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Verfasst von:Desrivières, Sylvane [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
 Mann, Karl [VerfasserIn]   i
 Rietschel, Marcella [VerfasserIn]   i
Titel:Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents
Verf.angabe:S Desrivières, A Lourdusamy, C Tao, R Toro, T Jia, E Loth, LM Medina, A Kepa, A Fernandes, B Ruggeri, FM Carvalho, G Cocks, T Banaschewski, GJ Barker, ALW Bokde, C Büchel, PJ Conrod, H Flor, A Heinz, J Gallinat, H Garavan, P Gowland, R Brühl, C Lawrence, K Mann, MLP Martinot, F Nees, M Lathrop, J-B Poline, M Rietschel, P Thompson, M Fauth-Bühler, MN Smolka, Z Pausova, T Paus, J Feng, G Schumann, and the IMAGEN Consortium
E-Jahr:2015
Jahr:11 February 2014
Jahr des Originals:2014
Umfang:12 S.
Fussnoten:Gesehen am 23.08.2017
Titel Quelle:Enthalten in: Molecular psychiatry
Ort Quelle:[London] : Springer Nature, 1997
Jahr Quelle:2015
Band/Heft Quelle:20(2015), 2, Seite 263-274
ISSN Quelle:1476-5578
Abstract:Despite the recognition that cortical thickness is heritable and correlates with intellectual ability in children and adolescents, the genes contributing to individual differences in these traits remain unknown. We conducted a large-scale association study in 1583 adolescents to identify genes affecting cortical thickness. Single-nucleotide polymorphisms (SNPs; n=54 837) within genes whose expression changed between stages of growth and differentiation of a human neural stem cell line were selected for association analyses with average cortical thickness. We identified a variant, rs7171755, associating with thinner cortex in the left hemisphere (P=1.12 × 10−7), particularly in the frontal and temporal lobes. Localized effects of this SNP on cortical thickness differently affected verbal and nonverbal intellectual abilities. The rs7171755 polymorphism acted in cis to affect expression in the human brain of the synaptic cell adhesion glycoprotein-encoding gene NPTN. We also found that cortical thickness and NPTN expression were on average higher in the right hemisphere, suggesting that asymmetric NPTN expression may render the left hemisphere more sensitive to the effects of NPTN mutations, accounting for the lateralized effect of rs7171755 found in our study. Altogether, our findings support a potential role for regional synaptic dysfunctions in forms of intellectual deficits.
DOI:doi:10.1038/mp.2013.197
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1038/mp.2013.197
 Volltext: http://www.nature.com.ezproxy.medma.uni-heidelberg.de/mp/journal/v20/n2/full/mp2013197a.html?foxtrotcallback=true
 DOI: https://doi.org/10.1038/mp.2013.197
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:adolescent
 cortical thickness
 intelligence
 lateralization
 neural stem cell
 neuroimaging
K10plus-PPN:1562680269
Verknüpfungen:→ Zeitschrift

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