The transforming growth factor-βs

• Verfasst von: Böttner, Martina [VerfasserIn]
• Verfasst von: Krieglstein, Kerstin [VerfasserIn]
• Verfasst von: Unsicker, Klaus [VerfasserIn]
• Titel: The transforming growth factor-βs
• Titelzusatz: structure, signaling, and roles in nervous system development and functions
• Verf.angabe: Martina Böttner, Kerstin Krieglstein, and Klaus Unsicker
• Umfang: 14 S.
• Fussnoten: Gesehen am 02.06.2017
• Titel Quelle: Enthalten in: Journal of neurochemistry
• Jahr Quelle: 2000
• Band/Heft Quelle: 75(2000), 6, S. 2227-2240
• ISSN Quelle: 1471-4159
• DOI: doi:10.1046/j.1471-4159.2000.0752227.x
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1559432616

Abstract

Abstract: Transforming growth factor-βs (TGF-βs) are amongthe most widespread and versatile cytokines. Here, we first provide a briefoverview of their molecular biology, biochemistry, and signaling. We thenreview distribution and functions of the three mammalian TGF-β isoforms,β1, β2, and β3, and their receptors in the developing and adultnervous system. Roles of TGF-βs in the regulation of radial glia,astroglia, oligodendroglia, and microglia are addressed. Finally, we reviewthe current state of knowledge concerning the roles of TGF-βs incontrolling neuronal performances, including the regulation of proliferationof neuronal precursors, survival/death decisions, and neuronaldifferentiation.