The role of cell adhesion molecules for navigating axons

• Verfasst von: Pollerberg, G. Elizabeth [VerfasserIn]
• Verfasst von: Thelen, Karsten [VerfasserIn]
• Verfasst von: Theiß, Martin [VerfasserIn]
• Verfasst von: Hochlehnert, Birgit [VerfasserIn]
• Titel: The role of cell adhesion molecules for navigating axons
• Titelzusatz: density matters
• Verf.angabe: G.E. Pollerberg, K. Thelen, M.O. Theiss, B.C. Hochlehnert
• Umfang: 14 S.
• Fussnoten: Gesehen am 10.05.2017
• Titel Quelle: Enthalten in: Mechanisms of development
• Jahr Quelle: 2013
• Band/Heft Quelle: 130(2013), 6/8, S. 359-372
• ISSN Quelle: 1872-6356
• DOI: doi:10.1016/j.mod.2012.11.002
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1558386556

Abstract

Cell adhesion molecules of the immunoglobulin-super-family (IgSF-CAMs) do not only have a physical effect, mediating merely attachment between cell surfaces. For navigating axons, IgSF-CAMs also exert an instructive impact: Upon activation, they elicit intracellular signalling cascades in the tip of the axon, the growth cone, which regulate in a spatio-temporally concerted action both speed and direction of the axon. Density and distribution of IgSF-CAMs in the growth cone plasma membrane play important roles for the activation of IgSF-CAMs, their clustering, and the adhesive forces they acquire, as well as for the local restriction and effective propagation of their intracellular signals.