Biology and engineering of stem cell niches

• Titel: Biology and engineering of stem cell niches
• Mitwirkende: Vishwakarma, Ajaykumar [HerausgeberIn]
• Mitwirkende: Karp, Jeffrey M. [HerausgeberIn]
• Verf.angabe: edited by Ajaykumar Vishwakarma, Jeffrey M. Karp
• Verlagsort: London ; San Diego, CA
• Verlag: Academic Press
• E-Jahr: 2017
• Jahr: [2017]
• Umfang: 1 Online-Ressource (xv, 625 Seiten)
• Illustrationen: Illustrationen
• ISBN: 978-0-12-802756-1
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe
• Sach-SW: Stem cells
• Sach-SW: Electronic books
• K10plus-PPN: 1657485544
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext
• Lokale URL UB: Bibliothek der Medizinischen Fakultät Mannheim der Universität Heidelberg
• Bibliothek/Idn: UW / m3397143721
• Lokale URL Inst.: Zum Volltext

Abstract

Front Cover -- BIOLOGY AND ENGINEERING OF STEM CELL NICHES -- BIOLOGY AND ENGINEERING OF STEM CELL NICHES -- Copyright -- Contents -- List of Contributors -- Foreword -- 1 - Biology of Stem Cell Niches and Molecular Mechanisms -- 1 - The Need to Study, Mimic, and Target Stem Cell Niches -- 1. INTRODUCTION -- 1.1 The Stem Cell Niche in Health and Disease -- 1.2 Components of Stem Cell Niche -- 2. BIOLOGY OF THE STEM CELL NICHE -- 2.1 Behavior of Stem Cells: Hierarchical Versus Stochastic Model -- 2.2 Embryonic and Adult Stem Cell Niches -- 3. BIOCHEMICAL AND BIOPHYSICAL REGULATION OF STEM CELL BEHAVIOR -- 3.1 Extracellular Matrix and Biochemical Cues -- 3.2 Soluble Growth Factors and Ligands -- 3.3 Physical Cues and Matrix Mechanics -- 3.4 Oxygen and Metabolism -- 3.5 Immune Cells, Inflammation, and Immunomodulation -- 4. MIMICKING THE STEM CELL NICHE: BIOENGINEERING TOOLS AND TECHNIQUES -- 5. BIOENGINEERING SPECIALIZED ARTIFICIAL STEM CELL NICHES FOR CLINICAL THERAPIES -- References -- 2 - Harnessing the Biology of Stem Cells' Niche -- 1. INTRODUCTION -- 2. COMPONENTS OF THE STEM CELL NICHE -- 2.1 Cellular Components -- 2.2 Noncellular Components -- 3. INTEGRATIVE NETWORKS REGULATING THE NICHE -- 4. DISTINCT NICHES FOR DIFFERENT STAGES OF DIFFERENTIATION -- 5. NEOPLASTIC TRANSFORMATION AND DISTURBANCE OF THE TISSUE ECOSYSTEM -- 6. CONCLUSION -- ABBREVIATIONS AND ACRONYMS -- Glossary -- References -- 3 - Pluripotent Stem Cell Microenvironment -- 1. INTRODUCTION -- 2. PLURIPOTENT CELL MICROENVIRONMENT IN THE EARLY MAMMALIAN EMBRYO -- 2.1 Lineage Specification in the Preimplantation Embryo -- 2.2 Role of Extraembryonic Cells in Development of the Pluripotent Cells -- 2.2.1 Interactions Between Inner and Outer Blastomeres During the ICM Versus TE Specification and Associated Signals -- 2.2.2 Cellular Interplay Between the PrE and the Epiblast.