| Verf.angabe: | Nicole Heussinger, MD, Evangelos Kontopantelis, PhD, Janina Gburek-Augustat, MD, Andreas Jenke, MD, Gesa Vollrath, MD, Rudolf Korinthenberg, MD, Peter Hofstetter, MD, Sascha Meyer, MD, Isabel Brecht, MD, Barbara Kornek, MD, Peter Herkenrath, MD, Mareike Schimmel, MD, Kirsten Wenner, MD, Martin Häusler, MD, Soeren Lutz, MD, Michael Karenfort, MD, Astrid Blaschek, MD, Martin Smitka, MD, Stephanie Karch, MD, Martin Piepkorn, MD, Kevin Rostasy, MD, Thomas Lücke, MD, Peter Weber, MD, Regina Trollmann, MD, Jörg Klepper, MD, Martin Häussler, MD, Regina Hofmann, MD, Robert Weissert, MD, PhD, Andreas Merkenschlager, MD, and Mathias Buttmann, MD for GRACE-MS (German-speaking Research Alliance for ChildrEn with Multiple Sclerosis) |
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| Abstract: | We retrospectively evaluated predictors of conversion to multiple sclerosis (MS) in 357 children with isolated optic neuritis (ON) as a first demyelinating event who had a median follow-up of 4.0 years. Multiple Cox proportional-hazards regressions revealed abnormal cranial magnet resonance imaging (cMRI; hazard ratio [HR] = 5.94, 95% confidence interval [CI] = 3.39-10.39, p < 0.001), presence of cerebrospinal fluid immunoglobulin G oligoclonal bands (OCB; HR = 3.69, 95% CI = 2.32-5.86, p < 0.001), and age (HR = 1.08 per year of age, 95% CI = 1.02-1.13, p = 0.003) as independent predictors of conversion, whereas sex and laterality (unilateral vs bilateral) had no influence. Combined cMRI and OCB positivity indicated a 26.84-fold higher HR for developing MS compared to double negativity (95% CI = 12.26−58.74, p < 0.001). Accordingly, cerebrospinal fluid analysis may supplement cMRI to determine the risk of MS in children with isolated ON. Ann Neurol 2015;77:1076-1082 |
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