Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Karakhanova, Svetlana [VerfasserIn]   i
 Link, Julia [VerfasserIn]   i
 Heinrich, Moritz [VerfasserIn]   i
 Shevchenko, Ivan [VerfasserIn]   i
 Yang, Yuhui [VerfasserIn]   i
 Hassenpflug, Matthias [VerfasserIn]   i
 Ahn, Katharina von [VerfasserIn]   i
 Maier, Caroline [VerfasserIn]   i
 Umansky, Viktor [VerfasserIn]   i
 Werner, Jens [VerfasserIn]   i
 Bazhin, Alexandr V. [VerfasserIn]   i
Titel:Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer
Titelzusatz:importance of myeloid-derived suppressor cells
Verf.angabe:Svetlana Karakhanova, Julia Link, Moritz Heinrich, Ivan Shevchenko, Yuhui Yang, Matthias Hassenpflug, Henriette Bunge, Katharina von Ahn, Ramona Brecht, Andreas Mathes, Caroline Maier, Viktor Umansky, Jens Werner, Alexandr V. Bazhin
E-Jahr:2015
Jahr:22 Jan 2015
Umfang:14 S.
Fussnoten:Gesehen am 24.05.2017
Titel Quelle:Enthalten in: OncoImmunology
Ort Quelle:Abingdon : Taylor & Franics, 2012
Jahr Quelle:2015
Band/Heft Quelle:4(2015,4) Artikel-Nummer e998519, 14 Seiten
ISSN Quelle:2162-402X
Abstract:Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. PDAC cells activate tumor-specific immune responses but simultaneously trigger a strong immunosuppression. We showed that PDAC cells produce high amount of chronic inflammatory mediators and PDAC tumors build an immunosuppressive cytokine milieu, which correlates with tumor progression. We observed a low frequency of dendritic cells (DC) and a pronounced accumulation of macrophages and myeloid-derived suppressor cells (MDSC) in murine PDAC tumors. A strong accumulation of MDSC has also been demonstrated in the peripheral blood of resected PDAC patients. While DC and macrophages seem not to play a significant role in this PDAC model in the context of immunosuppression, MDSC are highly suppressive, and their accumulation is associated with an increase in intratumoral VEGF concentration during the PDAC progression. Application of the phosphodiesterase-5 inhibitor sildenafil led to a prolonged survival of PDAC-bearing female mice, which was due to the decrease in MDSC frequencies and in the systemic VEGF level. This led to a restoration of anticancer immune responses, manifested in the recovery of T lymphocyte functions and in an increase in the frequency of conventional CD4+ T cells in tumors and IFNγ level in serum of PDAC-bearing mice. Thus, MDSC are strongly involved in the PDAC-associated immunosuppression and that their depletion could create new approaches for therapy of PDAC.
DOI:doi:10.1080/2162402X.2014.998519
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1080/2162402X.2014.998519
 DOI: https://doi.org/10.1080/2162402X.2014.998519
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:ARG-1, arginase-1
 DC, dendritic cells
 immune suppression
 MDSC
 MDSC, myeloid-derived suppressor cells
 NO, nitric oxide
 orthotopic Panc02 model
 pancreatic adenocarcinoma
 PDAC, pancreatic ductal adenocarcinoma
 TIL, tumor-infiltrating leukocytes
 Tregs, regulatory T cells
K10plus-PPN:1558996133
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68122760   QR-Code
zum Seitenanfang