| |  Online-Ressource |
|---|
| Verfasst von: | Münter, Sylvia [VerfasserIn]  |
|---|
| | Sabass, Benedikt [VerfasserIn] |
|---|
| | Kudryashev, Mikhail [VerfasserIn] |
|---|
| | Hegge, Stephan [VerfasserIn] |
|---|
| | Engel, Ulrike [VerfasserIn] |
|---|
| | Matuschewski, Kai [VerfasserIn] |
|---|
| | Schwarz, Ulrich S. [VerfasserIn] |
|---|
| | Frischknecht, Friedrich [VerfasserIn] |
|---|
| Titel: | Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites |
|---|
| Verf.angabe: | Sylvia Münter, Benedikt Sabass, Christine Selhuber-Unkel, Mikhail Kudryashev, Stephan Hegge, Ulrike Engel, Joachim P. Spatz, Kai Matuschewski, Ulrich S. Schwarz, and Friedrich Frischknecht |
|---|
| E-Jahr: | 2009 |
|---|
| Jahr: | December 16, 2009 |
|---|
| Umfang: | 12 S. |
|---|
| Teil: | volume:6 |
|---|
| | year:2009 |
|---|
| | number:6 |
|---|
| | pages:551-562 |
|---|
| | extent:12 |
|---|
| Fussnoten: | Gesehen am 22.05.2017 |
|---|
| Titel Quelle: | Enthalten in: Cell host and microbe |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2007 |
|---|
| Jahr Quelle: | 2009 |
|---|
| Band/Heft Quelle: | 6(2009), 6, Seite 551-562 |
|---|
| ISSN Quelle: | 1934-6069 |
|---|
| Abstract: | Sporozoites are the highly motile stages of the malaria parasite injected into the host's skin during a mosquito bite. In order to navigate inside of the host, sporozoites rely on actin-dependent gliding motility. Although the major components of the gliding machinery are known, the spatiotemporal dynamics of the proteins and the underlying mechanism powering forward locomotion remain unclear. Here, we show that sporozoite motility is characterized by a continuous sequence of stick-and-slip phases. Reflection interference contrast and traction force microscopy identified the repeated turnover of discrete adhesion sites as the underlying mechanism of this substrate-dependent type of motility. Transient forces correlated with the formation and rupture of distinct substrate contact sites and were dependent on actin dynamics. Further, we show that the essential sporozoite surface protein TRAP is critical for the regulated formation and rupture of adhesion sites but is dispensable for retrograde capping. |
|---|
| DOI: | doi:10.1016/j.chom.2009.11.007 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1016/j.chom.2009.11.007 |
|---|
| | Kostenfrei: Volltext: http://www.sciencedirect.com/science/article/pii/S1931312809003849 |
|---|
| | DOI: https://doi.org/10.1016/j.chom.2009.11.007 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | CELLBIO |
|---|
| | MICROBIO |
|---|
| K10plus-PPN: | 1558864814 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites / Münter, Sylvia [VerfasserIn]; December 16, 2009 (Online-Ressource)
