Evolutionary relationships and diversification of barhl genes within retinal cell lineages

• Verfasst von: Schuhmacher, Laura-Nadine [VerfasserIn]
• Verfasst von: Albadri, Shahad [VerfasserIn]
• Verfasst von: Ramialison, Mirana [VerfasserIn]
• Verfasst von: Poggi, Lucia [VerfasserIn]
• Titel: Evolutionary relationships and diversification of barhl genes within retinal cell lineages
• Verf.angabe: Laura-Nadine Schuhmacher, Shahad Albadri, Mirana Ramialison and Lucia Poggi
• Fussnoten: Gesehen am 10.05.2017
• Titel Quelle: Enthalten in: BMC evolutionary biology
• Jahr Quelle: 2011
• Band/Heft Quelle: (2011,11) Artikelnummer 340, 17 Seiten
• ISSN Quelle: 1471-2148
• DOI: doi:10.1186/1471-2148-11-340
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1558386122

Abstract

Basic helix-loop-helix and homeodomain transcription factors have been shown to specify all different neuronal cell subtypes composing the vertebrate retina. The appearance of gene paralogs of such retina-specific transcription factors in lower vertebrates, with differently evolved function and/or conserved non-coding elements, might provide an important source for the generation of neuronal diversity within the vertebrate retinal architecture. In line with this hypothesis, we investigated the evolution of the homeobox Barhl family of transcription factors, barhl1 and barhl2, in the teleost and tetrapod lineages. In tetrapod barhl2, but not barhl1, is expressed in the retina and is important for amacrine cell specification. Zebrafish has three barhl paralogs: barhl1.1, barhl1.2 and barhl2, but their precise spatio-temporal retinal expression, as well as their function is yet unknown.