Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Stöbe, Petra [VerfasserIn]   i
 Boy, Aurelia Lara [VerfasserIn]   i
 Lohmann, Ingrid [VerfasserIn]   i
Titel:Multifactorial regulation of a Hox target gene
Verf.angabe:Petra Stöbe, Sokrates M. A. Stein, Anette Habring-Müller, Daniela Bezdan, Aurelia L. Fuchs, Stefanie D. Hueber, Haijia Wu, Ingrid Lohmann
Umfang:14 S.
Fussnoten:Gesehen am 08.05.2017
Titel Quelle:Enthalten in: Public Library of Science: PLoS Genetics
Jahr Quelle:2009
Band/Heft Quelle:5(2009), 3, S. e1000412
ISSN Quelle:1553-7404
Abstract:Author Summary Bilateral animals share a common genetic mechanism to control development along the anterior-posterior body axis, and transcription factors of the Hox class are key regulators of this conserved process. It is thought that Hox proteins drive morphological diversification of body segments by differentially controlling the expression of downstream genes. However, due to their highly conserved DNA binding domain, the homeodomain, Hox proteins alone bind to very similar and frequently occurring sequences in the genome. This implies that Hox proteins alone are likely insufficient to activate or repress their target genes in a proper spatio-temporal fashion. In contrast to this observation, Hox proteins have very specific effects during development and execute their function with high precision. A solution to this paradox could lie in the context-specific interaction of Hox proteins with other transcriptional regulators; however, only a few examples are known. By analysing the mechanism underlying the regulation of the Hox target gene reaper, we identified a set of eight transcription factors to be important for the precise spatio-temporal regulation of this gene. Based on our findings, we suggest that Hox proteins functionally interact with a plethora of unrelated transcription factors on small, yet complex enhancer elements to execute their specific functions throughout development of diverse organisms.
DOI:doi:10.1371/journal.pgen.1000412
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Kostenfrei: Verlag: http://dx.doi.org/10.1371/journal.pgen.1000412
 Kostenfrei: Verlag: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000412
 DOI: https://doi.org/10.1371/journal.pgen.1000412
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1558299408
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68116803   QR-Code
zum Seitenanfang