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Verfasst von:Pimpl, Peter [VerfasserIn]   i
 Hillmer, Stefan [VerfasserIn]   i
 Robinson, David G. [VerfasserIn]   i
Titel:Golgi-mediated vacuolar sorting of the endoplasmic reticulum chaperone BiP may play an active role in quality control within the secretory pathway
Verf.angabe:Peter Pimpl, J. Philip Taylor, Christopher Snowden, Stefan Hillmer, David G.Robinson, Jurgen Denecke
E-Jahr:2006
Jahr:January 2006
Umfang:14 S.
Fussnoten:Gesehen am 11.05.2017
Titel Quelle:Enthalten in: The plant cell
Ort Quelle:Rockville, Md. : Soc., 1989
Jahr Quelle:2006
Band/Heft Quelle:18(2006), 1, Seite 198-211
ISSN Quelle:1532-298X
Abstract:Quality control in the endoplasmic reticulum (ER) prevents the arrival of incorrectly or incompletely folded proteins at their final destinations and targets permanently misfolded proteins for degradation. Such proteins have a high affinity for the ER chaperone BiP and are finally degraded via retrograde translocation from the ER lumen back to the cytosol. This ER-associated protein degradation (ERAD) is currently thought to constitute the main disposal route, but there is growing evidence for a vacuolar role in quality control. We show that BiP is transported to the vacuole in a wortmannin-sensitive manner in tobacco (Nicotiana tabacum) and that it could play an active role in this second disposal route. ER export of BiP occurs via COPII-dependent transport to the Golgi apparatus, where it competes with other HDEL receptor ligands. When HDEL-mediated retrieval from the Golgi fails, BiP is transported to the lytic vacuole via multivesicular bodies, which represent the plant prevacuolar compartment. We also demonstrate that a subset of BiP-ligand complexes is destined to the vacuole and differs from those likely to be disposed of via the ERAD pathway. Vacuolar disposal could act in addition to ERAD to maximize the efficiency of quality control in the secretory pathway.
DOI:doi:10.1105/tpc.105.036665
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1105/tpc.105.036665
 kostenfrei: Volltext: https://academic.oup.com/plcell/article/18/1/198/6114777
 DOI: https://doi.org/10.1105/tpc.105.036665
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1558535675
Verknüpfungen:→ Zeitschrift

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