Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools

• Verfasst von: Ramialison, Mirana [VerfasserIn]
• Verfasst von: Aghaallaei, Nargessadat [VerfasserIn]
• Verfasst von: Ettwiller, Laurence [VerfasserIn]
• Verfasst von: Wittbrodt, Beate [VerfasserIn]
• Verfasst von: Wittbrodt, Joachim [VerfasserIn]
• Titel: Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools
• Verf.angabe: Mirana Ramialison, Baubak Bajoghli, Narges Aghaallaei, Laurence Ettwiller, Sylvain Gaudan, Beate Wittbrodt, Thomas Czerny, Joachim Wittbrodt
• Fussnoten: Gesehen am 16.05.2017
• Titel Quelle: Enthalten in: Genome biology
• Jahr Quelle: 2008
• Band/Heft Quelle: 9(2008) Artikelnummer R145, 11 Seiten
• ISSN Quelle: 1474-760X
• DOI: doi:10.1186/gb-2008-9-10-r145
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1558680950

Abstract

The pax2/5/8 genes belonging to the PAX family of transcription factors are key developmental regulators that are involved in the patterning of various embryonic tissues. More particularly, their function in inner ear specification has been widely described. However, little is known about the direct downstream targets and, so far, no global approaches have been performed to identify these target genes in this particular tissue.