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| Verfasst von: | Meitinger, Franz [VerfasserIn]  |
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| | Khmelinskii, Anton [VerfasserIn] |
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| | Kurtulmus, Bahtiyar [VerfasserIn] |
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| | Palani, Saravanan [VerfasserIn] |
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| | Knop, Michael [VerfasserIn] |
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| | Pereira, Gislene [VerfasserIn] |
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| Titel: | A memory system of negative polarity cues prevents replicative aging |
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| Verf.angabe: | Franz Meitinger, Anton Khmelinskii, Sandrine Morlot, Bahtiyar Kurtulmus, Saravanan Palani, Amparo Andres-Pons, Birgit Hub, Michael Knop, Gilles Charvin, and Gislene Pereira |
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| E-Jahr: | 2014 |
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| Jahr: | November 20, 2014 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 22.05.2017 |
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| Titel Quelle: | Enthalten in: Cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
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| Jahr Quelle: | 2014 |
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| Band/Heft Quelle: | 159(2014), 5, Seite 1056-1069 |
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| ISSN Quelle: | 1097-4172 |
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| Abstract: | Summary Cdc42 is a highly conserved master regulator of cell polarity. Here, we investigated the mechanism by which yeast cells never re-establish polarity at cortical sites (cytokinesis remnants [CRMs]) that have previously supported Cdc42-mediated growth as a paradigm to mechanistically understand how Cdc42-inhibitory polarity cues are established. We revealed a two-step mechanism of loading the Cdc42 antagonist Nba1 into CRMs to mark these compartments as refractory for a second round of Cdc42 activation. Our data indicate that Nba1 together with a cortically tethered adaptor protein confers memory of previous polarization events to translate this spatial legacy into a biochemical signal that ensures the local singularity of Cdc42 activation. “Memory loss” mutants that repeatedly use the same polarity site over multiple generations display nuclear segregation defects and a shorter lifespan. Our work thus established CRMs as negative polarity cues that prevent Cdc42 reactivation to sustain the fitness of replicating cells. |
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| DOI: | doi:10.1016/j.cell.2014.10.014 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1016/j.cell.2014.10.014 |
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| | kostenfrei: Volltext: http://www.sciencedirect.com/science/article/pii/S0092867414013026 |
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| | DOI: https://doi.org/10.1016/j.cell.2014.10.014 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1558850465 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ memory system of negative polarity cues prevents replicative aging / Meitinger, Franz [VerfasserIn]; November 20, 2014 (Online-Ressource)
