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Verfasst von:Triphan, Simon M. F. [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
Titel:Oxygen enhanced lung MRI by simultaneous measurement of T1 and T2* during free breathing using ultrashort TE
Verf.angabe:Simon M.F. Triphan, Dipl Phys, Felix A. Breuer, PhD, Daniel Gensler, Dipl Phys, Hans-Ulrich Kauczor, MD and Peter M. Jakob, PhD
Umfang:7 S.
Fussnoten:Gesehen am 07.06.2017
Titel Quelle:Enthalten in: Journal of magnetic resonance imaging
Jahr Quelle:2015
Band/Heft Quelle:41(2015), 6, S. 1708-1714
ISSN Quelle:1522-2586
Abstract:Purpose: to provide a robust method for the simultaneous quantification of T1 and T2* in the human lung during free breathing. Breathing pure oxygen accelerates T1 and T2* relaxation in the lung. While T1 shortening reflects an increased amount of dissolved molecular oxygen in lung tissue, T2* shortening shows an increased concentration of oxygen in the alveolar gas. Therefore, both parameters reflect different aspects of the oxygen uptake and provide complementary lung functional information.Materials and Methods: a segmented inversion recovery Look-Locker multiecho sequence based on a multiecho 2D ultrashort TE (UTE) was employed for simultaneous T1 and T2* quantification. The radial projections follow a modified golden angle ordering, allowing for respiratory self-gating and thus the reconstruction of a series of differently T1 and T2*-weighted images in arbitrary breathing states. The method was evaluated in nine healthy volunteers while breathing room air and pure oxygen, with two volunteers examined at five oxygen concentrations. Results: relative differences of ΔT1 between 7.9% and 12.7% and of ΔT2* between 13.2% and 6.0% were found. Conclusion: the proposed method provides inherently coregistered, quantitative T1 and T2* maps in both expiration and inspiration from a single measurement acquired during free breathing and is thus well suited for clinical application.J. Magn. Reson. Imaging 2015;41:1708-1714. © 2014 Wiley Periodicals, Inc.
DOI:doi:10.1002/jmri.24692
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1002/jmri.24692
 Verlag: http://onlinelibrary.wiley.com/doi/10.1002/jmri.24692/abstract
 DOI: https://doi.org/10.1002/jmri.24692
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1559524103
Verknüpfungen:→ Zeitschrift

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