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Verfasst von:Green, Anna C. [VerfasserIn]   i
 Marx, Alexander [VerfasserIn]   i
 Ströbel, Philipp [VerfasserIn]   i
Titel:Type A and AB thymomas
Titelzusatz:histological features associated with increased stage
Verf.angabe:Anna C. Green, Alexander Marx, Philipp Ströbel, Marianne Mason, Eric Lim, Simon Jordan, George Ladas, Michael Dusmet, Alexandra Rice & Andrew G. Nicholson
Jahr:2015
Umfang:8 S.
Fussnoten:Published online: 11 August 2014 ; Gesehen am 06.07.2017
Titel Quelle:Enthalten in: Histopathology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1977
Jahr Quelle:2015
Band/Heft Quelle:66(2015), 6, Seite 884-891
ISSN Quelle:1365-2559
Abstract:Aims The current WHO classification of thymic epithelial neoplasms describes type A and type AB thymomas as behaving ‘like benign neoplasms’. However, recent published data suggest that rare cases may show more aggressive behaviour. The aim of this study was to assess the frequency of atypical cases, and to determine whether atypia is associated with more advanced disease. Methods and results One hundred and twenty-one thymomas (type A, n = 68; type AB, n = 53) were retrospectively reviewed for ‘atypical’ features (nuclear pleomorphism, mitotic activity, and necrosis). Logistic regression was used to ascertain the association with increasing Masaoka-Koga stage. Where available, follow-up data were also reviewed. There were 72 stage I, 42 stage II, five stage III and two stage IV tumours. Only the presence of necrosis showed a significant association with increased stage in univariate and multivariate analysis. Nuclear atypia and increased mitotic activity were not associated with increasing stage of disease. Conclusions Our data support the concept of there being more aggressive atypical variants of both type A and type AB thymoma, and suggest that the presence of necrosis could be used to predict aggressive behaviour.
DOI:doi:10.1111/his.12512
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1111/his.12512
 Volltext: http://onlinelibrary.wiley.com/doi/10.1111/his.12512/abstract
 DOI: https://doi.org/10.1111/his.12512
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:atypia
 grade
 Masaoka-Koga
 stage
 thymoma
K10plus-PPN:1560523069
Verknüpfungen:→ Zeitschrift

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