Segregation of yeast nuclear pores

• Verfasst von: Khmelinskii, Anton [VerfasserIn]
• Verfasst von: Keller, Philipp J. [VerfasserIn]
• Verfasst von: Lorenz, Holger [VerfasserIn]
• Verfasst von: Schiebel, Elmar [VerfasserIn]
• Verfasst von: Knop, Michael [VerfasserIn]
• Titel: Segregation of yeast nuclear pores
• Verf.angabe: Anton Khmelinskii, Philipp J. Keller, Holger Lorenz, Elmar Schiebel & Michael Knop
• E-Jahr: 2010
• Jahr: 22 July 2010
• Umfang: 2 S.
• Fussnoten: Gesehen am 11.08.2017
• Titel Quelle: Enthalten in: Nature
• Ort Quelle: London [u.a.] : Nature Publ. Group, 1869
• Jahr Quelle: 2010
• Band/Heft Quelle: 466(2010), 7305, Seite E1-E2
• ISSN Quelle: 1476-4687
• DOI: doi:10.1038/nature09255
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cell biology
• K10plus-PPN: 156237544X

Abstract

Arising from: Z. Shcheprova, S. Baldi, S. B. Frei, G. Gonnet & Y. Barral Nature 454, 728-734 (2008). During mitosis in Saccharomyces cerevisiae, senescence factors such as extrachromosomal ribosomal DNA circles (ERCs) are retained in the mother cell and excluded from the bud/daughter cell. Shcheprova et al. proposed a model suggesting segregation of ERCs through their association with nuclear pore complexes (NPCs) and retention of pre-existing NPCs in the mother cell during mitosis. However, this model is inconsistent with previous data and we demonstrate here that NPCs do efficiently migrate from the mother into the bud. Therefore, binding to NPCs does not seem to explain the retention of ERCs in the mother cell.