Emergence of heterogeneity in acute leukemias

• Verfasst von: Stiehl, Thomas [VerfasserIn]
• Verfasst von: Lutz, Christoph [VerfasserIn]
• Verfasst von: Marciniak-Czochra, Anna [VerfasserIn]
• Titel: Emergence of heterogeneity in acute leukemias
• Verf.angabe: Thomas Stiehl, Christoph Lutz, Anna Marciniak-Czochra
• Fussnoten: Gesehen am 16.08.2017
• Titel Quelle: Enthalten in: Biology direct
• Jahr Quelle: 2016
• Band/Heft Quelle: 11(2016) Artikel-Nummer 51, 19 Seiten
• ISSN Quelle: 1745-6150
• DOI: doi:10.1186/s13062-016-0154-1
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1562476092

Abstract

Leukemias are malignant proliferative disorders of the blood forming system. Sequencing studies demonstrate that the leukemic cell population consists of multiple clones. The genetic relationship between the different clones, referred to as the clonal hierarchy, shows high interindividual variability. So far, the source of this heterogeneity and its clinical relevance remain unknown. We propose a mathematical model to study the emergence and evolution of clonal heterogeneity in acute leukemias. The model allows linking properties of leukemic clones in terms of self-renewal and proliferation rates to the structure of the clonal hierarchy.