patterns and, finally, point towards pharmacological approaches targeting these processes.