Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Horn, Dominik [VerfasserIn]   i
 Heß, Jochen [VerfasserIn]   i
 Freier, Kolja [VerfasserIn]   i
 Hoffmann, Jürgen [VerfasserIn]   i
 Freudlsperger, Christian [VerfasserIn]   i
Titel:Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma
Verf.angabe:Dominik Horn, Jochen Hess, Kolja Freier, Jürgen Hoffmann & Christian Freudlsperger
Umfang:11 S.
Fussnoten:Gesehen am 13.06.2017
Titel Quelle:Enthalten in: Expert opinion on therapeutic targets
Jahr Quelle:2015
Band/Heft Quelle:19(2015), 6, S. 795-805
ISSN Quelle:1744-7631
Abstract:Introduction: Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by high resistance to radiotherapy, which critically depends on both altered signaling pathways within tumor cells and their dynamic interaction with the tumor microenvironment.Areas covered: This review covers EGFR-phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT)-mechanistic target of rapamycin (mTOR) signaling in HNSCC. The role of each pathway node in radioresistance is discussed. Preclinical and clinical innovative aspects of targeting EGFR-PI3K-AKT and mTOR are demonstrated. Ongoing clinical trials and future perspectives are presented.Expert opinion: Different cellular signaling pathways seem to mediate radioresistance in advanced HNSCC and various molecular targeted therapies are currently being investigated to sensitize tumor cells to radiotherapy. Recently, new insights in the mutational landscape of HNSCC unraveled critical alterations in putative oncogenes and tumor suppressor genes and have emphasized the importance of PI3K and the corresponding upstream and downstream signaling pathways in pathogenesis and treatment response. The frequent activation of the EGFR-PI3K-AKT-mTOR pathway in HNSCC and its implication in the context of radiosensitivity make this pathway one of the most promising targets in the therapy of HNSCC patients. Clinical studies targeting EGFR and mTOR in combination with radiotherapy are under investigation.
DOI:doi:10.1517/14728222.2015.1012157
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1517/14728222.2015.1012157
 DOI: https://doi.org/10.1517/14728222.2015.1012157
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:155971364X
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68128120   QR-Code
zum Seitenanfang