Selective coupling between theta phase and neocortical fast gamma oscillations during REM-sleep in mice

• Verfasst von: Scheffzük, Claudia [VerfasserIn]
• Verfasst von: Draguhn, Andreas [VerfasserIn]
• Verfasst von: Brankačk, Jurij [VerfasserIn]
• Titel: Selective coupling between theta phase and neocortical fast gamma oscillations during REM-sleep in mice
• Verf.angabe: Claudia Scheffzük, Valeriy I. Kukushka, Alexei L. Vyssotski, Andreas Draguhn, Adriano B.L. Tort, Jurij Brankačk
• E-Jahr: 2011
• Jahr: December 5, 2011
• Umfang: 9 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 18.12.2024
• Titel Quelle: Enthalten in: PLOS ONE
• Ort Quelle: San Francisco, California, US : PLOS, 2006
• Jahr Quelle: 2011
• Band/Heft Quelle: 6(2011), 12 vom: Dez., Artikel-ID e28489, Seite 1-9
• ISSN Quelle: 1932-6203
• DOI: doi:10.1371/journal.pone.0028489
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Animal behavior
• Sach-SW: Electroencephalography
• Sach-SW: Gamma spectrometry
• Sach-SW: Hippocampus
• Sach-SW: Mice
• Sach-SW: Neocortex
• Sach-SW: Parietal lobe
• Sach-SW: Rodents
• K10plus-PPN: 1486091946

Abstract

Background The mammalian brain expresses a wide range of state-dependent network oscillations which vary in frequency and spatial extension. Such rhythms can entrain multiple neurons into coherent patterns of activity, consistent with a role in behaviour, cognition and memory formation. Recent evidence suggests that locally generated fast network oscillations can be systematically aligned to long-range slow oscillations. It is likely that such cross-frequency coupling supports specific tasks including behavioural choice and working memory. Principal Findings We analyzed temporal coupling between high-frequency oscillations and EEG theta activity (4-12 Hz) in recordings from mouse parietal neocortex. Theta was exclusively present during active wakefulness and REM-sleep. Fast oscillations occurred in two separate frequency bands: gamma (40-100 Hz) and fast gamma (120-160 Hz). Theta, gamma and fast gamma were more prominent during active wakefulness as compared to REM-sleep. Coupling between theta and the two types of fast oscillations, however, was more pronounced during REM-sleep. This state-dependent cross-frequency coupling was particularly strong for theta-fast gamma interaction which increased 9-fold during REM as compared to active wakefulness. Theta-gamma coupling increased only by 1.5-fold. Significance State-dependent cross-frequency-coupling provides a new functional characteristic of REM-sleep and establishes a unique property of neocortical fast gamma oscillations. Interactions between defined patterns of slow and fast network oscillations may serve selective functions in sleep-dependent information processing.