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Verfasst von:Bollmann, Stella [VerfasserIn]   i
 Brandeis, Daniel [VerfasserIn]   i
Titel:Developmental changes in gamma-aminobutyric acid levels in attention-deficit/hyperactivity disorder
Verf.angabe:S. Bollmann, C. Ghisleni, S.-S. Poil, E. Martin, J. Ball, D. Eich-Höchli, R.A.E Edden, P. Klaver, L. Michels, D. Brandeis, R.L. O'Gorman
E-Jahr:2015
Jahr:23 June 2015
Fussnoten:Gesehen am 11.04.2017
Titel Quelle:Enthalten in: Translational Psychiatry
Ort Quelle:London : Nature Publishing Group, 2011
Jahr Quelle:2015
Band/Heft Quelle:5(2015,6) Artikel-Nummer e589, 8 Seiten
ISSN Quelle:2158-3188
Abstract:While the neurobiological basis and developmental course of attention-deficit/hyperactivity disorder (ADHD) have not yet been fully established, an imbalance between inhibitory/excitatory neurotransmitters is thought to have an important role in the pathophysiology of ADHD. This study examined the changes in cerebral levels of GABA+, glutamate and glutamine in children and adults with ADHD using edited magnetic resonance spectroscopy. We studied 89 participants (16 children with ADHD, 19 control children, 16 adults with ADHD and 38 control adults) in a subcortical voxel (children and adults) and a frontal voxel (adults only). ADHD adults showed increased GABA+ levels relative to controls (P=0.048), while ADHD children showed no difference in GABA+ in the subcortical voxel (P>0.1), resulting in a significant age by disorder interaction (P=0.026). Co-varying for age in an analysis of covariance model resulted in a nonsignificant age by disorder interaction (P=0.06). Glutamine levels were increased in children with ADHD (P=0.041), but there was no significant difference in adults (P>0.1). Glutamate showed no difference between controls and ADHD patients but demonstrated a strong effect of age across both groups (P<0.001). In conclusion, patients with ADHD show altered levels of GABA+ in a subcortical voxel which change with development. Further, we found increased glutamine levels in children with ADHD, but this difference normalized in adults. These observed imbalances in neurotransmitter levels are associated with ADHD symptomatology and lend new insight in the developmental trajectory and pathophysiology of ADHD.
DOI:doi:10.1038/tp.2015.79
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1038/tp.2015.79
 kostenfrei: Volltext: https://www.nature.com/articles/tp201579
 DOI: https://doi.org/10.1038/tp.2015.79
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1556521618
Verknüpfungen:→ Zeitschrift

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