Fate restriction and multipotency in retinal stem cells

• Verfasst von: Centanin, Lázaro [VerfasserIn]
• Verfasst von: Höckendorf, Burkhard [VerfasserIn]
• Verfasst von: Wittbrodt, Joachim [VerfasserIn]
• Titel: Fate restriction and multipotency in retinal stem cells
• Verf.angabe: Lázaro Centanin, Burkhard Hoeckendorf, and Joachim Wittbrodt
• E-Jahr: 2011
• Jahr: December 1, 2011
• Umfang: 10 S.
• Fussnoten: Gesehen am 13.02.2017
• Titel Quelle: Enthalten in: Cell stem cell
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 2007
• Jahr Quelle: 2011
• Band/Heft Quelle: 9(2011), 6, Seite 553-562
• ISSN Quelle: 1875-9777
• DOI: doi:10.1016/j.stem.2011.11.004
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1553385810

Abstract

Stem cells have the capacity to both self-renew and generate postmitotic cells. Long-term tracking of individual clones in their natural environment constitutes the ultimate way to validate postembryonic stem cells. We identify retinal stem cells (RSCs) using the spatiotemporal organization of the fish retina and follow the complete offspring of a single cell during the postnatal life. RSCs generate two tissues of the adult fish retina, the neural retina (NR) and the retinal-pigmented epithelium (RPE). Despite their common embryonic origin and tight coordination during continuous organ growth, we prove that NR and RPE are maintained by dedicated RSCs that contribute in a fate-restricted manner to either one or the other tissue. We show that in the NR, RSCs are multipotent and generate all neuron types and glia. The clonal origin of these different cell types from a multipotent NSC has far-reaching implications for cell type and tissue homeostasis.