Observations on the structure of myelin lacking the major proteolipid protein

• Verfasst von: Yool, Donald A. [VerfasserIn]
• Verfasst von: Klugmann, Matthias [VerfasserIn]
• Verfasst von: Nave, Klaus-Armin [VerfasserIn]
• Titel: Observations on the structure of myelin lacking the major proteolipid protein
• Titelzusatz: scientific correspondence
• Verf.angabe: D. Yool, M. Klugmann, J.A. Barrie, M.C. McCulloch, K.-A. Nave, I.R. Griffiths
• Umfang: 4 S.
• Fussnoten: Gesehen am 08.06.2017
• Titel Quelle: Enthalten in: Neuropathology & applied neurobiology
• Jahr Quelle: 2002
• Band/Heft Quelle: 28(2002), 1, S. 75-78
• ISSN Quelle: 1365-2990
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1559588225

Abstract

Proteolipid protein (PLP) and its smaller DM20 isoform account for approximately 50% of protein in central nervous system myelin, suggesting an important role in myelination. PLP/DM20-deficient mice generated by gene targeting techniques assemble large amounts of myelin, although it displays a variety of defects at the intraperiod line (IPL) when prepared for conventional electron microscopy. The appearance of the PLP/DM20-deficient myelin prepared by freeze substitution showed a similar range of IPL defects to that prepared by conventional fixation and also included regions containing a normal IPL.