Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland

• Verfasst von: Stehle, Jörg H. [VerfasserIn]
• Verfasst von: Foulkes, Nicholas S. [VerfasserIn]
• Titel: Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland
• Verf.angabe: Jörg H. Stehle, Nicholas S. Foulkes, Carlos A. Molina, Valérie Simonneaux, Paul Pévet & Paolo Sassone-Corsi
• Umfang: 7 S.
• Fussnoten: Gesehen am 12.05.2017
• Titel Quelle: Enthalten in: Nature <London>
• Jahr Quelle: 1993
• Band/Heft Quelle: 365(1993), 6444, S. 314-320
• ISSN Quelle: 1476-4687
• DOI: doi:10.1038/365314a0
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1558572996

Abstract

Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful represser of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.