Vertebrate-type intron-rich genes in the marine annelid platynereis dumerilii

• Verfasst von: Raible, Florian [VerfasserIn]
• Verfasst von: Bork, Peer [VerfasserIn]
• Verfasst von: Arendt, Detlev [VerfasserIn]
• Titel: Vertebrate-type intron-rich genes in the marine annelid platynereis dumerilii
• Verf.angabe: Florian Raible, Kristin Tessmar-Raible, Kazutoyo Osoegawa, Patrick Wincker, Claire Jubin, Guillaume Balavoine, David Ferrier, Vladimir Benes, Pieter de Jong, Jean Weissenbach, Peer Bork, Detlev Arendt
• Umfang: 2 S.
• Fussnoten: Gesehen am 17.05.2017
• Titel Quelle: Enthalten in: Science
• Jahr Quelle: 2005
• Band/Heft Quelle: 310(2005), 5752, S. 1325-1326
• ISSN Quelle: 1095-9203
• DOI: doi:10.1126/science.1119089
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1558730249

Abstract

Previous genome comparisons have suggested that one important trend in vertebrate evolution has been a sharp rise in intron abundance. By using genomic data and expressed sequence tags from the marine annelid Platynereis dumerilii, we provide direct evidence that about two-thirds of human introns predate the bilaterian radiation but were lost from insect and nematode genomes to a large extent. A comparison of coding exon sequences confirms the ancestral nature of Platynereis and human genes. Thus, the urbilaterian ancestor had complex, intron-rich genes that have been retained in Platynereis and human. Genes resembling intron-rich human genes are found in a marine polychaete, indicating their presence in the bilateral ancestor and their secondary loss in other invertebrates.