Nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP offered as cell substrate

• Verfasst von: Jährling, Steffen [VerfasserIn]
• Verfasst von: Thelen, Karsten [VerfasserIn]
• Verfasst von: Wolfram, Tobias [VerfasserIn]
• Verfasst von: Pollerberg, G. Elizabeth [VerfasserIn]
• Titel: Nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP offered as cell substrate
• Titelzusatz: spacing determines attachment and differentiation of neurons
• Verf.angabe: Steffen Jaehrling, Karsten Thelen, Tobias Wolfram, and G. Elisabeth Pollerberg
• Umfang: 7 S.
• Fussnoten: Gesehen am 09.05.2017
• Titel Quelle: Enthalten in: Nano letters
• Jahr Quelle: 2009
• Band/Heft Quelle: 9(2009), 12, S. 4115-4121
• ISSN Quelle: 1530-6992
• DOI: doi:10.1021/nl9023325
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1558346104

Abstract

The density/spacing of plasma membrane proteins is thought to be crucial for their function; clear-cut experimental evidence, however, is still rare. We examined nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP with respect to their impact on neuron attachment and neurite growth. Data analysis/modeling revealed that these cellular responses improve with increasing DM-GRASP density, with the exception of one spacing which does not allow for the anchorage of a cytoskeletal protein (spectrin) to three DM-GRASP molecules.