| |  Online-Ressource |
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| Verfasst von: | Larribere, Lionel [VerfasserIn]  |
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| | Wu, Huizi [VerfasserIn] |
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| | Novak, Daniel [VerfasserIn] |
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| | Galach, Marta [VerfasserIn] |
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| | Bernhardt, Mathias [VerfasserIn] |
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| | Orouji, Elias [VerfasserIn] |
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| | Weina, Kasia [VerfasserIn] |
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| | Knappe, Nathalie [VerfasserIn] |
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| | Umansky, Ludmila [VerfasserIn] |
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| | Beckhove, Philipp [VerfasserIn] |
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| | Umansky, Viktor [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| Titel: | NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model |
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| Verf.angabe: | Lionel Larribere, Huizi Wu, Daniel Novak, Marta Galach, Mathias Bernhardt, Elias Orouji, Kasia Weina, Nathalie Knappe, Christos Sachpekidis, Ludmila Umansky, Philipp Beckhove, Viktor Umansky, Sofie De Schepper, Dieter Kaufmann, Robert Ballotti, Corine Bertolotto, Jochen Utikal |
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| E-Jahr: | 2015 |
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| Jahr: | July 2015 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 07.04.2017 |
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| Titel Quelle: | Enthalten in: Pigment cell & melanoma research |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 2008 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 28(2015), 4, Seite 407-416 |
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| ISSN Quelle: | 1755-148X |
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| Abstract: | Neurofibromatosis type 1 (NF1) is a frequent genetic disease leading to the development of Schwann cell-derived neurofibromas or melanocytic lesions called café-au-lait macules (CALMs). The molecular mechanisms involved in CALMs formation remain largely unknown. In this report, we show for the first time pathophysiological mechanisms of abnormal melanocyte differentiation in a human NF1+/−-induced pluripotent stem cell (iPSC)-based model. We demonstrate that NF1 patient-derived fibroblasts can be successfully reprogrammed in NF1+/− iPSCs with active RAS signaling and that NF1 loss induces senescence during melanocyte differentiation as well as in patient's-derived CALMs, revealing a new role for NF1 in the melanocyte lineage. |
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| DOI: | doi:10.1111/pcmr.12369 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1111/pcmr.12369 |
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| | Volltext: http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12369/abstract |
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| | DOI: https://doi.org/10.1111/pcmr.12369 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | café-au-lait macules |
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| | induced pluripotent stem cell |
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| | melanocyte |
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| | neurofibromatosis type 1 |
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| | oncogene-induced senescence |
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| K10plus-PPN: | 1556431414 |
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| Verknüpfungen: | → Zeitschrift |
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NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model / Larribere, Lionel [VerfasserIn]; July 2015 (Online-Ressource)
