Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Keller, Philipp J. [VerfasserIn]  |
| Knop, Michael [VerfasserIn]  |
Titel: | Evolution of mutational robustness in the yeast genome |
Titelzusatz: | a link to essential genes and meiotic recombination hotspots |
Verf.angabe: | Philipp J. Keller, Michael Knop |
Fussnoten: | Gesehen am 14.08.2017 |
Titel Quelle: | Enthalten in: Public Library of Science: PLoS Genetics |
Jahr Quelle: | 2009 |
Band/Heft Quelle: | 5(2009,6) Artikel-Nummer e1000533, 20 Seiten |
ISSN Quelle: | 1553-7404 |
Abstract: | Deleterious mutations inevitably emerge in any evolutionary process and are speculated to decisively influence the structure of the genome. Meiosis, which is thought to play a major role in handling mutations on the population level, recombines chromosomes via non-randomly distributed hot spots for meiotic recombination. In many genomes, various types of genetic elements are distributed in patterns that are currently not well understood. In particular, important (essential) genes are arranged in clusters, which often cannot be explained by a functional relationship of the involved genes. Here we show by computer simulation that essential gene (EG) clustering provides a fitness benefit in handling deleterious mutations in sexual populations with variable levels of inbreeding and outbreeding. We find that recessive lethal mutations enforce a selective pressure towards clustered genome architectures. Our simulations correctly predict (i) the evolution of non-random distributionsof meiotic crossovers, (ii) the genome-wide anti-correlation of meiotic crossovers and EG clustering, (iii) the evolution of EG enrichment in pericentromeric regions and (iv) the associated absence of meiotic crossovers (cold centromeres). Our results furthermore predict optimal crossover rates for yeast chromosomes, which match the experimentally determined rates. Using a Saccharomyces cerevisiae conditional mutator strain, we show that haploid lethal phenotypes result predominantly from mutation of single loci and generally do not impair mating, which leads to an accumulation of mutational load following meiosis and mating. We hypothesize that purging of deleterious mutations in essential genes constitutes an important factor driving meiotic crossover. Therefore, the increased robustness of populations to deleterious mutations, which arises from clustered genome architectures, may provide a significant selective force shaping crossover distribution. Our analysis reveals a new aspectof the evolution of genome architectures that complements insights about molecular constraints, such as the interference of pericentromeric crossovers with chromosome segregation. |
DOI: | doi:10.1371/journal.pgen.1000533 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
DOI: https://doi.org/10.1371/journal.pgen.1000533 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1562393650 |
Verknüpfungen: | → Zeitschrift |
Evolution of mutational robustness in the yeast genome / Keller, Philipp J. [VerfasserIn] (Online-Ressource)
68149713