Pretransplant metabolic distress predicts relapse of acute myeloid leukemia after allogeneic stem cell transplantation

• Verfasst von: Dietrich, Sascha [VerfasserIn]
• Verfasst von: Radujković, Aleksandar [VerfasserIn]
• Verfasst von: Krämer, Alwin [VerfasserIn]
• Verfasst von: Hegenbart, Ute [VerfasserIn]
• Verfasst von: Ho, Anthony Dick [VerfasserIn]
• Verfasst von: Dreger, Peter [VerfasserIn]
• Verfasst von: Luft, Thomas [VerfasserIn]
• Titel: Pretransplant metabolic distress predicts relapse of acute myeloid leukemia after allogeneic stem cell transplantation
• Verf.angabe: Sascha Dietrich, Aleksandar Radujkovic, Friedrich Stölzel, Christine S. Falk, Axel Benner, Markus Schaich, Martin Bornhäuser, Gerhard Ehninger, Alwin Krämer, Ute Hegenbart, Anthony D. Ho, Peter Dreger, Thomas Luft
• Umfang: 7 S.
• Fussnoten: Gesehen am 22.05.2017
• Titel Quelle: Enthalten in: Transplantation
• Jahr Quelle: 2015
• Band/Heft Quelle: 99(2015), 5, S. 1065-1071
• ISSN Quelle: 1534-6080
• DOI: doi:10.1097/TP.0000000000000471
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 155888579X

Abstract

The impact of nutritional status on outcome of allogeneic stem cell transplantation (alloSCT) is controversial. This study investigates the influence of pretransplant weight loss and serologic indicators of nutritional homeostasis on relapse and death of acute myeloid leukemia (AML) after alloSCT. Pretransplant weight loss along with serum levels of total serum protein (TSP), albumin, C-reactive protein, and leptin were collected retrospectively in a training cohort (n = 149) and correlated with clinical outcome. Metabolic risk groups were defined and tested in an independent validation cohort (n = 167). We identified pretransplant weight loss and TSP as strong independent predictors of relapse and death. Patients in the metabolic high-risk group (low TSP and weight loss) had an increased risk for relapse (P = 0.0002) and death (P = 0.002), but a similar risk for acute graft-versus-host disease. Weight loss coincided with reduced pretransplant serum leptin levels. The adverseinfluence of weight loss and high metabolic risk on relapse and overall survival could be confirmed in the validation cohort and similarly in patients with less than or more than 5% blasts before alloSCT. Multivariate analysis of both cohorts revealed a hazard ratio for relapse of 7.78 (2.59-23.36, P = 0.0003) in the metabolic high risk group. Altered nutritional homeostasis before alloSCT correlates with recurrence of AML after transplantation. Studies addressing pretransplant nutritional interventions to reduce AML relapse rates are warranted.