Status: Bibliographieeintrag
Standort: ---
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| Online-Ressource |
Verfasst von: | Jerabek, Hansjörg [VerfasserIn]  |
| Heermann, Dieter W. [VerfasserIn]  |
Titel: | Expression-dependent folding of interphase chromatin |
Verf.angabe: | Hansjoerg Jerabek, Dieter W. Heermann |
Fussnoten: | Gesehen am 18.08.2017 |
Titel Quelle: | Enthalten in: Public Library of Science: PLoS one |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 7(2012,5) Artikel-Nummer e37525, 10 Seiten |
ISSN Quelle: | 1932-6203 |
Abstract: | Multiple studies suggest that chromatin looping might play a crucial role in organizing eukaryotic genomes. To investigate the interplay between the conformation of interphase chromatin and its transcriptional activity, we include information from gene expression profiles into a polymer model for chromatin that incorporates genomic loops. By relating loop formation to transcriptional activity, we are able to generate chromosome conformations whose structural and topological properties are consistent with experimental data. The model particularly allows to reproduce the conformational variations that are known to occur between highly and lowly expressed chromatin regions. As previously observed in experiments, lowly expressed regions of the simulated polymers are much more compact. Due to the changes in loop formation, the distributions of chromatin loops are also expression-dependent and exhibit a steeper decay in highly active regions. As a results of entropic interaction between differently looped parts of the chromosome, we observe topological alterations leading to a preferential positioning of highly transcribed loci closer to the surface of the chromosome territory. Considering the diffusional behavior of the chromatin fibre, the simulations furthermore show that the higher the expression level of specific parts of the chromatin fibre is, the more dynamic they are. The results exhibit that variations of loop formation along the chromatin fibre, and the entropic changes that come along with it, do not only influence the structural parameters on the local scale, but also effect the global chromosome conformation and topology. |
DOI: | doi:10.1371/journal.pone.0037525 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Kostenfrei: Verlag: http://dx.doi.org/10.1371/journal.pone.0037525 |
| Kostenfrei: Verlag: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037525 |
| DOI: https://doi.org/10.1371/journal.pone.0037525 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1562542052 |
Verknüpfungen: | → Zeitschrift |
Expression-dependent folding of interphase chromatin / Jerabek, Hansjörg [VerfasserIn] (Online-Ressource)
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