Analytical model for macromolecular partitioning during yeast cell division

• Verfasst von: Kinkhabwala, Ali [VerfasserIn]
• Verfasst von: Khmelinskii, Anton [VerfasserIn]
• Verfasst von: Knop, Michael [VerfasserIn]
• Titel: Analytical model for macromolecular partitioning during yeast cell division
• Verf.angabe: Ali Kinkhabwala, Anton Khmelinskii and Michael Knop
• Fussnoten: Gesehen am 09.08.2017
• Titel Quelle: Enthalten in: BMC Biophysics
• Jahr Quelle: 2014
• Band/Heft Quelle: 7(2014) Artikel-Nummer 10, 10 Seiten
• ISSN Quelle: 2046-1682
• DOI: doi:10.1186/s13628-014-0010-6
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1562281941

Abstract

Asymmetric cell division, whereby a parent cell generates two sibling cells with unequal content and thereby distinct fates, is central to cell differentiation, organism development and ageing. Unequal partitioning of the macromolecular content of the parent cell which includes proteins, DNA, RNA, large proteinaceous assemblies and organelles can be achieved by both passive (e.g. diffusion, localized retention sites) and active (e.g. motor-driven transport) processes operating in the presence of external polarity cues, internal asymmetries, spontaneous symmetry breaking, or stochastic effects. However, the quantitative contribution of different processes to the partitioning of macromolecular content is difficult to evaluate.