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Verfasst von:Jékely, Gáspár [VerfasserIn]   i
 Arendt, Detlev [VerfasserIn]   i
Titel:Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium
Verf.angabe:Gáspár Jékely, Detlev Arendt
E-Jahr:2006
Jahr:24 January 2006
Umfang:8 S.
Fussnoten:Gesehen am 17.05.2017
Titel Quelle:Enthalten in: Bioessays
Ort Quelle:Hoboken, NJ [u.a.] : Wiley, 1984
Jahr Quelle:2006
Band/Heft Quelle:28(2006), 2, Seite 191-198
ISSN Quelle:0265-9247
Abstract:The cilium/flagellum is a sensory-motile organelle ancestrally present in eukaryotic cells. For assembly cilia universally rely on intraflagellar transport (IFT), a specialised bidirectional transport process mediated by the ancestral and conserved IFT complex. Based on the homology of IFT complex proteins to components of coat protein I (COPI) and clathrin-coated vesicles, we propose that the non- vesicular, membrane-bound IFT evolved as a specialised form of coated vesicle transport from a protocoatomer complex. IFT thus shares common ancestry with all protocoatomer derivatives, including all vesicle coats and the nuclear pore complex (NPC). This has major implications for the evolutionary origin of the cilium. First, it reinforces the tenet that duplication and divergence of pre-existing structures, rather than symbiosis, were the major themes during cilium evolution. Second, it suggests that the initial step in the autogenous origin of the cilium was the establishment of a membrane patch with transmembrane proteins transported by the ancestral vesicle-coating IFT complex. We propose a scenario for how the initial membrane patch gradually protruded to enhance exposure to the environment, then started to move, and finally compartmentalised to render receptor signalling and ciliary beating more efficient. BioEssays 28: 191-198, 2006. © 2006 Wiley periodicals, Inc.
DOI:doi:10.1002/bies.20369
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1002/bies.20369
 kostenfrei: Volltext: http://onlinelibrary.wiley.com/doi/10.1002/bies.20369/abstract
 DOI: https://doi.org/10.1002/bies.20369
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1558728732
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