Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma

• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Titel: Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma
• Titelzusatz: the Beijing Eye Study 2011
• Verf.angabe: Jost B. Jonas, Ning Li Wang, Ya Xing Wang, Qi Sheng You, Xiao Bin Xie, Di Ya Yang and Liang Xu
• E-Jahr: 2015
• Jahr: 24 June 2014
• Jahr des Originals: 2014
• Umfang: 7 S.
• Fussnoten: Gesehen am 24.08.2017
• Titel Quelle: Enthalten in: Acta ophthalmologica
• Ort Quelle: Oxford : Blackwell, 2008
• Jahr Quelle: 2015
• Band/Heft Quelle: 93(2015), 1, Seite e7-e13
• ISSN Quelle: 1755-3768
• DOI: doi:10.1111/aos.12480
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Beijing Eye Study
• Sach-SW: cerebrospinal fluid pressure
• Sach-SW: glaucoma
• Sach-SW: intraocular pressure
• Sach-SW: open-angle glaucoma
• Sach-SW: trans-lamina cribrosa pressure difference
• K10plus-PPN: 1562710222

Abstract

Purpose: To examine whether an estimated trans-lamina cribrosa pressure difference (TLCPD) better than intraocular pressure (IOP) correlated with markers for glaucoma. Methods: The population-based Beijing Eye Study 2011 included 3468 individuals. Cerebrospinal fluid pressure (CSFP) was calculated as CSFP [mmHg] = 0.44 × Body Mass Index [kg/m2] + 0.16 × Diastolic Blood Pressure [mmHg] − 0.18 × Age [Years] − 1.91. TLCPD was IOP-CSFP. Results: In the non-glaucomatous population, mean TLCPD was 5.8 ± 4.1 mmHg and mean estimated CSFP was 8.9 ± 3.7 mmHg. IOP was higher (p = 0.008), CSFP was lower (p < 0.001), and TLCPD was (p < 0.001) higher in the glaucoma group than in the non-glaucomatous group. The intergroup difference was highest for TLCPD (2.1 mmHg) followed by CSFP (1.7 mmHg) and IOP (0.4 mmHg). Open-angle glaucoma (OAG) was associated with higher TLCPD [p < 0.001; odds ratio (OR): 1.14; 95% confidence intervals (CI): 1.08, 1.19] but not with IOP (p = 0.22; OR: 0.96; 95% CI: 0.89, 1.03). In contrast, angle-closure glaucoma (ACG) was associated with higher IOP (p = 0.03; B: 0.14; OR: 1.15; 95% CI: 1.01, 1.30) but not with TLCPD (p = 0.98), after adjustment for age and anterior chamber depth. Retinal nerve fibre layer thickness was associated with lower TLCPD (p = 0.036) but not with IOP (p = 0.96), after adjusting for gender, age, region of habitation, optic disc area and refractive error. Neuroretinal area and volume were associated with smaller TLCPD (p = 0.002, and p < 0.001, respectively), after adjusting for gender, optic disc area and refractive error, but not with IOP (p = 0.43 and p = 0.25, resp.). Conclusions: In OAG, but not in ACG, calculated TLCPD versus IOP showed a better association with glaucoma presence and amount of glaucomatous optic neuropathy. It supports the notion of a potential role of low CSFP in the pathogenesis of OAG.