How do glucocorticoids regulate lipid metabolism?

• Verfasst von: Guia, Roldan M. de [VerfasserIn]
• Verfasst von: Herzig, Stephan [VerfasserIn]
• Titel: How do glucocorticoids regulate lipid metabolism?
• Verf.angabe: Roldan M. de Guia, Stephan Herzig
• Jahr: 2015
• Umfang: 18 S.
• Fussnoten: Gesehen am 05.04.2017
• Titel Quelle: Enthalten in: Glucocorticoid signaling
• Ausgabe Quelle: 1st ed. 2015
• Ort Quelle: New York, NY : Springer, 2015
• Jahr Quelle: 2015
• Band/Heft Quelle: (2015), Seite 127-144
• ISBN Quelle: 978-1-4939-2895-8
• DOI: doi:10.1007/978-1-4939-2895-8_6
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adipose tissue
• Sach-SW: Biochemistry, general
• Sach-SW: Cholesterol metabolism
• Sach-SW: Endocrinology
• Sach-SW: Glucocorticoid hormones
• Sach-SW: Glucocorticoid receptor
• Sach-SW: Human Physiology
• Sach-SW: Lipid metabolism
• Sach-SW: Lipoprotein metabolism
• Sach-SW: Liver
• K10plus-PPN: 1556312717

Abstract

Glucocorticoids (GCs) and their cognate, intracellular receptor, the glucocorticoid receptor (GR) have been characterized as critical checkpoints in the hormonal control of energy homeostasis in mammals. Whereas physiological levels of GCs are required for proper metabolic control, aberrant GC action has been linked to a variety of severe metabolic diseases, including type 2 diabetes and obesity. As a member of the nuclear receptor superfamily of transcription factors, the GR translocates into the cell nucleus upon GC binding where it serves as a transcriptional regulator of distinct GC-responsive target genes that are in many cases associated with lipid regulatory pathways and thereby intricately control both physiological and pathophysiological systemic lipid homeostasis. Thus, this chapter focuses on the current knowledge of GC/GR function in lipid handling and its implications for systemic metabolic dysfunction.