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Verfasst von:Raible, Florian [VerfasserIn]   i
 Bork, Peer [VerfasserIn]   i
 Arendt, Detlev [VerfasserIn]   i
Titel:Opsins and clusters of sensory G-protein-coupled receptors in the sea urchin genome
Verf.angabe:Florian Raible, Kristin Tessmar-Raible, Enrique Arboleda, Tobias Kaller, Peer Bork, Detlev Arendt, Maria I. Arnone
Umfang:15 S.
Fussnoten:Gesehen am 17.05.2017
Titel Quelle:Enthalten in: Developmental biology
Jahr Quelle:2006
Band/Heft Quelle:300(2006), 1, S. 461-475
ISSN Quelle:0012-1606
Abstract:Rhodopsin-type G-protein-coupled receptors (GPCRs) contribute the majority of sensory receptors in vertebrates. With 979 members, they form the largest GPCR family in the sequenced sea urchin genome, constituting more than 3% of all predicted genes. The sea urchin genome encodes at least six Opsin proteins. Of these, one rhabdomeric, one ciliary and two Go-type Opsins can be assigned to ancient bilaterian Opsin subfamilies. Moreover, we identified four greatly expanded subfamilies of rhodopsin-type GPCRs that we call sea urchin specific rapidly expanded lineages of GPCRs (surreal-GPCRs). Our analysis of two of these groups revealed genomic clustering and single-exon gene structures similar to the most expanded group of vertebrate rhodopsin-type GPCRs, the olfactory receptors. We hypothesize that these genes arose by rapid duplication in the echinoid lineage and act as chemosensory receptors of the animal. In support of this, group B surreal-GPCRs are most prominently expressed in distinct classes of pedicellariae and tube feet of the adult sea urchin, structures that have previously been shown to react to chemical stimuli and to harbor sensory neurons in echinoderms. Notably, these structures also express different opsins, indicating that sea urchins possess an intricate molecular set-up to sense their environment.
DOI:doi:10.1016/j.ydbio.2006.08.070
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Kostenfrei: Verlag: http://dx.doi.org/10.1016/j.ydbio.2006.08.070
 Kostenfrei: Verlag: http://www.sciencedirect.com/science/article/pii/S0012160606011766
 DOI: https://doi.org/10.1016/j.ydbio.2006.08.070
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1558724516
Verknüpfungen:→ Zeitschrift

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