Distribution of the CCR5-delta32 deletion in Southwest Germany

• Verfasst von: Hütter, Gero [VerfasserIn]
• Verfasst von: Blüthgen, Christian [VerfasserIn]
• Verfasst von: Elvers-Hornung, Susanne [VerfasserIn]
• Verfasst von: Klüter, Harald [VerfasserIn]
• Verfasst von: Bugert, Peter [VerfasserIn]
• Titel: Distribution of the CCR5-delta32 deletion in Southwest Germany
• Verf.angabe: Gero Hütter, Christian Blüthgen, Susanne Elvers-Hornung, Harald Klüter, Peter Bugert
• E-Jahr: 2015
• Jahr: 1. August 2015
• Umfang: 7 S.
• Fussnoten: Gesehen am 23.05.2017
• Titel Quelle: Enthalten in: Journal of biological and clinical anthropology
• Ort Quelle: Stuttgart : Schweizerbart science publishers, 1924
• Jahr Quelle: 2015
• Band/Heft Quelle: 72(2015), 3, Seite 303-309
• ISSN Quelle: 2363-7099
• DOI: doi:10.1127/anthranz/2015/0479
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Baden-Wuerttemberg
• Sach-SW: Ccr5
• Sach-SW: Ccr5-Delta32
• Sach-SW: Distribution
• Sach-SW: Hiv-1
• K10plus-PPN: 155892809X

Abstract

A 32 base pair deletion in the c-c chemokine receptor gene 5 (CCR5) leads to an inactive protein. Carriers of this deletion must have had a selective advantage because the allelic frequency of the CCR5-delat32 mutation is much higher than expected. Furthermore, there is a decline from North to South Europe. For Germany there are just very few cross-sectional surveys available. Here we investigated a large number of healthy blood donors from Northern Baden-Wuerttemberg. We observed an allelic frequency of 9.21 % of the CCR5-delta32 deletion. The distribution did not follow the Hardy-Weinberg equilibrium suggesting that homozygous carriers of the deletion were overrepresented in this random sample.