Status: Bibliographieeintrag
Standort: ---
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| Online-Ressource |
Verfasst von: | Chakrabarti, Alokta [VerfasserIn]  |
| Witt, Olaf [VerfasserIn]  |
Titel: | HDAC8 |
Titelzusatz: | a multifaceted target for therapeutic interventions |
Verf.angabe: | Alokta Chakrabarti, Ina Oehme, Olaf Witt, Guilherme Oliveira, Wolfgang Sippl, Christophe Romier, Raymond J. Pierce, Manfred Jung |
Umfang: | 12 S. |
Fussnoten: | Gesehen am 30.03.2017 |
Titel Quelle: | Enthalten in: Trends in pharmacological sciences |
Jahr Quelle: | 2015 |
Band/Heft Quelle: | 36(2015), 7, S. 481-492 |
ISSN Quelle: | 1873-3735 |
Abstract: | Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections. It is a structurally well-characterized enzyme that also deacetylates nonhistone proteins. In cancer, HDAC8 is a major ‘epigenetic player’ that is linked to deregulated expression or interaction with transcription factors critical to tumorigenesis. In the parasite Schistosoma mansoni and in viral infections, HDAC8 is a novel target to subdue infection. The current challenge remains in the development of potent selective inhibitors that would specifically target HDAC8 with fewer adverse effects compared with pan-HDAC inhibitors. Here, we review HDAC8 as a drug target and discuss inhibitors with respect to their structural features and therapeutic interventions. |
DOI: | doi:10.1016/j.tips.2015.04.013 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.1016/j.tips.2015.04.013 |
| Verlag: http://www.sciencedirect.com/science/article/pii/S0165614715000899 |
| DOI: https://doi.org/10.1016/j.tips.2015.04.013 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1556110324 |
Verknüpfungen: | → Zeitschrift |
HDAC8 / Chakrabarti, Alokta [VerfasserIn] (Online-Ressource)
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