Information transfer in signaling pathways

• Verfasst von: Pahle, Jürgen [VerfasserIn]
• Verfasst von: Kummer, Ursula [VerfasserIn]
• Titel: Information transfer in signaling pathways
• Titelzusatz: a study using coupled simulated and experimental data
• Verf.angabe: Jürgen Pahle, Anne K. Green, C. Jane Dixon and Ursula Kummer
• Fussnoten: Gesehen am 24.05.2017
• Titel Quelle: Enthalten in: BMC bioinformatics
• Jahr Quelle: 2008
• Band/Heft Quelle: 9(2008) Artikel-Nummer 130, 14 Seiten
• ISSN Quelle: 1471-2105
• DOI: doi:10.1186/1471-2105-9-139
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1558951113

Abstract

The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown. Since quite diverse information has to be transported by one and the same signaling cascade (e.g. in case of different agonists), it is clear that the underlying mechanism is more complex than a simple binary switch which relies on the mere presence or absence of a particular species. Therefore, finding means to analyze the information transferred will help in deciphering how information is processed exactly in the cell. Using the information-theoretic measure transfer entropy, we studied the properties of information transfer in an example case, namely calcium signaling under different cellular conditions. Transfer entropy is an asymmetric and dynamic measure of the dependence of two (nonlinear) stochastic processes. We used calcium signaling since it is a well-studied example of complex cellular signaling. It has been suggestedthat specific information is encoded in the amplitude, frequency and waveform of the oscillatory Ca2+-signal.