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Verfasst von:Hirjak, Dusan [VerfasserIn]   i
 Wolf, Robert Christian [VerfasserIn]   i
 Remmele, Barbara [VerfasserIn]   i
 Thomann, Anne K. [VerfasserIn]   i
 Kubera, Katharina Maria [VerfasserIn]   i
 Schröder, Johannes [VerfasserIn]   i
 Thomann, Philipp [VerfasserIn]   i
Titel:Hippocampal formation alterations differently contribute to autobiographic memory deficits in mild cognitive impairment and Alzheimer's disease
Verf.angabe:Dusan Hirjak, Robert C. Wolf, Barbara Remmele, Ulrich Seidl, Anne K. Thomann, Katharina M. Kubera, Johannes Schröder, Klaus H. Maier-Hein, Philipp A. Thomann
E-Jahr:2017
Jahr:4 April 2017
Umfang:14 S.
Fussnoten:Gesehen am 06.07.2017
Titel Quelle:Enthalten in: Hippocampus
Ort Quelle:New York, NY [u.a.] : Wiley, 1991
Jahr Quelle:2017
Band/Heft Quelle:27(2017), 6, Seite 702-715
ISSN Quelle:1098-1063
Abstract:Autobiographical memory (AM) is part of declarative memory and includes both semantic and episodic aspects. AM deficits are among the major complaints of patients with Alzheimer's disease (AD) even in early or preclinical stages. Previous MRI studies in AD patients have showed that deficits in semantic and episodic AM are associated with hippocampal alterations. However, the question which specific hippocampal subfields and adjacent extrahippocampal structures contribute to deficits of AM in individuals with mild cognitive impairment (MCI) and AD patients has not been investigated so far. Hundred and seven participants (38 AD patients, 38 MCI individuals and 31 healthy controls [HC]) underwent MRI at 3 Tesla. AM was assessed with a semi-structured interview (E-AGI). FreeSurfer 5.3 was used for hippocampal parcellation. Semantic and episodic AM scores were related to the volume of 5 hippocampal subfields and cortical thickness in the parahippocampal and entorhinal cortex. Both semantic and episodic AM deficits were associated with bilateral hippocampal alterations. These associations referred mainly to CA1, CA2-3, presubiculum, and subiculum atrophy. Episodic, but not semantic AM loss was associated with cortical thickness reduction of the bilateral parahippocampal and enthorinal cortex. In MCI individuals, episodic, but not semantic AM deficits were associated with alterations of the CA1, presubiculum and subiculum. Our findings support the crucial role of CA1, presubiculum, and subiculum in episodic memory. The present results implicate that in MCI individuals, semantic and episodic AM deficits are subserved by distinct neuronal systems.
DOI:doi:10.1002/hipo.22726
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1002/hipo.22726
 Volltext: http://onlinelibrary.wiley.com/doi/10.1002/hipo.22726/abstract
 DOI: https://doi.org/10.1002/hipo.22726
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Alzheimer's disease
 autobiographical memory
 Freesurfer
 hippocampus
 Mild cognitive impairment
 MRI
K10plus-PPN:1560544651
Verknüpfungen:→ Zeitschrift

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