Comparison of gadofosveset (Vasovist®) with gadobenate dimeglumine (Multihance®)-enhanced MR angiography for high-grade carotid artery stenosis

• Verfasst von: Amarteifio, Erick [VerfasserIn]
• Verfasst von: Böckler, Dittmar [VerfasserIn]
• Verfasst von: Attigah, Nicolas [VerfasserIn]
• Verfasst von: Demirel, Serdar [VerfasserIn]
• Titel: Comparison of gadofosveset (Vasovist®) with gadobenate dimeglumine (Multihance®)-enhanced MR angiography for high-grade carotid artery stenosis
• Verf.angabe: E. Amarteifio, M. Essig, D. Böckler, N. Attigah, L. Schuster, S. Demirel
• Umfang: 9 S.
• Fussnoten: Available online:1 July 2014 ; Gesehen am 30.04.2017
• Titel Quelle: Enthalten in: Journal of neuroradiology
• Jahr Quelle: 2015
• Band/Heft Quelle: 42(2015), 4, S. 236-244
• ISSN Quelle: 1773-0406
• DOI: doi:10.1016/j.neurad.2014.03.002
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1556130465

Abstract

Summary: Objective To prove superiority of blood pool contrast agent gadofosveset over conventional contrast agent gadobenate dimeglumine for assessment of stenotic internal carotid artery (ICA). Methods: Eleven patients with high-grade ICA stenosis (≥ 75%), confirmed by duplex sonography, underwent MR angiography (MRA) with gadofosveset and gadobenate dimeglumine. Results: Agreement in stenosis grade was reached in 7 of 10 stenotic ICAs. In two ICAs, gadobenate dimeglumine led to underestimation of stenosis grade. There was a significant difference in signal intensity (pre-/post-stenotic segments), showing higher values for gadofosveset (P < 0.01; P < 0.05). Impression of contrast intensity with gadofosveset was better in 8 ICAs and only in 1 ICA with gadobenate dimeglumine (P < 0.05). Conclusion: Gadofosveset-enhanced MR angiography may be superior for assessment of high-grade ICA stenosis compared with gadobenate dimeglumine MR angiography.